Skip to main content

Secondary Schizophrenia

  • Chapter
  • First Online:
Book cover Psychotic Disorders

Part of the book series: Current Clinical Psychiatry ((CCPSY))

  • 1718 Accesses

Abstract

The number of medical diseases that can present with psychotic symptoms (delusions, hallucinations) is legion. A thorough differential diagnosis of psychosis is necessary to avoid the mistaken attribution of psychosis to a psychiatric disorder instead of a medical condition, which requires very different treatment. I outline a clinical approach for a patient with psychosis of unknown etiology that emphasizes the need to be pragmatic about the medical work-up as indiscriminate screening is neither feasible nor helpful. To organize this chapter, I use the primary (psychiatric) versus secondary (“organic”) distinction to review the medical etiologies of schizophrenia-like psychosis. In this scheme, schizophrenia due to a medical condition is referred to as secondary schizophrenia.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Cutting J. The phenomenology of acute organic psychosis. Comparison with acute schizophrenia. Br J Psychiatry. 1987;151:324–32.

    Article  CAS  PubMed  Google Scholar 

  2. Strohle A, Wrase J, Malach H, Gestrich C, Heinz A. Karl Bonhoeffer (1868–1948). Am J Psychiatry. 2008;165:575–6.

    Article  PubMed  Google Scholar 

  3. Strohle A, Wrase J, Malach H, Gestrich C, Heinz A. Dietrich Bonhoeffer (1906–1945). Am J Psychiatry. 2008;165:577–8.

    Article  PubMed  Google Scholar 

  4. Spitzer RL, First MB, Williams JB, Kendler K, Pincus HA, Tucker G. Now is the time to retire the term “organic mental disorders”. Am J Psychiatry. 1992;149:240–4.

    Article  CAS  PubMed  Google Scholar 

  5. World Health Organization. International Classification of Diseases 11th revision (ICD-11). Available from: https://icd.who.int/en/. Accessed on 7/1/2019.

  6. Freudenreich O. Differential diagnosis of psychotic symptoms: medical “mimics”: Psychiatric Times; 2012. Available from: https://www.psychiatrictimes.com/forensic-psychiatry/differential-diagnosis-psychotic-symptoms-medical-mimics. Accessed on 7/1/2019.

  7. Keshavan MS, Kaneko Y. Secondary psychoses: an update. World Psychiatry. 2013;12:4–15.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Johnstone EC, Macmillan JF, Crow TJ. The occurrence of organic disease of possible or probable aetiological significance in a population of 268 cases of first episode schizophrenia. Psychol Med. 1987;17:371–9.

    Article  CAS  PubMed  Google Scholar 

  9. Lubman DI, Velakoulis D, McGorry PD, Smith DJ, Brewer W, Stuart G, et al. Incidental radiological findings on brain magnetic resonance imaging in first-episode psychosis and chronic schizophrenia. Acta Psychiatr Scand. 2002;106:331–6.

    Article  CAS  PubMed  Google Scholar 

  10. Neumarker KJ. Karl Bonhoeffer and the concept of symptomatic psychoses. Hist Psychiatry. 2001;12:213–26.

    Article  CAS  PubMed  Google Scholar 

  11. Johnstone EC, Cooling NJ, Frith CD, Crow TJ, Owens DG. Phenomenology of organic and functional psychoses and the overlap between them. Br J Psychiatry. 1988;153:770–6.

    Article  CAS  PubMed  Google Scholar 

  12. De Ronchi D, Bellini F, Cremante G, Ujkaj M, Tarricone I, Selleri R, et al. Psychopathology of first-episode psychosis in HIV-positive persons in comparison to first-episode schizophrenia: a neglected issue. AIDS Care. 2006;18:872–8.

    Article  PubMed  Google Scholar 

  13. Marneros A. Schizophrenic first-rank symptoms in organic mental disorders. Br J Psychiatry. 1988;152:625–8.

    Article  CAS  PubMed  Google Scholar 

  14. Chouinard VA, Shinn AK, Valeri L, Chouinard PA, Gardner ME, Asan AE, et al. Visual hallucinations associated with multimodal hallucinations, suicide attempts and morbidity of illness in psychotic disorders. Schizophr Res. 2019;208:196–201.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Stevenson RJ, Langdon R, McGuire J. Olfactory hallucinations in schizophrenia and schizoaffective disorder: a phenomenological survey. Psychiatry Res. 2011;185:321–7.

