Abstract
A correlate of protection is an immunological assay that predicts protection against infection. In clinical vaccine trials, correlates of protection are widely used as surrogate endpoints for vaccine efficacy. The function specifying the relationship between immunogenicity values and the probability of protection against infection is called the protection curve. It is demonstrated how the parameters of the protection curve can be estimated from both challenge study data and vaccine efficacy data. Also explained is how a threshold of protection can be estimated from the protection curve. The generalizable of estimated protection curves is discussed.
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Nauta, J. (2020). Immune Correlates of Protection. In: Statistics in Clinical and Observational Vaccine Studies. Springer Series in Pharmaceutical Statistics. Springer, Cham. https://doi.org/10.1007/978-3-030-37693-2_11
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DOI: https://doi.org/10.1007/978-3-030-37693-2_11
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Publisher Name: Springer, Cham
Print ISBN: 978-3-030-37692-5
Online ISBN: 978-3-030-37693-2
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