Skip to main content

Coronary Collateral Circulation

  • Chapter
  • First Online:
  • 625 Accesses

Abstract

Coronary collateral circulation is the small vessel connections formed between one epicardial coronary artery and another. The existence of these coronary anastomoses was demonstrated by Fulton in 1963. Rentrop and Werner subsequently devised collateral classification systems using angiographic characteristics as surrogates for collateral function. While these classifications are widely used in the clinical setting, the gold standard assessment of collateral function is the invasively measured collateral flow index. Several clinical and angiographic variables correlate with the degree of collateralization, and well-developed collateral circulation has the potential to both preserve myocardial function and improve survival. This protective function is commonly seen in the presence of chronic total occlusions (CTOs), while with an acute coronary occlusion the collateral circulation is usually inadequate to prevent myocardial ischemia and injury. Beyond this protective role, in CTO percutaneous coronary intervention (PCI) the collaterals allow visualization of the distal coronary bed beyond the occlusive segment and provide retrograde access to the occluded vessel to facilitate recanalization. The specific collateral pathways available and the characteristics of the collateral anatomy have implications for the feasibility and safety of obtaining retrograde access to the target vessel. Performing an assessment of the collateral pathways and their anatomical characteristics during procedural planning can improve CTO PCI procedural efficiency and success.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Fulton WF. Arterial anastomoses in the coronary circulation. I. Anatomical features in normal and diseased hearts demonstrated by stereoarteriography. Scott Med J. 1963;8:420–34.

    Article  CAS  PubMed  Google Scholar 

  2. Seiler C. The human coronary collateral circulation. Eur J Clin Investig. 2010;40:465–76.

    Article  Google Scholar 

  3. Wustmann K, Zbinden S, Windecker S, Meier B, Seiler C. Is there functional collateral flow during vascular occlusion in angiographically normal coronary arteries? Circulation. 2003;107:2213–20.

    Article  PubMed  Google Scholar 

  4. Elsman P, van’t Hof AW, de Boer MJ, et al. Role of collateral circulation in the acute phase of ST-segment-elevation myocardial infarction treated with primary coronary intervention. Eur Heart J. 2004;25:854–8.

    Article  CAS  PubMed  Google Scholar 

  5. Fukai M, Ii M, Nakakoji T, et al. Angiographically demonstrated coronary collaterals predict residual viable myocardium in patients with chronic myocardial infarction: a regional metabolic study. J Cardiol. 2000;35:103–11.

    PubMed  CAS  Google Scholar 

  6. Habib GB, Heibig J, Forman SA, et al. Influence of coronary collateral vessels on myocardial infarct size in humans. Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. The TIMI Investigators. Circulation. 1991;83:739–46.

    Article  CAS  PubMed  Google Scholar 

  7. Hansen JF. Coronary collateral circulation: clinical significance and influence on survival in patients with coronary artery occlusion. Am Heart J. 1989;117:290–5.

    Article  CAS  PubMed  Google Scholar 

  8. Meier P, Gloekler S, Zbinden R, et al. Beneficial effect of recruitable collaterals: a 10-year follow-up study in patients with stable coronary artery disease undergoing quantitative collateral measurements. Circulation. 2007;116:975–83.

    Article  PubMed  Google Scholar 

  9. Meier P, Hemingway H, Lansky AJ, Knapp G, Pitt B, Seiler C. The impact of the coronary collateral circulation on mortality: a meta-analysis. Eur Heart J. 2012;33:614–21.

    Article  PubMed  Google Scholar 

  10. Perez-Castellano N, Garcia EJ, Abeytua M, et al. Influence of collateral circulation on in-hospital death from anterior acute myocardial infarction. J Am Coll Cardiol. 1998;31:512–8.

    Article  CAS  PubMed  Google Scholar 

  11. Seiler C, Meier P. Historical aspects and relevance of the human coronary collateral circulation. Curr Cardiol Rev. 2014;10:2–16.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Levin DC. Pathways and functional significance of the coronary collateral circulation. Circulation. 1974;50:831–7.

