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The Therapeutic Place and Value of Present and Future MAO-B Inhibitors — l-Deprenyl as the Gold Standard

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Inhibitors of Monoamine Oxidase B

Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

The establishment of MAO inhibitors in the early 1960s failed, not because of the lack of intended efficacy but because of accompanying side-effects, e.g., hypotension and hypertension, psychic alteration, and hepatotoxicity. With Johnston’s discovery in 1968 of the multiple forms (MAO-A, MAO-B), selective MAO inhibitors could be developed for the first time that considered substrate specificity. Thus, there was hope to reduce the initially observed side-effects. l-Deprenyl (selegiline), synthesized by Ecsery and developed as an antidepressant drug by Knoll, was such a substance. As an antidepressant l-deprenyl did not succeed, but as an anti-Parkinson drug it did [1]. Meanwhile, l-deprenyl has become the “gold standard” of MAO inhibitors. The clinical and theoretical innovations of the last decade have been decisively marked by l-deprenyl since it unites many synergistic biochemical and pharmacological properties. Any new MAO-B inhibitor must have comparable properties since they determine the therapeutic value. Some of these new inhibitors will be reviewed here in comparison to l-deprenyl.

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Authors
  1. P. Riederer
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  2. M. B. H. Youdim
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Editors and Affiliations

  1. Dept. of Pharmacology, ASTA Medica AG, Weismüllerstrasse 45, D-6000, Frankfurt/Main 1, Germany

    I. Szelenyi

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Riederer, P., Youdim, M.B.H. (1993). The Therapeutic Place and Value of Present and Future MAO-B Inhibitors — l-Deprenyl as the Gold Standard. In: Szelenyi, I. (eds) Inhibitors of Monoamine Oxidase B. Milestones in Drug Therapy. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-6348-3_18

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  • DOI: https://doi.org/10.1007/978-3-0348-6348-3_18

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-6349-0

  • Online ISBN: 978-3-0348-6348-3

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