Abstract
Ongoing national efforts to curb the opioid overdose epidemic have resulted in the development and implementation of national guidelines (e.g., Center for Disease Control and Prevention Guideline for Prescribing Opioids for Chronic Pain). This has had a downstream effect onto pediatric practice. However, the scope of problematic opioid prescribing and etiology of misuse/abuse in children and adolescents remain unclear. This raises concerns regarding the application of guidelines intended for the adult population onto pediatric practice. In this chapter, we examine the epidemiologic data of pediatric opioid prescribing patterns to understand the scope of the problem and present available practice guidelines for treatment of chronic non-malignant pain as applied to children and adolescents. Finally, we review the efforts in the State of Washington, which has been on the forefront of legislation to address opioid-related deaths to exemplify the concerns regarding federal and state regulatory interventions.
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References
Jones CM, Paulozzi LJ, Mack KA. Sources of prescription opioid pain relievers by frequency of past-year nonmedical use United States, 2008-2011. JAMA Intern Med. 2014;174(5):802–3. https://doi.org/10.1001/jamainternmed.2013.12809.
Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain--United States, 2016. JAMA. 2016;315(15):1624–45. https://doi.org/10.1001/jama.2016.1464.
Busse JW, Juurlink D, Guyatt GH. Addressing the limitations of the CDC guideline for prescribing opioids for chronic noncancer pain. CMAJ. 2016;188(17–18):1210–1. https://doi.org/10.1503/cmaj.161023.
Juurlink DN. Critiquing the CDC opioid guideline: some light from the heat. Clin Pharmacol Ther. 2018;103(6):966–8. https://doi.org/10.1002/cpt.1061.
Hedegaard HMA, Warner M. NCHS Data Brief, no 329. (2018). Drug overdose deaths in the United States, 1999–2017. (NCHS Data Brief, no 329). Hyattsville: National Center for Health Statistics. Retrieved from https://www.cdc.gov/nchs/products/databriefs/db329.htm.
Burke A. (2018). Assembymember Autumn Burke fights to protect children from opioid addiction. Retrieved from https://www.prnewswire.com/news-releases/assemblymember-autumn-burke-fights-to-protect-children-from-opioid-addiction-300602329.html.
Carr DB. NPS versus CDC: Scylla, Charybdis and the “Number Needed to [Under-] Treat”. Pain Med. 2016; https://doi.org/10.1093/pm/pnw104.
Howard RF. Current status of pain management in children. JAMA. 2003;290(18):2464–9. https://doi.org/10.1001/jama.290.18.2464.
Palermo TM, Valrie CR, Karlson CW. Family and parent influences on pediatric chronic pain: a developmental perspective. Am Psychol. 2014;69(2):142–52. https://doi.org/10.1037/a0035216.
Rabbitts JA, Zhou C, Groenewald CB, Durkin L, Palermo TM. Trajectories of postsurgical pain in children: risk factors and impact of late pain recovery on long-term health outcomes after major surgery. Pain. 2015;156(11):2383–9. https://doi.org/10.1097/j.pain.0000000000000281.
Schwaller F, Fitzgerald M. The consequences of pain in early life: injury-induced plasticity in developing pain pathways. Eur J Neurosci. 2014;39(3):344–52. https://doi.org/10.1111/ejn.12414.
Cummings EA, Reid GJ, Finley GA, McGrath PJ, Ritchie JA. Prevalence and source of pain in pediatric inpatients. Pain. 1996;68(1):25–31.
Groenewald CB, Rabbitts JA, Schroeder DR, Harrison TE. Prevalence of moderate-severe pain in hospitalized children. Paediatr Anaesth. 2012;22(7):661–8. https://doi.org/10.1111/j.1460-9592.2012.03807.x.
Taylor EM, Boyer K, Campbell FA. Pain in hospitalized children: a prospective cross-sectional survey of pain prevalence, intensity, assessment and management in a Canadian pediatric teaching hospital. Pain Res Manag. 2008;13(1):25–32.
Committee on Psychosocial Aspects of Child and Family Health, American Academy of Pediatrics; Task Force on Pain in Infants, Children, and Adolescents, American Pain Society. The assessment and management of acute pain in infants, children, and adolescents. (2001). In (Vol. 108, pp. 793–797): Pediatrics.
Fortuna RJ, Robbins BW, Caiola E, Joynt M, Halterman JS. Prescribing of controlled medications to adolescents and young adults in the United States. Pediatrics. 2010;126(6):1108–16. https://doi.org/10.1542/peds.2010-0791.
Richardson LP, Fan MY, McCarty CA, Katon W, Edlund M, DeVries A, et al. Trends in the prescription of opioids for adolescents with non-cancer pain. Gen Hosp Psychiatry. 2011;33(5):423–8. https://doi.org/10.1016/j.genhosppsych.2011.04.009.
Groenewald CB, Rabbitts JA, Gebert JT, Palermo TM. Trends in opioid prescriptions among children and adolescents in the United States: a nationally representative study from 1996 to 2012. Pain. 2016;157(5):1021–7. https://doi.org/10.1097/j.pain.0000000000000475.
Kaiser SV, Asteria-Penaloza R, Vittinghoff E, Rosenbluth G, Cabana MD, Bardach NS. National patterns of codeine prescriptions for children in the emergency department. Pediatrics. 2014;133(5):e1139–47. https://doi.org/10.1542/peds.2013-3171.
Sites BD, Beach ML, Davis MA. Increases in the use of prescription opioid analgesics and the lack of improvement in disability metrics among users. Reg Anesth Pain Med. 2014;39(1):6–12. https://doi.org/10.1097/AAP.0000000000000022.
Gaither JR, Shabanova V, Leventhal JM. US National Trends in pediatric deaths from prescription and illicit opioids, 1999-2016. JAMA Netw Open. 2018;1(8):e186558. https://doi.org/10.1001/jamanetworkopen.2018.6558.
Martins SS, Segura LE, Santaella-Tenorio J, Perlmutter A, Fenton MC, Cerda M, et al. Prescription opioid use disorder and heroin use among 12-34 year-olds in the United States from 2002 to 2014. Addict Behav. 2017;65:236–41. https://doi.org/10.1016/j.addbeh.2016.08.033.
Chumpitazi CE, Rees CA, Camp EA, Bernhardt MB. Decreased opioid prescribing in a pediatric emergency department after the rescheduling of hydrocodone. J Emerg Med. 2017;52(4):547–53. https://doi.org/10.1016/j.jemermed.2016.08.026.
Chung CP, Callahan ST, Cooper WO, Dupont WD, Murray KT, Franklin AD, et al. Outpatient opioid prescriptions for children and opioid-related adverse events. Pediatrics. 2018;142(2):e20172156. https://doi.org/10.1542/peds.2017-2156.
Gagne JJ, He M, Bateman BT. Trends in opioid prescription in children and adolescents in a commercially insured population in the United States, 2004-2017. JAMA Pediatr. 2018;173:98. https://doi.org/10.1001/jamapediatrics.2018.3668.
Guy GP Jr, Zhang K, Bohm MK, Losby J, Lewis B, Young R, et al. Vital signs: changes in opioid prescribing in the United States, 2006-2015. MMWR Morb Mortal Wkly Rep. 2017;66(26):697–704. https://doi.org/10.15585/mmwr.mm6626a4.
McCabe SE, West BT, Veliz P, McCabe VV, Stoddard SA, Boyd CJ. Trends in medical and nonmedical use of prescription opioids among US adolescents: 1976-2015. Pediatrics. 2017;139(4):e20162387. https://doi.org/10.1542/peds.2016-2387.
Pezalla EJ, Rosen D, Erensen JG, Haddox JD, Mayne TJ. Secular trends in opioid prescribing in the USA. J Pain Res. 2017;10:383–7. https://doi.org/10.2147/JPR.S129553.
Chai G, Governale L, McMahon AW, Trinidad JP, Staffa J, Murphy D. Trends of outpatient prescription drug utilization in US children, 2002-2010. Pediatrics. 2012;130(1):23–31. https://doi.org/10.1542/peds.2011-2879.
McCabe SE, Boyd CJ, Young A. Medical and nonmedical use of prescription drugs among secondary school students. J Adolesc Health. 2007;40(1):76–83. https://doi.org/10.1016/j.jadohealth.2006.07.016.
Levy S. Youth and the opioid epidemic. Pediatrics. 2019;143(2):e20182752. https://doi.org/10.1542/peds.2018-2752.
Hingson RW, Heeren T, Winter MR. Age at drinking onset and alcohol dependence: age at onset, duration, and severity. Arch Pediatr Adolesc Med. 2006;160(7):739–46. https://doi.org/10.1001/archpedi.160.7.739.
Le Strat Y, Dubertret C, Le Foll B. Impact of age at onset of cannabis use on cannabis dependence and driving under the influence in the United States. Accid Anal Prev. 2015;76:1–5. https://doi.org/10.1016/j.aap.2014.12.015.
Partnership for Drug-Free Kids (formerly known as The partnership at DrugFree.org). (2013). 2012 Partnership Attitude Tracking Study. Teens and Parents. (2013). Retrieved from https://drugfree.org/wp-content/uploads/2013/04/PATS-2012-FULL-REPORT2.pdf.
Voepel-Lewis T, Wagner D, Tait AR. Leftover prescription opioids after minor procedures: an unwitting source for accidental overdose in children. JAMA Pediatr. 2015;169(5):497–8. https://doi.org/10.1001/jamapediatrics.2014.3583.
Garbutt JM, Kulka K, Dodd S, Sterkel R, Plax K. Opioids in adolescents’ homes: prevalence, caregiver attitudes, and risk reduction opportunities. Acad Pediatr. 2018;19:103. https://doi.org/10.1016/j.acap.2018.06.012.
McDonald R, Campbell ND, Strang J. Twenty years of take-home naloxone for the prevention of overdose deaths from heroin and other opioids-conception and maturation. Drug Alcohol Depend. 2017;178:176–87. https://doi.org/10.1016/j.drugalcdep.2017.05.001.
Lankenau SE, Teti M, Silva K, Jackson Bloom J, Harocopos A, Treese M. Initiation into prescription opioid misuse amongst young injection drug users. Int J Drug Policy. 2012;23(1):37–44. https://doi.org/10.1016/j.drugpo.2011.05.014.
Schepis TS, Krishnan-Sarin S. Sources of prescriptions for misuse by adolescents: differences in sex, ethnicity, and severity of misuse in a population-based study. J Am Acad Child Adolesc Psychiatry. 2009;48(8):828–36. https://doi.org/10.1097/CHI.0b013e3181a8130d.
Johnston LD, O’Malley PM, Miech RA, Bachman JG, Schulenberg JE. Monitoring the Future national survey results on drug use,1975–2015: Overview, key findings on adolescent drug use. Ann Arbor: Institute for Social Research.The University of Michigan; 2016.
Miech R, Johnston L, O’Malley PM, Keyes KM, Heard K. Prescription opioids in adolescence and future opioid misuse. Pediatrics. 2015;136(5):e1169–77. https://doi.org/10.1542/peds.2015-1364.
McCabe SE, Veliz P, Schulenberg JE. Adolescent context of exposure to prescription opioids and substance use disorder symptoms at age 35: a national longitudinal study. Pain. 2016;157(10):2173–8. https://doi.org/10.1097/j.pain.0000000000000624.
Hooten WM, Brummett CM, Sullivan MD, Goesling J, Tilburt JC, Merlin JS, et al. A conceptual framework for understanding unintended prolonged opioid use. Mayo Clin Proc. 2017;92(12):1822–30. https://doi.org/10.1016/j.mayocp.2017.10.010.
Hooten WM, St Sauver JL, McGree ME, Jacobson DJ, Warner DO. Incidence and risk factors for progression from short-term to episodic or long-term opioid prescribing: a population-based study. Mayo Clin Proc. 2015;90(7):850–6. https://doi.org/10.1016/j.mayocp.2015.04.012.
Whiteside LK, Russo J, Wang J, Ranney ML, Neam V, Zatzick DF. Predictors of sustained prescription opioid use after admission for trauma in adolescents. J Adolesc Health. 2016;58(1):92–7. https://doi.org/10.1016/j.jadohealth.2015.08.011.
Harbaugh CM, Lee JS, Hu HM, McCabe SE, Voepel-Lewis T, Englesbe MJ, et al. Persistent opioid use among pediatric patients after surgery. Pediatrics. 2018;141(1):e20172439. https://doi.org/10.1542/peds.2017-2439.
Quinn PD, Hur K, Chang Z, Scott EL, Krebs EE, Bair MJ, et al. Association of mental health conditions and treatments with long-term opioid analgesic receipt among adolescents. JAMA Pediatr. 2018;172(5):423–30. https://doi.org/10.1001/jamapediatrics.2017.5641.
Krane EJ, Weisman SJ, Walco GA. The national opioid epidemic and the risk of outpatient opioids in children. Pediatrics. 2018;142(2):e20181623. https://doi.org/10.1542/peds.2018-1623.
Groenewald CB, Law EF, Fisher E, Beals-Erickson SE, Palermo TM. Associations between adolescent chronic pain and prescription opioid misuse in adulthood. J Pain. 2019;20(1):28–37. https://doi.org/10.1016/j.jpain.2018.07.007.
Chou R. 2009 clinical guidelines from the American Pain Society and the American Academy of Pain Medicine on the use of chronic opioid therapy in chronic noncancer pain: what are the key messages for clinical practice? Pol Arch Med Wewn. 2009;119(7–8):469–77.
