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Peptide-mediated Bone Tissue Engineering

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Racing for the Surface

Abstract

Bone is a highly vascularized tissue and one of the most dynamic tissues in terms of self-renewal throughout one’s life. It possesses a high regenerative capacity, which makes it possible that a majority of bone fractures will heal well without the need for major intervention. However, some large bone defects and fractures require medical intervention for bone repair and regeneration. Proteins, growth factors, and peptides have played a remarkable role in bone regeneration. However, the use of proteins and growth factors in tissue engineering has several limitations, such as cost and difficulty in production, immunogenicity, and a short half-life. In addition to these drawbacks, they have many active domains, which affect their functionality. Recently, an alternative to proteins and growth factors has emerged for the use in tissue engineering. This competent approach includes biomimetic peptides, which are amino acid sequences derived from the functional domains of soluble or extracellular matrix (ECM) proteins. Biological materials for tissue regeneration can be functionalized with these peptides to either mediate the adhesion of cells or to be released as soluble ligands. These short peptides are easy to design and synthesize, facilitating their use as cost-effective and efficient scaffolds for regenerative medicine. In this extensive chapter, several of the peptides that have potential for bone tissue engineering, including those that facilitate cell adhesion, prompt osteogenic differentiation of progenitor cells, or those that mediate angiogenesis which is a crucial requirement for proper bone regeneration will be discussed.

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Acknowledgments

Dr. Hana’a Iqbal is jointly supported by institutional post-doctoral fellowship program, International Center for Chemical and Biological sciences (ICCBS) in Pakistan and the TUBITAK Marmara Research Center (MAM) in Turkey. The authors also thank TUBITAK-MAM for research funding (Project Code: 5183402).

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Authors and Affiliations

  1. TUBITAK-Marmara Research Center, Genetic Engineering and Biotechnology Institute, Kocaeli, Turkey

    Abdullah Karadag, Hana’a Iqbal & Hilal Yazici

  2. Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

    Hana’a Iqbal

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  1. Abdullah Karadag
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  3. Hilal Yazici
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Correspondence to Hilal Yazici .

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  1. Department of Orthopaedics School of Medicine, West Virginia University, Morgantown, WV, USA

    Bingyun Li

  2. AO Research Institute Davos, Davos Platz, Graubünden, Switzerland

    Thomas Fintan Moriarty

  3. Department of Chemical Engineering, Northeastern University, Boston, MA, USA

    Thomas Webster

  4. Department of Mechanical Engineering, University of Manitoba, Winnipeg, MB, Canada

    Malcolm Xing

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Karadag, A., Iqbal, H., Yazici, H. (2020). Peptide-mediated Bone Tissue Engineering. In: Li, B., Moriarty, T., Webster, T., Xing, M. (eds) Racing for the Surface. Springer, Cham. https://doi.org/10.1007/978-3-030-34471-9_17

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