Skip to main content

Embolization of Cerebral Arteriovenous Malformations

  • Chapter
  • First Online:
Book cover Textbook of Catheter-Based Cardiovascular Interventions

Abstract

Effective treatment of cerebral arteriovenous malformations (AVMs) requires a multidisciplinary approach that appropriately applies the complementary modalities of microsurgical resection, endovascular embolization, and radiosurgery. Embolization is most commonly used as an adjunct to reduce the arterial supply to the AVM before surgery or radiosurgery. Additional indications for embolization include an attempt to achieve complete AVM obliteration, targeted treatment to eliminate high-risk features, and subtotal occlusion to palliate symptoms caused by an otherwise incurable AVM. In all cases, the risks and benefits of treatment must be weighed carefully when formulating a treatment strategy. For optimal management of cerebral AVMs, patients should have access to physicians experienced in open cerebrovascular surgery, endovascular embolization, and radiosurgery.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Berman MF, Sciacca RR, Pile-Spellman J, Stapf C, Connolly ES Jr, Mohr JP, et al. The epidemiology of brain arteriovenous malformations. Neurosurgery. 2000;47(2):389–96; discussion 397.

    Article  CAS  PubMed  Google Scholar 

  2. Luessenhop AJ, Spence WT. Artificial embolization of cerebral arteries. Report of use in a case of arteriovenous malformation. J Am Med Assoc. 1960;172:1153–5.

    Article  CAS  PubMed  Google Scholar 

  3. Al-Shahi R, Warlow C. A systematic review of the frequency and prognosis of arteriovenous malformations of the brain in adults. Brain. 2001;124(Pt 10):1900–26.

    Article  CAS  PubMed  Google Scholar 

  4. Leblanc GG, Golanov E, Awad IA, Young WL. Biology of vascular malformations of the brain NWC. Biology of vascular malformations of the brain. Stroke. 2009;40(12):e694–702. https://doi.org/10.1161/STROKEAHA.109.563692.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Brown RD Jr, Wiebers DO, Torner JC, O'Fallon WM. Incidence and prevalence of intracranial vascular malformations in Olmsted County, Minnesota, 1965 to 1992. Neurology. 1996;46(4):949–52.

    Article  PubMed  Google Scholar 

  6. Stapf C, Mast H, Sciacca RR, Berenstein A, Nelson PK, Gobin YP, et al. The New York Islands AVM Study: design, study progress, and initial results. Stroke. 2003;34(5):e29–33. https://doi.org/10.1161/01.STR.0000068784.36838.19.

    Article  PubMed  CAS  Google Scholar 

  7. Crawford PM, West CR, Chadwick DW, Shaw MD. Arteriovenous malformations of the brain: natural history in unoperated patients. J Neurol Neurosurg Psychiatry. 1986;49(1):1–10.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Mast H, Young WL, Koennecke HC, Sciacca RR, Osipov A, Pile-Spellman J, et al. Risk of spontaneous haemorrhage after diagnosis of cerebral arteriovenous malformation. Lancet. 1997;350(9084):1065–8.

    Article  CAS  PubMed  Google Scholar 

  9. Graf CJ, Perret GE, Torner JC. Bleeding from cerebral arteriovenous malformations as part of their natural history. J Neurosurg. 1983;58(3):331–7. https://doi.org/10.3171/jns.1983.58.3.0331.

    Article  PubMed  CAS  Google Scholar 

  10. Itoyama Y, Uemura S, Ushio Y, Kuratsu J, Nonaka N, Wada H, et al. Natural course of unoperated intracranial arteriovenous malformations: study of 50 cases. J Neurosurg. 1989;71(6):805–9. https://doi.org/10.3171/jns.1989.71.6.0805.

    Article  PubMed  CAS  Google Scholar 

  11. Jane JA, Kassell NF, Torner JC, Winn HR. The natural history of aneurysms and arteriovenous malformations. J Neurosurg. 1985;62(3):321–3. https://doi.org/10.3171/jns.1985.62.3.0321.

