Abstract
We describe an innovative approach to sensing bioelectric signals at high space-time resolution with low invasiveness based on growing small Silicon Nano Wires (SiNW) at low-temperature (200 °C). The resulting SiNWs are compatible with ICs, allowing on-site amplification of bioelectric signals. We report our preliminary results showing biocompatibility and neutrality of SiNWs used as seeding substrate for cells in culture. With this technology, we aim to produce a compact device allowing on-site, synched and high signal/noise recordings of a large amounts of biological signals from networks of excitable cells (e.g. neurons) or distinct subdomains of the cell membrane, thus providing super-resolved descriptions of the propagation of electric waveforms within living cells and networks.
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References
Sakmann B, Neher E (2009) Single-Channel Recording, 2nd edn. Springer, New York
Pine J (1980) Recording action potentials from cultured neurons with extracellular microcircuit electrodes. J Neurosci Methods 2:19–31 [PubMed: 7329089]
Lambacher A et al (2004) Electrical imaging of neuronal activity by multi-transistor-array. Appl Phys Mater Sci Process 79:1607–1611
Zheng W, Spencer RH, Kiss L (2004) High throughput assay technologies for ion channel drug discovery. Assay Drug Dev Technol 2:543–552 [PubMed: 15671652]
Herron TJ, Lee P, Jalife J (2012) Optical imaging of voltage and calcium in cardiac cells & tissues. J Circ Res 110:609–623
Cheng H, Lederer WJ, Cannell MB (1993) Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262:740–744
Matiukas A et al (2007) Near-infrared voltage-sensitive fluorescent dyes optimized for optical mapping in blood-perfused myocardium. Heart Rhythm 4:1441–1451
Fromherz P (2002) Electrical interfacing of nerve cells and semiconductor chips. ChemPhysChem 3:276–284
Timko BP et al (2009) Electrical recording from hearts with flexible nanowire device arrays. Nano Lett 9:914–918 [PubMed: 19170614]
Duan X et al (2011) Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor. Nat Nanotechnol
Xie C, Lin Z, Hanson L, Cui Y, Cui B (2012) Intracellular recording of action potentials by nanopillar electroporation. Nat Nanotechnol 7(3):185
Patent filed on the 22/09/2017, Ref code: IT0549-17- UNIVERSITÀ DEGLI STUDI DI ROMA-CB)
Piedimonte P et al (2019) Silicon nanowires to detect electric signals from living cells. Mater Res Express 6(8)
Piedimonte P et al (2019) Silicon Nanowires as Biocompatibile Electronics-Biology Interface. In: 2019 20th International conference on solid-state sensors, actuators and microsystems & eurosensors XXXIII
Piedimonte P et al (2019) Biocompatibility of silicon nanowires: A step towards IC detectors. In: Nanoinnovation 2018- AIP conference proceedings
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Authors wish to thank LFoundry for the information on the technology LF11iS-BSI.
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Piedimonte, P., Feyen, D.A.M., Mercola, M., Messina, E., Renzi, M., Palma, F. (2020). Silicon Nanowires as Contact Between the Cell Membrane and CMOS Circuits. In: Saponara, S., De Gloria, A. (eds) Applications in Electronics Pervading Industry, Environment and Society. ApplePies 2019. Lecture Notes in Electrical Engineering, vol 627. Springer, Cham. https://doi.org/10.1007/978-3-030-37277-4_28
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DOI: https://doi.org/10.1007/978-3-030-37277-4_28
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