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Complications of Nephroureterectomy

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Abstract

Open radical nephroureterectomy (ONU) and excision of the ipsilateral ureteral orifice with a periureteral cuff of the bladder is the gold standard for the treatment of upper tract urothelial cancer (UTUC). Laparoscopic techniques were introduced as a less invasive alternative in 1991 by Clayman et al. The use of minimally invasive nephroureterectomy (MINU) has increased for the management of UTUC with majority of nephroureterectomies being performed robotically. Patients with UTUC are often elderly and comorbid secondary to associated risk factors for developing this malignancy. Significant perioperative complications may occur in this surgical population with rates as high as 40%. Preoperative considerations include medical optimization, patient positioning, antibiotic prophylaxis, and deep venous thrombosis prophylaxis. Intraoperative vascular, bowel, and adjacent organ injuries are potential serious complications that can be life-threatening. The incidence and effects of many complications can be minimized with meticulous attention to the anatomical details and proper surgical techniques.

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References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29.

    Article  PubMed  Google Scholar 

  2. Cummings KB, Correa RJ Jr, Gibbons RP, Stoll HM, Wheelis RF, Mason JT. Renal pelvic tumors. J Urol. 1975;113(2):158–62.

    Article  PubMed  CAS  Google Scholar 

  3. Clayman RV, Kavoussi LR, Figenshau RS, Chandhoke PS, Albala DM. Laparoscopic nephroureterectomy: initial clinical case report. J Laparoendosc Surg. 1991;1(6):343–9.

    Article  PubMed  CAS  Google Scholar 

  4. Steinberg JR, Matin SF. Laparoscopic radical nephroureterectomy: dilemma of the distal ureter. Curr Opin Urol. 2004;14(2):61–5.

    Article  PubMed  Google Scholar 

  5. Gill IS, Soble JJ, Miller SD, Sung GT. A novel technique for management of the en bloc bladder cuff and distal ureter during laparoscopic nephroureterectomy. J Urol. 1999;161(2):430–4.

    Article  PubMed  CAS  Google Scholar 

  6. Shalhav AL, Dunn MD, Portis AJ, Elbahnasy AM, McDougall EM, Clayman RV. Laparoscopic nephroureterectomy for upper tract transitional cell cancer: the Washington University experience. J Urol. 2000;163(4):1100–4.

    Article  PubMed  CAS  Google Scholar 

  7. McNeill SA, Chrisofos M, Tolley DA. The long-term outcome after laparoscopic nephroureterectomy: a comparison with open nephroureterectomy. BJU Int. 2000;86(6):619–23.

    Article  PubMed  CAS  Google Scholar 

  8. Bariol SV, Stewart GD, McNeill SA, Tolley DA. Oncological control following laparoscopic nephroureterectomy: 7-year outcome. J Urol. 2004;172(5 Pt 1):1805–8.

    Article  PubMed  Google Scholar 

  9. Phe V, Cussenot O, Bitker MO, Roupret M. Does the surgical technique for management of the distal ureter influence the outcome after nephroureterectomy? BJU Int. 2011;108(1):130–8.

    Article  PubMed  Google Scholar 

  10. Guillonneau B, Jayet C, Tewari A, Vallancien G. Robot assisted laparoscopic nephrectomy. J Urol. 2001;166(1):200–1.

    Article  PubMed  CAS  Google Scholar 

  11. Rose K, Khan S, Godbole H, Olsburgh J, Dasgupta P, Guy S, et al. Robotic assisted retroperitoneoscopic nephroureterectomy—first experience and the hybrid port technique. Int J Clin Pract. 2006;60(1):12–4.

    Article  PubMed  CAS  Google Scholar 

  12. Trudeau V, Gandaglia G, Shiffmann J, Popa I, Shariat SF, Montorsi F, et al. Robot-assisted versus laparoscopic nephroureterectomy for upper-tract urothelial cancer: a population-based assessment of costs and perioperative outcomes. Can Urol Assoc J. 2014;8(9–10):E695–701.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Yu HY, Hevelone ND, Lipsitz SR, Kowalczyk KJ, Hu JC. Use, costs and comparative effectiveness of robotic assisted, laparoscopic and open urological surgery. J Urol. 2012;187(4):1392–8.

    Article  PubMed  Google Scholar 

  14. Hanske J, Sanchez A, Schmid M, Meyer CP, Abdollah F, Feldman AS, et al. A Comparison of 30-day Perioperative outcomes in open versus minimally invasive nephroureterectomy for upper tract urothelial carcinoma: analysis of 896 patients from the american college of surgeons-national surgical quality improvement program database. J Endourol. 2015;29(9):1052–8.

    Article  PubMed  Google Scholar 

  15. Lin YK, Deliere A, Lehman K, Harpster LE, Kaag MG, Raman JD. Critical analysis of 30 day complications following radical nephroureterectomy for upper tract urothelial carcinoma. Can J Urol. 2014;21(4):7369–73.

    PubMed  Google Scholar 

  16. Raman JD, Lin YK, Kaag M, Atkinson T, Crispen P, Wille M, et al. High rates of advanced disease, complications, and decline of renal function after radical nephroureterectomy. Urol Oncol. 2014;32(1):47 e9–14.

    Article  Google Scholar 

  17. Nelson EC, Evans CP. Complications of nephrectomy. In: Taneja SS, editor. Complications of urologic surgery: prevention and management. 4th ed. Philadelphia: Saunders, an imprint of Elsevier Inc.; 2009. p. 387–400.

    Google Scholar 

  18. Gill IS, Kavoussi LR, Clayman RV, Ehrlich R, Evans R, Fuchs G, et al. Complications of laparoscopic nephrectomy in 185 patients: a multi-institutional review. J Urol. 1995;154(2 Pt 1):479–83.

    PubMed  CAS  Google Scholar 

  19. Vallancien G, Cathelineau X, Baumert H, Doublet JD, Guillonneau B. Complications of transperitoneal laparoscopic surgery in urology: review of 1,311 procedures at a single center. J Urol. 2002;168(1):23–6.

    Article  PubMed  CAS  Google Scholar 

  20. Schafer M, Lauper M, Krahenbuhl L. Trocar and Veress needle injuries during laparoscopy. Surg Endosc. 2001;15(3):275–80.

    Article  PubMed  CAS  Google Scholar 

  21. Catarci M, Carlini M, Gentileschi P, Santoro E. Major and minor injuries during the creation of pneumoperitoneum. A multicenter study on 12,919 cases. Surg Endosc. 2001;15(6):566–9.

    Article  PubMed  CAS  Google Scholar 

  22. Chandler JG, Corson SL, Way LW. Three spectra of laparoscopic entry access injuries. J Am Coll Surg. 2001;192(4):478–90 (discussion 90–1).

    Google Scholar 

  23. Pareek G, Hedican SP, Gee JR, Bruskewitz RC, Nakada SY. Meta-analysis of the complications of laparoscopic renal surgery: comparison of procedures and techniques. J Urol. 2006;175(4):1208–13.

    Article  PubMed  Google Scholar 

  24. Fahlenkamp D, Rassweiler J, Fornara P, Frede T, Loening SA. Complications of laparoscopic procedures in urology: experience with 2,407 procedures at 4 German centers. J Urol. 1999;162(3 Pt 1):765–70 (discussion 70–1).

    Article  PubMed  CAS  Google Scholar 

  25. Soulie M, Seguin P, Richeux L, Mouly P, Vazzoler N, Pontonnier F, et al. Urological complications of laparoscopic surgery: experience with 350 procedures at a single center. J Urol. 2001;165(6 Pt 1):1960–3.

    PubMed  CAS  Google Scholar 

  26. Bird VG, Au JK, Sandman Y, De Los Santos R, Ayyathurai R, Shields JM. Comparison of different extraction sites used during laparoscopic radical nephrectomy. J Urol. 2009;181(4):1565–70.

    Article  PubMed  Google Scholar 

  27. Tisdale BE, Kapoor A, Hussain A, Piercey K, Whelan JP. Intact specimen extraction in laparoscopic nephrectomy procedures: Pfannenstiel versus expanded port site incisions. Urology. 2007;69(2):241–4.

    Article  PubMed  Google Scholar 

  28. Rassweiler J, Fornara P, Weber M, Janetschek G, Fahlenkamp D, Henkel T, et al. Laparoscopic nephrectomy: the experience of the laparoscopy working group of the German Urologic Association. J Urol. 1998;160(1):18–21.

    Article  PubMed  CAS  Google Scholar 

  29. Parsons JK, Varkarakis I, Rha KH, Jarrett TW, Pinto PA, Kavoussi LR. Complications of abdominal urologic laparoscopy: longitudinal five-year analysis. Urology. 2004;63(1):27–32.

    Article  PubMed  Google Scholar 

  30. Green DA, Grasso M. Complications of laparoscopic radical nephrectomy and nephroureterectomy. In: Ghavamian R, editor. Complications of Laparoscopic and Robotic Urologic Surgery. New York: Springer; 2010. p. 113–26.

    Chapter  Google Scholar 

  31. Kaneko N, Kobayashi Y, Okada Y. Anatomic variations of the renal vessels pertinent to transperitoneal vascular control in the management of trauma. Surgery. 2008;143(5):616–22.

    Article  PubMed  Google Scholar 

  32. Siqueira TM Jr, Kuo RL, Gardner TA, Paterson RF, Stevens LH, Lingeman JE, et al. Major complications in 213 laparoscopic nephrectomy cases: the Indianapolis experience. J Urol. 2002;168(4 Pt 1):1361–5.

    Article  PubMed  Google Scholar 

  33. Berger A, Haber GP, Kamoi K, Aron M, Desai MM, Kaouk JH, et al. Laparoscopic radical nephroureterectomy for upper tract transitional cell carcinoma: oncological outcomes at 7 years. J Urol. 2008;180(3):849–54 (discussion 54).

    Article  PubMed  Google Scholar 

  34. Soulie M, Salomon L, Seguin P, Mervant C, Mouly P, Hoznek A, et al. Multi-institutional study of complications in 1085 laparoscopic urologic procedures. Urology. 2001;58(6):899–903.

    Article  PubMed  CAS  Google Scholar 

  35. Kouba E, Smith AM, Derksen JE, Gunn K, Wallen E, Pruthi RS. Efficacy and safety of en bloc ligation of renal hilum during laparoscopic nephrectomy. Urology. 2007;69(2):226–9.

    Article  PubMed  Google Scholar 

  36. Buse S, Gilfrich C, Pfitzenmaier J, Bedke J, Haferkamp A, Hohenfellner M. En bloc stapler ligation of the renal vascular pedicle during laparoscopic nephrectomy. BJU Int. 2008;101(7):878–82.

    Article  PubMed  Google Scholar 

  37. Chan D, Bishoff JT, Ratner L, Kavoussi LR, Jarrett TW. Endovascular gastrointestinal stapler device malfunction during laparoscopic nephrectomy: early recognition and management. J Urol. 2000;164(2):319–21.

    Article  PubMed  CAS  Google Scholar 

  38. Friedman AL, Peters TG, Jones KW, Boulware LE, Ratner LE. Fatal and nonfatal hemorrhagic complications of living kidney donation. Ann Surg. 2006;243(1):126–30.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Ponsky L, Cherullo E, Moinzadeh A, Desai M, Kaouk J, Haber GP, et al. The Hem-o-lok clip is safe for laparoscopic nephrectomy: a multi-institutional review. Urology. 2008;71(4):593–6.

    Article  PubMed  Google Scholar 

  40. Hsi RS, Saint-Elie DT, Zimmerman GJ, Baldwin DD. Mechanisms of hemostatic failure during laparoscopic nephrectomy: review of Food and Drug Administration database. Urology. 2007;70(5):888–92.

    Article  PubMed  Google Scholar 

  41. Meng MV. Reported failures of the polymer self-locking (Hem-o-lok) clip: review of data from the Food and Drug Administration. J Endourol. 2006;20(12):1054–7.

    Article  PubMed  Google Scholar 

  42. Bishoff JT, Allaf ME, Kirkels W, Moore RG, Kavoussi LR, Schroder F. Laparoscopic bowel injury: incidence and clinical presentation. J Urol. 1999;161(3):887–90.

    Article  PubMed  CAS  Google Scholar 

  43. Breda A, Finelli A, Janetschek G, Porpiglia F, Montorsi F. Complications of laparoscopic surgery for renal masses: prevention, management, and comparison with the open experience. Eur Urol. 2009;55(4):836–50.

    Article  PubMed  Google Scholar 

  44. Simon SD, Castle EP, Ferrigni RG, Lamm DL, Swanson SK, Novicki DE, et al. Complications of laparoscopic nephrectomy: the Mayo clinic experience. J Urol. 2004;171(4):1447–50.

    Article  PubMed  Google Scholar 

  45. Permpongkosol S, Link RE, Su LM, Romero FR, Bagga HS, Pavlovich CP, et al. Complications of 2,775 urological laparoscopic procedures: 1993 to 2005. J Urol. 2007;177(2):580–5.

    Article  PubMed  Google Scholar 

  46. Canby-Hagino ED, Morey AF, Jatoi I, Perahia B, Bishoff JT. Fibrin sealant treatment of splenic injury during open and laparoscopic left radical nephrectomy. J Urol. 2000;164(6):2004–5.

    Article  PubMed  CAS  Google Scholar 

  47. Varkarakis IM, Allaf ME, Bhayani SB, Inagaki T, Su LM, Kavoussi LR, et al. Pancreatic injuries during laparoscopic urologic surgery. Urology. 2004;64(6):1089–93.

    Article  PubMed  Google Scholar 

  48. Del Pizzo JJ, Jacobs SC, Bishoff JT, Kavoussi LR, Jarrett TW. Pleural injury during laparoscopic renal surgery: early recognition and management. J Urol. 2003;169(1):41–4.

    Article  PubMed  Google Scholar 

  49. Aron M, Colombo JR Jr, Turna B, Stein RJ, Haber GP, Gill IS. Diaphragmatic repair and/or reconstruction during upper abdominal urological laparoscopy. J Urol. 2007;178(6):2444–50.

    Article  PubMed  Google Scholar 

  50. Montgomery JS, Wolf JS Jr. Venous thrombosis prophylaxis for urological laparoscopy: fractionated heparin versus sequential compression devices. J Urol. 2005;173(5):1623–6.

    Article  PubMed  Google Scholar 

  51. Rice KR, Brassell SA, McLeod DG. Venous thromboembolism in urologic surgery: prophylaxis, diagnosis, and treatment. Rev Urol. 2010;12(2–3):e111–24.

    PubMed  PubMed Central  Google Scholar 

  52. Forrest JB, Clemens JQ, Finamore P, Leveillee R, Lippert M, Pisters L, et al. AUA Best Practice Statement for the prevention of deep vein thrombosis in patients undergoing urologic surgery. J Urol. 2009;181(3):1170–7.

    Article  PubMed  Google Scholar 

  53. Muntener M, Schaeffer EM, Romero FR, Nielsen ME, Allaf ME, Brito FA, et al. Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomy. Urology. 2007;70(5):864–8.

    Article  PubMed  Google Scholar 

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Correspondence to Reza Ghavamian .

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Srivastava, A., Ghavamian, R. (2018). Complications of Nephroureterectomy. In: Eshghi, M. (eds) Urothelial Malignancies of the Upper Urinary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-51263-1_20

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  • DOI: https://doi.org/10.1007/978-3-319-51263-1_20

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