    Article  PubMed  CAS  Google Scholar 

  12. Ondra SL, Troupp H, George ED, Schwab K. The natural history of symptomatic arteriovenous malformations of the brain: a 24-year follow-up assessment. J Neurosurg. 1990;73(3):387–91. https://doi.org/10.3171/jns.1990.73.3.0387.

    Article  PubMed  CAS  Google Scholar 

  13. Al-Shahi R, Warlow CP. Quality of evidence for management of arteriovenous malformations of the brain. Lancet. 2002;360(9338):1022–23; author reply 3. https://doi.org/10.1016/S0140-6736(02)11107-X.

    Article  PubMed  Google Scholar 

  14. Mohr JP, Parides MK, Stapf C, Moquete E, Moy CS, Overbey JR, et al. Medical management with or without interventional therapy for unruptured brain arteriovenous malformations (ARUBA): a multicentre, non-blinded, randomised trial. Lancet. 2014;383(9917):614–21. https://doi.org/10.1016/S0140-6736(13)62302-8.

    Article  PubMed  CAS  Google Scholar 

  15. Flores BC, Klinger DR, Rickert KL, Barnett SL, Welch BG, White JA, et al. Management of intracranial aneurysms associated with arteriovenous malformations. Neurosurg Focus. 2014;37(3):E11. https://doi.org/10.3171/2014.6.FOCUS14165.

    Article  PubMed  Google Scholar 

  16. Redekop G, TerBrugge K, Montanera W, Willinsky R. Arterial aneurysms associated with cerebral arteriovenous malformations: classification, incidence, and risk of hemorrhage. J Neurosurg. 1998;89(4):539–46. https://doi.org/10.3171/jns.1998.89.4.0539.

    Article  PubMed  CAS  Google Scholar 

  17. Starke RM, Komotar RJ, Otten ML, Hahn DK, Fischer LE, Hwang BY, et al. Adjuvant embolization with N-butyl cyanoacrylate in the treatment of cerebral arteriovenous malformations: outcomes, complications, and predictors of neurologic deficits. Stroke. 2009;40(8):2783–90. https://doi.org/10.1161/STROKEAHA.108.539775.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Natarajan SK, Ghodke B, Britz GW, Born DE, Sekhar LN. Multimodality treatment of brain arteriovenous malformations with microsurgery after embolization with Onyx single-center experience and technical nuances. Neurosurgery. 2008;62(6):1213–25; discussion 25–6. https://doi.org/10.1227/01.neu.0000333293.74986.e5.

    Article  PubMed  Google Scholar 

  19. Spetzler RF, Martin NA. A proposed grading system for arteriovenous malformations. J Neurosurg. 1986;65(4):476–83. https://doi.org/10.3171/jns.1986.65.4.0476.

    Article  PubMed  CAS  Google Scholar 

  20. Andrade-Souza YM, Ramani M, Scora D, Tsao MN, ter Brugge K, Schwartz ML. Embolization before radiosurgery reduces the obliteration rate of arteriovenous malformations. Neurosurgery. 2007;60(3):443–51; discussion 51–2. https://doi.org/10.1227/01.NEU.0000255347.25959.D0.

    Article  PubMed  Google Scholar 

  21. Kano H, Kondziolka D, Flickinger JC, Park KJ, Iyer A, Yang HC, et al. Stereotactic radiosurgery for arteriovenous malformations after embolization: a case-control study. J Neurosurg. 2012;117(2):265–75. https://doi.org/10.3171/2012.4.JNS111935.

    Article  PubMed  Google Scholar 

  22. Schwyzer L, Yen CP, Evans A, Zavoian S, Steiner L. Long-term results of Gamma Knife surgery for partially embolized arteriovenous malformations. Neurosurgery. 2012;71(6):1139–47; discussion 47–8. https://doi.org/10.1227/NEU.0b013e3182720280.

    Article  PubMed  Google Scholar 

  23. Bing F, Doucet R, Lacroix F, Bahary JP, Darsaut T, Roy D, et al. Liquid embolization material reduces the delivered radiation dose: clinical myth or reality? AJNR Am J Neuroradiol. 2012;33(2):320–2. https://doi.org/10.3174/ajnr.A2943.

    Article  PubMed  Google Scholar 

  24. Sanborn MR, Park MS, McDougall CG, Albuquerque FC. Endovascular approaches to pial arteriovenous malformations. Neurosurg Clin N Am. 2014;25(3):529–37. https://doi.org/10.1016/j.nec.2014.04.009.

    Article  PubMed  Google Scholar 

  25. Abud DG, Riva R, Nakiri GS, Padovani F, Khawaldeh M, Mounayer C. Treatment of brain arteriovenous malformations by double arterial catheterization with simultaneous injection of Onyx: retrospective series of 17 patients. AJNR Am J Neuroradiol. 2011;32(1):152–8. https://doi.org/10.3174/ajnr.A2247.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  26. van Rooij WJ, Jacobs S, Sluzewski M, van der Pol B, Beute GN, Sprengers ME. Curative embolization of brain arteriovenous malformations with Onyx: patient selection, embolization technique, and results. AJNR Am J Neuroradiol. 2012;33(7):1299–304. https://doi.org/10.3174/ajnr.A2947.

  27. de Castro-Afonso LH, Nakiri GS, Oliveira RS, Santos MV, Santos AC, Machado HR, et al. Curative embolization of pediatric intracranial arteriovenous malformations using Onyx: the role of new embolization techniques on patient outcomes. Neuroradiology. 2016;58(6):585–94. https://doi.org/10.1007/s00234-016-1666-1.

    Article  CAS  PubMed  Google Scholar 

  28. Brown RD Jr, Wiebers DO, Forbes GS. Unruptured intracranial aneurysms and arteriovenous malformations: frequency of intracranial hemorrhage and relationship of lesions. J Neurosurg. 1990;73(6):859–63. https://doi.org/10.3171/jns.1990.73.6.0859.

    Article  PubMed  Google Scholar 

  29. Kim EJ, Halim AX, Dowd CF, Lawton MT, Singh V, Bennett J, et al. The relationship of coexisting extranidal aneurysms to intracranial hemorrhage in patients harboring brain arteriovenous malformations. Neurosurgery. 2004;54(6):1349–57; discussion 57–8.

    Article  PubMed  Google Scholar 

  30. Lasjaunias P, Piske R, Terbrugge K, Willinsky R. Cerebral arteriovenous malformations (C. AVM) and associated arterial aneurysms (AA). Analysis of 101 C. AVM cases, with 37 AA in 23 patients. Acta Neurochir (Wien). 1988;91(1–2):29–36.

    Article  CAS  Google Scholar 

  31. Marks MP, Lane B, Steinberg GK, Chang PJ. Hemorrhage in intracerebral arteriovenous malformations: angiographic determinants. Radiology. 1990;176(3):807–13. https://doi.org/10.1148/radiology.176.3.2389040.

    Article  PubMed  CAS  Google Scholar 

  32. Fox AJ, Girvin JP, Vinuela F, Drake CG. Rolandic arteriovenous malformations: improvement in limb function by IBC embolization. AJNR Am J Neuroradiol. 1985;6(4):575–82.

    PubMed  CAS  PubMed Central  Google Scholar 

  33. Kusske JA, Kelly WA. Embolization and reduction of the “steal” syndrome in cerebral arteriovenous malformations. J Neurosurg. 1974;40(3):313–21. https://doi.org/10.3171/jns.1974.40.3.0313.

    Article  PubMed  CAS  Google Scholar 

  34. Luessenhop AJ, Mujica PH. Embolization of segments of the circle of Willis and adjacent branches for management of certain inoperable cerebral arteriovenous malformations. J Neurosurg. 1981;54(5):573–82. https://doi.org/10.3171/jns.1981.54.5.0573.

    Article  PubMed  CAS  Google Scholar 

  35. Mast H, Mohr JP, Osipov A, Pile-Spellman J, Marshall RS, Lazar RM, et al. ‘Steal’ is an unestablished mechanism for the clinical presentation of cerebral arteriovenous malformations. Stroke. 1995;26(7):1215–20.

    Article  CAS  PubMed  Google Scholar 

  36. Rosenkranz M, Regelsberger J, Zeumer H, Grzyska U. Management of cerebral arteriovenous malformations associated with symptomatic congestive intracranial hypertension. Eur Neurol. 2008;59(1–2):62–6. https://doi.org/10.1159/000109263.

