Abstract
The skin is the largest organ of our body. Skin disease abnormalities which occur within the skin layers are difficult to examine visually and often require biopsies to make a confirmation on a suspected condition. Such invasive methods are not well-accepted by children and women due to the possibility of scarring. Optical coherence tomography (OCT) is a non-invasive technique enabling in vivo examination of sub-surface skin tissue without the need for excision of tissue. However, one of the challenges in OCT imaging is the interpretation and analysis of OCT images. In this review, we discuss the various methodologies in skin layer segmentation and how it could potentially improve the management of skin diseases. We also present a review of works which use advanced machine learning techniques to achieve layers segmentation and detection of skin diseases. Lastly, current challenges in analysis and applications are also discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Fercher AF, Mengedoht K, Werner W (1988) Eye-length measurement by interferometry with partially coherent light. Opt Lett 13(3):186–188. https://doi.org/10.1364/OL.13.000186
Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA et al (1991) Optical coherence tomography. Science (New York, NY) 254(5035):1178–1181
Mamalis A, Ho D, Jagdeo J (2015) Optical coherence tomography imaging of normal, chronologically aged, photoaged and photodamaged skin: a systematic review. Dermatol Surg 41(9):993–1005. https://doi.org/10.1097/dss.0000000000000457
Li A, Cheng J, Yow AP, Wall C, Wong DWK, Tey HL, Liu J (2015) Epidermal segmentation in high-definition optical coherence tomography. In: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 25–29 Aug. 2015, pp 3045–3048. https://doi.org/10.1109/EMBC.2015.7319034
Yow AP, Cheng J, Li A, Wall C, Wong DWK, Liu J, Tey HL (2015) Skin surface topographic assessment using in vivo high-definition optical coherence tomography. In: 2015 10th International Conference on Information, Communications and Signal Processing (ICICS), 2–4 Dec. 2015, pp 1–4. https://doi.org/10.1109/ICICS.2015.7459853
Srivastava R, Yow AP, Cheng J, Wong DWK, Tey HL (2017) Supervised 3D graph-based automated epidermal thickness estimation. In: 2017 IEEE 2nd International Conference on Signal and Image Processing (ICSIP), 4–6 Aug. 2017, pp 297–301. https://doi.org/10.1109/SIPROCESS.2017.8124552
Boykov Y, Kolmogorov V (2004) An experimental comparison of min-cut/max-flow algorithms for energy minimization in vision. IEEE Trans Pattern Anal Mach Intell 26(9):1124–1137. https://doi.org/10.1109/tpami.2004.60
Kang L, Xiaodong W, Chen DZ, Sonka M (2006) Optimal surface segmentation in volumetric images-a graph-theoretic approach. IEEE Trans Pattern Anal Mach Intell 28(1):119–134. https://doi.org/10.1109/TPAMI.2006.19
Srivastava R, Yow AP, Cheng J, Wong DWK, Tey HL (2018) Three-dimensional graph-based skin layer segmentation in optical coherence tomography images for roughness estimation. Biomed Opt Express 9(8):3590–3606. https://doi.org/10.1364/BOE.9.003590
Weissman J, Hancewicz T, Kaplan P (2004) Optical coherence tomography of skin for measurement of epidermal thickness by shapelet-based image analysis. Opt Express 12(23):5760–5769. https://doi.org/10.1364/OPEX.12.005760
Josse G, George J, Black D (2011) Automatic measurement of epidermal thickness from optical coherence tomography images using a new algorithm. Skin Res Technol 17(3):314–319. https://doi.org/10.1111/j.1600-0846.2011.00499.x
Taghavikhalilbad A, Adabi S, Clayton A, Soltanizadeh H, Mehregan D, Avanaki MRN (2017) Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin. Appl Opt 56(11):3116–3121. https://doi.org/10.1364/AO.56.003116
Askaruly S, Ahn Y, Kim H, Vavilin A, Ban S, Kim PU, Kim S, Lee H, Jung W (2019) Quantitative evaluation of skin surface roughness using optical coherence tomography in vivo. IEEE J Sel Top Quantum Electron 25(1):1–8. https://doi.org/10.1109/JSTQE.2018.2873489
Yow AP, Cheng J, Li A, Srivastava R, Liu J, Wong DWK, Tey HL (2016) Automated in vivo 3D high-definition optical coherence tomography skin analysis system. In: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 16–20 Aug. 2016, pp 3895–3898. https://doi.org/10.1109/EMBC.2016.7591579
Krizhevsky A, Sutskever I, Hinton GE (2012) ImageNet classification with deep convolutional neural networks, vol 25. https://doi.org/10.1145/3065386
Rawat W, Wang Z (2017) Deep convolutional neural networks for image classification: a comprehensive review. Neural Comput 29(9):2352–2449. https://doi.org/10.1162/NECO_a_00990
Greenspan H, Ginneken B, Summers RM (2016) Guest editorial deep learning in medical imaging: overview and future promise of an exciting new technique. IEEE Trans Med Imaging 35(5):1153–1159. https://doi.org/10.1109/TMI.2016.2553401
Litjens G, Kooi T, Bejnordi BE, Setio AAA, Ciompi F, Ghafoorian M, van der Laak JAWM, van Ginneken B, Sánchez CI (2017) A survey on deep learning in medical image analysis. Med Image Anal 42:60–88. https://doi.org/10.1016/j.media.2017.07.005
Choy G, Khalilzadeh O, Michalski M, Do S, Samir AE, Pianykh OS, Geis JR, Pandharipande PV, Brink JA, Dreyer KJ (2018) Current applications and future impact of machine learning in radiology. Radiology 288(2):318–328. https://doi.org/10.1148/radiol.2018171820
Ting DSW, Pasquale LR, Peng L, Campbell JP, Lee AY, Raman R, Tan GSW, Schmetterer L, Keane PA, Wong TY (2019) Artificial intelligence and deep learning in ophthalmology. Br J Ophthalmol 103(2):167–175. https://doi.org/10.1136/bjophthalmol-2018-313173
Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP (2018) Machine learning in cardiovascular medicine: are we there yet? Heart 104(14):1156–1164. https://doi.org/10.1136/heartjnl-2017-311198
Levine AB, Schlosser C, Grewal J, Coope R, Jones SJM, Yip S (2019) Rise of the machines: advances in deep learning for cancer diagnosis. Trends Cancer 5(3):157–169. https://doi.org/10.1016/j.trecan.2019.02.002
Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542:115. https://doi.org/10.1038/nature21056
Haenssle HA, Fink C, Schneiderbauer R, Toberer F, Buhl T, Blum A, Kalloo A, Hassen ABH, Thomas L, Enk A, Uhlmann L (2018) Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists. Ann Oncol 29(8):1836–1842. https://doi.org/10.1093/annonc/mdy166
Han SS, Kim MS, Lim W, Park GH, Park I, Chang SE (2018) Classification of the clinical images for benign and malignant cutaneous tumors using a deep learning algorithm. J Invest Dermatol 138(7):1529–1538. https://doi.org/10.1016/j.jid.2018.01.028
Marchetti MA, Codella NCF, Dusza SW, Gutman DA, Helba B, Kalloo A, Mishra N, Carrera C, Celebi ME, DeFazio JL, Jaimes N, Marghoob AA, Quigley E, Scope A, Yelamos O, Halpern AC (2018) Results of the 2016 International Skin Imaging Collaboration International Symposium on Biomedical Imaging challenge: comparison of the accuracy of computer algorithms to dermatologists for the diagnosis of melanoma from dermoscopic images. J Am Acad Dermatol 78(2):270–277.e271. https://doi.org/10.1016/j.jaad.2017.08.016
Mandache D, Dalimier E, Durkin JR, Boceara C, Olivo-Marin J, Meas-Yedid V (2018) Basal cell carcinoma detection in full field OCT images using convolutional neural networks. In: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018), 4–7 April 2018, pp 784–787. https://doi.org/10.1109/ISBI.2018.8363689
Boone M, Suppa M, Miyamoto M, Marneffe A, Jemec G, Del Marmol V (2016) In vivo assessment of optical properties of basal cell carcinoma and differentiation of BCC subtypes by high-definition optical coherence tomography. Biomed Opt Express 7(6):2269–2284. https://doi.org/10.1364/boe.7.002269
Li A, Cheng J, Yow AP, Srivastava R, Wong DW, Hong Liang T, Jiang L (2016) Automated basal cell carcinoma detection in high-definition optical coherence tomography. Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference 2016:2885–2888. https://doi.org/10.1109/embc.2016.7591332
Pfister M, Schutzenberger K, Pfeiffenberger U, Messner A, Chen Z, Dos Santos VA, Puchner S, Garhofer G, Schmetterer L, Groschl M, Werkmeister RM (2019) Automated segmentation of dermal fillers in OCT images of mice using convolutional neural networks. Biomed Opt Express 10(3):1315–1328. https://doi.org/10.1364/boe.10.001315
Ronneberger O, Fischer P, Brox T (2015) U-Net: convolutional networks for biomedical image segmentation. In: Cham, Medical Image Computing and Computer-Assisted Intervention – MICCAI 2015. Springer International Publishing, pp 234–241
Santos VA, Schmetterer L, Stegmann H, Pfister M, Messner A, Schmidinger G, Garhofer G, Werkmeister RM (2019) CorneaNet: fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning. Biomed Opt Express 10(2):622–641. https://doi.org/10.1364/BOE.10.000622
De Fauw J, Ledsam JR, Romera-Paredes B, Nikolov S, Tomasev N, Blackwell S, Askham H, Glorot X, O’Donoghue B, Visentin D, van den Driessche G, Lakshminarayanan B, Meyer C, Mackinder F, Bouton S, Ayoub K, Chopra R, King D, Karthikesalingam A, Hughes CO, Raine R, Hughes J, Sim DA, Egan C, Tufail A, Montgomery H, Hassabis D, Rees G, Back T, Khaw PT, Suleyman M, Cornebise J, Keane PA, Ronneberger O (2018) Clinically applicable deep learning for diagnosis and referral in retinal disease. Nat Med 24(9):1342–1350. https://doi.org/10.1038/s41591-018-0107-6
Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R, Raman R, Nelson PC, Mega JL, Webster DR (2016) Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. JAMA 316(22):2402–2410. https://doi.org/10.1001/jama.2016.17216
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Yow, A.P. et al. (2020). Techniques and Applications in Skin OCT Analysis. In: Lee, G., Fujita, H. (eds) Deep Learning in Medical Image Analysis . Advances in Experimental Medicine and Biology, vol 1213. Springer, Cham. https://doi.org/10.1007/978-3-030-33128-3_10
Download citation
DOI: https://doi.org/10.1007/978-3-030-33128-3_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-33127-6
Online ISBN: 978-3-030-33128-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)