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PLGA-Based Mucosal Nanovaccines

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Abstract

Poly(D,L-lactic-co-glycolic acid) (PLGA or PLG) is a linear copolymer composed of lactic and glycolic acids with biodegradability and biocompatibility properties recognized by the FDA. PLGA nanoparticles have been applied in vaccinology as antigen delivery vehicles capable of protecting antigens from degradation and being efficiently captured by antigen presenting cells. The current status on the development of PLGA-based nanovaccines is presented in this chapter and the key perspectives for this topic identified. Bacterial, viral, and allergic diseases have been targeted by using PLGA-based formulations. For most of the candidates enhanced humoral responses providing immunoprotection against experimental pathogen challenges has been achieved. Enhancement of cytotoxic lymphocyte responses has also been proven, generating relevant perspectives in the field of cancer immunotherapy. The promising findings from the evaluations of PLGA-based nanovaccines justifies the completion of preclinical evaluations for many candidates and, given the experience on the use of PLGA in the biomedical field, the beginning of clinical trials is anticipated in the short term. Therefore, among the currently available nanomaterials, PLGA nanoparticles are one of the most promising for the development of nanovaccines.

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Authors and Affiliations

  1. Facultad de Ciencias Químicas, Centro de Investigación en Ciencias de la Salud y Biomedicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico

    Sergio Rosales-Mendoza

  2. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí , San Luis Potosí, Mexico

    Omar González-Ortega

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  1. Sergio Rosales-Mendoza
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  2. Omar González-Ortega
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Rosales-Mendoza, S., González-Ortega, O. (2019). PLGA-Based Mucosal Nanovaccines. In: Nanovaccines. Springer, Cham. https://doi.org/10.1007/978-3-030-31668-6_4

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