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Urticaria

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Dermatology in Public Health Environments

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Abstract

Acute urticaria and angioedema can be part of the clinical spectrum of anaphylaxis and thus present a lethal risk if left untreated. Chronic urticaria, on the other hand, is a disease with major negative impact on the patients’ daily activities and can therefore worsen their quality of life. Many causes are attributed in acute or chronic urticaria; however, most of them are spontaneous. The first line of treatment of urticaria are antihistaminic drugs, while for chronic urticaria The International Consensus of Urticaria recommend antihistamine doses of up to four-fold the standard doses. The second line of treatment consists of cyclosporine, omalizumab, or montelukast.

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References

  1. Cousin F, Philips K, Favier B, Bienvenu J, Nicolas JF. Drug-induced urticaria. Eur J Dermatol. 2001;11:181–7.

    CAS  PubMed  Google Scholar 

  2. Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z, Canonica GW, et al. The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update. Allergy. 2014;69:868–87.

    Article  CAS  PubMed  Google Scholar 

  3. Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, Sheikh J, Weldon D, Zuraw B, Bernstein DI, Blessing-Moore J, Cox L, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CR, Schuller DE, Spector SL, Tilles SA, Wallace D. The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 2014;133:1270–7.

    Article  PubMed  Google Scholar 

  4. Pite H, Wedi B, Borrego LM, Kapp A, Raap U. Management of childhood urticaria: current knowledge and practical recommendations. Acta Derm Venereol. 2013;93(5):500–8.

    Article  PubMed  Google Scholar 

  5. Sabroe RA. Acute urticaria. Immunol Allergy Clin North Am. 2014;34(1):11–21.

    Article  PubMed  Google Scholar 

  6. Criado PR, Criado RF, Maruta CW, Reis VM. Chronic urticaria in adults: state-of-the-art in the new millenium. An Bras Dermatol. 2015;90(1):74–89.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Criado PR, Jardim Criado RF, Sotto MN, Pagliari C, Takakura CH, Vasconcellos C. Dermal dendrocytes FXIIIA+ phagocytizing extruded mast cell granules in drug-induced acute urticaria. J Eur Acad Dermatol Venereol. 2013;27(1):e105–12.

    Article  CAS  PubMed  Google Scholar 

  8. Hizal M, Tuzun B, Wolf R, Tuzun Y. The relationship between Helicobacter pylori IgG antibody and autologous serum test in chronic urticaria. Int J Dermatol. 2000;39:443–5.

    Article  CAS  PubMed  Google Scholar 

  9. Federman DG, Kirsner RS, Moriarty JP, Concato J. The effect of antibiotic therapy for patients infected with Helicobacter pylori who have chronic urticaria. J Am Acad Dermatol. 2003;49:861–4.

    Article  PubMed  Google Scholar 

  10. Burova KP, Mallet AI, Greaves MW. Is Helicobacter pylori a cause of urticaria? Br J Dermatol. 1999;51:42.

    Google Scholar 

  11. Greaves MW. Chronic idiopathic urticaria and H pylori: not directly causative but could there be a link? ACI Int. 2001;13:23–6.

    Google Scholar 

  12. Tharp MD, Thirlby R, Sullivan TJ. Gastrin induces histamine release from human cutaneous mast cells. J Allergy Clin Immunol. 1984;74:159–65.

    Article  CAS  PubMed  Google Scholar 

  13. Lessof MH, Gant V, Hinuma K, Murphy GM, Dowling RH. Recurrent urticaria and reduced diamine oxidase activity. Clin Exp Allergy. 1990;20:373–6.

    Article  CAS  PubMed  Google Scholar 

  14. Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85:1185–96.

    Article  CAS  PubMed  Google Scholar 

  15. Asero R. Multiple intolerance to food additives. J Allergy Clin Immunol. 2002;110:531–2.

    Article  PubMed  Google Scholar 

  16. Simon RA. Additive-induced urticaria: experience with monosodium glutamate(MSG). J Nutr. 2000;130:1063S–6S.

    Article  CAS  PubMed  Google Scholar 

  17. Di Lorenzo G, Pacor ML, Mansueto P, Martinelli N, Esposito-Pellitteri M, Lo Bianco C, et al. Food-additive-induced urticaria: a survey of 838 patients with recurrent chronic idiopathic urticaria. Int Arch Allergy Immunol. 2005;138:235–42.

