Abstract
Entamoeba histolytica, the etiological agent of amebiasis interacts with and feeds on the gut microbiota. Several studies have emphasized the close relationship between E. histolytica and the bacteria and its impact on the parasite’s pathogenesis. In this work we present an integrated omics analysis of the effect of E. coli and other bacteria on the resistance of E. histolytica to oxidative stress.
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Abbreviations
- GAPDH:
-
Glyceraldehyde-3-phosphate dehydrogenase putative
- HKB:
-
Heat killed bacteria
- HKBOS:
-
Heat killed bacteria exposed to oxidative stress
- LB:
-
Live bacteria
- LRR:
-
Leucine rich repeat proteins
- MDH:
-
Malate dehydrogenase
- OS:
-
Oxidative stress
- OX:
-
Oxidized proteins
- OX-RAC:
-
Resin assisted capture of oxidized proteins
- NS:
-
Nitrosative stress
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Acknowledgements and Funding
We would like to acknowledge the assistance of Ms. Shruti Nagaraja in the preparation of Fig. 3.1.
This study was supported by grants from the Israel Science Foundation (260/16), the US-Israel Binational Science Foundation (2015211), the Niedersachsen-Israel ZN3454 program and the European ERA-NET Infect-ERA program AMOEBAC (Israel Ministry of Health Grant 031L000).
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Shaulov, Y., Ankri, S. (2020). Integrative Omics Analysis of the Effect of Bacteria on the Resistance of Entamoeba histolytica to Oxidative Stress. In: Guillen, N. (eds) Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-44826-4_3
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