    Article  PubMed  Google Scholar 

  16. Legesse B, Freudenreich O, Murray E, Price B. A case report of confusional psychosis with abrupt onset and rapid resolution of symptoms. Psychosomatics. 2011;52:468–71.

    Article  PubMed  Google Scholar 

  17. Waters F, Fernyhough C. Hallucinations: a systematic review of points of similarity and difference across diagnostic classes. Schizophr Bull. 2017;43:32–43.

    Article  PubMed  Google Scholar 

  18. Freudenreich O, Schulz SC, Goff DC. Initial medical work-up of first-episode psychosis: a conceptual review. Early Interv Psychiatry. 2009;3:10–8.

    Article  PubMed  Google Scholar 

  19. Fogel BS, Duffy J, McNamara ME, Salloway S. Skeptics and enthusiasts in neuropsychiatry. J Neuropsychiatry Clin Neurosci. 1992;4:458–62.

    Article  CAS  PubMed  Google Scholar 

  20. Caton CL, Drake RE, Hasin DS, Dominguez B, Shrout PE, Samet S, et al. Differences between early-phase primary psychotic disorders with concurrent substance use and substance-induced psychoses. Arch Gen Psychiatry. 2005;62:137–45.

    Article  PubMed  Google Scholar 

  21. Reinhardt MM, Cohen CI. Late-life psychosis: diagnosis and treatment. Curr Psychiatry Rep. 2015;17:1.

    Article  PubMed  Google Scholar 

  22. Freudenreich O, Holt DJ, Cather C, Goff DC. The evaluation and management of patients with first-episode schizophrenia: a selective, clinical review of diagnosis, treatment, and prognosis. Harv Rev Psychiatry. 2007;15:189–211.

    Article  PubMed  Google Scholar 

  23. Freudenreich O, Holt DJ, Goff DC. Psychotic patients. In: Stern TA, Freudenreich O, Smith FA, Fricchione GL, Rosenbaum JF, editors. Massachusetts General Hospital handbook of general hospital psychiatry. 7th ed. Edinburgh: Elsevier; 2018. p. 109–21.

    Google Scholar 

  24. Branson BM, Handsfield HH, Lampe MA, Janssen RS, Taylor AW, Lyss SB, et al. Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep. 2006;55:1–17.

    PubMed  Google Scholar 

  25. Baldessarini RJ, Finklestein S, Arana GW. The predictive power of diagnostic tests and the effect of prevalence of illness. Arch Gen Psychiatry. 1983;40:569–73.

    Article  CAS  PubMed  Google Scholar 

  26. Katzman GL, Dagher AP, Patronas NJ. Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA. 1999;282:36–9.

    Article  CAS  PubMed  Google Scholar 

  27. Manchanda R, Norman R, Malla A, Harricharan R, Takhar J, Northcott S. EEG abnormalities and two year outcome in first episode psychosis. Acta Psychiatr Scand. 2005;111:208–13.

    Article  CAS  PubMed  Google Scholar 

  28. Salinsky M, Kanter R, Dasheiff RM. Effectiveness of multiple EEGs in supporting the diagnosis of epilepsy: an operational curve. Epilepsia. 1987;28:331–4.

    Article  CAS  PubMed  Google Scholar 

  29. Henao-Martinez AF, Johnson SC. Diagnostic tests for syphilis: new tests and new algorithms. Neurol Clin Pract. 2014;4:114–22.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry. 1999;56:940–5.

    Article  CAS  PubMed  Google Scholar 

  31. Murphy KC, Jones RG, Griffiths E, Thompson PW, Owen MJ. Chromosome 22q11 deletions. An under-recognised cause of idiopathic learning disability. Br J Psychiatry. 1998;172:180–3.

    Article  CAS  Google Scholar 

  32. Besterman AD, Moreno-De-Luca D, Nurnberger JI Jr. 21st-century genetics in psychiatric residency training: how do we get there? JAMA Psychiatry. 2019;76(3):231–2.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Brownlie BE, Rae AM, Walshe JW, Wells JE. Psychoses associated with thyrotoxicosis – ‘thyrotoxic psychosis.’ A report of 18 cases, with statistical analysis of incidence. Eur J Endocrinol. 2000;142:438–44.

    Article  CAS  PubMed  Google Scholar 

  34. Heinrich TW, Grahm G. Hypothyroidism presenting as psychosis: myxedema madness revisited. Prim Care Companion J Clin Psychiatry. 2003;5:260–6.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Saad MF, Adams F, Mackay B, Ordonez NG, Leavens ME, Samaan NA. Occult Cushing’s disease presenting with acute psychosis. Am J Med. 1984;76:759–66.

    Article  CAS  PubMed  Google Scholar 

  36. Benabarre A, Bosch X, Plana MT, Lecube A, Vieta E, Cirera E, et al. Relapsing paranoid psychosis as the first manifestation of pheochromocytoma. J Clin Psychiatry. 2005;66:949–50.

    Article  PubMed  Google Scholar 

  37. Walterfang M, Fietz M, Fahey M, Sullivan D, Leane P, Lubman DI, et al. The neuropsychiatry of Niemann-Pick type C disease in adulthood. J Neuropsychiatry Clin Neurosci. 2006;18:158–70.

    Article  PubMed  Google Scholar 

  38. Tishler PV, Woodward B, O’Connor J, Holbrook DA, Seidman LJ, Hallett M, et al. High prevalence of intermittent acute porphyria in a psychiatric patient population. Am J Psychiatry. 1985;142:1430–6.

    Article  CAS  PubMed  Google Scholar 

  39. Wright MT. Neuropsychiatric illness in systemic lupus erythematosus: insights from a patient with erotomania and Geschwind’s Syndrome. Am J Psychiatry. 2010;167:502–7.

    Article  PubMed  Google Scholar 

  40. Appenzeller S, Cendes F, Costallat LT. Acute psychosis in systemic lupus erythematosus. Rheumatol Int. 2008;28:237–43.

    Article  PubMed  Google Scholar 

  41. Wilcox RA, To T, Koukourou A, Frasca J. Hashimoto’s encephalopathy masquerading as acute psychosis. J Clin Neurosci. 2008;15:1301–4.

    Article  CAS  PubMed  Google Scholar 

  42. Cascella NG, Kryszak D, Bhatti B, Gregory P, Kelly DL, Mc Evoy JP, et al. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull. 2011;37:94–100.

    Article  PubMed  Google Scholar 

  43. Foster AR, Caplan JP. Paraneoplastic limbic encephalitis. Psychosomatics. 2009;50:108–13.

    Article  PubMed  Google Scholar 

  44. Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369:499–511.

    Article  PubMed  Google Scholar 

  45. Douglass AB, Hays P, Pazderka F, Russell JM. Florid refractory schizophrenias that turn out to be treatable variants of HLA-associated narcolepsy. J Nerv Ment Dis. 1991;179:12–7.

    Article  CAS  PubMed  Google Scholar 

  46. Cao M. Advances in narcolepsy. Med Clin North Am. 2010;94:541–55.

    Article  CAS  PubMed  Google Scholar 

  47. Chemerinski E, Robinson RG. The neuropsychiatry of stroke. Psychosomatics. 2000;41:5–14.

    Article  CAS  PubMed  Google Scholar 

  48. Sachdev P. Schizophrenia-like psychosis and epilepsy: the status of the association. Am J Psychiatry. 1998;155:325–36.

    Article  CAS  PubMed  Google Scholar 

  49. Devinsky O. Postictal psychosis: common, dangerous, and treatable. Epilepsy Curr. 2008;8:31–4.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Blumer D, Wakhlu S, Montouris G, Wyler AR. Treatment of the interictal psychoses. J Clin Psychiatry. 2000;61:110–22.

    Article  CAS  PubMed  Google Scholar 

  51. Getz K, Hermann B, Seidenberg M, Bell B, Dow C, Jones J, et al. Negative symptoms in temporal lobe epilepsy. Am J Psychiatry. 2002;159:644–51.

    Article  PubMed  Google Scholar 

  52. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci. 1995;3:89–97.

    CAS  PubMed  Google Scholar 

  53. Feinstein A. The neuropsychiatry of multiple sclerosis. Can J Psychiatr. 2004;49:157–63.

    Article  Google Scholar 

  54. Hyde TM, Ziegler JC, Weinberger DR. Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis. Arch Neurol. 1992;49:401–6.

    Article  CAS  PubMed  Google Scholar 

  55. Dalmau J, Tuzun E, Wu HY, Masjuan J, Rossi JE, Voloschin A, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007;61:25–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Kayser MS, Titulaer MJ, Gresa-Arribas N, Dalmau J. Frequency and characteristics of isolated psychiatric episodes in anti-N-methyl-d-aspartate receptor encephalitis. JAMA Neurol. 2013;70:1133–9.

    Article  PubMed  Google Scholar 

  57. Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016;15:391–404.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Jorgensen A, Hansen BS, Stanislaus S, During S, Jorgensen MB, Pinborg LH, et al. Anti-N-methyl-D-aspartate receptor encephalitis is an important differential diagnosis in acute psychiatric disease. Acta Psychiatr Scand. 2015;131:69–70.

    Article  CAS  PubMed  Google Scholar 

  59. Pollak TA, Rogers JP, Nagele RG, Peakman M, Stone JM, David AS, et al. Antibodies in the diagnosis, prognosis, and prediction of psychotic disorders. Schizophr Bull. 2019;45:233–46.

    Article  PubMed  Google Scholar 

  60. Saether SG, Schou M, Kondziella D. What is the significance of onconeural antibodies for psychiatric symptomatology? A systematic review. BMC Psychiatry. 2017;17:161.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Freudenreich O, Flaherty AW. Patients with abnormal movements. In: Stern TA, Freudenreich O, Smith FA, Fricchione GL, Rosenbaum JF, editors. Massachusetts general handbook of general hospital psychiatry. 7th ed. Edinburgh: Elsevier; 2018. p. 231–29.

    Google Scholar 

  62. Amann B, Sterr A, Thoma H, Messer T, Kapfhammer HP, Grunze H. Psychopathological changes preceding motor symptoms in Huntington’s disease: a report on four cases. World J Biol Psychiatry. 2000;1:55–8.

    Article  CAS  PubMed  Google Scholar 

  63. Dening TR, Berrios GE. Wilson’s disease. Psychiatric symptoms in 195 cases. Arch Gen Psychiatry. 1989;46:1126–34.

    Article  CAS  PubMed  Google Scholar 

  64. Zimbrean PC, Schilsky ML. The spectrum of psychiatric symptoms in Wilson’s disease: treatment and prognostic considerations. Am J Psychiatry. 2015;172:1068–72.

    Article  PubMed  Google Scholar 

  65. Holroyd S, Currie L, Wooten GF. Prospective study of hallucinations and delusions in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2001;70:734–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Fenelon G, Soulas T, Zenasni F, Cleret de Langavant L, et al. Mov Disord. 2010;25:763–6.

    Article  PubMed  Google Scholar 

  67. Fujii D, Fujii DC. Psychotic disorder due to traumatic brain injury: analysis of case studies in the literature. J Neuropsychiatry Clin Neurosci. 2012;24:278–89.

    Article  PubMed  Google Scholar 

  68. Murray PS, Kumar S, Demichele-Sweet MA, Sweet RA. Psychosis in Alzheimer’s disease. Biol Psychiatry. 2014;75:542–52.

    Article  PubMed  Google Scholar 

  69. Craig D, Mirakhur A, Hart DJ, McIlroy SP, Passmore AP. A cross-sectional study of neuropsychiatric symptoms in 435 patients with Alzheimer’s disease. Am J Geriatr Psychiatry. 2005;13:460–8.

    Article  PubMed  Google Scholar 

  70. El Haj M, Gallouj K, Dehon H, Roche J, Laroi F. Hallucinations in Alzheimer’s disease: failure to suppress irrelevant memories. Cogn Neuropsychiatry. 2018;23:142–53.

    Article  PubMed  Google Scholar 

  71. McKeith IG, Dickson DW, Lowe J, Emre M, O’Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65:1863–72.

    Article  CAS  PubMed  Google Scholar 

  72. Nagahama Y, Okina T, Suzuki N, Matsuda M, Fukao K, Murai T. Classification of psychotic symptoms in dementia with Lewy bodies. Am J Geriatr Psychiatry. 2007;15:961–7.

    Article  PubMed  Google Scholar 

  73. Lin YW, Truong D. Diffuse Lewy body disease. J Neurol Sci. 2019;399:144–50.

    Article  CAS  PubMed  Google Scholar 

  74. Madhusoodanan S, Danan D, Moise D. Psychiatric manifestations of brain tumors: diagnostic implications. Expert Rev Neurother. 2007;7:343–9.

