Exploring Brain Hemodynamic Response Patterns via Deep Recurrent Autoencoder

Abstract

For decades, task-based functional MRI (tfMRI) has been widely used in exploring functional brain networks and modeling brain activities. A variety of brain activity analysis methods for tfMRI data have been developed. However, these methods are mainly shallow models and are limited in faithfully modeling the complex spatial-temporal diverse and concurrent functional brain activities. Recently, recurrent neural networks (RNNs) demonstrate great superiority in modeling temporal dependency signals and autoencoder models have been proven to be effective in automatically estimating the optimal representations of the original data. These characteristics meet the requirement of modeling hemodynamic response patterns in tfMRI data. In order to take the advantages of both models, we proposed a novel unsupervised framework of deep recurrent autoencoder (DRAE) for modeling tfMRI data in this work. The basic idea of the DRAE model is to combine the deep recurrent neural network and autoencoder to automatically characterize the meaningful functional brain networks and corresponding diverse and complex hemodynamic response patterns underlying tfMRI data simultaneously. The proposed DRAE model has been tested on the motor tfMRI dataset of HCP 900 subjects release and all seven tfMRI datasets of HCP Q1 release. Extensive experimental results demonstrated the great superiority of the proposed method.

S. Zhao and Y. Cui—Co-first authors.