Abstract
All science began as description, skewed through our subjective senses (Bohm 1980). Physics, chemistry, and biology were all established within these same circumstances. However, the two former disciplines have ultimately become “hard” mechanistic sciences by being thoroughly grounded within prediction, testable, and refutable. Despite its so-called mechanisms, only biology has remained descriptive (Nicholson 2012; Moss 2012). Roadblocks have limited our understanding of the origin and development of biological forms, and have hindered the advancement of the biological sciences (Torday 2013). Yet, when biology is deconstructed in reverse in both time and space back to its unicellular origins, then its evolution can be followed forward from generation to generation (Torday and Rehan 2012).
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References
Amaral FGD, Cipolla-Neto J (2018) A brief review about melatonin, a pineal hormone. Arch Endocrinol Metab 62(4):472–479
Aronson L (2019) Elderhood. Bloomsbury Publishing, New York
Avery ME, Mead J (1959) Surface properties in relation to atelectasis and hyaline membrane disease. AMA J Dis Child 97:517–523
Bacallao R, Fine LG (1989) Molecular events in the organization of renal tubular epithelium: from nephrogenesis to regeneration. Am J Phys 257:F913–F924
Baluška F (2009) Cell-cell channels, viruses, and evolution. Ann N Y Acad Sci 1178:106–119
Baluška F, Miller WB Jr (2018) Senomic view of the cell: senome versus genome. Commun Integr Biol 11(3):1–9
Berner RA, Vandenbrooks JM, Ward PD (2007) Evolution. Oxygen and evolution. Science 316:557–558
Besnard V, Wert SE, Stahlman MT, Postle AD, Xu Y, Ikegami M, Whitsett JA (2009) Deletion of scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. J Biol Chem 284:4018–4030
Bloch K (1992) Sterol molecule: structure, biosynthesis, and function. Steroids 57:378–383
Bloom M, Evans E, Mouritsen OG (1991) Physical properties of the fluid lipid-bilayer component of cell membranes: a perspective. Q Rev Biophys 24:293–397
Bohm D (1980) Wholeness and the implicate order. Routledge, London
Bosch RJ, Rodríguez-Puyol D, Bover J, Rodríguez-Puyol M (1999) Parathyroid hormone-related protein: roles in the glomerulus. Exp Nephrol 7:212–216
Burcham ZM, Pechal JL, Schmidt CJ, Bose JL, Rosch JW, Benbow ME, Jordan HR (2019) Bacterial community succession, transmigration, and differential gene transcription in a controlled vertebrate decomposition model. Front Microbiol 10:745
Carroll SB (2005a) Endless forms most beautiful. W.W. Norton and Co., New York
Carroll SB (2005b) Evolution at two levels: on genes and form. PLoS Biol 3:e245
Cavalier-Smith T (2000) Membrane heredity and early chloroplast evolution. Trends Plant Sci 5:174–182
Cazzolla Gatti R (2018) Endogenosymbiosis: from hypothesis to empirical evidence towards a Unified Symbiogenetic theory. Theor Biol Forum 111:13–26
Cerny L, Torday JS, Rehan VK (2008) Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook. Lung 186:75–89
Chipman AD (2010) Parallel evolution of segmentation by co-option of ancestral gene regulatory networks. BioEssays 32:60–70
Clements JA, Nellenbogen J, Trahan HJ (1970) Pulmonary surfactant and evolution of the lungs. Science 169:603–604
Cohen S (1997) EGF and its receptor: historical perspective. Introduction. J Mammary Gland Biol Neoplasia 2:93–96
Cotler J, Duan LM, Hou PY, Wilczek F, Xu D, Yin ZQ, Zu C (2016) Experimental test of entangled histories. Preprint arXiv:1601.02943
Cristofalo V, Roberts J, Adelman R (1972) Exploration in aging. Plenum, New York
Csete M, Walikonis J, Slawny N, Wei Y, Korsnes S, Doyle JC, Wold B (2001) Oxygen-mediated regulation of skeletal muscle satellite cell proliferation and adipogenesis in culture. J Cell Physiol 189:189–196
Daniels CB, Orgeig S (2003) Pulmonary surfactant: the key to the evolution of air breathing. News Physiol Sci 18:151–157
Daniels CB, Orgeig S, Sullivan LC, Ling N, Bennett MB, Schürch S, Val AL, Brauner CJ (2004) The origin and evolution of the surfactant system in fish: insights into the evolution of lungs and swim bladders. Physiol Biochem Zool 77:732–749
Darwin C (1859) On the origin of species by means of natural selection, or the preservation of favoured races in the struggle for life. John Murray, London
Dasgupta C, Sakurai R, Wang Y, Guo P, Ambalavanan N, Torday JS, Rehan VK (2009) Hyperoxia-induced neonatal rat lung injury involves activation of TGF-{beta} and Wnt signaling and is protected by rosiglitazone. Am J Physiol Lung Cell Mol Physiol 296:L1031–L1041
de Duve C (1999) Evolution of the peroxisome. Ann N Y Acad Sci 168(2):369–381
de Laat SW, Boonstra J, Defize LH, Kruijer W, van der Saag PT, Tertoolen LG, van Zoelen EJ, den Hertog J (1999) Growth factor signaling. Int J Dev Biol 43:681–691
De Loof A (2015a) How to deduce and teach the logical and unambiguous answer, namely L = ∑C, to “What is Life?” using the principles of communication? Commun Integr Biol 8:1–11
De Robertis EM, Larraín J, Oelgeschläger M, Wessely O (2000) The establishment of Spemann’s organizer and patterning of the vertebrate embryo. Nat Rev Genet 1:171–181
Deacon TW (2011) Incomplete nature: how mind emerged from matter. WW Norton, New York
Deuber C, Terhaar M (2011) Hyperoxia in very preterm infants: a systematic review of the literature. J Perinat Neonatal Nurs 25:268–274
DiRocco DP, Kobayashi A, Taketo MM, McMahon AP, Humphreys BD (2013) Wnt4/β-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 24:1399–1412
Dobzhansky T (1973) Nothing in biology makes sense except in the light of evolution. Am Biol Teach 35:125–129
Ferrara N, Komici K, Corbi G, Pagano G, Furgi G, Rengo C, Femminella GD, Leosco D, Bonaduce D (2014) β-adrenergic receptor responsiveness in aging heart and clinical implications. Front Physiol 4:396
Foley J, Longely BJ, Wysolmerski JJ, Dreyer BE, Broadus AE, Philbrick WM (1998) PTHrP regulates epidermal differentiation in adult mice. J Invest Dermatol 111:1122–1128
Frisch RE (1994) The right weight: body fat, menarche and fertility. Proc Nutr Soc 53:113–129
Futuyma D (1998) Evolutionary biology. Sinauer Associates, Sunderland
Gardinier JD, Rostami N, Juliano L, Zhang C (2018) Bone adaptation in response to treadmill exercise in young and adult mice. Bone Rep 8:29–37
Gentili C, Morelli S, de Boland AR (2003) Characterization of PTH/PTHrP receptor in rat duodenum: effects of ageing. J Cell Biochem 88:1157–1167
Gerhart J, Kirschner M (1997) Cells, embryos, and evolution. Wiley, Hoboken
Gilbert SF (2014) Symbiosis as the way of eukaryotic life: the dependent co-origination of the body. J Biosci 39:201–209
Gómez-Linton DR, Alavez S, Alarcón-Aguilar A, López-Diazguerrero NE, Konigsberg M, Pérez-Flores LJ (2019) Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging. Biogerontology 20:583–603
Gould SJ, Vrba ES (1982) Exaptation—a missing term in the science of form. Paleobiology 8:4–15
Grobstein C (1967) Mechanisms of organogenetic tissue interaction. Natl Cancer Inst Monogr 26:279–299
Hall BK (2012) Parallelism, deep homology, and evo-devo. Evol Dev 14:29–33
Haque MM, Nilsson EE, Holder LB, Skinner MK (2016) Genomic clustering of differential DNA methylated regions (epimutations) associated with the epigenetic transgenerational inheritance of disease and phenotypic variation. BMC Genomics 17:418
