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Advances in Polysaccharide-Based Antimicrobial Delivery Vehicles

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Racing for the Surface

Abstract

Antimicrobial resistance is one of the major causes for morbidity and mortality in sepsis patients. Trying to circumvent the challenge with newer antibiotics has led to the drug misuse and bacterial recalcitrance. Recently, polysaccharides have proffered inexplicable contributions in the field of antimicrobial drug delivery. Structural hierarchy and tunability in biochemical and mechanical properties make polysaccharides unique. Some of the polysaccharides in the naïve state itself pose antimicrobial properties in inhibiting bacterial colonization via blocking carbohydrate receptor associated with host–bacterial responses. While, rest of the saccharides upon modification delivers antibacterial drugs onto targeted sites with sustained or burst release depending upon the need. Ongoing research keeps pace in promoting polysaccharides for local as well as systemic therapy due to its attractive features, mainly biocompatibility, mechanical strength, stimuli responsiveness, protein affinity and reduced toxicity. This chapter presents the updates of prominent polysaccharides involved in the field of antimicrobial drug delivery.

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  1. Vaishali Pawar, M. C. Bavya, K. Vimal Rohan and Rohit Srivastava contributed equally to this work.

Authors and Affiliations

  1. Indian Institute of Technology, Mumbai, Maharashtra, India

    Vaishali Pawar, M. C. Bavya & Rohit Srivastava

  2. Pariyaram Medical College, Pariyaram, Kerala, India

    K. Vimal Rohan

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  1. Vaishali Pawar
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  2. M. C. Bavya
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  3. K. Vimal Rohan
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  4. Rohit Srivastava
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Correspondence to Rohit Srivastava .

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Editors and Affiliations

  1. Department of Orthopaedics, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. Microbiology Lab, AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Engineering and Medicine, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Pawar, V., Bavya, M.C., Rohan, K.V., Srivastava, R. (2020). Advances in Polysaccharide-Based Antimicrobial Delivery Vehicles. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34475-7_12

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