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Complex Anorectal Fistulas

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Abstract

The optimal management of complex anorectal fistulas such as recurrent fistula-in-ano, rectourethral fistula, and ileal-pouch fistula remains the subject of ongoing scientific research and academic debate. While numerous surgical procedures are available, overall there is absence of a standardized approach to the treatment of such conditions due to the lack of randomized clinical trial data, heterogeneity of patient populations reported in various studies, and wide ranges of reported outcome. When faced with a patient with anorectal fistulous disease, the aim of any intervention is to eradicate the fistula, to prevent recurrence, to minimize postoperative complications, and to preserve anal continence. The history and physical examination along with selective imaging to delineate the anatomy of the fistula are critical to individualize the patient’s treatment. When possible, simple procedures should be attempted first if there is a potential for success before more complex procedures are considered. It is important to convey to the patient the expectations and limitations of surgical treatment, including the need for multiple operations, the risk of failure, and the potential poor anorectal and urinary function.

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References

  1. Steele SR, Kumar R, Feingold D, Rafferty JL, Buie WD. The standards practice task force, the American Society of Colon and Rectal Surgeons. Practice parameters for the treatment of perianal abscess and fistula-in-ano. Dis Colon Rectum. 2011;54:1465–74.

    PubMed  Google Scholar 

  2. Abbas MA, Jackson C, Haigh PI. Predictors of outcome for anal fistula surgery. Arch Surg. 2011;146(9):1011–6.

    PubMed  Google Scholar 

  3. Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36:77–97.

    CAS  PubMed  Google Scholar 

  4. Deen KI, Williams JG, Hutchinson R, Keighley MR, Kumar D. Fistulas in ano: endoanal ultrasonographic assessment assists decision making for surgery. Gut. 1994;35:391–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Poen AC, Felt-Bersma RJF, Eijsbouts QA, Cuesta MA, Meuwissen SG. Hydrogen peroxide-enhanced transanal ultrasound in the assessment of fistula-in-ano. Dis Colon Rectum. 1998;41:1147–52.

    CAS  PubMed  Google Scholar 

  6. Ratto C, Gentile E, Merico M, Spinazzola C, Mangini G, Sofo L, Doglietto G. How can the assessment of fistula-in-ano be improved? Dis Colon Rectum. 2000;43:1375–82.

    CAS  PubMed  Google Scholar 

  7. Santoro GA, Fortling B. The advantages of volume rendering in three-dimensional endosonography of the anorectum. Dis Colon Rectum. 2007;50:359–68.

    PubMed  Google Scholar 

  8. Vanbeckevoort D, Bielen D, Vanslembrouck R, Van Assche G. Magnetic resonance imaging of perianal fistulas. Magn Reson Imaging Clin N Am. 2014;22:113–23.

    PubMed  Google Scholar 

  9. Weisman N, Abbas MA. Can pre-operative anal ultrasound predict surgical outcome for fistula-in-ano? Dis Colon Rectum. 2008;51:1089–92.

    PubMed  Google Scholar 

  10. Buchanan G, Halligan S, Williams A, Cohen CR, Tarroni D, Phillips RK, Bartram CI. Effect of MRI on clinical outcome of recurrent fistula-in-ano. Lancet. 2002;360:1661–2.

    PubMed  Google Scholar 

  11. Orsoni P, Barthet M, Portier F, Panuel M, Desjeux A, Grimaud JC. Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn’s disease. Br J Surg. 1999;86:360–4.

    CAS  PubMed  Google Scholar 

  12. Schwartz DA, Wiersema MJ, Dudiak KM, Fletcher JG, Clain JE, Tremaine WJ, Zinsmeister AR, Norton ID, Boardman LA, Devine RM, Wolff BG, Young-Fadok TM, Diehl NN, Pemberton JH, Sandborn WJ. A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulas. Gastroenterology. 2001;121:1064–72.

    CAS  PubMed  Google Scholar 

  13. Buchanan GN, Bartram CI, Williams AB, Halligan S, Cohen CR. Value of hydrogen peroxide enhancement of three-dimensional endoanal ultrasound in fistula-in-ano. Dis Colon Rectum. 2005;48:141–7.

    PubMed  Google Scholar 

  14. West RL, Zimmerman DD, Dwarkasing S, Hussain SM, Hop WC, Schouten WR, Kuipers EJ, Felt-Bersma RJ. Prospective comparison of hydrogen peroxide-enhanced three-dimensional endoanal ultrasonography and endoanal magnetic resonance imaging of perianal fistulas. Dis Colon Rectum. 2003;46:1407–15.

    CAS  PubMed  Google Scholar 

  15. Ratto C, Grillo E, Parello A, Costamagna G, Doglietto GB. Endoanal ultrasound-guided surgery for anal fistula. Endoscopy. 2005;37:722–8.