    Article  PubMed  Google Scholar 

  37. Simon SD, Yao TL, Rosenbaum BP, Reig A, Mericle RA. Resolution of trigeminal neuralgia after palliative embolization of a cerebellopontine angle arteriovenous malformation. Cent Eur Neurosurg. 2009;70(3):161–3. https://doi.org/10.1055/s-0029-1215567.

    Article  PubMed  CAS  Google Scholar 

  38. Han PP, Ponce FA, Spetzler RF. Intention-to-treat analysis of Spetzler-Martin grades IV and V arteriovenous malformations: natural history and treatment paradigm. J Neurosurg. 2003;98(1):3–7. https://doi.org/10.3171/jns.2003.98.1.0003.

    Article  PubMed  Google Scholar 

  39. Miyamoto S, Hashimoto N, Nagata I, Nozaki K, Morimoto M, Taki W, et al. Posttreatment sequelae of palliatively treated cerebral arteriovenous malformations. Neurosurgery. 2000;46(3):589–94; discussion 94–5.

    Article  CAS  PubMed  Google Scholar 

  40. Wikholm G, Lundqvist C, Svendsen P. The Göteborg cohort of embolized cerebral arteriovenous malformations: a 6-year follow-up. Neurosurgery. 2001;49(4):799–805; discussion 805–6.

    Article  CAS  PubMed  Google Scholar 

  41. Spetzler RF, Wilson CB, Weinstein P, Mehdorn M, Townsend J, Telles D. Normal perfusion pressure breakthrough theory. Clin Neurosurg. 1978;25:651–72.

    Article  CAS  PubMed  Google Scholar 

  42. Luessenhop AJ, Presper JH. Surgical embolization of cerebral arteriovenous malformations through internal carotid and vertebral arteries. Long-term results. J Neurosurg. 1975;42(4):443–51. https://doi.org/10.3171/jns.1975.42.4.0443.

    Article  PubMed  CAS  Google Scholar 

  43. Spetzler RF, Martin NA, Carter LP, Flom RA, Raudzens PA, Wilkinson E. Surgical management of large AVM’s by staged embolization and operative excision. J Neurosurg. 1987;67(1):17–28. https://doi.org/10.3171/jns.1987.67.1.0017.

    Article  PubMed  CAS  Google Scholar 

  44. Brothers MF, Kaufmann JC, Fox AJ, Deveikis JP. n-Butyl 2-cyanoacrylate – substitute for IBCA in interventional neuroradiology: histopathologic and polymerization time studies. AJNR Am J Neuroradiol. 1989;10(4):777–86.

    PubMed  CAS  PubMed Central  Google Scholar 

  45. Spiegel SM, Vinuela F, Goldwasser JM, Fox AJ, Pelz DM. Adjusting the polymerization time of isobutyl-2 cyanoacrylate. AJNR Am J Neuroradiol. 1986;7(1):109–12.

    PubMed  CAS  PubMed Central  Google Scholar 

  46. Taki W, Yonekawa Y, Iwata H, Uno A, Yamashita K, Amemiya H. A new liquid material for embolization of arteriovenous malformations. AJNR Am J Neuroradiol. 1990;11(1):163–8.

    PubMed  CAS  PubMed Central  Google Scholar 

  47. Chaloupka JC, Vinuela F, Vinters HV, Robert J. Technical feasibility and histopathologic studies of ethylene vinyl copolymer (EVAL) using a swine endovascular embolization model. AJNR Am J Neuroradiol. 1994;15(6):1107–15.

    PubMed  CAS  PubMed Central  Google Scholar 

  48. Murayama Y, Vinuela F, Ulhoa A, Akiba Y, Duckwiler GR, Gobin YP, et al. Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile. Neurosurgery. 1998;43(5):1164–75.

    Article  CAS  PubMed  Google Scholar 

  49. Jahan R, Murayama Y, Gobin YP, Duckwiler GR, Vinters HV, Vinuela F. Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery. 2001;48(5):984–95; discussion 95–7.

    PubMed  CAS  Google Scholar 

  50. Weber W, Kis B, Siekmann R, Jans P, Laumer R, Kuhne D. Preoperative embolization of intracranial arteriovenous malformations with Onyx. Neurosurgery. 2007;61(2):244–52; discussion 52–4. https://doi.org/10.1227/01.NEU.0000255473.60505.84.

    Article  PubMed  Google Scholar 

  51. U.S. Food and Drug Administration. Catheter entrapment with the ev3 Onyx liquid embolic system. FDA Safety Communication. 2016. Archived at https://archive-it.org/collections/7993?q=Catheter+entrapment+with+the+ev3+Onyx+liquid+embolic+system&page=1&show=ArchivedPages. Accessed November 1, 2017.

  52. Ozturk MH, Unal H, Dinc H. Embolization of an AVM with acrylic glue through a new microcatheter with detachable tip: an amazing experience. Neuroradiology. 2008;50(10):903–4. https://doi.org/10.1007/s00234-008-0442-2.

    Article  PubMed  Google Scholar 

  53. Altschul D, Paramasivam S, Ortega-Gutierrez S, Fifi JT, Berenstein A. Safety and efficacy using a detachable tip microcatheter in the embolization of pediatric arteriovenous malformations. Childs Nerv Syst. 2014;30(6):1099–107. https://doi.org/10.1007/s00381-014-2404-9.

    Article  PubMed  Google Scholar 

  54. Herial NA, Khan AA, Suri MF, Sherr GT, Qureshi AI. Liquid embolization of brain arteriovenous malformation using novel detachable tip micro catheter: a technical report. J Vasc Interv Neurol. 2014;7(5):64–8.

    PubMed  PubMed Central  Google Scholar 

  55. Herial NA, Khan AA, Sherr GT, Qureshi MH, Suri MF, Qureshi AI. Detachable-tip microcatheters for liquid embolization of brain arteriovenous malformations and fistulas: a United States single-center experience. Neurosurgery. 2015;11(Suppl 3):404–11; discussion 11. https://doi.org/10.1227/NEU.0000000000000839.

    Article  PubMed  Google Scholar 

  56. Fifi JT. Experience with detachable tip microcatheter. Oral presentation. Center for Endovascular Surgery: Mount Sinai; 2014.

    Google Scholar 

  57. Jafar JJ, Davis AJ, Berenstein A, Choi IS, Kupersmith MJ. The effect of embolization with N-butyl cyanoacrylate prior to surgical resection of cerebral arteriovenous malformations. J Neurosurg. 1993;78(1):60–9. https://doi.org/10.3171/jns.1993.78.1.0060.

    Article  PubMed  CAS  Google Scholar 

  58. DeMeritt JS, Pile-Spellman J, Mast H, Moohan N, Lu DC, Young WL, et al. Outcome analysis of preoperative embolization with N-butyl cyanoacrylate in cerebral arteriovenous malformations. AJNR Am J Neuroradiol. 1995;16(9):1801–7.

    PubMed  CAS  PubMed Central  Google Scholar 

  59. Kwon Y, Jeon SR, Kim JH, Lee JK, Ra DS, Lee DJ, et al. Analysis of the causes of treatment failure in Gamma Knife radiosurgery for intracranial arteriovenous malformations. J Neurosurg. 2000;93(Suppl 3):104–6. https://doi.org/10.3171/jns.2000.93.supplement.

  60. Starke RM, Komotar RJ, Hwang BY, Fischer LE, Otten ML, Merkow MB, et al. A comprehensive review of radiosurgery for cerebral arteriovenous malformations: outcomes, predictive factors, and grading scales. Stereotact Funct Neurosurg. 2008;86(3):191–9. https://doi.org/10.1159/000126945.

    Article  PubMed  Google Scholar 

  61. Lunsford LD, Kondziolka D, Flickinger JC, Bissonette DJ, Jungreis CA, Maitz AH, et al. Stereotactic radiosurgery for arteriovenous malformations of the brain. J Neurosurg. 1991;75(4):512–24. https://doi.org/10.3171/jns.1991.75.4.0512.