    Article  CAS  PubMed  Google Scholar 

  13. Rentrop KP, Cohen M, Blanke H, Phillips RA. Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol. 1985;5:587–92.

    Article  CAS  PubMed  Google Scholar 

  14. Arras M, Ito WD, Scholz D, Winkler B, Schaper J, Schaper W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest. 1998;101:40–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Ito WD, Arras M, Winkler B, Scholz D, Schaper J, Schaper W. Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion. Circ Res. 1997;80:829–37.

    Article  CAS  PubMed  Google Scholar 

  16. Sasayama S, Fujita M. Recent insights into coronary collateral circulation. Circulation. 1992;85:1197–204.

    Article  CAS  PubMed  Google Scholar 

  17. Buschmann I, Schaper W. The pathophysiology of the collateral circulation (arteriogenesis). J Pathol. 2000;190:338–42.

    Article  CAS  PubMed  Google Scholar 

  18. van Royen N, Piek JJ, Buschmann I, Hoefer I, Voskuil M, Schaper W. Stimulation of arteriogenesis; a new concept for the treatment of arterial occlusive disease. Cardiovasc Res. 2001;49:543–53.

    Article  PubMed  Google Scholar 

  19. Fujita M, Sasayama S, Ejiri M, Asanoi H, Nakajima H, Miwa K. Coronary collateral development after acute myocardial infarction. Clin Cardiol. 1988;11:525–8.

    Article  CAS  PubMed  Google Scholar 

  20. Rentrop KP, Feit F, Sherman W, Thornton JC. Serial angiographic assessment of coronary artery obstruction and collateral flow in acute myocardial infarction. Report from the second Mount Sinai–New York University Reperfusion Trial. Circulation. 1989;80:1166–75.

    Article  CAS  PubMed  Google Scholar 

  21. Schwartz H, Leiboff RH, Bren GB, et al. Temporal evolution of the human coronary collateral circulation after myocardial infarction. J Am Coll Cardiol. 1984;4:1088–93.

    Article  CAS  PubMed  Google Scholar 

  22. van den Akker J, Schoorl MJ, Bakker EN, Vanbavel E. Small artery remodeling: current concepts and questions. J Vasc Res. 2010;47:183–202.

    Article  PubMed  Google Scholar 

  23. de Marchi SF, Gloekler S, Meier P, et al. Determinants of preformed collateral vessels in the human heart without coronary artery disease. Cardiology. 2011;118:198–206.

    Article  PubMed  Google Scholar 

  24. Helfant RH, Kemp HG, Gorlin R. Coronary atherosclerosis, coronary collaterals, and their relation to cardiac function. Ann Intern Med. 1970;73:189–93.

    Article  CAS  PubMed  Google Scholar 

  25. Piek JJ, van Liebergen RA, Koch KT, Peters RJ, David GK. Clinical, angiographic and hemodynamic predictors of recruitable collateral flow assessed during balloon angioplasty coronary occlusion. J Am Coll Cardiol. 1997;29:275–82.

    Article  CAS  PubMed  Google Scholar 

  26. Pohl T, Seiler C, Billinger M, et al. Frequency distribution of collateral flow and factors influencing collateral channel development. Functional collateral channel measurement in 450 patients with coronary artery disease. J Am Coll Cardiol. 2001;38:1872–8.

    Article  CAS  PubMed  Google Scholar 

  27. Werner GS, Ferrari M, Betge S, Gastmann O, Richartz BM, Figulla HR. Collateral function in chronic total coronary occlusions is related to regional myocardial function and duration of occlusion. Circulation. 2001;104:2784–90.

    Article  CAS  PubMed  Google Scholar 

  28. Werner GS, Ferrari M, Heinke S, et al. Angiographic assessment of collateral connections in comparison with invasively determined collateral function in chronic coronary occlusions. Circulation. 2003;107:1972–7.

    Article  PubMed  Google Scholar 

  29. Pijls NH, van Son JA, Kirkeeide RL, De Bruyne B, Gould KL. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation. 1993;87:1354–67.

    Article  CAS  PubMed  Google Scholar 

  30. Seiler C, Fleisch M, Garachemani A, Meier B. Coronary collateral quantitation in patients with coronary artery disease using intravascular flow velocity or pressure measurements. J Am Coll Cardiol. 1998;32:1272–9.

