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Autoimmune Bullous Dermatoses

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Dermatology in Public Health Environments

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Abstract

Autoimmune bullous dermatoses are acquired diseases associated with pathogenic autoantibodies against structural proteins that maintain cell–cell and cell–matrix adhesions in the skin and mucous membranes. They are classified as acantholytic (or intraepidermal) bullous dermatoses or non-acantholytic (or subepidermal) bullous dermatoses. Etiopathogenic, clinical, and therapeutic aspects are discussed in this chapter.

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Authors and Affiliations

  1. Federal and Catholic University of Pelotas, Pelotas, Brazil

    Hiram de Almeida Larangeira Jr. MD, PhD

Authors
  1. Hiram de Almeida Larangeira Jr. MD, PhD
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Correspondence to Hiram de Almeida Larangeira Jr. MD, PhD .

Editor information

Editors and Affiliations

  1. Dermatology Service of Clinical, Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

    Renan Rangel Bonamigo

  2. Health Secretary of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Sergio Ivan Torres Dornelles

Glossary

Acantholysis

Loss of epithelial intercellular contact, showing isolated round keratinocytes.

Bullous pemphigoid

Blistering dermatoses without acantholysis, caused by hemidesmosomal lesions.

Desmosome

Cell structure that adheres epithelial cells to each other, composed of two plaques, one in each cell, connected by transmembranous proteins.

Direct immunofluorescence

Laboratory investigation to detect antibodies in tissues.

Hemidesmosome

Cell structure that adheres the basal keratinocyte to the basement membrane, composed of one plaque, also connected by transmembranous proteins.

Pemphigus group

Blistering dermatoses with acantholysis caused by desmosomal lesions.

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de Almeida Larangeira, H. (2018). Autoimmune Bullous Dermatoses. In: Bonamigo, R., Dornelles, S. (eds) Dermatology in Public Health Environments. Springer, Cham. https://doi.org/10.1007/978-3-319-33919-1_24

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  • DOI: https://doi.org/10.1007/978-3-319-33919-1_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-33917-7

  • Online ISBN: 978-3-319-33919-1

  • eBook Packages: MedicineMedicine (R0)

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