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Cell Cycle as a Fault Tolerant Control System

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Book cover Advanced, Contemporary Control

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 1196))

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Abstract

We present models focused on the control mechanisms in cell cycle, allowing to predict the propagation of faults and its consequences for the cell fate. Development of such models is a two-stage process. First a graph representing molecules and interaction among them is built, through an extensive search of bioinformatic databases and publications. Such graph can be subsequently used to find cutting nodes, representing proteins or complexes or cutting edges, representing biochemical processes that are needed by control mechanisms. The second step is modeling and development of a dynamical model, e.g. in the form of ordinary differential equations that describe changes in concentration of the molecules involved in control mechanisms.

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Acknowledgment

This work was partially supported by Silesian University of Technology internal grant in the year 2020.

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Authors and Affiliations

  1. Department of Systems Biology and Engineering, Silesian University of Technology, Akademicka 16, 44-100, Gliwice, Poland

    Jaroslaw Smieja, Andrzej Swierniak & Roman Jaksik

Authors
  1. Jaroslaw Smieja
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  2. Andrzej Swierniak
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  3. Roman Jaksik
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Corresponding author

Correspondence to Jaroslaw Smieja .

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Editors and Affiliations

  1. Institute of Automatic Control, Lodz University of Technology, Lodz, Poland

    Andrzej Bartoszewicz

  2. Institute of Automatic Control, Lodz University of Technology, Lodz, Poland

    Jacek Kabziński

  3. Systems Research Institute, Polish Academy of Sciences, Warsaw, Poland

    Janusz Kacprzyk

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Smieja, J., Swierniak, A., Jaksik, R. (2020). Cell Cycle as a Fault Tolerant Control System. In: Bartoszewicz, A., Kabziński, J., Kacprzyk, J. (eds) Advanced, Contemporary Control. Advances in Intelligent Systems and Computing, vol 1196. Springer, Cham. https://doi.org/10.1007/978-3-030-50936-1_47

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