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Acne Therapy

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Plewig and Kligman´s Acne and Rosacea

Abstract

This chapter provides a unifying model for acne therapy on the basis of transcriptomic regulation. Evidence from the literature will be presented that treatment-induced overexpression of the transcription factor p53, known as the guardian of the genome, is the critical effector of anti-acne therapies, which controls IGF-1 and androgen signaling, sebocyte homeostasis, and sebum production.

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    Disclaimer

    Adherence to our treatment recommendations will not ensure successful treatment in every situation. Our opinion for the treatment of acne should not be interpreted as setting a standard of care, but reflects our clinical and scientific experience in the pathogenesis and treatment of acne. The ultimate choice of specific therapies must be made by the physician in light of any circumstances presented by the individual patient and possible variations in the course of the disease. It is not the intention of this chapter to repeat acne treatment recommendations easily accessible such as European and US acne treatment guidelines.

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    Authors and Affiliations

    1. Department of Dermatology and Allergy, Ludwig-Maximilian-University Munich, Munich, Germany

      Gerd Plewig

    2. Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany

      Bodo Melnik

    3. Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany

      WenChieh Chen

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    1. Gerd Plewig
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    2. Bodo Melnik
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    Plewig, G., Melnik, B., Chen, W. (2019). Acne Therapy. In: Plewig and Kligman´s Acne and Rosacea. Springer, Cham. https://doi.org/10.1007/978-3-319-49274-2_7

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