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Nanogels-Based Mucosal Vaccines

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Nanovaccines

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Abstract

Innovative vaccines are required to fight human and animal diseases. Improved immunogenicity, safety, easy administration, and low cost are among the innovations that are pursued in this field. Nanogels are materials with attractive features to meet these requirements; they consist of solid, jelly like materials produced by crosslinking of synthetic or natural polymers (or a combination of both) with a high water-holding capacity. Herein, the state of the art of nanogels-based vaccines is provided. Synthesis and functionalization methods for nanogels are described. Thus far, several groups have evaluated nanogels as vaccine delivery vehicles leading to promising data for nanovaccines against cancer, obesity, and infectious diseases. The most advanced candidates are nanovaccines against cancer, based on cholesteryl pullulan nanogels, that have been evaluated in clinical trials revealing proper immunogenicity and safety. The key perspectives for this topic include expanding the assessment of mucosal vaccines and implementing green syntheses approaches, which could lead to lower production cost and enhanced safety.

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Authors and Affiliations

  1. Facultad de Ciencias Químicas, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

    Sergio Rosales-Mendoza

  2. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí , San Luis Potosí, Mexico

    Omar González-Ortega

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  1. Sergio Rosales-Mendoza
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  2. Omar González-Ortega
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Rosales-Mendoza, S., González-Ortega, O. (2019). Nanogels-Based Mucosal Vaccines. In: Nanovaccines. Springer, Cham. https://doi.org/10.1007/978-3-030-31668-6_6

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