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Biofilms in Human Diseases: Treatment and Control pp 285–298Cite as

Biofilm and Antimicrobial Resistance

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Abstract

Biofilm-forming bacteria cause severe health problems in patients with implanted devices by attachment of cells to surface matrix. Antibiotics can act on planktonic bacteria more easily than biofilm bacteria. Biofilm bacteria have several mechanisms for combatting antibiotic action on them. Poor penetration of antibiotics, exopolysaccharide, eDNA in matrix degradation has a role in antibiotic resistance. Limited nutrient, slow growth, the response of adaptive stress and persister cell formation also cause multilevel protections for antibiotic resistance. Genetically horizontal gene transfer and higher mutation frequency also show a pivotal role in antimicrobial resistance in biofilm bacteria.

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Authors and Affiliations

  1. Department of Microbiology, Dr RMLIMS, Lucknow, India

    Vineeta Mittal

Authors
  1. Vineeta Mittal
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Correspondence to Vineeta Mittal .

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Editors and Affiliations

  1. Faculty of Bio-Sciences, Institute of Bio-Sciences and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh, India

    Sunil Kumar

  2. Faculty of Biotechnology, Institute of Bio-Sciences and Technology, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh, India

    Niharika Chandra

  3. Institute of Management, Commerce and Economics, Shri Ramswaroop Memorial University, Barabanki, Uttar Pradesh, India

    Leena Singh

  4. Department of Chemistry, COMSATS University Islamabad, Islamabad, Pakistan

    Muhammad Zaffar Hashmi

  5. Institute of Microbial Technology, Amity University, Noida, India

    Ajit Varma

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Mittal, V. (2019). Biofilm and Antimicrobial Resistance. In: Kumar, S., Chandra, N., Singh, L., Hashmi, M., Varma, A. (eds) Biofilms in Human Diseases: Treatment and Control. Springer, Cham. https://doi.org/10.1007/978-3-030-30757-8_18

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