Abstract
Hanseniasis is a systemic and infectious disease whose etiologic agent (Mycobacterium leprae or Hansen’s bacillus) has a predilection for and primarily affects the skin and peripheral nerves. It presents chronic evolution that can be interrupted by acute episodes known as hansenic reaction. Diagnosis is mainly clinical, based on a good anamnesis and physical examination of the skin and nerve trunks. The multidrug therapy employed today was first proposed by the WHO in 1982 and is a combination of two (rifampicin and dapsone) or three (rifampicin, dapsone, and clofazimine) drugs that are safe and effective in treating hanseniasis and preventing the emergence of drug resistance. If untreated, the disease can progress to other organs and can cause nerve damage, leading to muscle weakness and atrophy, and permanent physical disabilities and deformities characteristic of the disease. These deformities are responsible for the stigma and prejudice against persons affected by hanseniasis. Prevention of disabilities begins with diagnosing hanseniasis sufficiently early, treating the disease with multidrug therapy, and recognizing and treating reactions and neuritis. Reporting of the disease is mandatory worldwide.
References
Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL. The continuing challenges of leprosy. Clin Microbiol Rev. 2006;19(2):338–81.
Editorial. The disease Hanseniasis: a periodical to combat leprostigma. 1977;1(1):4–15.
Brazil Law No. 9,010, of March 29, 1995.
World Health Organization. Leprosy health topics. Captured: 29 Apr 2016. Available in: http://www.who.int/topics/leprosy/en/.
Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância das Doenças Transmissíveis. Diretrizes para vigilância, atenção e eliminação da Hanseníase como problema de saúde pública: manual técnico-operacional [recurso eletrônico] (Guidelines for Surveillance, attention and elimination of Leprosy as a Public Health Problem: technical and operacional manual)/Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Vigilância das Doenças Transmissíveis. – Brasília: Ministério da Saúde, 2016. Available in: www.saude.gov.br/bvs.
Brasil. Portaria No. 149, de 3 de fevereiro de 2016. (Brazil Decree No. 149, of February 3, 2016). Diário Oficial da União de 4 de fevereiro de 2016, p. 45.
World Health Organization. Prevalence of Hanseniasis around the world reported to WHO at beginning January 2011. Captured: 20 May 2016. Available in: http://www.who.int/lep/situation/prevalence/en/.
World Health Organization. New cases detection rates of Hanseniasis, WHO, January 2012. Captured: 20 May 2016. Available in: http://www.who.int/lep/situation/Leprosy_DR_2011.pdf?ua=1.
Brasil. Ministério da Saúde. Situação epidemiológica da Hanseniase no Brasil no ano de 2014. Available in: www.saude.org.br.
Yawalkar SJ. Leprosy for medical practitioners and paramedical workers. Switzerland: Novartis Foundation; 2002.
Job CK, Chandi SM. Differential diagnosis of leprosy. A guide book for Histopathologists. India: Karigiri Leprosy Education Programme; 2001.
Worobec SM. Treatment of leprosy: Hansen’s disease in the early 21st century. Dermatol Ther. 2009;22:518–37.
World Health Organization. Enhanced global strategy for further reducing the disease burden due to leprosy. Questions and answers. India: World Health Organization; 2012.
Contin LA, Alves CJM, Fogagnolo L, Nassif PW, Barreto JA, Lauris JRP, Nogueira. Use of the ML-flow test as a tool in classifying and treating leprosy. An Bras Dermatol. 2011;86(1):91–5.
Summary of the Report of the International Leprosy Association (ILA) technical forum. Int J Lep. 2002;70(1):S3–5.
Report of the International Leprosy Association (ILA) technical forum. The diagnosis and classification of leprosy. Int J Lepr. 2002;70(1):S23–31.
Pfaltzgraff RE. How to diagnose and classify leprosy: a study guide. New Jersey: American Leprosy Missions; 1988.
Eidt LM. O mundo da vida do ser hanseniano: sentimentos e vivências (The world of life of being Hanseniasis patient: feelings and experiences). [dissertation]. Porto Alegre: Pontifícia Universidade Católica do Rio Grande do Sul; 2000.
Eidt LM. Being leprous: feelings and experiences. Hansenol Int. 2004;29(1):21–7.
Wheate HW, Pearson JMH. A practical guide to the diagnosis and treatment of leprosy in the basic health unit. 3rd ed. Wurzburg: German Leprosy Relief Association; 1985.
Matsuoka M. Drug resistance in leprosy. Jpn J Infect Dis. 2010;63:1–7.
Opromolla DVA. Multidrug therapy. An Bras Dermatol. 1990;65(1):37–40.
Nakata N, Masanori K, Makino M. Mutation analysis of the Mycobacterium leprae folP1 Gene and Dapsone resistance. Antimicrob Agents Chemother. 2011;55(2):762–6.
Li W, Sakamuri RM, Lions DE, Orcullo FM, Shinde V, Dela Pena EL, Maghanoy AA, et al. Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches. Antimicrob Agents Chemother. 2011;55(11):5384–7.
Gupta UD, Katoch K, Katoch VM. Study of rifampicin resistance and comparison on dapsone resistance of M. leprae in pre- and post-MDT. Indian J Lepr. 2009;81(3):131–4.
Hernández E, Cardona-Castro N, Rodriguez G, Villegas S, Beltrán C, Kimura M, Vissa VD, et al. Estudio de resistencia a la rifampicina y la dapsona en tres pacientes con recurrencia de lepra. Rev Panm Salud Publica. 2008;23(2):73–7.
Matsuoka M, Suzuki Y, Garcia IE, Fafutis M, Vargas-González A, Carreño-Martinez C, Fukushima Y, Nakajima C. Possible mode of emergence for drug-resistant leprosy is revealed by an analysis of samples from Mexico. Jpn J Infect Dis. 2010;63:412–6.
Matsuoka M. Our hole in sentinel surveillance for drug resistance in leprosy by global leprosy programme. [Abstract]. Nihon Hansenbyo Gakkai Zasshi. 2011;80(3):287.
Sarno EM, Gallo MEN, Almeida SMR, Nery JAC, Borges E. Multidrug therapy in leprosy callified as paucibacillary. An Bras Dermatol. 1990;65(1):41–2.
Kai M, Phuc NHN, Ha N, THBD P, Nguyen KH, Miyamoto Y, Maeda Y, et al. Analysis of drug-resistant strains of Mycobacterium leprae in an endemic area of Vietnam. Clin Infect Dis. 2011;52(5):e127–32.
World Health Organization. Global strategy for further reducing the leprosy burden and sustaining leprosy control activities (2006–2010). New Delhi: Operational Guidelines. World Health Organization; 2006.
World Health Organization. Enhanced global strategy for further reducing the disease burden due to leprosy (2011–2015). Operational guidelines (updated). India: World Health Organization; 2009.
Matrat S, Cambau E, Jarlier V, Aubry A. Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to Fluoroquinolones? Antimicrob Agents Chemother. 2008;52(2):745–7.
Li W, Matsuoka M, Kai M, Thapa P, Khadge S, Hagge DA, Brennan PJ, Vissa V. J Clin Microbiol. 2012;50(3):742–53.
Yokoyama K, Kim H, Mukai T, Matsuoka M, Nakajima C, Suzuki Y. Amino acid substitutions at position 95 in GyrA can add fluoroquinolone resistance to Mycobacterium leprae. Antimicrob Agents Chemother. 2012;56(2):697–702.
Kim H, Suzuki H, Matsuoka M, Matsuaba T, Yokoyana K, Nakajima C, Suzuki Y. Molecular mechanism of the acquisition of new-quinolone resistance in Mycobacterium leprae and M. tuberculosis and rapid differentiation methods for resistant bacilli. Nihon Hansenbyo Gakkai Zasshi. 2011;80(1):17–27.
Kamath S, Vaccaro SA, Rea TH, Ochoa MT. Recognizing and managing the immunologic reactions in leprosy. J Am Acad Dermatol. 2014;71(4):795–803.
Proença NG. Thalidomide – an eclectic medicine in dermatology. An Bra Dermatol. 1990;65(1):11–4.
World Health Organization. Guidelines for the management of severe erythema nodosum leprosum (ENL) reactions. Captured: 26 Apr 2016. Available in: http://www.who.int/lep/mdt/en/
Kaimal S, Thappa DM. Relapse in leprosy. Ind J Dermatol Venereol Leprol. 2009;75(2):126–65.
World Health Organization. The final push strategy to eliminate leprosy as a Public Health Problem. 1st ed. Geneva: World Health Organization; 2002.
Brasil. Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Quimioprofilaxia de contatos de doentes de hanseníase com rifampicina em dose única. Relatório de recomendação No. 165 de Julho/2015. Captured: 13 May 2016. Available in: http://conitec.gov.br.
Ferreira SB, Yonekura T, Takahashi J, Ignotti E, Cortela DCB, Soaares CB. Rifampicin chemoprophylaxis in preventing leprosy in contacts of patients with leprosy: a comprehensive systematic review protocol. JBI Database System Rev Implement Rep. 2015;13(2):84–100.
Santos DS, Duppre NC, Sales AN, Nery JAC, Sarno EN and Hacker MA. Kinship and leprosy in the contacts of leprosy patients: cohort at the Souza Araújo Outpatient Clinic, Rio de Janeiro, RJ, 1987–2010. J Trop Med. 2013;1–8. Article ID 596316. doi:https://doi.org/10.1155/2013/596316.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Glossary
- ML Flow
-
Rapid test lateral flow to M. leprae. It is an immunochromatographic test strip comprising nitrocellulose with a detection reagent made of wool fiber with anti-human IgM antibody labeled with colloidal gold dried from one side, and an absorption strip on the other.
- PGL-1 or phenolic glycolipid 1
-
The main antigenic glycolipid of Hansen’s bacillus, the main antigenic determinant being the last part of di- and trisaccharide of the molecule. It is one of the first specific antigens isolated from M. leprae.
- Ridley–Jopling classification
-
A classification of leprosy/hanseniasis for research purposes. This classification made by Ridley and Jopling was based on clinical, histologic, and immunologic differences in the disease, but they are continuous and compose a disease spectrum.
Rights and permissions
Copyright information
© 2018 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Eidt, L.M. (2018). Hanseniasis. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_5
Download citation
DOI: https://doi.org/10.1007/978-3-319-33919-1_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-33917-7
Online ISBN: 978-3-319-33919-1
eBook Packages: MedicineMedicine (R0)