Hastings RH, Duong H, Burton DW, Deftos LJ (1994) Alveolar epithelial cells express and secrete parathyroid hormone-related protein. Am J Respir Cell Mol Biol 11:701–706
Hayflick L (2007) Biological aging is no longer an unsolved problem. Ann N Y Acad Sci 1100:1–13
Henry J (2001) Moving heaven and earth: copernicus and the solar system. Cambridge University Press, Cambridge
Horowitz NH (1945) On the evolution of biochemical syntheses. Proc Natl Acad Sci U S A 31:153–157
Hughes NC, Jacobs DK (2005) The end of everything: metazoan terminal addition. Evol Dev 7:497
Irie N, Kuratani S (2011) Comparative transcriptome analysis reveals vertebrate phylotypic period during organogenesis. Nat Commun 2:248
Ishikawa M, Ouchi Y, Akishita M, Kozaki K, Toba K, Namiki A, Yamaguchi T, Ito H, Orimo H (1995) Age-related decrease in the effect of parathyroid hormone-related protein on cytosolic free calcium level and tension in rat aortic smooth muscle. Naunyn Schmiedeberg’s Arch Pharmacol 351:517–522
Jacobs DK, Hughes NC, Fitz-Gibbon ST, Winchell CJ (2005) Terminal addition, the Cambrian radiation and the Phanerozoic evolution of bilaterian form. Evol Dev 7:498–514
Jobe AH (2016) Mechanisms of lung injury and bronchopulmonary dysplasia. Am J Perinatol 33:1076–1078
Kalimi M (1984) Glucocorticoid receptors: from development to aging. A review. Mech Ageing Dev 24:129–138
Karaplis AC, Vautour L (1997) Parathyroid hormone-related peptide and the parathyroid hormone/parathyroid hormone-related peptide receptor in skeletal development. Curr Opin Nephrol Hypertens 6:308–313
Khan AH, Zou Z, Xiang Y, Chen S, Tian XL (2019) Conserved signaling pathways genetically associated with longevity across the species. Biochim Biophys Acta Mol basis Dis 1865:1745–1755
Kirkwood T (1977) Evolution of ageing. Nature 270:301–304
Kovacs T, Csongei V, Feller D, Ernszt D, Smuk G, Sarosi V, Jakab L, Kvell K, Bartis D, Pongracz JE (2014) Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence. Aging Cell 13:838–849
Kurihara H, Sakai T (2017) Cell biology of mesangial cells: the third cell that maintains the glomerular capillary. Anat Sci Int 92:173–186
Li YF, Langholz B, Salam MT, Gilliland FD (2005) Maternal and grandmaternal smoking patterns are associated with early childhood asthma. Chest 127(4):1232–1241
Martinez AA, Steventon B (2018) On the nature and function of organizers. Development 145:dev159525
Matsui Y, Okamura D (2015) Mechanisms of germ-cell specification in mouse embryos. BioEssays 27(2):136–143
Maturana HR, Varela FJ (1980) Problems in the neurophysiology of cognition. In: Autopoiesis and cognition. Springer, Dordrecht
Mayr E (1961) Cause and effect in biology. Science 131:1501–1506
Medawar PB (1952) An unsolved problem of biology. H.K. Lewis & Co., London
Meziani F, Van Overloop B, Schneider F, Gairard A (2005) Parathyroid hormone-related protein-induced relaxation of rat uterine arteries: influence of the endothelium during gestation. J Soc Gynecol Investig 12:14–19
Miller WB (2013) The microcosm within: evolution and extinction in the hologenome. Universal Publishers, Boca Raton
Miller WB (2016a) Cognition, information fields and hologenomic entanglement: evolution in light and shadow. Biology (Basel) 5(2):21
Miller WB (2016b) The eukaryotic microbiome: origins and implications for fetal and neonatal life. Front Pediatr 4:96
Miller WB Jr, Torday JS (2018) Four domains: the fundamental unicell and Post-Darwinian cognition-based evolution. Prog Biophys Mol Biol 140:49–73
Miller WB Jr, Torday JS (2019) Reappraising the exteriorization of the mammalian testes through evolutionary physiology. Commun Integr Biol 12:38–54
Mitchell P (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism. Nature 191:144–148
Morris SC (1993) The fossil record and the early evolution of the metazoa. Nature 361:219–225
Morris DG, Sheppard D (2006) Pulmonary emphysema: when more is less. Physiology (Bethesda) 21:396–403
Moss L (2012) Is the philosophy of mechanism philosophy enough? Stud Hist Phil Biol Biomed Sci 43:164–172
Nestler EJ (2016) Transgenerational epigenetic contributions to stress responses: fact or fiction? PLoS Biol 14:e1002426
Nicholas TE (1996) Pulmonary surfactant: no mere paint on the alveolar wall. Respirology 1:247–257
Nicholson DJ (2012) The concept of mechanism in biology. Stud Hist Phil Biol Biomed Sci 43:152–163
Noble D (2012) A theory of biological relativity: no privileged level of causation. Interface Focus 2:55–64
Noble R, Noble D (2017) Was the watchmaker blind? or was she one-eyed? Biology 6:47
Nowacki M, Landweber LF (2009) Epigenetic inheritance in ciliates. Curr Opin Microbiol 12:638–643
Olsson L, Levit GS, Hoßfeld U (2017) The “Biogenetic law” in zoology: from Ernst Haeckel’s formulation to current approaches. Theory Biosci 136:19–29
Payne JL, Groves JR, Jost AB, Nguyen T, Moffitt SE, Hill TM, Skotheim JM (2012) Late paleozoic fusulinoidean gigantism driven by atmospheric hyperoxia. Evolution 66:2929–2939
Perez MF, Lehner B (2019) Intergenerational and transgenerational epigenetic inheritance in animals. Nat Cell Biol 21:143–151
Perry SF, Carrier DR (2006) The coupled evolution of breathing and locomotion as a game of leapfrog. Physiol Biochem Zool 79:997–999
Perry SF, Wilson RJ, Straus C, Harris MB, Remmers JE (2001) Which came first, the lung or the breath? Comp Biochem Physiol A Mol Integr Physiol 129:37–47
Rachner TD, Hofbauer LC, Göbel A, Tsourdi E (2019) Novel therapies in osteoporosis: PTH-related peptide analogs and inhibitors of sclerostin. J Mol Endocrinol 62:R145–R154
Rehan VK, Fong J, Lee R, Sakurai R, Wang ZM, Dahl MJ, Lane RH, Albertine KH, Torday JS (2011) Mechanism of reduced lung injury by high-frequency nasal ventilation in a preterm lamb model of neonatal chronic lung disease. Pediatr Res 70:462–466
Rehan VK, Liu J, Sakurai R, Torday JS (2013) Perinatal nicotine-induced transgenerational asthma. Am J Physiol Lung Cell Mol Physiol 305:L501–L507
Rehan V, Torday J (2003) Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation. Cell Biochem Biophys 38:239–250
Ricarte FR, Le Henaff C, Kolupaeva VG, Gardella TJ, Partridge NC (2018) Parathyroid hormone(1–34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A-CRTC3 signaling. J Biol Chem 293:20200–20213
Richardson MK, Keuck G (2002) Haeckel’s ABC of evolution and development. Biol Rev Camb Philos Soc 77:495–528
Richmond DL, Oates AC (2012) The segmentation clock: inherited trait or universal design principle? Curr Opin Genet Dev 22:600–666
Roth G, Hess G (1972) Changes in the mechanisms of hormone and neurotransmitter action during aging: current status of the role of receptor and post-receptor alterations. Mech Ageing Dev 20:75–194
Rubin LP, Kifor O, Hua J, Brown EM, Torday JS (1994) Parathyroid hormone (PTH) and PTH-related protein stimulate surfactant phospholipid synthesis in rat fetal lung, apparently by a mesenchymal-epithelial mechanism. Biochim Biophys Acta 1223:91–100
Sáenz JP, Grosser D, Bradley AS, Lagny TJ, Lavrynenko O, Broda M, Simons K (2015) Hopanoids as functional analogues of cholesterol in bacterial membranes. Proc Natl Acad Sci U S A 112:11971–11976
Scarpace PJ, Tumer N, Mader SL (1991) Beta-adrenergic function in aging. Basic mechanisms and clinical implications. Drugs Aging 1:116–129
Schrodinger E (1944) What is life? Macmillan, New York
Schultz CJ, Torres E, Londos C, Torday JS (2002) Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells. Am J Physiol Lung Cell Mol Physiol 283:L288–L296
Shapiro JA (2011) Evolution: a view from the 21st century. FT Press, Upper Saddle River
Shapiro JA (2017a) Biological action in read–write genome evolution. Interface Focus 7:20160115
Shapiro JA (2017b) Exploring the read-write genome: mobile DNA and mammalian adaptation. Crit Rev Biochem Mol Biol 52:1–17
Shapiro JA (2017c) Living organisms author their read-write genomes in evolution. Biology 6(4):E42
Sharma A (2017) Transgenerational epigenetics: integrating soma to germline communication with gametic inheritance. Mech Ageing Dev 163:15–22
Shubin N, Tabin C, Carroll S (2009) Deep homology and the origins of evolutionary novelty. Nature 457:818–823
Smith A (1790) The theory of moral sentiments. A. Millar, London
Smith H (1959) From fish to philosopher. Little Brown, Boston
Smocovitis VB (1996) Unifying biology. Princeton University Press, Princeton
Soshnikova N (2014) Hox genes regulation in vertebrates. Dev Dyn 243:49–58
Spemann H, Mangold H (2001) Induction of embryonic primordia by implantation of organizers from a different species. Int J Dev Biol 45:13–38
Steves CJ, Spector TD, Jackson SH (2012) Ageing, genes, environment and epigenetics: what twin studies tell us now, and in the future. Age Ageing 41:581–586
Storr SJ, Woolston CM, Zhang Y, Martin SG (2013) Redox environment, free radical, and oxidative DNA damage. Antioxid Redox Signal 18:2399–2408
Theobald DL (2012) A formal test of the theory of universal common ancestry. Nature 465:219–222
Thisse B, Thisse C (2015) Formation of the vertebrate embryo: moving beyond the Spemann organizer. Semin Cell Dev Biol 42:94–102
Todaro GJ, Fryling C, De Larco JE (1980) Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc Natl Acad Sci U S A 77:5258–5262
Tontonoz P, Hu E, Spiegelman BM (1995) Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor gamma. Curr Opin Genet Dev 5:571–576
Torday JS (2013) Evolutionary biology redux. Perspect Biol Med 56:455–484
Torday JS (2015a) The cell as the mechanistic basis for evolution. WIREs Syst Biol Med 7:275–284
Torday JS (2015b) A central theory of biology. Med Hypotheses 85:49–57
Torday JS (2016a) Heterochrony as diachronically modified cell-cell interactions. Biology (Basel) 5(1):4
Torday JS (2016b) The cell as the first niche construction. Biology (Basel) 5(2):19
Torday JS (2016c) Life is simple-biologic complexity is an epiphenomenon. Biology (Basel) 5(2):17
Torday JS (2018a) Quantum mechanics predicts evolutionary biology. Prog Biophys Mol Biol 135:11–15
Torday JS (2018b) From cholesterol to consciousness. Prog Biophys Mol Biol 132:52–56
Torday JS (2019) The singularity of nature. Prog Biophys Mol Biol 142:23–31
Torday JS, Miller WB Jr (2016a) The unicellular state as a point source in a quantum biological system. Biology (Basel) 5(2):25
Torday JS, Miller WB Jr (2016b) Biologic relativity: who is the observer and what is observed? Prog Biophys Mol Biol 121:29–34
Torday JS, Miller WB Jr (2016c) Life is determined by its environment. Int J Astrobiol 15:345–350
Torday JS, Miller WB Jr (2016d) Phenotype as agent for epigenetic inheritance. Biology (Basel) 5(3):30
Torday JS, Miller WB Jr (2016e) On the evolution of the mammalian brain. Front Syst Neurosci 10:1–9
Torday JS, Miller WB Jr (2017) The resolution of ambiguity as the basis for life: a cellular bridge between Western reductionism and Eastern holism. Prog Biophys Mol Biol 131:288–297
Torday JS, Miller WB Jr (2018a) The cosmologic continuum from physics to consciousness. Prog Biophys Mol Biol 140:41–48
Torday JS, Miller WB Jr (2018b) A systems approach to physiologic evolution: from micelles to consciousness. J Cell Physiol 233:162–167
Torday JS, Miller WB Jr (2018c) Terminal addition in a cellular world. Prog Biophys Mol Biol 135:1–10
Torday JS, Rehan VK (2002) Stretch-stimulated surfactant synthesis is coordinated by the paracrine actions of PTHrP and leptin. Am J Physiol Lung Cell Mol Physiol 283:L130–L135
Torday JS, Rehan VK (2003) Mechanotransduction determines the structure and function of lung and bone: a theoretical model for the pathophysiology of chronic disease. Cell Biochem Biophys 37:235–246
Torday JS, Rehan VK (2004) Deconvoluting lung evolution using functional/comparative genomics. Am J Respir Cell Mol Biol 31:8–12
Torday JS, Rehan VK (2006) Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network. Pediatr Res 60:382–388
Torday JS, Rehan VK (2007) The evolutionary continuum from lung development to homeostasis and repair. Am J Physiol Lung Cell Mol Physiol 292:L608–L611
Torday JS, Rehan VK (2009) Lung evolution as a cipher for physiology. Physiol Genomics 38:1–6
Torday JS, Rehan VK (2011) A cell-molecular approach predicts vertebrate evolution. Mol Biol Evol 28:2973–2981
Torday JS, Rehan VK (2012) Evolutionary biology, cell-cell communication and complex disease. Wiley, Hoboken
Torday JS, Rehan VK (2016) On the evolution of the pulmonary alveolar lipofibroblast. Exp Cell Res 340:215–219
Torday JS, Rehan VK (2017) Evolution, the logic of biology. Wiley, Hoboken
Torday JS, Sun H, Qin J (1998) Prostaglandin E2 integrates the effects of fluid distension and glucocorticoid on lung maturation. Am J Phys 274:L106–LL11
Torday JS, Sun H, Wang L, Torres E, Sunday ME, Rubin LP (2002) Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol 282:L405–L410
Torday JS, Torday DP, Gutnick J, Qin J, Rehan V (2001) Biologic role of fetal lung fibroblast triglycerides as antioxidants. Pediatr Res 49:843–849
Urs R, Kotecha S, Hall GL, Simpson SJ (2018) Persistent and progressive long-term lung disease in survivors of preterm birth. Paediatr Respir Rev 28:87–94
Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, De Langhe S, Kemp PJ, Riccardi D, Torday J, Bellusci S, Shi W, Lubkin SR, Jesudason E (2010) Lung organogenesis. Curr Top Dev Biol 90:73–158
Wei YH, Lu CY, Wei CY, Ma YS, Lee HC (2001) Oxidative stress in human aging and mitochondrial disease-consequences of defective mitochondrial respiration and impaired antioxidant enzyme system. Chin J Physiol 44:1–11
Whitsett JA, Weaver TE (2015) Alveolar development and disease. Am J Respir Cell Mol Biol 53:1–7
Williams GC (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11:398–411
Zhang W, Du G, Zhou J, Chen J (2018a) Regulation of sensing, transportation, and catabolism of nitrogen sources in saccharomyces cerevisiae. Microbiol Mol Biol Rev 82:e00040
Zheng W, Wang Z, Collins JE, Andrews RM, Stemple D, Gong Z (2011) Comparative transcriptome analyses indicate molecular homology of zebrafish swimbladder and mammalian lung. PLoS One 6(8):e24019
Zhang Y, Chen G, Gu Z, Sun H, Karaplis A, Goltzman D, Miao D (2018b) DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide. Int J Biol Sci 14:508–517
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Torday, J., Miller Jr., W. (2020). Conclusion. In: Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-38133-2_16
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