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Acquired Diseases of the Nervous System

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Book cover Keeling’s Fetal and Neonatal Pathology

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Abstract

Acquired disorders of the nervous system are responsible for considerable perinatal mortality and for devastating chronic handicap in children, usually manifesting as cerebral palsy. Data from the Centers for Disease Control and Prevention (CDC) suggest a prevalence of cerebral palsy of between 1.5 and more than 4 per 1000 live births (http://www.cdc.gov/ncbddd/cp/data.html). Identification of acquired lesions and their distinction from genetic disorders can be difficult because damage to the fetal brain disrupts the normal sequence of development and can lead to malformations. Furthermore, a number of genetic disorders can cause destructive lesions in the fetal and perinatal brain that resemble acquired insults. This chapter describes the more common acquired conditions likely to be encountered in routine postmortem examinations of neonates and fetuses.

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Authors and Affiliations

  1. Department of Academic Neuropathology, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Midlothian, UK

    Colin Smith BSc, MB ChB, MD, FRCPath

  2. Developmental Biology and Cancer Programme and Department of Histopathology, UCL Institute of Child Health and Great Ormond Street Hospital, London, UK

    Thomas S. Jacques MA,PhD,MB,BChir,MRCP,FRCPath

Authors
  1. Colin Smith BSc, MB ChB, MD, FRCPath
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  2. Thomas S. Jacques MA,PhD,MB,BChir,MRCP,FRCPath
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Corresponding author

Correspondence to Colin Smith BSc, MB ChB, MD, FRCPath .

Editor information

Editors and Affiliations

  1. Department of Pathology Department of Obstetrics and Gynaecology, University of Adelaide, North Adelaide, South Australia, Australia

    T. Yee Khong

  2. Department of Histopathology, Women’s & Children’s Hospital, North Adelaide, South Australia, Australia

    T. Yee Khong

  3. Department of Histopathology, University Hospitals of Leicester NHS Trust Leicester Royal Infirmary, Leicester, UK

    Roger D. G. Malcomson

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Smith, C., Jacques, T.S. (2015). Acquired Diseases of the Nervous System. In: Khong, T.Y., Malcomson, R.D.G. (eds) Keeling’s Fetal and Neonatal Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-19207-9_29

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  • DOI: https://doi.org/10.1007/978-3-319-19207-9_29

  • Publisher Name: Springer, Cham

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