    Article  CAS  PubMed  Google Scholar 

  31. Seiler C. Collateral circulation of the heart. London: Springer; 2009.

    Book  Google Scholar 

  32. Koerselman J, de Jaegere PP, Verhaar MC, Grobbee DE, van der Graaf Y, Group SS. Prognostic significance of coronary collaterals in patients with coronary heart disease having percutaneous transluminal coronary angioplasty. Am J Cardiol. 2005;96:390–4.

    Article  PubMed  Google Scholar 

  33. Seiler C. The human coronary collateral circulation. Heart. 2003;89:1352–7.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Bache RJ, Schwartz JS. Myocardial blood flow during exercise after gradual coronary occlusion in the dog. Am J Phys. 1983;245:H131–8.

    CAS  Google Scholar 

  35. Antoniucci D, Valenti R, Moschi G, et al. Relation between preintervention angiographic evidence of coronary collateral circulation and clinical and angiographic outcomes after primary angioplasty or stenting for acute myocardial infarction. Am J Cardiol. 2002;89:121–5.

    Article  PubMed  Google Scholar 

  36. Werner GS, Emig U, Mutschke O, Schwarz G, Bahrmann P, Figulla HR. Regression of collateral function after recanalization of chronic total coronary occlusions: a serial assessment by intracoronary pressure and Doppler recordings. Circulation. 2003;108:2877–82.

    Article  PubMed  Google Scholar 

  37. Cohen M, Rentrop KP. Limitation of myocardial ischemia by collateral circulation during sudden controlled coronary artery occlusion in human subjects: a prospective study. Circulation. 1986;74:469–76.

    Article  CAS  PubMed  Google Scholar 

  38. Kodama K, Kusuoka H, Sakai A, et al. Collateral channels that develop after an acute myocardial infarction prevent subsequent left ventricular dilation. J Am Coll Cardiol. 1996;27:1133–9.

    Article  CAS  PubMed  Google Scholar 

  39. Di Carli M, Sherman T, Khanna S, et al. Myocardial viability in asynergic regions subtended by occluded coronary arteries: relation to the status of collateral flow in patients with chronic coronary artery disease. J Am Coll Cardiol. 1994;23:860–8.

    Article  PubMed  Google Scholar 

  40. Elhendy A, Cornel JH, Roelandt JR, et al. Impact of severity of coronary artery stenosis and the collateral circulation on the functional outcome of dyssynergic myocardium after revascularization in patients with healed myocardial infarction and chronic left ventricular dysfunction. Am J Cardiol. 1997;79:883–8.

    Article  CAS  PubMed  Google Scholar 

  41. Seiler C, Engler R, Berner L, et al. Prognostic relevance of coronary collateral function: confounded or causal relationship? Heart. 2013;99:1408–14.

    Article  PubMed  Google Scholar 

  42. McEntegart MB, Badar AA, Ahmad FA, et al. The collateral circulation of coronary chronic total occlusions. EuroIntervention. 2016;11:e1596–603.

    Article  PubMed  Google Scholar 

  43. Hoefer IE, van Royen N, Buschmann IR, Piek JJ, Schaper W. Time course of arteriogenesis following femoral artery occlusion in the rabbit. Cardiovasc Res. 2001;49:609–17.

    Article  CAS  PubMed  Google Scholar 

  44. Lovell MJ, Mathur A. Cardiac stem cell therapy: progress from the bench to bedside. Heart. 2010;96:1531–7.

    Article  PubMed  Google Scholar 

  45. Meier P, Seiler C. The coronary collateral circulation—clinical relevances and therapeutic options. Heart. 2013;99:897–8.

    Article  Google Scholar 

  46. Fulton WFM. Immersion radiography of injected specimens. Br J Radiol. 1963;36:687.

    Article  Google Scholar 

  47. Okamura A, Yamane M, Muto M, et al. Complications during retrograde approach for chronic coronary total occlusion: Subanalysis of Japanese multicenter registry. Cathet Cardiovasc Intervent. 2016;88:7–14.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Novalia Purnama Sidik .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sidik, N.P., Spratt, J., McEntegart, M. (2018). Coronary Collateral Circulation. In: Lanzer, P. (eds) Textbook of Catheter-Based Cardiovascular Interventions. Springer, Cham. https://doi.org/10.1007/978-3-319-55994-0_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-55994-0_31

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-55993-3

  • Online ISBN: 978-3-319-55994-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics