Skip to main content
SpringerLink
Log in

Factor V Leiden and Prothrombin Mutation: Common Thrombophilias

  • Chapter
  • First Online:
Consults in Obstetric Anesthesiology

  • 130 Accesses

Abstract

This chapter discusses the common inherited thrombophilias: factor V Leiden and prothrombin gene mutation. The chapter describes the epidemiology and pathophysiology of factor V Leiden and prothrombin gene mutation and states how the disorders affect pregnancy. The peripartum medical and anesthetic management of women with these conditions is discussed.

Please also refer to chapter 89 “Inherited Thrombophilias”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Calderwood C, Greer I. The role of factor V Leiden in maternal health and the outcome of pregnancy. Curr Drug Targets. 2005;6:567–76.

    Article  CAS  Google Scholar 

  2. Pierangeli S, Leader B, Barilaro G, Willis R, Branch D. Acquired and inherited thrombophilia disorders in pregnancy. Obstet Gynecol Clin N Am. 2011;38:271–95.

    Article  Google Scholar 

  3. Franchini M, Giuseppe L. Factor V Leiden in women: a thrombotic risk factor or an evolutionary advantage? Semin Thromb Hemost. 2011;37:275–9.

    Article  Google Scholar 

  4. American College of Obstetricians and Gynecologists. Inherited thrombophilias in pregnancy. Practice bulletin no. 138. Obstet Gynecol. 2013;122:706–17.

    Article  Google Scholar 

  5. Iaccarino D, Monopoli D, Rampino K, Sangiorgi G, Modena M. Acute ST elevation myocardial infarction in early puerperium due to left main coronary thrombosis in a woman with thrombophilic state: a case report. J Cardiovasc Med. 2010;11:758–61.

    Article  Google Scholar 

  6. Fickert P, Ramschak H, Kenner L, Hoefler G, Hinterleitner T, Petritsch W, et al. Acute Budd-Chiari syndrome with fulminant hepatic failure in a pregnant woman with factor V Leiden mutation. Gastroenterology. 1996;111:1670–3.

    Article  CAS  Google Scholar 

  7. van Nordennen J, Camu F. Postpartum seizures after epidural analgesia: a patient with a mutation of the factor V Leiden and prothrombin gene. J Clin Anesth. 2007;19:549–50.

    Article  Google Scholar 

  8. Franchini M, Veneri D, Salvagno G, Manzato F, Lippi G. Inherited thrombophilia. Crit Rev Clin Lab Sci. 2006;43:249–90.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. UBC Department of Anesthesiology, Pharmacology and Therapeutics, BC Women’s Hospital, Vancouver, BC, Canada

    James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC

  2. Department of Anesthesia, BC Women’s Hospital, Vancouver, BC, Canada

    James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC & Joanne Douglas CM, MD, FRCPC

Authors
  1. James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joanne Douglas CM, MD, FRCPC
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC .

Editor information

Editors and Affiliations

  1. Associate Professor, Department of Anesthesiology, Columbia University Medical Center, New York, NY, USA

    Suzanne K. W. Mankowitz

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Brown, J.P.R., Douglas, J. (2018). Factor V Leiden and Prothrombin Mutation: Common Thrombophilias. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_58

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59680-8_58

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59679-2

  • Online ISBN: 978-3-319-59680-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation