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Molecular Targeted Therapy for Advanced Oral Cancer

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Textbook of Oral Cancer

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

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Abstract

The standard therapy for unresected locally advanced and recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) is platinum-based chemotherapy with or without concomitant or sequential radiotherapy. In treating patients with recurrent or metastatic HNSCC (including oral cavity cancer) introducing cetuximab to platinum-based chemotherapy with fluorouracil significantly extends the median overall survival. There is no evidence, however, that targeted therapy is effective for the first-line treatment in patients with unresectable locally advanced HNSCC. Adverse events are reported to be higher than that of chemotherapy alone.

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Authors and Affiliations

  1. Department of Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University, Nagoya, Japan

    Toru Nagao

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  1. Toru Nagao
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Correspondence to Toru Nagao .

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  1. Faculty of Dentistry, Oral & Craniofacial Sciences,, King’s College London, London, UK

    Saman Warnakulasuriya

  2. Department of Orofacial Sciences, Schools of Dentistry and Medicine, University of California San Francisco, San Francisco, CA, USA

    John S. Greenspan

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Nagao, T. (2020). Molecular Targeted Therapy for Advanced Oral Cancer. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_27

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  • DOI: https://doi.org/10.1007/978-3-030-32316-5_27

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