    Article  PubMed  Google Scholar 

  18. Goga D, Vaillant L, Pandraud L, Mateu J, Ballon G, Beutter P. The elimination of dental and sinusal infectious foci in dermatologic pathology. A double-blind study in 27 cases confined to chronic urticaria. Rev Stomatol Chir Maxillofac. 1988;89:273–5.

    CAS  PubMed  Google Scholar 

  19. Vaida GA, Goldman MA, Bloch KJ. Testing for hepatitis B virus in patients with chronic urticaria and angioedema. J Allergy Clin Immunol. 1983;72:193–8.

    Article  CAS  PubMed  Google Scholar 

  20. Siddique N, Pereira BN, Hasan AS. Hepatitis C and urticaria: cause and effect? Allergy. 2004;59:668.

    Article  CAS  PubMed  Google Scholar 

  21. Nenoff P, Domula E, Willing U, Herrmann J. Giardia lamblia – cause of urticaria and pruritus or accidental association? Hautarzt. 2006;57:518–20. 521–2

    Article  CAS  PubMed  Google Scholar 

  22. Demirci M, Yildirim M, Aridogan BC, Baysal V, Korkmaz M. Tissue parasites inpatients with chronic urticaria. J Dermatol. 2003;30:777–81.

    Article  PubMed  Google Scholar 

  23. Ismail MA, Khalafallah O. Toxocara canis and chronic urticaria in Egyptian patients. J Egypt Soc Parasitol. 2005;35:833–40.

    PubMed  Google Scholar 

  24. Gulalp B, Koseoglu Z, Toprak N, Satar S, Sebe A, Gokel Y, et al. Ruptured hydatid cyst following minimal trauma and few signs on presentation. Neth J Med. 2007;65:117–8.

    CAS  PubMed  Google Scholar 

  25. Pattison DA, Speare R. Strongyloidiasis in personnel of the Regional Assistance Mission to Solomon Islands (RAMSI). Med J Aust. 2008;189:203–6.

    PubMed  Google Scholar 

  26. Marseglia GL, Marseglia A, Licari A, Castellazzi AM, Ciprandi G. Chronic urticaria caused by Hymenoleptis nana in an adopted girl. Allergy. 2007;62:821–2.

    Article  CAS  PubMed  Google Scholar 

  27. Zuel-Fakkar NM, Abdel Hameed DM, Hassanin OM. Study of Blastocystis hominis isolates in urticaria: a case-control study. Clin Exp Dermatol. 2011;36:908–10.

    Article  CAS  PubMed  Google Scholar 

  28. Kaji K, Yoshiji H, Yoshikawa M, Yamazaki M, Ikenaka Y, Noguchi R, et al. Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: a case report. World J Gastroenterol. 2007;13:3760–2.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Criado PR, Belda Junior W, Criado RF, Vasconcelos e Silva R, Vasconcellos C. Bedbugs (Cimicidae infestation): the worldwide renaissance of an old partner of human kind. Braz J Infect Dis. 2011;15:74–80.

    PubMed  Google Scholar 

  30. Spiewak R, Lundberg M, Johansson G, Buczek A. Allergy to pigeon tick (Argas reflexus) in Upper Silesia, Poland. Ann Agric Environ Med. 2006;13:107–12.

    PubMed  Google Scholar 

  31. Armentia A, Martin-Gil FJ, Pascual C, Martin-Esteban M, Callejo A, Martinez C. Anisakis simplex allergy after eating chicken meat. J Investig Allergol Clin Immunol. 2006;16:258–63.

    CAS  PubMed  Google Scholar 

  32. Daschner A, De Frutos C, Valls A, Vega F. Anisakis simplex sensitization-associated urticaria: short-lived immediate type or prolonged acute urticaria. Arch Dermatol Res. 2010;302:625–9.