Chou R, Fanciullo GJ, Fine PG, Adler JA, Ballantyne JC, Davies P, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113–30. https://doi.org/10.1016/j.jpain.2008.10.008.
Mu A, Weinberg E, Moulin DE, Clarke H. Pharmacologic management of chronic neuropathic pain: review of the Canadian Pain Society consensus statement. Can Fam Physician. 2017;63(11):844–52.
Nuckols TK, Anderson L, Popescu I, Diamant AL, Doyle B, Di Capua P, Chou R. Opioid prescribing: a systematic review and critical appraisal of guidelines for chronic pain. Ann Intern Med. 2014;160(1):38–47. https://doi.org/10.7326/0003-4819-160-1-201401070-00732.
Anand KJ, International Evidence-Based Group for Neonatal, P. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med. 2001;155(2):173–80.
World Health Organization. WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Geneva: World Health Organization; 2012.
Parniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Toth M, et al. EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis. Pancreatology. 2018;18(2):146–60. https://doi.org/10.1016/j.pan.2018.01.001.
Fletcher ND, Glotzbecker MP, Marks M, Newton PO, Harms Study G. Development of consensus-based best practice guidelines for postoperative care following posterior spinal fusion for adolescent idiopathic scoliosis. Spine (Phila Pa 1976). 2017;42(9):E547–54. https://doi.org/10.1097/BRS.0000000000001865.
Ericsson E, Brattwall M, Lundeberg S. Swedish guidelines for the treatment of pain in tonsil surgery in pediatric patients up to 18 years. Int J Pediatr Otorhinolaryngol. 2015;79(4):443–50. https://doi.org/10.1016/j.ijporl.2015.01.016.
Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131–57. https://doi.org/10.1016/j.jpain.2015.12.008.
Herndon CM, Arnstein P, Darnall B, Hartrick C, Hecht K, Lyons M, Maleki J, Manworren R, Miaskowski C, Sehgal N. American Pain Society’s Principles of Analgesic Use, 7th ed. 2016.
Bohnert ASB, Guy GP Jr, Losby JL. Opioid prescribing in the United States before and after the centers for disease control and prevention’s 2016 opioid guideline. Ann Intern Med. 2018;169(6):367–75. https://doi.org/10.7326/M18-1243.
Monitto CL, Hsu A, Gao S, Vozzo PT, Park PS, Roter D, et al. Opioid prescribing for the treatment of acute pain in children on hospital discharge. Anesth Analg. 2017;125(6):2113–22. https://doi.org/10.1213/ANE.0000000000002586.
Parikh JM, Amolenda P, Rutledge J, Szabova A, Chidambaran V. An update on the safety of prescribing opioids in pediatrics. Expert Opin Drug Saf. 2019;18:1–17. https://doi.org/10.1080/14740338.2019.1571037.
Franklin G, Sabel J, Jones CM, Mai J, Baumgartner C, Banta-Green CJ, et al. A comprehensive approach to address the prescription opioid epidemic in Washington State: milestones and lessons learned. Am J Public Health. 2015;105(3):463–9. https://doi.org/10.2105/AJPH.2014.302367.
Walco G. Managing chronic non-cancer pain in children and adolescents. In: W. S. A. M. D. Group, editor. Interagency guideline on prescribing opioids for pain. 3rd ed. Olympia: State of Washington; 2015. p. 45–7.
Collaborative B. (2017). Dental guideline on prescribing opioids for acute pain management. Retrieved from http://www.breecollaborative.org/wp-content/uploads/Dental-Opioid-Recommendations-Final-2017.pdf.
Denisco RC, Kenna GA, O’Neil MG, Kulich RJ, Moore PA, Kane WT, et al. Prevention of prescription opioid abuse: the role of the dentist. J Am Dent Assoc. 2011;142(7):800–10.
Harbaugh CM, Nalliah RP, Hu HM, Englesbe MJ, Waljee JF, Brummett CM. Persistent opioid use after wisdom tooth extraction. JAMA. 2018;320(5):504–6. https://doi.org/10.1001/jama.2018.9023.
Collaborative B. (2018). Prescribing opioids for postoperative pain. Retrieved from http://www.breecollaborative.org/wp-content/uploads/Supplemental-Bree-AMDG-Postop-pain-Draft-Final.pdf.
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Tham, S.W., Groenewald, C.B., Walco, G.A. (2020). Evidence-Based Guidelines for Opioid Therapy in Pediatrics. In: Shah, R., Suresh, S. (eds) Opioid Therapy in Infants, Children, and Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-36287-4_5
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