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Near Infrared Fluorescence Applications in Urinary Bladder Cancer

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Video Atlas of Intraoperative Applications of Near Infrared Fluorescence Imaging

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Abstract

Bladder cancer is a common malignancy. Cystectomy with urinary diversion and pelvic lymph node dissection is the best treatment method when the bladder wall is invaded. Recently, cisplatin-based neoadjuvant chemotherapy has been added to the treatment of selected groups of patients, improving their 5-year survival rate. Conventional methods of bladder removal with a template lymphadenectomy do not always bring satisfactory results as far as cancer-free survival is concerned. Improving visualization of the lymphatic vessels can advance the procedure of removing micrometastases, thus offering better treatment results. New methods of image-guided surgery with the use of near infrared camera systems and fluorescent dyes—such as indocyanine green, or ICG—have emerged, allowing for live intraoperative visualization of the bladder tumor site, personalized estimation of the lymphatic flow from the tumor site, and safe bowel preparation, especially in laparoscopic and robotic operations. The technology of infrared fluorescence imaging is developing, and its application in bladder cancer, as well as in other malignancies, is evolving rapidly. New systems and new techniques are used to help prepare a surgeon to the operation by customizing every case and thus limiting postoperative complications. There are still some issues regarding techniques involving bladder cancer surgery fluorescence that need to be solved, such as tissue penetration of fluorescence in obese patients and prolonged procedure; still, the benefits seem to be very encouraging.

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References

  1. Stenzl A, Cowan NC, De Santis M, Kuczyk MA, Merseburger AS, Ribal MJ, et al. Treatment of muscle-invasive and metastatic bladder cancer: update of the EAU guidelines. Eur Urol. 2011;59(6):1009–18.

    Article  CAS  Google Scholar 

  2. Torre LA, Bray F, Siegel RL, Ferlay J. Interpretation of model in modelling ecological niche.pdf. 2015;65(2):87–108.

    Google Scholar 

  3. Witjes JA, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, et al. EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines. Eur Urol. 2013;65(4):778–92.

    Article  Google Scholar 

  4. Van der Pas MHGM, Meijer S, Hoekstra OS, Riphagen II, De Vet HCW, Knol DL, et al. Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis. Lancet Oncol. 2011;12(6):540–50.

    Article  Google Scholar 

  5. Vale CL. Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data. Eur Urol. 2005;48(2):202–5.

    Article  Google Scholar 

  6. Yin M, Joshi M, Meijer RP, Glantz M, Holder S, Harvey HA, et al. Neoadjuvant chemotherapy for muscle-invasive bladder cancer: a systematic review and two-step meta-analysis. Oncologist [Internet]. 2016;21(6):708–15. Available from: http://theoncologist.alphamedpress.org/lookup/doi/10.1634/theoncologist.2015–0440.

  7. Simone G, Papalia R, Ferriero M, Guaglianone S, Castelli E, Collura D, et al. Stage-specific impact of extended versus standard pelvic lymph node dissection in radical cystectomy. Int J Urol. 2013;20(4):390–7.

    Article  Google Scholar 

  8. Holmer M, Bendahl P-O, Davidsson T, Gudjonsson S, Mansson W, Liedberg F. Extended lymph node dissection in patients with urothelial cell carcinoma of the bladder: can it make a difference? World J Urol. 2009;27(4):521–6.

    Article  Google Scholar 

  9. Poulsen AL, Horn T, Steven K. Radical cystectomy: extending the limits of pelvic lymph node dissection improves survival for patients with bladder cancer confined to the bladder wall. J Urol. 1998;160(6 Pt 1):2015–9; discussion 2020.

    CAS  PubMed  Google Scholar 

  10. Zlotta AR. Limited, extended, superextended, megaextended pelvic lymph node dissection at the time of radical cystectomy: what should we perform? Eur Urol. Switzerland. 2012;61:243–4.

    Article  Google Scholar 

  11. Zehnder P, Studer UE, Skinner EC, Dorin RP, Cai J, Roth B, et al. Super extended versus extended pelvic lymph node dissection in patients undergoing radical cystectomy for bladder cancer: a comparative study. J Urol. 2011;186(4):1261–8.

    Article  Google Scholar 

  12. Billy GG. NIH Public Access. 2015;6(9):790–5.

    Google Scholar 

  13. Davison KK, Birch LL. NIH Public Access. 2008;64(12):2391–404.

    Google Scholar 

  14. Polom K, Murawa D, Rho Y-S, Nowaczyk P, Hunerbein M, Murawa P. Current trends and emerging future of indocyanine green usage in surgery and oncology: a literature review. Cancer. 2011;117(21):4812–22.

    Article  Google Scholar 

  15. Polom K, Murawa D, Rho YS, Spychala A, Murawa P. Skin melanoma sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green and indocyanine green with human serum albumin. Br J Dermatol. England. 2012;166:682–3.

    Google Scholar 

  16. Polom K, Murawa D, Nowaczyk P, Rho YS, Murawa P. Breast cancer sentinel lymph node mapping using near infrared guided indocyanine green and indocyanine green—human serum albumin in comparison with gamma emitting radioactive colloid tracer. Eur J Surg Oncol. 2012;38(2):137–42.

    Article  CAS  Google Scholar 

  17. Rosenblatt R, Johansson M, Alamdari F, Sidiki A, Holmström B, Hansson J, et al. Sentinel node detection in muscle-invasive urothelial bladder cancer is feasible after neoadjuvant chemotherapy in all pT stages, a prospective multicenter report. World J Urol. 2017;35(6):921–7.

    Article  CAS  Google Scholar 

  18. Tee SR, Devane LA, Evoy D, Rothwell J, Geraghty J, Prichard RS, et al. Meta-analysis of sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with initial biopsy-proven node-positive breast cancer. Br J Surg [Internet]. 2018;105(12):1541–52. Available from: http://doi.wiley.com/10.1002/bjs.10986.

    Article  CAS  Google Scholar 

  19. Menon M, Hemal AK, Tewari A, Shrivastava A, Shoma AM, El-Tabey NA, et al. Nerve-sparing robot-assisted radical cystoprostatectomy and urinary diversion. BJU Int. 2003;92(3):232–6.

    Article  CAS  Google Scholar 

  20. Parekh DJ, Messer J, Fitzgerald J, Ercole B, Svatek R. Perioperative outcomes and oncologic efficacy from a pilot prospective randomized clinical trial of open versus robotic assisted radical cystectomy. J Urol [Internet]. 2013;189(2):474–9. Available from: https://doi.org/10.1016/j.jur0.2012.09.077.

    Article  Google Scholar 

  21. Polom W, Markuszewski M, Cytawa W, Czapiewski P, Lass P, Matuszewski M. Fluorescent versus radioguided lymph node mapping in bladder cancer. Clin Genitourin Cancer [Internet]. 2017;15(3):e405–9. Available from: https://doi.org/10.1016/j.clgc.2016.11.007.

    Article  Google Scholar 

  22. Manny TB, Hemal AK. Fluorescence-enhanced robotic radical cystectomy using unconjugated indocyanine green for pelvic lymphangiography, tumor marking, and mesenteric angiography: the initial clinical experience. Urology [Internet]. 2014;83(4):824–9. Available from: https://doi.org/10.1016/j.urology.2013.11.042.

    Article  Google Scholar 

  23. Markuszewski M, Polom W, Cytawa W, Czapiewski P, Lass P, Matuszewski M. Comparison of real-time fluorescent indocyanine green and99mTc-nanocolloid radiotracer navigation in sentinel lymph node biopsy of penile cancer. Clin Genitourin Cancer [Internet]. 2015;13(6):574–80. Available from: https://doi.org/10.1016/j.clgc.2015.06.005.

    Article  Google Scholar 

  24. Połom W, Markuszewski M, Cytawa W, Lass P, Matuszewski M. Radio-guided lymph node mapping in bladder cancer using SPECT/CT and intraoperative γ-probe methods. Clin Nucl Med. 2016;41(8):e362–7.

    Article  Google Scholar 

  25. van den Berg NS, Buckle T, KleinJan GH, van der Poel HG, van Leeuwen FWB. Multispectral fluorescence imaging during robot-assisted laparoscopic sentinel node biopsy: a first step towards a fluorescence-based anatomic roadmap. Eur Urol [Internet]. 2017;72(1):110–7. Available from: https://doi.org/10.1016/j.eurur0.2016.06.012.

    Article  Google Scholar 

  26. Zelken JA, Tufaro AP. Current trends and emerging future of indocyanine green usage in surgery and oncology: an update. Ann Surg Oncol. 2015;22:1271–83.

    Article  Google Scholar 

  27. Van Der Poel HG, Buckle T, Brouwer OR, Valdés Olmos RA, Van Leeuwen FWB. Intraoperative laparoscopic fluorescence guidance to the sentinel lymph node in prostate cancer patients: clinical proof of concept of an integrated functional imaging approach using a multimodal tracer. Eur Urol. 2011;60(4):826–33.

    Article  Google Scholar 

  28. Hawrysz DJ, Sevick-Muraca EM. Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents. Neoplasia [Internet]. 2000;2(5):388–417. Available from: http://linkinghub.elsevier.com/retrieve/pii/S147655860080010X.

    Article  CAS  Google Scholar 

  29. Chu W, Chennamsetty A, Toroussian R, Lau C. Anaphylactic shock after intravenous administration of indocyanine green during robotic partial nephrectomy. Urol Case Rep [Internet]. 2017;12:37–8. Available from: https://doi.org/10.1016/j.eucr.2017.02.006.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology, Medical University of Gdansk, Gdansk, Pomorskie, Poland

    Wojciech Polom & Marcin Matuszewski

  2. Department of Oncological Surgery, Medical University of Gdansk, Gdansk, Pomorskie, Poland

    Karol Polom

Authors
  1. Wojciech Polom
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  3. Marcin Matuszewski
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Corresponding author

Correspondence to Wojciech Polom .

Editor information

Editors and Affiliations

  1. Department of General Surgery, Digestive Disease and Surgery Institute Cleveland Clinic Foundation, Cleveland, OH, USA

    Essa M. Aleassa

  2. Division of General Surgery Division of Surgical Oncology MetroHealth System, Cleveland, OH, USA

    Kevin M. El-Hayek

Electronic Supplementary Material

Indocyanine green (ICG) injection in cystoscopy (MOV 108189 kb)

Injection site bladder (WMV 4322 kb)

Sentinel lymph nodes identification (WMV 5407 kb)

Sentinel lymph node after excision (WMV 7044 kb)

Ileal conduit angiography (WMV 7691 kb)

Camera position during open procedure (MOV 10672 kb)

Indocyanine green (ICG) spillage and field contamination (WMV 6719 kb)

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Polom, W., Polom, K., Matuszewski, M. (2020). Near Infrared Fluorescence Applications in Urinary Bladder Cancer. In: Aleassa, E., El-Hayek, K. (eds) Video Atlas of Intraoperative Applications of Near Infrared Fluorescence Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-38092-2_23

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  • DOI: https://doi.org/10.1007/978-3-030-38092-2_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-38091-5

  • Online ISBN: 978-3-030-38092-2

  • eBook Packages: MedicineMedicine (R0)

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