    Article  PubMed  CAS  Google Scholar 

  62. Steiner L, Lindquist C, Adler JR, Torner JC, Alves W, Steiner M. Clinical outcome of radiosurgery for cerebral arteriovenous malformations. J Neurosurg. 1992;77(1):1–8. https://doi.org/10.3171/jns.1992.77.1.0001.

    Article  PubMed  CAS  Google Scholar 

  63. Gobin YP, Laurent A, Merienne L, Schlienger M, Aymard A, Houdart E, et al. Treatment of brain arteriovenous malformations by embolization and radiosurgery. J Neurosurg. 1996;85(1):19–28. https://doi.org/10.3171/jns.1996.85.1.0019.

    Article  PubMed  CAS  Google Scholar 

  64. Henkes H, Nahser HC, Berg-Dammer E, Weber W, Lange S, Kuhne D. Endovascular therapy of brain AVMs prior to radiosurgery. Neurol Res. 1998;20(6):479–92.

    Article  CAS  PubMed  Google Scholar 

  65. Back AG, Vollmer D, Zeck O, Shkedy C, Shedden PM. Retrospective analysis of unstaged and staged Gamma Knife surgery with and without preceding embolization for the treatment of arteriovenous malformations. J Neurosurg. 2008;109(Suppl):57–64. https://doi.org/10.3171/JNS/2008/109/12/S10.

    Article  PubMed  Google Scholar 

  66. Blackburn SL, Ashley WW Jr, Rich KM, Simpson JR, Drzymala RE, Ray WZ, et al. Combined endovascular embolization and stereotactic radiosurgery in the treatment of large arteriovenous malformations. J Neurosurg. 2011;114(6):1758–67. https://doi.org/10.3171/2011.1.JNS10571.

    Article  PubMed  Google Scholar 

  67. Valavanis A, Yasargil MG. The endovascular treatment of brain arteriovenous malformations. Adv Tech Stand Neurosurg. 1998;24:131–214.

    Article  CAS  PubMed  Google Scholar 

  68. Fournier D, TerBrugge KG, Willinsky R, Lasjaunias P, Montanera W. Endovascular treatment of intracerebral arteriovenous malformations: experience in 49 cases. J Neurosurg. 1991;75(2):228–33. https://doi.org/10.3171/jns.1991.75.2.0228.

    Article  PubMed  CAS  Google Scholar 

  69. Vinuela F, Duckwiler G, Guglielmi G. Contribution of interventional neuroradiology in the therapeutic management of brain arteriovenous malformations. J Stroke Cerebrovasc Dis. 1997;6(4):268–71.

    Article  CAS  PubMed  Google Scholar 

  70. Yu SC, Chan MS, Lam JM, Tam PH, Poon WS. Complete obliteration of intracranial arteriovenous malformation with endovascular cyanoacrylate embolization: initial success and rate of permanent cure. AJNR Am J Neuroradiol. 2004;25(7):1139–43.

    PubMed  PubMed Central  Google Scholar 

  71. Elsenousi A, Aletich VA, Alaraj A. Neurological outcomes and cure rates of embolization of brain arteriovenous malformations with n-butyl cyanoacrylate or Onyx: a meta-analysis. J Neurointerv Surg. 2016;8(3):265–72. https://doi.org/10.1136/neurintsurg-2014-011427. Epub 2014 Dec 24.

    Article  PubMed  Google Scholar 

  72. Katsaridis V, Papagiannaki C, Aimar E. Curative embolization of cerebral arteriovenous malformations (AVMs) with Onyx in 101 patients. Neuroradiology. 2008;50(7):589–97. https://doi.org/10.1007/s00234-008-0382-x.

    Article  PubMed  Google Scholar 

  73. Maimon S, Strauss I, Frolov V, Margalit N, Ram Z. Brain arteriovenous malformation treatment using a combination of Onyx and a new detachable tip microcatheter, SONIC: short-term results. AJNR Am J Neuroradiol. 2010;31(5):947–54. https://doi.org/10.3174/ajnr.A1959.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  74. Saatci I, Geyik S, Yavuz K, Cekirge HS. Endovascular treatment of brain arteriovenous malformations with prolonged intranidal Onyx injection technique: long-term results in 350 consecutive patients with completed endovascular treatment course. J Neurosurg. 2011;115(1):78–88. https://doi.org/10.3171/2011.2.JNS09830.