    Article  CAS  PubMed  Google Scholar 

  33. Leznoff A, Josse RG, Denburg J, Dolovich J. Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol. 1983;119:636–40.

    Article  CAS  PubMed  Google Scholar 

  34. Leznoff A, Sussman GL. Syndrome of idiopathic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients. J Allergy Clin Immunol. 1989;84:66–71.

    Article  CAS  PubMed  Google Scholar 

  35. Zauli D, Grassi A, Ballardini G, Contestabile S, Zucchini S, Bianchi FB. Thyroid autoimmunity in chronic idiopathic urticaria. Am J Clin Dermatol. 2002;3:525–8.

    Article  PubMed  Google Scholar 

  36. Turktas I, Gokcora N, Demirsoy S, Cakir N, Onal E. The association of chronic urticaria and angioedema with autoimmune thyroiditis. Int J Dermatol. 1997;36:187–90.

    Article  CAS  PubMed  Google Scholar 

  37. Rottem M. Chronic urticaria and autoimmune thyroid disease: is there a link? Autoimmun Rev. 2003;2:69–72.

    Article  PubMed  Google Scholar 

  38. Konstantinou GN, Asero R, Maurer M, Sabroe RA, Schmid-Grendelmeier P, Grattan CE. EAACI/GA(2)LEN task force consensus report: the autologous serum skin test in urticaria. Allergy. 2009;64:1256–68.

    Article  PubMed  CAS  Google Scholar 

  39. Tedeschi A, Cottini M, Asero R. Simultaneous occurrence of chronic autoimmune urticaria and nonallergic asthma: a common mechanism? Eur Ann Allergy Clin Immunol. 2009;41:56–9.

    PubMed  CAS  Google Scholar 

  40. Confino-Cohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A. Chronic urticaria and autoimmunity: associations found in a large population study. J Allergy Clin Immunol. 2012;129:1307–13.

    Article  PubMed  Google Scholar 

  41. Cugno M, Marzano AV, Asero R, Tedeschi A. Activation of blood coagulation in chronic urticaria: pathophysiologic and clinical implications. Intern Emerg Med. 2010;5:97–101.

    Article  PubMed  Google Scholar 

  42. Asero R, Tedeschi A, Riboldi P, Griffini S, Bonanni E, Cugno M. Severe chronic urticaria is associated with elevated plasma levels of D-dimer. Allergy. 2008;63:176–80.

    CAS  PubMed  Google Scholar 

  43. Takahagi S, Mihara S, Iwamoto K, Morioke S, Okabe T, Kameyoshi Y, et al. Coagulation/fibrinolysis and inflammation markers are associated with disease activity in patients with chronic urticaria. Allergy. 2010;65:649–56.

    Article  CAS  PubMed  Google Scholar 

  44. Konstantinou GN, Asero R, Ferrer M, Knol EF, Maurer M, Raap U, et al. EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria. Allergy. 2013;68:27–36.

    Article  CAS  PubMed  Google Scholar 

  45. Augey F, Gunera-Saad N, Bensaid B, Nosbaum A, Berard F, Nicolas JF. Chronic spontaneous urticaria is not an allergic disease. Eur J Dermatol. 2011;21:349–53.

    PubMed  Google Scholar 

  46. Caliskaner Z, Ozturk S, Turan M, Karaayvaz M. Skin test positivity to aeroallergens in the patients with chronic urticaria without respiratory disease. J Investig Allergol Clin Immunol. 2004;14:50–4.

    CAS  PubMed  Google Scholar 

  47. Kozel MM, Mekkes JR, Bossuyt PM, Bos JD. Natural course of physical and chronic urticaria and angioedema in 220 patients. J Am Acad Dermatol. 2001;45:387–91.

    Article  CAS  PubMed  Google Scholar 

  48. Młynek A, Zalewska-Janowska A, Martus P, Staubach P, Zuberbier T, Maurer M. How to assess disease activity in patients with chronic urticaria? Allergy. 2008;63:777–80.

    Article  PubMed  Google Scholar 

  49. Grattan CEH. The urticaria spectrum: recognition of clinical patterns can help management. Clin Exp Dermatol. 2004;29:217–21.

