Skip to main content
SpringerLink
Log in

Factor XI Deficiency

  • Chapter
  • First Online:
Consults in Obstetric Anesthesiology

  • 106 Accesses

Abstract

This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of factor XI deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with factor XI deficiency, including treatment of acute hemorrhage.

Please also refer to chapter 88 “Inherited Bleeding Disorders”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Pike G, Bolton-Maggs P. Factor deficiencies in pregnancy. Hematol Oncol Clin N Am. 2011;25:359–78.

    Article  Google Scholar 

  2. Peyvandi F, Garagiola I, Menegatti M. Gynecological and obstetrical manifestations of inherited bleeding disorders in women. J Thromb Haemost. 2011;9:236–45.

    Article  Google Scholar 

  3. Katz D, Beilin Y. Disorders of coagulation in pregnancy. Br J Anaesth. 2015;115:ii75–88.

    Article  Google Scholar 

  4. Silver R, Major H. Maternal coagulation disorders and postpartum hemorrhage. Clin Obstet Gynecol. 2010;53:252–64.

    Article  Google Scholar 

  5. Bolton-Maggs P. Bleeding problems in factor XI deficient women. Haemophilia. 1999;5:155–9.

    Article  CAS  Google Scholar 

  6. David A, Paterson-Brown S, Letsky E. Factor XI deficiency presenting in pregnancy: diagnosis and management. Br J Obstet Gynecol. 2002;109:840–3.

    Article  Google Scholar 

  7. Kadir R, Lee C, Sabin C, Pollard D, Economides D. Pregnancy in women with von Willebrand’s disease or factor XI deficiency. Br J Obstet Gynecol. 1998;105:314–21.

    Article  CAS  Google Scholar 

  8. Reuveni A, Orbach-Zinger S, Eidelman L, Ginosar Y, Ioscovich A. Peripartum anesthetic management of patients with Factor XI deficiency. J Perinat Med. 2014;42:295–300.

    Article  CAS  Google Scholar 

  9. Chi C, Kulkarni A, Lee C, Kadir R. The obstetric experience of women with factor XI deficiency. Acta Obstet Gynecol. 2009;88:1095–100.

    Article  CAS  Google Scholar 

  10. Myers B, Pavord S, Kean L, Hill M, Dolan G. Pregnancy outcomes in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency. Br J Obstet Gynecol. 2007;114:643–6.

    Article  CAS  Google Scholar 

  11. Singh A, Harnett M, Connors J, Camann W. Factor XI deficiency and obstetrical anesthesia. Anesth Analg. 2009;108:1882–5.

    Article  CAS  Google Scholar 

  12. Setty S, Reddell A, England A, Gomez K, Kadir R. The role of recombinant factor VIIa for obstetric block in women with severe factor XI deficiency. Haemophilia. 2011;17:906–9.

    Article  CAS  Google Scholar 

  13. Connelly N, Brull S. Anesthetic management of a patient with Factor XI deficiency and Factor XI inhibitor undergoing a cesarean section. Anesth Analg. 1993;76:1365.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. UBC Department of Anesthesiology, Pharmacology and Therapeutics, BC Women’s Hospital, Vancouver, BC, Canada

    James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC

  2. Department of Anesthesia, BC Women’s Hospital, Vancouver, BC, Canada

    James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC & Joanne Douglas CM, MD, FRCPC

Authors
  1. James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joanne Douglas CM, MD, FRCPC
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC .

Editor information

Editors and Affiliations

  1. Associate Professor, Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA

    Suzanne K. W. Mankowitz

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Brown, J.P.R., Douglas, J. (2018). Factor XI Deficiency. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_61

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59680-8_61

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59679-2

  • Online ISBN: 978-3-319-59680-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation