Abstract
One of the greatest challenges for the surgical placement of dental implants is the lack of adequate bone volume. Many techniques are available but they are both technique sensitive, and the results are not always predictable. Tissue engineering through the use of biologics provides a strategy for enhancing bone regeneration. Though this is a relatively new strategy, this chapter focuses on technologies that are available for clinicians to utilize at this time.
References
Alio JL, Rodriguez AE, Wróbel Dudzińska D (2015) Eye platelet-rich plasma in the treatment of ocular surface disorders. Curr Opin Ophthalmol 26:325–326
Anitua E (1999) Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 14:529–535
Baboolal TG, Boxall SA et al (2014) Multipotential stromal cell abundance in cellular bone allograft: comparison with fresh age-matched iliac crest bone and bone marrow aspirate. Regen Med 9:593–607
Bleuming SA, He XC, Kodach LL et al (2007) Bone morphogenetic protein signaling suppress tumorigenesis at gastric epithelial transition zones in mice. Cancer Res 67:8149–8155
Boyne PJ, Lily LC, Marx RE et al (2005) De novo bone induction by recombinant bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg 63:1693–1707
Cardaropoli D (2009) Vertical ridge augmentation with the use of recombinant human platelet-derived growth factor-BB and bovine bone mineral: a case report. Int J Periodontics Restor Dent 29:289–295
Choukroun I (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:299–303
Choukroun J, Adda F, Schoeffler C (2000) Une opportunite´ en paro-implantologie: le PRF. Implantodontie 42:55–62
Choukroun J, Diss A, Simonpieri A et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e56–e60
Clipet F, Tricot S, Alno N, Massot M (2012) In vitro effects of Choukroun’s platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology. Implant Dent 21:51–56
Cmolik BL, Spero JA, Magovern GJ (1993) Redo cardiac surgery: late bleeding complications from topical thrombin-induced factor five deficiency. J Thorac Cardiovasc Surg 105:222–228
Del Torto M, Enea D, Panfoli N et al (2014) Hamstrings anterior cruciate ligament reconstruction with and without platelet rich fibrin matrix. Knee Surg Sports Traumatol Arthrosc 31:1–9
Dohan DM, Choukroun J, Diss A et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e37–e44
Dohan Ehrenfest DM, de Peppo GM (2009) Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors 27:63–69
Filho CH, Kerkis I et al (2007) Allogenous bone grafts improved by bone marrow stem cells and platelet growth factors: clinical case reports. Artif Organs 31:2681 2
Fiorellini JP, Howell TH, Cochran D et al (2005) Randomized study evaluating recombinant human bone morphogenetic protein-2 for extraction socket augmentation. J Periodontol 76:605–613
Froum SJ, Wallace SS, Tarnow DP, Cho SC (2002) Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: three bilateral case reports. Int J Periodontics Restor Dent 22:45–53
Gonshor A, McAllister BS et al (2011) Histologic and histomorphometric evaluation of an allograft stem cell-based matrix sinus augmentation procedure. Int J Oral Maxillofac Implants 26:123 n a
He L, Lin Y, Hu X et al (2009) A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:707–713
Herford AS, Boyne PJ (2008) Reconstruction of mandibular continuity defects with bone morphogenetic protein-2 (rhBMP-2). J Oral Maxillofac Surg 66:616–624
Hinsbergh VW, Collen A, Koolwijk P (2001) Role of fibrin matrix in angiogenesis. Ann N Y Acad Sci 936:426–437
Hood AG, Hill AG, Reeder GD (1993) Perioperative autologous sequestration. III: a new physiologic glue with wound healing properties. Proc Am Acad Cardiovasc Perfusion 14:126–130
Howell TH, Fiorellini J, Jones A et al (1997) A feasibility study evaluating rhBMP-2/absorbable collage sponge device for local alveolar ridge preservation or augmentation. Int J Periodontics Restor Dent 17:124–139
Iasella JM, Greenwell H, Miller R (2003) Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol 74:990–999
Kaigler A (2015) Bone engineering of maxillary sinus bone deficiencies using enriched CD90+ stem cell therapy: a randomized clinical trial. J Bone Miner Res 30:1206–1216
Kang YH, Jeon SH, Park JY et al (2011) Platelet-rich fibrin is a bioscaffold and reservoir of growth factors for tissue regeneration. Tissue Eng Part A 17:349–359
Kassolis JD, Rosen PS, Reynolds MA (2000) Alveolar ridge and sinus augmentation utilizing platelet-rich plasma in combination with freeze-dried bone allograft: case series. J Periodontol 71:1654–1661
Koo S, Alshihri A et al (2012) Cellular allograft in the treatment of a severe periodontal intrabony defect: a case report. Clin Adv Periodontics 2:35–39
Lekovic V, Milinkovic I, Aleksic Z et al (2012) Platelet-rich fibrin and bovine porous bone mineral vs. platelet-rich fibrin in the treatment of intrabony periodontal defects. J Periodontal Res 47(4):409–417
Li Q, Pan S, Dangaria SJ (2013) Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. Biomed Res Int 2013:1–13
Lynch SE (1999) Introduction to tissue engineering. In: Lynch SE, Genco RJ, Marx RE (eds) Tissue engineering: applications in maxillofacial and periodontics. Quintessence, Chicago 1999, pp xi–xviii
McAllister B (2011) Stem cell-containing allograft matrix enhances periodontal regeneration: case presentations. Int J Periodontics Restor Dent 31:149–155
McAllister B, Eshraghi T (2013) Alveolar ridge augmentation with allograft stem cell stem cellograft stem cellence; 19. Clin Adv Periodontics 3:1–7
McGuire MK, Kao RT, Nevins M et al (2006) rhPDGF-BB promotes healing of periodontal defects: 24 month clinical and radiographic observations. Int J Periodontics Restor Dent 26:223–231
Milano F, van Baal JW, Buttar NS et al (2007) Bone morphogenetic protein 4 expressed in esophagitis induces a columnar phenotype in esophageal squamous cells. Gastroenterology 132:2412–2421
Misch C, Wang HL (2011) Clinical recombinant human bone morphogenetic protein-2 for bone augmentation before dental implant placement. Clin Adv Periodontics 1:118–131
Nevins ML, Reynolds MA (2011) Tissue engineering with recombinant human platelet-derived growth factor BB for implant site development. Compendium 32:18–28
Nevins M, Giannobile WV, McGuire MK et al (2005) rhPDGF-BB enhances periodontal healing. J Periodontol 76:2205–2215
Nevins ML, Camelo M, Schupbach P et al (2011) Human buccal plate extraction socket regeneration with recombinant platelet-derived growth factor BB or enamel matrix derivative. Int J Periodontics Restor Dent 31:481–492
Nevins M, McGuire MK, Kao RT et al (2013) PDGF promotes periodontal regeneration in localized osseous defects: 36 month extension results from a randomized, controlled, double-masked clinical trial. J Periodontol 84:456–464
Pilipchuk SP, Plonka AB, Monje A et al (2015) Tissue engineering for bone regeneration and osseointegration in the oral cavity. Dent Mater 31:317–338
Reddi AH, Reddi A (2009) Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev 20:341–342
Rickert D, Sauerbier S et al (2011) Maxillary sinus floor elevation with bovine bone mineral combined with either autogenous bone or autogenous stem cells: a prospective randomized clinical trial. Clin Oral Implants Res 22:251
Rosenberg ES, Torosian J (2000) Sinus grafting using platelet-rich plasma—Initial case presentation. Pract Periodontics Aesthet Dent 12:843–850
Roussy Y, Bertrand Duchesne MP, Gagnon G (2007) Activation of human platelet-rich plasmas: effect on growth factors release, cell division and in vivo bone formation. Clin Oral Implants Res 18:639–648
Sánchez AR, Sheridan PJ, Kupp LI (2003) Is platelet-rich plasma the perfect enhancement factor? A current review. Int J Oral Maxillofac Implants 18(1):93–103
Saygin NE, Tokiyasu Y, Giannobile WV et al (2000) Growth factors regulate expression of mineral associated genes in cementoblasts. J Periodontol 71:1591–1600
Schär MO, Diaz-Romero J, Kohl S et al (2015) Platelet-rich concentrates differentially release growth factors and induce cell migration in vitro. Clin Orthop Relat Res 473:1635–1643
Scheyer ET, McGuire MK (2011) Growth factor-mediated sinus augmentation grafting with recombinant human platelet-derived growth factor-BB (rhPDGF-591-1600-16001-1600n). Clin Adv Periodontics 1:4–15
Sclafani AP, Azzi J (2015) Platelet preparations for use in facial rejuvenation and wound healing: a critical review of current literature. Aesthet Plast Surg 39:495–505
Shanaman R, Filstein MR, Danesh-Meyer MJ (2001) Localized ridge augmentation using GBR and platelet-rich plasma: case reports. Int J Periodontics Restor Dent 21:345–355
Simion M, Rocchietta I, Dellavia C (2007) Three-dimensional ridge augmentation with xenograft and recombinant human platelet-derived growth factor-BB in humans: report of two cases. Int J Periodontics Restor Dent 27:109–115
Simion M, Rocchietta I, Monforte M et al (2008) Three-dimensional alveolar bone reconstruction with a combination of recombinant human platelet-derived growth factor BB and guided bone regeneration. Int J Periodontics Restor Dent 28:239–243
Simmonds MC, Brown JVE, Heirs MK et al (2013) Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data. Ann Intern Med 158:877–889
Simon BI, Gupta P, Tajbakhsh S (2011) Quantitative evaluation of extraction socket healing following the use of autologous platelet-rich fibrin matrix in humans. Int J Periodontics Restor Dent 31:285–295
Simonpieri A, Choukroun J, Del Corso M et al (2011) Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte- and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dent 20:2–12
Sindler AJ, Behmanesh S, Reynolds MA (2013) Evaluation of allogenic cellular bone graft for ridge augmentation: a case report. Clin Adv Periodontics 3:159–165
Suttapreyasri S, Leepong N (2013) Influence of platelet-rich fibrin on alveolar ridge preservation. J Craniofac Surg 24:1088–1094
Tajima N, Ohba S, Sawase T et al (2013) Evaluation of sinus floor augmentation with simultaneous implant placement using platelet-rich fibrin as sole grafting material. Int J Oral Maxillofac Implants 28:77–83
Tsay RC, Vo J, Burke A et al (2005) Differential growth factor retention by platelet-rich plasma composites. J Oral Maxillofac Surg 63:521–528
van den Dolder J, Mooren R, Vloon AP et al (2006) Platelet-rich plasma: quantification of growth factor levels and the effect on growth and differentiation of rat bone marrow cells. Tissue Eng 12:3067–3073
Wu CL, Lee SS, Tsai CH (2012) Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts. Aust Dent J 57:207–212
Xu FT, Li HM, Yin QS et al (2015) Effect of activated autologous platelet-rich plasma on proliferation and osteogenic differentiation of human adipose-derived stem cells in vitro. Am J Transl Res 7:257–270
Zhang Y, Tangl S, Huber CD (2012) Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. J Craniomaxillofac Surg 40:321–328
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Clark, D., Roitman, I., Fagan, M.C., Kao, R.T. (2017). Tissue Engineering Approach to Implant Site Development. In: Karateew, E. (eds) Implant Aesthetics. Springer, Cham. https://doi.org/10.1007/978-3-319-50706-4_15
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DOI: https://doi.org/10.1007/978-3-319-50706-4_15
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