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Essential Pharmaceutics pp 183–187Cite as

Nasal Drug Delivery

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Part of the book series: AAPS Introductions in the Pharmaceutical Sciences ((AAPSINSTR))

Abstract

This chapter covers the fundamentals of nasal drug delivery. Anatomical barriers to drug delivery, examples and functions of commonly used excipients, and device design are reviewed. Analytical procedures relevant to testing the performance of nasal drug products are also introduced.

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Further Reading

  1. Suggested readings for the student include the following texts:

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  2. Arora P, Sharma S, Garg S. Permeability issues in nasal drug delivery. Drug Discov Today. 2002;7(18):967–75.

    Article  CAS  Google Scholar 

  3. Djupesland PG. Nasal drug delivery devices: characteristics and performance in a clinical perspective—a review. Drug Deliv Transl Res. 2013;3(1):42–62.

    Article  CAS  Google Scholar 

  4. Warnken ZN, Smyth HD, Davis DA, Weitman S, Kuhn JG, Williams RO III. Personalized medicine in nasal delivery: the use of patient-specific administration parameters to improve nasal drug targeting using 3D-printed nasal replica casts. Mol Pharm. 2018;15(4):1392–402.

    Article  CAS  Google Scholar 

  5. Warnken Z, Smyth HD, Williams RO. Route-specific challenges in the delivery of poorly water-soluble drugs. In: Formulating poorly water soluble drugs. Cham: Springer; 2016. p. 1–39.

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  6. Warnken Z, Kim Y, Mansour H, Williams RO III, Smyth HDC. Fundamentals in nasal drug delivery. In: Inhalation aerosols: physical and biological basis for therapy. 3rd ed. Boca Raton: CRC Press; 2019.

    Google Scholar 

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Author information

Authors and Affiliations

  1. College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

    Ashlee D. Brunaugh, Hugh D. C. Smyth & Robert O. Williams III

Authors
  1. Ashlee D. Brunaugh
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  2. Hugh D. C. Smyth
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  3. Robert O. Williams III
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© 2019 American Association of Pharmaceutical Scientists

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Brunaugh, A.D., Smyth, H.D.C., Williams III, R.O. (2019). Nasal Drug Delivery. In: Essential Pharmaceutics. AAPS Introductions in the Pharmaceutical Sciences. Springer, Cham. https://doi.org/10.1007/978-3-030-31745-4_12

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