    Article  CAS  PubMed  Google Scholar 

  50. Malmros H. Auto serum test. Nord Med. 1946;29:150–1.

    Google Scholar 

  51. Sabroe RA, Greaves MW. Chronic idiopathic urticaria with functional autoantibodies: 12 years on. Br J Dermatol. 2006;154:813–9.

    Article  CAS  PubMed  Google Scholar 

  52. Yıldız H, Karabudak O, Doğan B, Harmanyeri Y. Evaluation of autologous plasma skin test in patients with chronic idiopathic urticaria. Br J Dermatol. 2011;165:1205–9.

    Article  PubMed  Google Scholar 

  53. Asero R, Tedeschi A, Riboldi P, Cugno M. Plasma of patients with chronic urticaria shows signs of thrombin generation, and its intradermal injection causes wheal and-flare reaction much more frequently than frequently than autologous serum. J Allergy Clin Immunol. 2006;117:1113–7.

    Article  CAS  PubMed  Google Scholar 

  54. Metz M, Gimenez-Arnau A, Borzova E, Grattan CE, Magerl M, Maurer M. Frequency and clinical implications of skin autoreactivity to serum versus plasma in patients with chronic urticaria. J Allergy Clin Immunol. 2009;123:705–6.

    Article  PubMed  Google Scholar 

  55. Criado PR, Criado RFJ, Maruta CW, Martins JEC, Rivitti EA. Urticaria. An Bras Dermatol. 2005;80:613–30.

    Article  Google Scholar 

  56. Criado PR, Criado RFJ, Maruta CW, Machado CDA. Histamine, histamine receptors and antihistamines: new concepts. An Bras Dermatol. 2010;85:195–210.

    Article  PubMed  Google Scholar 

  57. Pires JS, de Ue APF, Furlani EJ, de Souza PK, Rotta O. Dapsone as an alternative to the treatment of chronic urticaria nonresponsive to antihistamines. An Bras Dermatol. 2008;83:413–8.

    Article  Google Scholar 

  58. Criado RF, Criado PR, Martins JE, Valente NY, Michalany NS, Vasconcellos C. Urticaria unresponsive to antihistaminic treatment: an open study of therapeutic options based on histopathologic features. J Dermatolog Treat. 2008;19:92–6.

    Article  CAS  PubMed  Google Scholar 

  59. Jauregui I, Ferrer M, Montoro J, Davila I, Bartra J, del Cuvillo A, et al. Antihistamines in the treatment of chronic urticaria. J Investig Allergol Clin Immunol. 2007;17:41–52.

    CAS  PubMed  Google Scholar 

  60. Kalivas J, Breneman D, Tharp M, Bruce S, Bigby M. Urticaria: clinical efficacy of cetirizine in comparison with hydroxyzine and placebo. J Allergy Clin Immunol. 1990;86:1014–8.

    Article  CAS  PubMed  Google Scholar 

  61. Zuberbier T, Bindslev-Jensen C, Canonica W, Grattan CE, Greaves MW, Henz BM, et al. EAACI/GA2LEN/EDF. EAACI/GA2LEN/EDF guideline: management of urticaria. Allergy. 2006;61:321–31.

    Article  CAS  PubMed  Google Scholar 

  62. Asero R. Chronic unremitting urticaria: is the use of antihistamines above the licensed dose effective? A preliminary study of cetirizine at licensed and above-licensed doses. Clin Exp Dermatol. 2007;32:34–8.

    Article  CAS  PubMed  Google Scholar 

  63. Black AK, Greaves MW. Antihistamines in urticaria and angioedema. Clin Allergy Immunol. 2002;17:249–86.

    CAS  PubMed  Google Scholar 

  64. Kozel MM, Sabroe RA. Chronic urticaria: aetiology, management and current and future treatment options. Drugs. 2004;64:2515–36.