    Article  PubMed  Google Scholar 

  75. Iosif C, Mendes GA, Saleme S, Ponomarjova S, Silveira EP, Caire F, et al. Endovascular transvenous cure for ruptured brain arteriovenous malformations in complex cases with high Spetzler-Martin grades. J Neurosurg. 2015;122(5):1229–38. https://doi.org/10.3171/2014.9.JNS141714.

    Article  PubMed  Google Scholar 

  76. Martinez-Galdamez M, Saura P, Saura J, Muniz J, Albisua J, Perez-Higueras A. Transvenous Onyx embolization of a subependymal deep arteriovenous malformation with a single drainage vein: technical note. J Neurointerv Surg. 2014;6(3):e20. https://doi.org/10.1136/neurintsurg-2012-010603.rep.

    Article  PubMed  Google Scholar 

  77. Pereira VM, Marcos-Gonzalez A, Radovanovic I, Bijlenga P, Narata AP, Moret J, et al. Transvenous embolization of a ruptured deep cerebral arteriovenous malformation. A technical note. Interv Neuroradiol. 2013;19(1):27–34.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Renieri L, Limbucci N, Consoli A, Rosi A, Nappini S, Giordano F, et al. Transvenous embolization: a report of 4 pediatric cases. J Neurosurg Pediatr. 2015;15(4):445–50. https://doi.org/10.3171/2014.11.PEDS13437.

    Article  PubMed  Google Scholar 

  79. Crowley RW, Ducruet AF, Kalani MY, Kim LJ, Albuquerque FC, McDougall CG. Neurological morbidity and mortality associated with the endovascular treatment of cerebral arteriovenous malformations before and during the Onyx era. J Neurosurg. 2015;122(6):1492–7. https://doi.org/10.3171/2015.2.JNS131368.

    Article  PubMed  CAS  Google Scholar 

  80. Debrun GM, Aletich V, Ausman JI, Charbel F, Dujovny M. Embolization of the nidus of brain arteriovenous malformations with n-butyl cyanoacrylate. Neurosurgery. 1997;40(1):112–20; discussion 20–1.

    PubMed  CAS  Google Scholar 

  81. Hartmann A, Pile-Spellman J, Stapf C, Sciacca RR, Faulstich A, Mohr JP, et al. Risk of endovascular treatment of brain arteriovenous malformations. Stroke. 2002;33(7):1816–20.

    Article  CAS  PubMed  Google Scholar 

  82. Taylor CL, Dutton K, Rappard G, Pride GL, Replogle R, Purdy PD, et al. Complications of preoperative embolization of cerebral arteriovenous malformations. J Neurosurg. 2004;100(5):810–2. https://doi.org/10.3171/jns.2004.100.5.0810.

    Article  PubMed  Google Scholar 

  83. Frizzel RT, Fisher WS 3rd. Cure, morbidity, and mortality associated with embolization of brain arteriovenous malformations: a review of 1246 patients in 32 series over a 35-year period. Neurosurgery. 1995;37(6):1031–9; discussion 9-40.

    Article  CAS  PubMed  Google Scholar 

  84. Loh Y, Duckwiler GR, Onyx Trial Investigators. A prospective, multicenter, randomized trial of the Onyx liquid embolic system and N-butyl cyanoacrylate embolization of cerebral arteriovenous malformations. Clinical article. J Neurosurg. 2010;113(4):733–41. https://doi.org/10.3171/2010.3.JNS09370.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to thank the Neuroscience Publications staff of Barrow Neurological Institute for their invaluable assistance in the preparation of this chapter.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Felipe C. Albuquerque MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Flores, B.C., See, A.P., Ducruet, A.F., Albuquerque, F.C. (2018). Embolization of Cerebral Arteriovenous Malformations. In: Lanzer, P. (eds) Textbook of Catheter-Based Cardiovascular Interventions. Springer, Cham. https://doi.org/10.1007/978-3-319-55994-0_69

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-55994-0_69

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55993-3

  • Online ISBN: 978-3-319-55994-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics