Skip to main content

Prothrombin (Factor II) Deficiency

  • Chapter
  • First Online:
Book cover Consults in Obstetric Anesthesiology

Abstract

This chapter outlines the pathophysiology, clinical presentation, inheritance, and incidence of prothrombin deficiency. The chapter describes the interaction with pregnancy and discusses the medical and anesthetic management of pregnant women with prothrombin deficiency, including treatment of acute hemorrhage.

Please also refer to chapter 88 “Inherited Bleeding Disorders”.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Silver R, Major H. Maternal coagulation disorders and postpartum hemorrhage. Clin Obstet Gynecol. 2010;53:252–64.

    Article  Google Scholar 

  2. Peyvandi F, Garagiola I, Menegatti M. Gynecological and obstetrical manifestations of inherited bleeding disorders in women. J Thromb Haemost. 2011;9:236–45.

    Article  Google Scholar 

  3. Chi C, Kadir R. Inherited bleeding disorders in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2012;26:103–17.

    Article  Google Scholar 

  4. Pike G, Bolton-Maggs P. Factor deficiencies in pregnancy. Hematol Oncol Clin North Am. 2011;25:359–78.

    Article  Google Scholar 

  5. Mumford A, Ackroyd S, Alikhan R, Bowles L, Chowdary P, Grainger J, et al. Guideline for the diagnosis and management of the rare coagulation disorders. A United Kingdom Haemophilia Centre Doctors’ Organization guideline on behalf of the British Committee for Standards in Haematology. Br J Haematol. 2014;167:304–26.

    Article  CAS  Google Scholar 

  6. Catanzarite VA, Novotny WF, Cousins LM, Schneider JM. Pregnancies in a patient with congenital absence of prothrombin activity: case report. Am J Perinatol. 1997;14(3):135–8.

    Article  CAS  Google Scholar 

  7. Harel R, Shani D, Donohoe K. A case of congenital prothrombin deficiency and idiopathic thrombocytopenic purpura in a pregnant female. Blood Coagul Fibrinolysis. 2017;28(1):100–1.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James P. R. Brown MBChB, MRCP, FRCA, MD, FRCPC .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Brown, J.P.R., Douglas, J. (2018). Prothrombin (Factor II) Deficiency. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_132

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-59680-8_132

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59679-2

  • Online ISBN: 978-3-319-59680-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics