Pharmaceutical preparations

Abstract

The manufacture of a dry pharmaceutical preparation containing sufficient number of viable bifidobacteria was dependent upon advances in the technique of bacterial cultivation, the knowledge of the physiological-therapeutical significance for humans and animals, as well as advances in the technique of drying. Some important milestones to this were:

• 1956 Töpfer, GmbH., Dietmannsried, W. Germany, introduced on the market the first bifidobacteria preparation EUGALAN in powder form for the regeneration of the gut flora (Töpfer, GmbH, 1980).

• 1962 As a result of work reported by Kludas (1959 b), Med. J. Carl Pflüger, Berlin, W. Germany introduced on the market a freeze — dried preparation containing bifidobacteria for the regeneration of the gut flora (Süss, 1977; Med. J. Carl Pflüger, 1980).

• 1964 Töpfer, GmbH, Dietmannsried, W. Germany, introduced on the market the first infants preparation containing bifidobacteria LACTANA B-milk). The preparation represented a further development of the basic work of Mayer in 1948 (Töpfer, GmbH, 1980).

• 1968 Nisshin Flour Milling Co. Ltd., Tokyo, Japan: Probably the first utilization of animal strains and first commercial bifidobacteria preparation for veterinary use (Kobayashi, 1980).