Abstract
Polymorphous adenocarcinoma affects children and adults and presents at a mean age of approximately 60 years. Women are involved more than men. The majority of cases involve minor salivary glands, presenting as single or multiple masses. Most cases of polymorphous adenocarcinoma behave as low- to intermediate-grade malignancies. Polymorphous adenocarcinoma may be well-circumscribed or infiltrative, comprised almost exclusively of one cell type (ductal), and exhibit a variety of architectural patterns (solid, trabecular, cribriform, microcystic, and papillary-cystic) (Figs. 24.1, 24.2, 24.3, 24.4, 24.5, 24.6, 24.7, 24.8, 24.9, 24.10, 24.11, 24.12, 24.13, 24.14, 24.15, 24.16, 24.17, 24.18, 24.19, 24.20, 24.21, 24.22, 24.22, 24.23, 24.24, 24.25, 24.26, 24.27 and 24.28).
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Darling MR, Schneider JW, Phillips VM. Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers. Oral Oncol. 2002;38(7):641–5.
Edwards PC, Bhuiya T, Kelsch RD. C-kit expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and monomorphic adenoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95(5):586–93.
Edwards PC, Bhuiya T, Kelsch RD. Assessment of p63 expression in the salivary gland neoplasms adenoid cystic carcinoma, polymorphous low-grade adenocarcinoma, and basal cell and canalicular adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(5):613–9.
Evans HL, Luna MA. Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol. 2000;24(10):1319–28.
Martins C, Fonseca I, Roque L, Ribeiro C, Soares J. Cytogenetic similarities between two types of salivary gland carcinomas: adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma. Cancer Genet Cytogenet. 2001;128(2):130–6.
Penner CR, Folpe AL, Budnick SD. C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Mod Pathol. 2002;15(7):687–91.
Saenz-Santamaria J, Catalina-Fernandez I. Polymorphous low-grade adenocarcinoma of the salivary gland. Diagnosis by fine needle aspiration cytology. Acta Cytol. 2004;48(1):52–6.
Simpson RH, Pereira EM, Ribeiro AC, Abdulkadir A, Reis-Filho JS. Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology. 2002;41(3):250–9.
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García, J.J. (2019). Polymorphous Adenocarcinoma. In: Atlas of Salivary Gland Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-09021-4_24
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DOI: https://doi.org/10.1007/978-3-319-09021-4_24
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