    CAS  PubMed  Google Scholar 

  16. Buchanan GN, Halligan S, Bartram CI, Williams AB, Tarroni D, Cohen CR. Clinical examination, endosonography and MR imaging in preoperative assessment of fistula in ano: comparison with outcome-based reference standard. Radiology. 2004;233:674–81.

    PubMed  Google Scholar 

  17. Sahni VA, Ahmad R, Burling D. Which method is best for imaging of perianal fistula? Abdom Imaging. 2008;33:26–30.

    PubMed  Google Scholar 

  18. Soerensen MM, Pedersen BG, Santoro GA, Buntzen S, Bek K, Laurberg S. Long-term function and morphology of the anal sphincters and the pelvic floor after primary repair of obstetric anal sphincter injury. Colorectal Dis. 2014;16:347–55.

    Google Scholar 

  19. Vitton V, Ben Hadj Amor W, Baumstarck K, Behr M, Bouvier M, Grimaud JC. Comparison of three-dimensional high-resolution manometry and endoanal ultrasound in the diagnosis of anal sphincter defects. Colorectal Dis. 2013;15:607–11.

    Google Scholar 

  20. Limura E, Giordano P. Modern management of anal fistula. World J Gastroenterol. 2015;21:12–20.

    Google Scholar 

  21. Subhas G, Singh Bhullar J, Al-Omari A, Unawane A, Mittal VK, Pearlman R. Setons in the treatment of anal fistula: review of variations in materials and techniques. Dig Surg. 2012;29:292–300.

    CAS  PubMed  Google Scholar 

  22. Abbas MA, Sherman M. Endorectal advancement flap. In: Fleshman J, Wexner SD, editors. Master techniques in colon and rectal surgery. 1st ed. Baltimore, USA: Lippincott Williams & Wilkins; 2012.

    Google Scholar 

  23. Rojanasakul A, Pattanaarun J, Sahakitrungruang C, Tantiphlachiva K. Total anal sphincter saving technique for fistula-in-ano: the ligation of intersphincteric fistula tract. J Med Assoc Thai. 2007;90:581–6.

    PubMed  Google Scholar 

  24. Ellis CN. Outcomes with the use of bioprosthetic grafts to reinforce the ligation of the intersphincteric fistula tract (BioLIFT procedure) for the management of complex anal fistulas. Dis Colon Rectum. 2010;53:1361–4.

    PubMed  Google Scholar 

  25. Sirikurnpiboon S, Awapittaya B, Jivapaisarnpong P. Ligation of intersphincteric fistula tract and its modification: results from treatment of complex fistula. World J Gastrointest Surg. 2013;5:123–8.

    PubMed  PubMed Central  Google Scholar 

  26. Ratto C, Litta F, Parello A, Zaccone G, Donisi L, De Simone V. Fistulotomy with end-to-end primary sphincteroplasty for anal fistula: results from a prospective study. Dis Colon Rectum. 2013;56:226–33.

    PubMed  Google Scholar 

  27. The Surgisis AFP anal fistula plug: report of a consensus conference. Colorectal Dis. 2008;10:17–20.

    Google Scholar 

  28. Ommer A, Herold A, Joos A, Schmidt C, Weyand G, Bussen D. Gore BioA Fistula Plug in the treatment of high anal fistulas – initial results from a German multicenter study. Ger Med Sci. 2012;10:1–17.

    Google Scholar 

  29. Swinscoe MT, Ventakasubramaniam AK, Jayne DG. Fibrin glue for fistula-in-ano: the evidence reviewed. Tech Coloproctol. 2005;9:89–94.

    CAS  PubMed  Google Scholar 

  30. Meinero P, Mori L. Video-assisted anal fistula treatment (VAAFT): a novel sphincter-saving procedure for treating complex anal fistulas. Tech Coloproctol. 2011;15:417–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Giamundo P, Geraci M, Tibaldi L, Valente M. Closure of fistula-in-ano with laser-FiLaC™: an effective novel sphincter-saving procedure for complex disease. Colorectal Dis. 2014;16:110–5.

    CAS  PubMed  Google Scholar 

  32. Georgiev-Hristov T, García-Arranz M, García-Olmo D. Adipose tissue-derived products for complex fistula treatment. Tech Coloproctol. 2013;17:675–6.

    CAS  PubMed  Google Scholar 

  33. Beaulieu R, Bonekamp D, Sandone C, Gearhart S. Fistula-in-ano: when to cut, tie, plug, or sew. J Gastrointest Surg. 2013;17:1143–52.

    PubMed  Google Scholar 

  34. Gupta PJ, Gupta SN, Heda PS. Which treatment for anal fistula? Cut or cover, plug or paste, loop or lift. Acta Chir Iugosl. 2012;59:15–20.

    PubMed  Google Scholar 

  35. Zbar AP, Ramesh J, Beer-Gabel M, Salazar R, Pescatori M. Conventional cutting vs. internal anal sphincter-preserving seton for high trans-sphincteric fistula: a prospective randomized manometric and clinical trial. Tech Coloproctol. 2003;7:89–94.

    CAS  PubMed  Google Scholar 

  36. García-Aguilar J, Belmonte C, Wong DW, Goldberg SM, Madoff RD. Cutting seton versus two-stage seton fistulotomy in the surgical management of high anal fistula. Br J Surg. 1998;85:243–5.

    PubMed  Google Scholar 

  37. Vial M, Parés D, Pera M, Grande L. Faecal incontinence after seton treatment for anal fistulae with and without surgical division of internal anal sphincter: a systematic review. Colorectal Dis. 2010;12:172–8.

    CAS  PubMed  Google Scholar 

  38. Hasegawa H, Radley S, Keighley MR. Long-term results of cutting seton fistulotomy. Acta Chir Iugoslavica. 2000;47:19–21.

    CAS  Google Scholar 

  39. Isbister WH, Sanea N. The cutting seton: an experience at King Faisal Specialist Hospital. Dis Colon Rectum. 2001;44:722–7.

    CAS  PubMed  Google Scholar 

  40. Mentes BB, Oktemer S, Tezcaner T, Azili C, Leventoğlu S, Oğuz M. Elastic one-stage cutting seton for the treatment of high anal fistulas: preliminary results. Tech Coloproctol. 2004;8:159–62.

    CAS  PubMed  Google Scholar 

  41. Williams JG, Farrands PA, Williams AB, Taylor BA, Lunniss PJ, Sagar PM, Varma JS, George BD, et al. The treatment of anal fistula: ACPGBI position statement. Colorectal Dis. 2007;9 Suppl 4:18–50.

    PubMed  Google Scholar 

  42. Abbas MA, Lemus-Rangel R, Hamadani A. Long-term outcome of endorectal advancement flap for complex anorectal fistulae. Am Surgeon. 2008;74:921–4.

    PubMed  Google Scholar 

  43. Perez F, Arroyo A, Serrano P, Sánchez A, Candela F, Perez MT, Calpena R. Randomized clinical and manometric study of advancement flap versus fistulotomy with sphincter reconstruction in the management of complex fistula-in-ano. Am J Surg. 2006;192:34–40.

    PubMed  Google Scholar 

  44. Zimmerman DD, Briel JW, Gosselink MP, Schouten WR. Anocutaneous advancement flap repair of transsphincteric fistulas. Dis Colon Rectum. 2001;44:1474–80.

    CAS  PubMed  Google Scholar 

  45. Ortiz H, Marzo J. Endorectal flap advancement repair and fistulectomy for high trans-sphincteric and suprasphincteric fistulas. Br J Surg. 2000;87:1680–3.

    CAS  PubMed  Google Scholar 

  46. Schouten WR, Zimmerman DD, Briel JW. Transanal advancement flap repair of transsphincteric fistulas. Dis Colon Rectum. 1999;42:1419–23.

    CAS  PubMed  Google Scholar 

  47. Jarrar A, Church J. Advancement flap repair: a good option for complex anorectal fistulas. Dis Colon Rectum. 2011;54:1537–41.

    PubMed  Google Scholar 

  48. Dubsky PC, Stift A, Friedl J, Teleky B, Herbst F. Endorectal advancement flaps in the treatment of high anal fistula of cryptoglandular origin: full-thickness vs. mucosal-rectum flaps. Dis Colon Rectum. 2008;51:852–7.

    PubMed  Google Scholar 

  49. van der Hagen SJ, Baeten CG, Soeters PB, van Gemert WG. Autologous platelet derived grow factors (platelet rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular peri-anal fistulae: a pilot study. Colorectal Dis. 2011;13:784–90.

    Google Scholar 

  50. Zimmerman DD, Delemarre JB, Gosselink MP, Hop WC, Briel JW, Schouten WR. Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas. Br J Surg. 2003;90:351–4.

    CAS  PubMed  Google Scholar 

  51. Zimmerman DD, Gosselink MP, Mitalas LE, Mitalas LE, Delemarre JB, Hop WJ, Briel JW, Schouten WR. Smoking impairs rectal mucosal blood flow- a pilot study: possible implications for transanal advancement flap repair. Dis Colon Rectum. 2005;48:1228–32.

    PubMed  Google Scholar 

  52. Shanwani A, Nor AM, Amri N. Ligation of the intersphincteric fistula tract (LIFT): a sphincter-saving technique for fistula-in-ano. Dis Colon Rectum. 2010;53:39–42.

    CAS  PubMed  Google Scholar 

  53. Aboulian A, Kaji AH, Kumar RR. Early result of ligation of the intersphincteric fistula tract for fistula-in-ano. Dis Colon Rectum. 2011;54:289–92.

    PubMed  Google Scholar 

  54. Tan KK, Tan IJ, Lim FS, Koh DC, Tsang CB. The anatomy of failures following the ligation of intersphincteric tract technique for anal fistula: a review of 93 patients over 4 years. Dis Colon Rectum. 2011;54:1368–72.

    PubMed  Google Scholar 

  55. Abcarian AM, Estrada JJ, Park J, Corning C, Chaudhry V, Cintron J, Prasad L, Abcarian H. Ligation of intersphincteric fistula tract: early results of a pilot study. Dis Colon Rectum. 2012;55:778–82.

    PubMed  Google Scholar 

  56. Mushaya C, Bartlett L, Schulze B, Ho YH. Ligation of intersphincteric fistula tract compared with advancement flap for complex anorectal fistulas requiring initial seton drainage. Am J Surg. 2012;204:283–9.

    PubMed  Google Scholar 

  57. Ooi K, Skinner I, Croxford M, Faragher I, McLaughlin S. Managing fistula-in-ano with ligation of the intersphincteric fistula tract procedure: the Western Hospital experience. Colorectal Dis. 2012;14:599–603.

    CAS  PubMed  Google Scholar 

  58. Wallin UG, Mellgren AF, Madoff RD, Goldberg SM. Does ligation of the intersphincteric fistula tract raise the bar in fistula surgery? Dis Colon Rectum. 2012;55:1173–8.

    PubMed  Google Scholar 

  59. Han JG, Yi BQ, Wang ZJ, Zheng Y, Cui JJ, Yu XQ, Zhao BC, Yang XQ. Ligation of the intersphincteric fistula tract plus a bioprosthetic anal fistula plug (LIFT-Plug): a new technique for fistula-in-ano. Colorectal Dis. 2013;15:582–6.

    CAS  PubMed  Google Scholar 

  60. van Onkelen RS, Gosselink MP, Schouten WR. Ligation of the intersphincteric fistula tract in low transsphincteric fistulae: a new technique to avoid fistulotomy. Colorectal Dis. 2013;15:587–91.

    PubMed  Google Scholar 

  61. Lehmann JP, Graf W. Efficacy of LIFT for recurrent anal fistulas. Colorectal Dis. 2013;15:592–5.

    PubMed  Google Scholar 

  62. Sileri P, Giarratano G, Franceschilli L, Limura E, Perrone F, Stazi A, Toscana C, Gaspari AL. Ligation of the intersphincteric fistula tract (LIFT): a minimally invasive procedure for complex anal fistula: two-year results of a prospective multicentric study. Surg Innov. 2014;21:476–80.

    PubMed  Google Scholar 

  63. Yassin NA, Hammond TM, Lunniss PJ, Phillips RK. Ligation of the intersphincteric fistula tract in the management of anal fistula. A systematic review. Colorectal Dis. 2013;15:527–35.

    CAS  PubMed  Google Scholar 

  64. Vergara-Fernandez O, Espino-Urbina LA. Ligation of the intersphincteric fistula tract: what is the evidence in a review? World J Gastroenterol. 2013;19:6805–13.

    PubMed  PubMed Central  Google Scholar 

  65. Hong KD, Kang S, Kalaskar S, Wexner SD. Ligation of intersphincteric fistula tract (LIFT) to treat anal fistula: systematic review and meta-analysis. Tech Coloproctol. 2014;18:685–91.

    CAS  PubMed  Google Scholar 

  66. Tan KK, Alsuwaigh R, Tan AM, Tan IJ, Liu X, Koh DC. To LIFT or to flap? Which surgery to perform following seton insertion for high anal fistulas? Dis Colon Rectum. 2012;55:1273–7.

    PubMed  Google Scholar 

  67. Madbouly KM, El Shazly W, Abbas KS, Hussein AM. Ligation of intersphincteric fistula tract versus mucosal advancement flap in patients with high transsphincteric fistula-in-ano: a prospective randomized trial. Dis Colon Rectum. 2014;57:1202–8.

    PubMed  Google Scholar 

  68. Chew MH, Lee PJ, Koh CE, Chew HE. Appraisal of the LIFT and BIOLIFT procedure: initial experience and short-term outcomes of 33 consecutive patients. Int J Colorectal Dis. 2013;28:1489–96.

    PubMed  Google Scholar 

  69. Garg P, Song J, Bhatia A, Kalia H, Menon GR. The efficacy of anal fistula plug in fistula-in-ano: a systematic review. Colorectal Dis. 2010;12:965–70.

    CAS  PubMed  Google Scholar 

  70. Johnson EK, Gaw JU, Armstrong DN. Efficacy of anal fistula plug vs. fibrin glue in closure of anorectal fistulas. Dis Colon Rectum. 2006;49:371–6.

    PubMed  Google Scholar 

  71. Champagne BJ, O'Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN. Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum. 2006;49:1817–21.

    PubMed  Google Scholar 

  72. Schwandner O, Stadler F, Dietl O, Wirsching RP, Fuerst A. Initial experience on efficacy in closure of cryptoglandular and Crohn's transsphincteric fistulas by the use of the anal fistula plug. Int J Colorectal Dis. 2008;23:319–24.

    CAS  PubMed  Google Scholar 

  73. Christoforidis D, Etzioni DA, Goldberg SM, Madoff RD, Mellgren A. Treatment of complex anal fistulas with the collagen fistula plug. Dis Colon Rectum. 2008;51:1482–7.

    PubMed  Google Scholar 

  74. Thekkinkattil DK, Botterill I, Ambrose NS, Lundby L, Sagar PM, Buntzen S, Finan PJ. Efficacy of the anal fistula plug in complex anorectal fistulae. Colorectal Dis. 2009;11:584–7.

    CAS  PubMed  Google Scholar 

  75. Starck M, Bohe M, Zawadzki A. Success rate of closure of high transsphincteric fistula using anal fistula plug. Dis Colon Rectum. 2008;51:692.

    Google Scholar 

  76. Lawes DA, Efron JE, Abbas MA, Tejirian T, Hamadani A, Young-Fadok TM, Heppell J. Early experience with the bioabsorbable anal fistula plug. World J Surg. 2008;32:1157–9.

    CAS  PubMed  Google Scholar 

  77. Safar B, Jobanputra S, Sands D, Weiss EG, Nogueras JJ, Wexner SD. Anal fistula plug: initial experience and outcomes. Dis Colon Rectum. 2009;52:248–52.

    PubMed  Google Scholar 

  78. Ortiz H, Marzo J, Ciga MA, Oteiza F, Armendáriz P, de Miguel M. Randomized clinical trial of anal fistula plug versus endorectal advancement flap for the treatment of high cryptoglandular fistula in ano. Br J Surg. 2009;96:608–12.

    CAS  PubMed  Google Scholar 

  79. Wang JY, Garcia-Aguilar J, Sternberg JA, Abel ME, Varma MG. Treatment of transsphincteric anal fistulas: are fistula plugs an acceptable alternative? Dis Colon Rectum. 2009;52:692–7.

    PubMed  Google Scholar 

  80. McGee MF, Champagne BJ, Stulberg JJ, Reynolds H, Marderstein E, Delaney CP. Tract length predicts successful closure with anal fistula plug in cryptoglandular fistulas. Dis Colon Rectum. 2010;53:1116–20.

    PubMed  Google Scholar 

  81. Anyadike C, Attuwaybi B, Visco J, Butler B, Barrios G. The anal fistula plug in simple and complex fistula-in-ano: a western New York experience. Dis Colon Rectum. 2010;53:575.

    Google Scholar 

  82. van Koperen PJ, Bemelman WA, Gerhards MF, Janssen LW, van Tets WF, van Dalsen AD, Slors JF. The anal fistula plug treatment compared with the mucosal advancement flap for cryptoglandular high transsphincteric perianal fistula: a double-blinded multicenter randomized trial. Dis Colon Rectum. 2011;54:387–93.

    PubMed  Google Scholar 

  83. O'Riordan JM, Datta I, Johnston C, Baxter NN. A systematic review of the anal fistula plug for patients with Crohn's and non-Crohn's related fistula-in-ano. Dis Colon Rectum. 2012;55:351–8.

    CAS  PubMed  Google Scholar 

  84. Muhlmann MD, Hayes JL, Merrie AE, Parry BR, Bissett IP. Complex anal fistulas: plug or flap? ANZ J Surg. 2011;81:720–4.

    PubMed  Google Scholar 

  85. Heydari A, Attinà GM, Merolla E, Piccoli M, Fazlalizadeh R, Melotti G. Bioabsorbable synthetic plug in the treatment of anal fistulas. Dis Colon Rectum. 2013;56:774–9.

    PubMed  Google Scholar 

  86. Buchberg B, Masoomi H, Choi J, Bergman H, Mills S, Stamos MJ. A tale of two (anal fistula) plugs: is there a difference in short-term outcomes? Am Surg. 2010;76:1150–3.

    PubMed  Google Scholar 

  87. Cintron JR, Park JJ, Orsay CP, Pearl RK, Nelson RL, Sone JH, Song R, Abcarian H. Repair of fistulas-in-ano using fibrin adhesive: long-term follow-up. Dis Colon Rectum. 2000;43:944–9.

    CAS  PubMed  Google Scholar 

  88. Sentovich SM. Fibrin glue for anal fistulas: long-term results. Dis Colon Rectum. 2003;46:498–502.

    PubMed  Google Scholar 

  89. Loungnarath R, Dietz DW, Mutch MG, Birnbaum EH, Kodner IJ, Fleshman JW. Fibrin glue treatment of complex anal fistulas has low success rate. Dis Colon Rectum. 2004;47:432–6.

    PubMed  Google Scholar 

  90. van Koperen PJ, Wind J, Bemelman WA, Slors JF. Fibrin glue and transanal rectal advancement flap for high transsphincteric perianal fistulas; is there any advantage? Int J Colorectal Dis. 2008;23:697–701.

    PubMed  PubMed Central  Google Scholar 

  91. Singer M, Cintron J, Nelson R, Orsay C, Bastawrous A, Pearl R, Sone J, Abcarian H. Treatment of fistulas-in-ano with fibrin sealant in combination with intra-adhesive antibiotics and/or surgical closure of the internal fistula opening. Dis Colon Rectum. 2005;48:799–808.

    PubMed  Google Scholar 

  92. Jain SK, Kaza RC, Pahwa M, Bansal S. Role of cyanoacrylate in the management of low fistula in ano: a prospective study. Int J Colorectal Dis. 2008;23:355–8.

    CAS  PubMed  Google Scholar 

  93. Barillari P, Basso L, Larcinese A, Gozzo P, Indinnimeo M. Cyanoacrylate glue in the treatment of ano-rectal fistulas. Int J Colorectal Dis. 2006;21:791–4.

    PubMed  Google Scholar 

  94. Buchanan GN, Bartram CI, Phillips RK, Gould SW, Halligan S, Rockall TA, Sibbons P, Cohen RG. Efficacy of fibrin sealant in the management of complex anal fistula. Dis Colon Rectum. 2003;46:1167–74.

    PubMed  Google Scholar 

  95. Jacob TJ, Perakath B, Keighley MR. Surgical intervention for anorectal fistula. Cochrane Database Syst Rev. 2010.

    Google Scholar 

  96. Parkash S, Lakshmiratan V, Gajendran V. Fistula-in-ano: treatment by fistulectomy, primary closure and reconstitution. Aust N Z J Surg. 1985;55:23–7.

    CAS  PubMed  Google Scholar 

  97. Christiansen J, Rønholt C. Treatment of recurrent high anal fistula by total excision and primary sphincter reconstruction. Int J Colorectal Dis. 1995;10:207–9.

    CAS  PubMed  Google Scholar 

  98. Roig JV, García-Armengol J, Jordán JC, Moro D, García-Granero E, Alós R. Fistulectomy and sphincteric reconstruction for complex cryptoglandular fistulas. Colorectal Dis. 2010;12:145–52.

    Google Scholar 

  99. Kraemer M, Picke D. Fistulotomy with primary sphincter repair for the treatment of anal fistula. Coloproctology. 2011;33:104–8.

    Google Scholar 

  100. Arroyo A, Perez-Legaz J, Moya P, Armananzes L, Lacueva J, Perez-Vicente F, Candela F, Calpena R. Fistulotomy and sphincter reconstruction in the treatment of complex fistula-in-ano. Long-term clinical and manometric results. Ann Surg. 2012;255:935–9.

    PubMed  Google Scholar 

  101. Ommer A, Herold A, Berg E, Furst A, Sailer M, Schiedeck T. German Society for General and Visceral Surgery. Cryptoglandular anal fistulas. Dtsch Arztebl Int. 2011;108:707–13.

    PubMed  PubMed Central  Google Scholar 

  102. Kochhar G, Saha S, Andley M, Kumar A, Saurabh G, Pusuluri R, Bhise V, Kumar A. Video-assisted anal fistula treatment. JSLS. 2014;18:e2014.00127.

    PubMed  PubMed Central  Google Scholar 

  103. Wałęga P, Romaniszyn M, Nowak W. VAAFT: a new minimally invasive method in the diagnostics and treatment of anal fistulas-initial results. Pol Przegl Chir. 2014;86:7–10.

    PubMed  Google Scholar 

  104. Oztürk E, Gülcü B. Laser ablation of fistula tract: a sphincter preserving method for treating fistula-in-ano. Dis Colon Rectum. 2014;57:360–4.

    PubMed  Google Scholar 

  105. Herreros MD, Garcia-Arranz M, Guadalajara H, De-La-Quintana P, Garcia-Olmo D, Collaborative Group FATT. Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum. 2012;55:762–72.

    CAS  PubMed  Google Scholar 

  106. Keller DS, Aboseif SR, Lesser T, Abbass MA, Tsay AT, Abbas MA. Algorithm based multidisciplinary team treatment approach to rectourethral fistula. Int J Colorectal Disease. 2015;30:631–8.

    Google Scholar 

  107. Lane BR, Stein DE, Remzi FH, Strong SA, Fazio VW, Angermeier KW. Management of radiotherapy induced rectourethral fistula. J Urol. 2006;175:1382–7.

    PubMed  Google Scholar 

  108. Hechenbleikner EM, Buckley JC, Wick EC. Acquired rectourethral fistulas in adults: a systematic review of surgical repair techniques and outcomes. Dis Colon Rectum. 2013;56:374–83.

    PubMed  Google Scholar 

  109. Hanna JM, Turley R, Castleberry A, Hopkins T, Peterson AC, Mantyh C, Migaly J. Surgical management of complex rectourethral fistulas in irradiated and nonirradiated patients. Dis Colon Rectum. 2014;57:1105–12.

    PubMed  Google Scholar 

  110. Chun L, Abbas MA. Rectourethral fistula following laparoscopic radical prostatectomy. Tech Coloproctol. 2011;15:297–300.

