Abstract
This chapter discusses the pathophysiology, inheritance, and epidemiology of protein C and protein S deficiencies. The chapter discusses the impact of protein C and protein S deficiencies on pregnant women and details suggested medical and anesthetic management of affected individuals.
Keywords
Please also refer to chapter 89 “Inherited Thrombophilias”.
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Sugiura M. Pregnancy and delivery in protein C-deficiency. Curr Drug Targets. 2005;6:577–83.
Pierangeli S, Leader B, Barilaro G, Willis R, Ware Branch D. Acquired and inherited thrombophilia disorders in pregnancy. Obstet Gynecol Clin North Am. 2011;38:271–95.
American College of Obstetricians and Gynecologists Women’s Health Care Physicians. ACOG practice bulletin no. 138: inherited thrombophilias in pregnancy. Obstet Gynecol. 2013;122:706–17.
Franchini M, Veneri D, Salvagno G, Manzato F, Lippi G. Inherited thrombophilia. Crit Rev Clin Lab Sci. 2006;43:249–90.
Sekiyama K, Itoh H, Sagawa N, Tatsumi K, Yura S, Takayama H, et al. Successful management of a pregnant woman with heterozygous protein C deficiency using activated protein C concentrate. J Obstet Gynaecol Res. 2003;29:412–5.
Richards E, Makris M, Preston F. The successful use of protein C concentrate during pregnancy in a patient with type 1 protein C deficiency, previous thrombosis and recurrent fetal loss. Br J Haematol. 1997;98:660–1.
Manco-Johnson M, Nuss R. Protein C concentrate prevents peripartum thrombosis. Am J Hematol. 1992;40:69–70.
Ebina Y, Yamada H, Kato E, Yamamoto R, Sakuragi N, Fujimoto S. Thromboprophylaxis with low molecular weight heparin in thrombophilia-complicated pregnancy. J Obstet Gynaecol Res. 2002;28:251–7.
Hiroe S, Itoh H, Matsumoto H, Takahasi S, Sato Y, Yamada S et al. Case of Budd–Chiari syndrome 3 months after vaginal delivery. J Obstet Gynaecol Res. 2008;34:605–8.
Ranasinghe J, Kafi S, Oppenheimer J, Birnbach D. Hemorrhagic stroke following elective cesarean delivery. Int J Obs Anesth. 2008;17:271–4.
Morikawa M, Yamada H, Kato E, Wda S, Suzuki S, Sakuragi N et al. Failure of thromboprophylaxis in pregnancy caused by dual deficiencies of protein S and protein C. Semin Thromb Hemost. 2005;31:261–5.
Roos K, Pascuzzi R, Kuharik M, et al. Postpartum intracranial venous thrombosis associated with dysfunctional protein C and deficiency of protein S. Obstet Gynecol. 1990;76:492–4.
Fan S, Yeh M, Tsay W. Caesarean section in a patient with protein S deficiency. Anaesthesia. 1995;50:251.
Abramovitz S, Beilin Y. Anesthetic management of the parturient with protein S deficiency and ischemic heart disease. Anesth Analg. 1999;89:709–10.
Atakan R, Borekci B, Ozturk G, Akcay M, Kadanali S. Acute mesenteric venous thrombosis due to protein S deficiency in a pregnant woman. J Obstet Gynaecol Res. 2009;35:804–7.
Vela J, Diaz-Cascajosa J, Crespo J, Buil J. Protein S deficiency and retinal arteriolar occlusion in pregnancy. Eur J Ophthalmol. 2007;17:1004–6.
Konishi H, Miyoshi T, Neki R, Fukuda T, Ishibashi-Ueda H, Ogo T, et al. Intrapartum temporary inferior vena cava filters are rarely indicated in pregnant women with deep venous thromboses. J Vasc Surg Venous Lymphat Disord. 2015;3:370–5.
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Brown, J.P.R., Douglas, J. (2018). Protein C and S Deficiencies. In: Mankowitz, S. (eds) Consults in Obstetric Anesthesiology. Springer, Cham. https://doi.org/10.1007/978-3-319-59680-8_131
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DOI: https://doi.org/10.1007/978-3-319-59680-8_131
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