Abstract
There are several different liver disorders which may occur concurrently post-HSCT. This chapter covers the history of hepatitis C virus (HCV) before the development of direct-acting antiviral therapy. The case discusses an HCV-negative patient who received a transplant from his HCV-positive donor. The patient had well-established hepatic GVHD but later developed a rapid rise in his aminotransferases coupled with a rapid rise in his HCV viral copy number. The pathology of fibrosing cholestatic hepatitis (FCH) is described and compared with the pathologic features typical of hepatic GVHD. The differential diagnoses of rapidly rising posttransplant liver tests are discussed.
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References
Strasser SI, Sullivan KM, Myerson D, et al. Cirrhosis of the liver in long-term marrow transplant survivors. Blood. 1999;93(10):3259–66.
de Latour RP, Ribaud P, Robin M, et al. Allogeneic hematopoietic cell transplant in HCV-infected patients. J Hepatol. 2008;48(6):1008–17.
McDonald GB, Slattery JT, Bouvier ME, et al. Cyclophosphamide metabolism, liver toxicity, and mortality following hematopoietic stem cell transplantation. Blood. 2003;101(5):2043–8.
Strasser SI, Myerson D, Spurgeon CL, et al. Hepatitis C virus infection and bone marrow transplantation: a cohort study with 10-year follow-up. Hepatology. 1999;29(6):1893–9.
Ljungman P, Johansson N, Aschan J, et al. Long-term effects of hepatitis-C virus-infection in allogeneic bone-marrow transplant recipients. Blood. 1995;86(4):1614–8.
Lefkowitch JH, Schiff ER, Davis GL, et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group. Gastroenterology. 1993;104(2):595–603.
Oliver NT, Nieto YL, Blechacz B, Anderlini P, Ariza-Heredia E, Torres HA. Severe hepatitis C reactivation as an early complication of hematopoietic cell transplantation. Bone Marrow Transplant. 2017;52(1):138–40.
Torres HA, McDonald GB. How I treat hepatitis C virus infection in patients with hematologic malignancies. Blood. 2016;128(11):1449–57.
Shulman HM, McDonald GB, Matthews D, et al. An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology. 1980;79(6):1178–91.
Kleiner D. Liver histology in the diagnosis and prognosis of drug-induced liver injury. Clin Liver Dis. 2014;4(1):12–26.
McDonald GB, Frieze D. A problem-oriented approach to liver disease in oncology patients. Gut. 2008;57(7):987–1003.
Inamoto Y, Storer BE, Petersdorf EW, et al. Incidence, risk factors, and outcomes of sclerosis in patients with chronic graft-versus-host disease. Blood. 2013;121(25):5098–103.
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Loeb, K.R., Shulman, H.M. (2019). Rapidly Progressing Cholestatic Liver Failure After Allogeneic Stem Cell Transplant from Hepatitis C Virus-Positive Donor (FCHCV). In: Yeung, C., Shulman, H. (eds) Pathology of Graft vs. Host Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-42099-8_15
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DOI: https://doi.org/10.1007/978-3-319-42099-8_15
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