    Article  CAS  PubMed  Google Scholar 

  65. Weller K, Ziege C, Staubach P, Brockow K, Siebenhaar F, Krause K, et al. H1-antihistamine up-dosing in chronic spontaneous urticaria: patients’ perspective of effectiveness and side effects – a retrospective survey study. PLoS One. 2011;6:e23931.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  66. Sanchez-Borges M, Caballero-Fonseca F, Capriles-Hulett A. Treatment of recalcitrant chronic urticaria with nonsedating antihistamines: is there evidence for updosing? J Investig Allergol Clin Immunol. 2013;23:141–4.

    CAS  PubMed  Google Scholar 

  67. Fedorowicz Z, van Zuuren EJ, Hu N. Histamine H2-receptor antagonists for urticaria. Cochrane Database Syst Rev. 2012;3:CD008596.

    Google Scholar 

  68. Grattan CE, O’Donnell BF, Francis DM, Niimi N, Barlow RJ, Seed PT, et al. Randomized double-blind study of cyclosporine in chronic ‘idiopathic’ urticaria. Br J Dermatol. 2000;143:365–72.

    Article  CAS  PubMed  Google Scholar 

  69. Hollander SM, Joo SS, Wedner HJ. Factors that predict the success of cyclosporine treatment for chronic urticaria. Ann Allergy Asthma Immunol. 2011;107:523–8.

    Article  CAS  PubMed  Google Scholar 

  70. Di Leo E, Nettis E, Aloia AM, Moschetta M, Carbonara M, Dammacco F, et al. Cyclosporine-A efficacy in chronic idiopathic urticaria. Int J Immunopathol Pharmacol. 2011;24:195–200.

    Article  PubMed  Google Scholar 

  71. Vena GA, Cassano N, Colombo D, Peruzzi E, Pigatto P, Neo-I-30 Study Group. Cyclosporine in chronic idiopathic urticaria: a double-blind, randomized, placebo-controlled trial. J Am Acad Dermatol. 2006;55:705–9.

    Article  PubMed  Google Scholar 

  72. Neverman L, Weinberger M. Treatment of chronic urticaria in children with antihistamines and cyclosporine. J Allergy Clin Immunol Pract. 2014;2:434–8.

    Article  PubMed  Google Scholar 

  73. Kessel A, Toubi E. Cyclosporine-A in severe chronic urticaria: the option for long term therapy. Allergy. 2010;65:1478–82.

    Article  CAS  PubMed  Google Scholar 

  74. Sagi L, Solomon M, Baum S, Lyakhovitsky A, Trau H, Barzilai A. Evidence for methotrexate as a useful treatment for steroid-dependent chronic urticaria. Acta Derm Venereol. 2011;91:303–6.

    Article  PubMed  Google Scholar 

  75. Perez A, Woods A, Grattan CE. Methotrexate: a useful steroid-sparing agent in recalcitrant chronic urticaria. Br J Dermatol. 2010;162:191–4.

    Article  CAS  PubMed  Google Scholar 

  76. Asero R. Oral cyclophosphamide in a case of cyclosporine and steroid-resistant chronic urticaria showing autoreactivity on autologous serum skin testing. Clin Exp Dermatol. 2005;30:582–3.

    Article  CAS  PubMed  Google Scholar 

  77. O’Donnell BF, Barr RM, Black AK, Francis DM, Kermani F, Niimi N, et al. Intravenous immunoglobulin in autoimmune chronic urticaria. Br J Dermatol. 1998;138:101–6.

    Article  PubMed  Google Scholar 

  78. Pereira C, Tavares B, Carrapatoso I, Loureiro G, Faria E, Machado D, et al. Lowdose intravenous gammaglobulin in the treatment of severe autoimmune urticaria. Eur Ann Allergy Clin Immunol. 2007;39:237–42.

    CAS  PubMed  Google Scholar 

  79. Mitzel-Kaoukhov H, Staubach P, Muller-Brenne T. Effect of high-dose intravenous immunoglobulin treatment in therapy-resistant chronic spontaneous urticaria. Ann Allergy Asthma Immunol. 2010;104:253–8.

    Article  CAS  PubMed  Google Scholar 

  80. Maurer M, Altrichter S, Bieber T, Biedermann T, Brautigam M, Seyfried S, et al. Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. J Allergy Clin Immunol. 2011;128:202–209.e5.

