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Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children

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Histiocytic Disorders

Abstract

This chapter recounts the history of classification of LCH, the association with certain risk factors and with other malignancies, and the patterns of disease reported. In it, the history of LCH as a disease is told, from classification as three different diseases to unification as a single disease with a variable presentation. The chapter goes into further detail about the variety of different manifestations in different organ systems and assesses the evidence for suspected risk factors to LCH.

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Authors and Affiliations

  1. The Children’s Center for Cancer and Blood Diseases, Children’s Hospital Los Angeles, Los Angeles, CA, USA

    Etai Adam MD & Rima Jubran MD, PhD

  2. Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Sheila Weitzman MB, BCh, FCP(SA), FRCP(C)

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  1. Etai Adam MD
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  2. Rima Jubran MD, PhD
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  3. Sheila Weitzman MB, BCh, FCP(SA), FRCP(C)
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Correspondence to Rima Jubran MD, PhD .

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Editors and Affiliations

  1. University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada

    Oussama Abla

  2. Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany

    Gritta Janka

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Adam, E., Jubran, R., Weitzman, S. (2018). Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children. In: Abla, O., Janka, G. (eds) Histiocytic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-59632-7_3

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