    CAS  PubMed  Google Scholar 

  111. Blumberg JM, Lesser T, Tran VQ, Aboseif SR, Bellman GC, Abbas MA. Management of rectal injuries sustained during laparoscopic radical prostatectomy. Urology. 2009;73(1):163–6.

    PubMed  Google Scholar 

  112. Thomas C, Jones J, Jager W, Hampel C, Thuroff JW, Gillitzer R. Incidence, clinical symptoms and management of rectourethral fistulas after radical prostatectomy. J Urol. 2010;183:608–12.

    PubMed  Google Scholar 

  113. Voelzke BB, McAninch JW, Breyer BN, Glass AS, Garcia-Aguilar J. Transperineal management for postoperative and radiation rectourethral fistulas. J Urol. 2013;189:966–71.

    PubMed  Google Scholar 

  114. Bukowski TP, Chakrabarty A, Powell IJ, Frontera R, Perlmutter AD, Montie JE. Acquired rectourethral fistula: methods of repair. J Urol. 1995;153:730–3.

    CAS  PubMed  Google Scholar 

  115. Lacarriere E, Suaud L, Caremel R, Rouache L, Tuech JJ, Pfister C. Rectourethral fistulae: diagnosis and management. Review of the literature. Prog Urol. 2011;21:585–94.

    CAS  PubMed  Google Scholar 

  116. Choi JH, Jeon BG, Choi SG, Han EC, Ha HK, Oh HK, Choe EK, Moon SH, Ryoo SB, Park KJ. Rectourethral fistula: systemic review of and experiences with various surgical treatment methods. Ann Coloproctol. 2014;30:35–41.

    PubMed  PubMed Central  Google Scholar 

  117. Lesser T, Aboseif S, Abbas MA. Combined endorectal advancement flap with alloderm graft repair of radiation and cryoablation-induced rectourethral fistula. American Surg. 2008;74:341–5.

    Google Scholar 

  118. Patsouras D, Yassin NA, Phillips RK. Clinical outcomes of colo-anal pull-through procedure for complex rectal conditions. Colorectal Dis. 2014;16:253–8.

    CAS  PubMed  Google Scholar 

  119. Linder BJ, Umbreit EC, Larson D, Dozois EJ, Thapa P, Elliott DS. Effect of prior radiotherapy and ablative therapy on surgical outcomes for the treatment of rectourethral fistulas. J Urol. 2013;190:1287–91.

    PubMed  Google Scholar 

  120. Youssef AH, Fath-Alla M, El-Kassaby AW. Perineal subcutaneous dartos pedicled flap as a new technique for repairing urethrorectal fistula. J Urol. 1999;161:1498–500.

    CAS  PubMed  Google Scholar 

  121. Garofalo TE, Delaney CP, Jones SM, Remzi FH, Fazio VW. Rectal advancement flap repair of rectourethral fistula: a 20-year experience. Dis Colon Rectum. 2003;46:762–9.

    PubMed  Google Scholar 

  122. Wexner SD, Ruiz DE, Genua J, Nogueras JJ, Weiss EG, Zmora O. Gracilis muscle interposition for the treatment of rectourethral, rectovaginal, and pouch-vaginal fistulas: results in 53 patients. Ann Surg. 2008;248:39–43.

    PubMed  Google Scholar 

  123. Kasraeian A, Rozet F, Cathelineau X, Barret E, Galiano M, Vallancien G. Modified York-Mason technique for repair of iatrogenic rectourinary fistula: the montsouris experience. J Urol. 2009;181:1178–83.

    PubMed  Google Scholar 

  124. Vanni AJ, Buckley JC, Zinman LN. Management of surgical and radiation induced rectourethral fistulas with an interposition muscle flap and selective buccal mucosal onlay graft. J Urol. 2010;184:2400–4.

    PubMed  Google Scholar 

  125. Ghoniem G, Elmissiry M, Weiss E, Langford C, Abdelwahab H, Wexner S. Transperineal repair of complex rectourethral fistula using gracilis muscle flap interposition--can urinary and bowel functions be preserved? J Urol. 2008;179:1882–6.

    PubMed  Google Scholar 

  126. Gupta G, Kumar S, Kekre NS, Gopalakrishnan G. Surgical management of rectourethral fistula. Urology. 2008;71:267–71.

    PubMed  Google Scholar 

  127. Ulrich D, Roos J, Jakse G, Pallua N. Gracilis muscle interposition for the treatment of recto-urethral and rectovaginal fistulas: a retrospective analysis of 35 cases. J Plast Reconstr Aesthet Surg. 2009;62:352–6.

    PubMed  Google Scholar 

  128. Samplaski MK, Wood HM, Lane BR, Remzi FH, Lucas A, Angermeier KW. Functional and quality-of-life outcomes in patients undergoing transperineal repair with gracilis muscle interposition for complex rectourethral fistula. Urology. 2011;77:736–41.

    PubMed  Google Scholar 

  129. Lee TG, Park SS, Lee SJ. Treatment of a recurrent rectourethral fistula by using transanal rectal flap advancement and fibrin glue: a case report. J Korean Soc Coloproctol. 2012;28:165–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  130. Al-Ali M, Kashmoula D, Saoud IJ. Experience with 30 posttraumatic rectourethral fistulas: presentation of posterior transsphincteric anterior rectal wall advancement. J Urol. 1997;158:421–4.

    CAS  PubMed  Google Scholar 

  131. Spotnitz WD. Fibrin sealant: past, present, and future: a brief review. World J Surg. 2010;34:632–4.

    PubMed  Google Scholar 

  132. Takano S, Boutros M, Wexner SD. Gracilis muscle transposition for complex perineal fistulas and sinuses: a systematic literature review of surgical outcomes. J Am Coll Surg. 2014;219:313–23.

    PubMed  Google Scholar 

  133. Varma MG, Wang JY, Garcia-Aguilar J, Shelton AA, McAninch JW, Goldberg SM. Dartos muscle interposition flap for the treatment of rectourethral fistula. Dis Colon Rectum. 2007;50:1849–55.

    PubMed  Google Scholar 

  134. Shah NS, Remzi F, Massmann A, Baixauli J, Fazio VW. Management and treatment outcome of pouch-vaginal fistulas following restorative proctocolectomy. Dis Colon Rectum. 2003;46:911–7.

    PubMed  Google Scholar 

  135. Maslekar S, Sagar PM, Harji D, Bruce C, Griffiths B. The challenge of pouch-vaginal fistulas: a systematic review. Tech Coloproctol. 2012;16:405–14.

    CAS  PubMed  Google Scholar 

  136. Kim NK, Lim DJ, Yun SH, Sohn SK, Min JS. Ultralow anterior resection and coloanal anastomosis for distal rectal cancer: functional and oncological results. Int J Colorectal Dis. 2001;16:234–7.

    CAS  PubMed  Google Scholar 

  137. Guerrieri M, Gesuita R, Ghiselli R, Lezoche G, Budassi A, Baldarelli M. Treatment of rectal cancer by transanal endoscopic microsurgery: experience with 425 patients. World J Gastroenterol. 2014;20:9556–63.

    PubMed  PubMed Central  Google Scholar 

  138. Musters GD, Lapid O, Bemelman WA, Tanis PJ. Surgery for complex perineal fistula following rectal cancer treatment using biological mesh combined with gluteal perforator flap. Tech Coloproctol. 2014;18:955–9.

    CAS  PubMed  Google Scholar 

  139. Lolohea S, Lynch AC, Robertson GB, Frizelle FA. Ileal pouch-anal anastomosis-vaginal fistula: a review. Dis Colon Rectum. 2005;48:1802–10.

    CAS  PubMed  Google Scholar 

  140. Gaertner WB, Witt J, Madoff RD, Mellgren A, Finne CO, Spencer MP. Ileal pouch fistulas after restorative proctocolectomy: management and outcomes. Tech Coloproctol. 2014;18:1061–6.

    CAS  PubMed  Google Scholar 

  141. Mallick IH, Hull TL, Remzi FH, Kiran RP. Management and outcome of pouch-vaginal fistulas after IPAA surgery. Dis Colon Rectum. 2014;57:490–6.

    PubMed  Google Scholar 

  142. Heriot AG, Tekkis PP, Smith JJ, Bona R, Cohen RG, Nicholls RJ. Management and outcome of pouch-vaginal fistulas following restorative proctocolectomy. Dis Colon Rectum. 2005;48:451–8.

    PubMed  Google Scholar 

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Correspondence to Maher A. Abbas MD, FACS, FASCRS .

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LIFT procedure. Mark the intersphincteric groove. Courtesy of Sarah Vogler, MD (M4V 4084 kb)

LIFT procedure. Dissect out the tract in the groove. Courtesy of Sarah Vogler, MD (M4V 26,172 kb)

LIFT procedure. Open the external opening. Courtesy of Sarah Vogler, MD (M4V 7595 kb)

LIFT procedure. Suture ligate the tract in the groove. Courtesy of Sarah Vogler, MD (M4V 20,815 kb)

LIFT procedure. Divide the tract after ligation. Courtesy of Sarah Vogler, MD (M4V 22,172 kb)

LIFT procedure. Oversew the tract. Courtesy of Sarah Vogler, MD (M4V 10,502 kb)

LIFT procedure. Test the tract to ensure not still open with H2O2. Courtesy of Sarah Vogler, MD (M4V 19,147 kb)

LIFT procedure. Closure of the wound. Courtesy of Sarah Vogler, MD (M4V 2826 kb)

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Santoro, G.A., Abbas, M.A. (2016). Complex Anorectal Fistulas. In: Steele, S.R., Hull, T.L., Read, T.E., Saclarides, T.J., Senagore, A.J., Whitlow, C.B. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-25970-3_15

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