    Article  CAS  PubMed  Google Scholar 

  81. Khan DA. Alternative agents in refractory chronic urticaria: evidence and considerations on their selection and use. J Allergy Clin Immunol Pract. 2013;1:433–440.e1.

    Article  PubMed  Google Scholar 

  82. Saini S, Rosen KE, Hsieh HJ, Wong DA, Conner E, Kaplan A, et al. A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria. J Allergy Clin Immunol. 2011;128:567–73.e1.

    Article  CAS  PubMed  Google Scholar 

  83. Maurer M, Rosen K, Hsieh HJ, Saini S, Grattan C, Gimenez-Arnau A, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013;368:924–35.

    Article  CAS  PubMed  Google Scholar 

  84. Asero R, Tedeschi A, Cugno M. Treatment of chronic urticaria. Immunol Allergy Clin N Am. 2014;34:105–16.

    Article  Google Scholar 

  85. Chakravarty SD, Yee AF, Paget SA. Rituximab successfully treats refractory chronic autoimmune urticaria caused by IgE receptor autoantibodies. J Allergy Clin Immunol. 2011;128:1354–5.

    Article  CAS  PubMed  Google Scholar 

  86. Arkwright PD. Anti-CD20 or anti-IgE therapy for severe chronic autoimmune urticaria. J Allergy Clin Immunol. 2009;123:510–1.

    Article  PubMed  Google Scholar 

  87. Mallipeddi R, Grattan CE. Lack of response of severe steroid-dependent chronic urticaria torituximab. Clin Exp Dermatol. 2007;32:333–4.

    Article  CAS  PubMed  Google Scholar 

  88. Wilson LH, Eliason MJ, Leiferman KM, Hull CM, Powell DL. Treatment of refractory chronic urticaria with tumor necrosis factor-alfa inhibitors. J Am Acad Dermatol. 2011;64:1221–2.

    Article  PubMed  Google Scholar 

  89. Piconi S, Trabattoni D, Iemoli E, Fusi ML, Villa ML, Milazzo F, et al. Immune profiles of patients with chronic idiopathic urticaria. Int Arch Allergy Immunol. 2002;128:59–66.

    Article  CAS  PubMed  Google Scholar 

  90. Hermes B, Prochazka AK, Haas N, Jurgovsky K, Sticherling M, Henz BM. Upregulation of TNF-alpha and IL-3 expression in lesional and uninvolved skin indifferent types of urticaria. J Allergy ClinImmunol. 1999;103:307–14.

    Article  CAS  Google Scholar 

  91. Reeves GE, Boyle MJ, Bonfield J, Dobson P, Loewenthal M. Impact of hydroxychloroquine therapy on chronic urticaria: chronic autoimmune urticaria study and evaluation. Intern Med J. 2004;34:182–6.

    Article  CAS  PubMed  Google Scholar 

  92. Pho LN, Eliason MJ, Regruto M, Hull CM, Powell DL. Treatment of chronic urticaria with colchicine. J Drugs Dermatol. 2011;10:1423–8.

    CAS  PubMed  Google Scholar 

  93. Noda S, Asano Y, Sato S. Long-term complete resolution of severe chronic idiopathic urticaria after dapsone treatment. J Dermatol. 2012;39:496–7.

    Article  PubMed  Google Scholar 

  94. Engin B, Ozdemir M. Prospective randomized nonblinded clinical trial on the use of dapsone plus antihistamine vs. antihistamine in patients with chronic idiopathic urticaria. J Eur Acad Dermatol Venereol. 2008;22:481–6.

    Article  CAS  PubMed  Google Scholar 

  95. Khan S, Lynch N. Efficacy of montelukast as added therapy in patients with chronic idiopathic urticaria. Inflamm Allergy Drug Targets. 2012;11:235–43.

    Article  CAS  PubMed  Google Scholar 

  96. Criado PR, Antinori LC, Maruta CW, Reis VM. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis. An Bras Dermatol. 2013;88:355–60.

    Article  PubMed Central  PubMed  Google Scholar 

  97. Asero R, Tedeschi A, Cugno M. Heparin and tranexamic acid therapy may be effective in treatment-resistant chronic urticaria with elevated d-dimer: a pilot study. Int Arch Allergy Immunol. 2010;152:384–9.

