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Capsule and Tablet Dosage Forms

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Essential Pharmaceutics

Part of the book series: AAPS Introductions in the Pharmaceutical Sciences ((AAPSINSTR))

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Abstract

This chapter provides an overview of the design, manufacturing, and formulation of capsule and tablet-based drug products. Manufacturing methods for producing both capsules and tablets are extensively discussed, and figures are incorporated to aid student understanding. Frequently used excipient categories are provided along with general functions and examples. A review of USP-recommended analytical tests is also included. Lastly, this chapter introduces techniques for formulating poorly water soluble drugs in capsule and tablet dosage forms.

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Further Reading

  1. Suggested readings for the student include the following texts:

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  2. Huang S, Mao C, Williams RO III, Yang CY. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016;105(12):3549–61.

    Article  CAS  Google Scholar 

  3. Jermain SV, Brough C, Williams RO III. Amorphous solid dispersions and nanocrystal technologies for poorly water-soluble drug delivery–an update. Int J Pharm. 2018;535(1–2):379–92.

    Article  CAS  Google Scholar 

  4. Liu X, Feng X, Williams RO, Zhang F. Characterization of amorphous solid dispersions. J Pharm Investig. 2018;48(1):19–41.

    Article  Google Scholar 

  5. Ma X, Williams RO III. Characterization of amorphous solid dispersions: an update. J Drug Deliv Sci Technol. 2019;50:113–24.

    Article  CAS  Google Scholar 

  6. Varum FJ, Hatton GB, Basit AW. Food, physiology and drug delivery. Int J Pharm. 2013;457(2):446–60.

    Article  CAS  Google Scholar 

  7. Huang S, Mao C, Williams RO III, Yang C-Y. Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions. J Pharm Sci. 2016;105:3549–61.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

    Ashlee D. Brunaugh, Hugh D. C. Smyth & Robert O. Williams III

Authors
  1. Ashlee D. Brunaugh
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  2. Hugh D. C. Smyth
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  3. Robert O. Williams III
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© 2019 American Association of Pharmaceutical Scientists

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Brunaugh, A.D., Smyth, H.D.C., Williams III, R.O. (2019). Capsule and Tablet Dosage Forms. In: Essential Pharmaceutics. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-31745-4_3

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