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Development of Biopharmaceutical Drug-Device Products pp 613–637Cite as

Chapter 25: Peptide Drug/Device Combinations

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Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 35))

Abstract

Peptides play an important role in human physiology, and peptide deficiencies or dysfunction can lead to disease or illness. Therefore, the role that peptides play in disease treatment goes back many years, starting with the use of insulin in patients with type 1 diabetes almost a century ago. The range of targets available for peptide therapeutics and the limitations associated with peptide delivery and therapeutic effect require consideration. This chapter will review the history of the use of peptides as therapeutics, address some challenges in clinical use, and touch on major advances in the use of peptides as drugs. It will also address issues related with formulation and formulation development; peptide bond formation methods; the use of excipients; the synthesis of peptides, as well as aggregation, separation, and purification; and characterisation and stability testing. It further explores the pharmacokinetics of peptides and various routes of drug delivery and challenges related to peptide delivery.

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Authors and Affiliations

  1. Immunocore, Oxfordshire, UK

    Shahid Uddin

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  1. Shahid Uddin
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Correspondence to Shahid Uddin .

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Editors and Affiliations

  1. Formulation Development New Biological Entities, AbbVie (United States), North Chicago, IL, USA

    Feroz Jameel

  2. Drug Product Development (Retired), AbbVie (United States), North Chicago, IL, USA

    John W. Skoug

  3. Combination Product Development, AbbVie, Inc., North Chicago, IL, USA

    Robert R. Nesbitt

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Uddin, S. (2020). Chapter 25: Peptide Drug/Device Combinations. In: Jameel, F., Skoug, J., Nesbitt, R. (eds) Development of Biopharmaceutical Drug-Device Products. AAPS Advances in the Pharmaceutical Sciences Series, vol 35. Springer, Cham. https://doi.org/10.1007/978-3-030-31415-6_25

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