    Article  CAS  PubMed  Google Scholar 

  98. Samarasinghe V, Marsland AM. Class action of oral coumarins in the treatment ofa patient with chronic spontaneous urticaria and delayed-pressure urticaria. Clin Exp Dermatol. 2012;37:741–3.

    Article  CAS  PubMed  Google Scholar 

  99. Chua SL, Gibbs S. Chronic urticaria responding to subcutaneous heparin sodium. Br J Dermatol. 2005;153:216–7.

    Article  CAS  PubMed  Google Scholar 

  100. Parslew R, Pryce D, Ashworth J, Friedmann PS. Warfarin treatment of chronic idiopathic urticaria and angio-oedema. Clin Exp Allergy. 2000;30:1161–5.

    Article  CAS  PubMed  Google Scholar 

  101. Karaayvaz M, Calişkaner Z, Turan M, Akar A, Ozturk S, Ozanguc N. Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. J Dermatol Treat. 2002;13:165–72.

    Article  CAS  Google Scholar 

  102. Temboury Molina C, Alins Sahun Y, Cerecedo CI. Recurrent urticaria and autoimmune thyroiditis: the influence of thyroxin treatment on the outcome of the urticaria. An Pediatr (Barc). 2012;77:66–7.

    Article  CAS  Google Scholar 

  103. Gupta MA, Gupta AK. Chronic idiopathic urticaria and post-traumatic stress disorder (PTSD): an under-recognized comorbidity. Clin Dermatol. 2012;30:351–4.

    Article  PubMed  Google Scholar 

  104. Hunkin V, Chung MC. Chronic idiopathic urticaria, psychological comorbidity and posttraumatic stress: the impact of alexithymia and repression. Psychiatr Q. 2012;83:431–47.

    Article  PubMed  Google Scholar 

  105. Staubach P, Dechene M, Metz M, Magerl M, Siebenhaar F, Weller K, et al. High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria. Acta Derm Venereol. 2011;91:557–61.

    Article  PubMed  Google Scholar 

  106. O’Donnell BF. Urticaria: impact on quality of life and economic cost. Immunol Allergy Clin N Am. 2014;34:89–104.

    Article  Google Scholar 

  107. Rabelo-Filardi R, Daltro-Oliveira R, Campos RA. Parameters associated with chronic spontaneous urticaria duration and severity: a systematic review. Int Arch Allergy Immunol. 2013;161:197–204.

    Article  PubMed  Google Scholar 

  108. Sanchez-Borges M, Asero R, Ansotegui IJ, Baiardini I, Bernstein JA, Canonica GW, et al. Diagnosis and treatment of urticaria and angioedema: a worldwide perspective. World Allergy Organ J. 2012;5:125–47.

    Article  PubMed Central  PubMed  Google Scholar 

  109. Ye YM, Jin HJ, Hwang EK, Nam YH, Kim JH, Shin YS. Coexistence of chronic urticaria and metabolic syndrome: clinical implications. Acta Derm Venereol. 2013;93:156–60.

    Article  CAS  PubMed  Google Scholar 

  110. De Benedictis FM, De Benedictis D, Canonica GW. New oral H1 antihistamines in children: facts and unmeet needs. Allergy. 2008;63:1395–404. doi:https://doi.org/10.1111/j.1398–9995.2008.01771.x.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Scholl of Medicine – ABC, Santo André, Brazil

    Roberta Fachini Jardim Criado

  2. Department of Dermatology, School of Medicine, Sao Paulo University, São Paulo, Brazil

    Paulo Ricardo Criado

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  1. Roberta Fachini Jardim Criado
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  2. Paulo Ricardo Criado
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Correspondence to Roberta Fachini Jardim Criado .

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  1. Dermatology Service of Clinical, Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Renan Rangel Bonamigo

  2. Health Secretary of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Sergio Ivan Torres Dornelles

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Criado, R.F.J., Criado, P.R. (2018). Urticaria. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_63

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  • DOI: https://doi.org/10.1007/978-3-319-33919-1_63

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