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Conclusions

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The Nitrile Imine 1,3-Dipole

Abstract

In the six decades following the initial synthetic report on the use of NIs, an enormous number of publications have exploited the unique properties of this valuable species. The 2007 rediscovery of the benefits of 2,5-diaryl tetrazole photolysis in particular has revitalised the field Wang et al. (Org Lett 9:4155–4158, 2007 [1]), with a number of new and exciting applications of the dipole emerging, relative to the limited literature activity of the 1980s and 1990s.

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References

  1. Wang Y, Rivera CI, Vera A, Lin Q (2007) Convenient synthesis of highly functionalized Pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition. Org Lett 9:4155–4158

    Article  CAS  Google Scholar 

  2. Li Z, Qian L, Li L, Bernhammer JC, Huynh HV, Lee J-S, Yao SQ (2015) Tetrazole photoclick chemistry: reinvestigating its suitability as a bioorthogonal reaction and potential applications. Angew Chem Int Ed Engl 55:2002–2006

    Article  Google Scholar 

  3. Herner A, Marjanovic J, Lewandowski TM, Marin V, Patterson M, Miesbauer L, Ready D, Williams J, Vasudevan A, Lin Q (2016) 2-Aryl-5-carboxytetrazole as a new photoaffinity label for drug target identification. J Am Chem Soc 138:14609–14615

    Article  CAS  Google Scholar 

  4. Heiler C, Offenloch JT, Blasco E, Barner-Kowollik C (2017) Photochemically induced folding of single chain polymer nanoparticles in water. ACS Macro Lett 6:56–61

    Article  CAS  Google Scholar 

  5. An P, Wu H-Y, Lewandowski TM, Lin Q (2018) Hydrophilic Azaspiroalkenes as robust bioorthogonal reporters. Chem Commun 54:14005–14008

    Article  CAS  Google Scholar 

  6. An P, Lin Q (2018) Sterically shielded Tetrazoles for a fluorogenic photoclick reaction: tuning cycloaddition rate and product fluorescence. Org Biomol Chem 16:5241–5244

    Article  CAS  Google Scholar 

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Correspondence to Craig Jamieson .

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Jamieson, C., Livingstone, K. (2020). Conclusions. In: The Nitrile Imine 1,3-Dipole. Springer, Cham. https://doi.org/10.1007/978-3-030-43481-6_5

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