    Article  PubMed  Google Scholar 

  75. Evans DL, Edelsohn GA, Golden RN. Organic psychosis without anemia or spinal cord symptoms in patients with vitamin B12 deficiency. Am J Psychiatry. 1983;140:218–21.

    Article  CAS  PubMed  Google Scholar 

  76. Herr KD, Norris ER, Frankel BL. Acute psychosis in a patient with vitamin B(12) deficiency and coincident cervical stenosis. Psychosomatics. 2002;43:234–6.

    Article  PubMed  Google Scholar 

  77. Prakash R, Gandotra S, Singh LK, Das B, Lakra A. Rapid resolution of delusional parasitosis in pellagra with niacin augmentation therapy. Gen Hosp Psychiatry. 2008;30:581–4.

    Article  PubMed  Google Scholar 

  78. Steadman P. Herpes simplex mimicking functional psychosis. Biol Psychiatry. 1992;32:211–2.

    Article  CAS  PubMed  Google Scholar 

  79. Friedrich F, Geusau A, Greisenegger S, Ossege M, Aigner M. Manifest psychosis in neurosyphilis. Gen Hosp Psychiatry. 2009;31:379–81.

    Article  PubMed  Google Scholar 

  80. Poissy J, Wolff M, Dewilde A, Rozenberg F, Raschilas F, Blas M, et al. Factors associated with delay to acyclovir administration in 184 patients with herpes simplex virus encephalitis. Clin Microbiol Infect. 2009;15:560–4.

    Article  CAS  PubMed  Google Scholar 

  81. Alvarez-Segura M, Villero S, Portugal E, Mayoral M, Montilla P, Fraguas D. Psychosis induced by decreased CD4+ T cell and high viral load in human immunodeficiency virus infection: a case report. Biol Psychiatry. 2008;64:e3–4.

    Article  PubMed  Google Scholar 

  82. Roelcke U, Barnett W, Wilder-Smith E, Sigmund D, Hacke W. Untreated neuroborreliosis: Bannwarth’s syndrome evolving into acute schizophrenia-like psychosis. A case report. J Neurol. 1992;239:129–31.

    Article  CAS  PubMed  Google Scholar 

  83. Cummings J, Lai TJ, Hemrungrojn S, Mohandas E, Yun Kim S, Nair G, et al. Role of donepezil in the management of neuropsychiatric symptoms in Alzheimer’s disease and dementia with Lewy bodies. CNS Neurosci Ther. 2016;22:159–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Dubovsky AN, Arvikar S, Stern TA, Axelrod L. The neuropsychiatric complications of glucocorticoid use: steroid psychosis revisited. Psychosomatics. 2012;53:103–15.

    Article  CAS  PubMed  Google Scholar 

  85. Schneider LS, Tariot PN, Dagerman KS, Davis SM, Hsiao JK, Ismail MS, et al. Effectiveness of atypical antipsychotic drugs in patients with Alzheimer’s disease. N Engl J Med. 2006;355:1525–38.

    Article  CAS  PubMed  Google Scholar 

  86. Maust DT, Kim HM, Seyfried LS, Chiang C, Kavanagh J, Schneider LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiat. 2015;72:438–45.

    Article  Google Scholar 

  87. Hsu WT, Esmaily-Fard A, Lai CC, Zala D, Lee SH, Chang SS, et al. Antipsychotics and the risk of cerebrovascular accident: a systematic review and meta-analysis of observational studies. J Am Med Dir Assoc. 2017;18:692–9.

    Article  PubMed  Google Scholar 

  88. Stevens JR, Jarrahzadeh T, Brendel RW, Stern TA. Strategies for the prescription of psychotropic drugs with black box warnings. Psychosomatics. 2014;55:123–33.

    Article  PubMed  Google Scholar 

  89. Sahli ZT, Tarazi FI. Pimavanserin: novel pharmacotherapy for Parkinson’s disease psychosis. Expert Opin Drug Discov. 2018;13:103–10.

    Article  CAS  PubMed  Google Scholar 

  90. Cummings J, Isaacson S, Mills R, Williams H, Chi-Burris K, Corbett A, et al. Pimavanserin for patients with Parkinson’s disease psychosis: a randomised, placebo-controlled phase 3 trial. Lancet. 2014;383:533–40.

    Article  CAS  PubMed  Google Scholar 

  91. Moreno GM, Gandhi R, Lessig SL, Wright B, Litvan I, Nahab FB. Mortality in patients with Parkinson disease psychosis receiving pimavanserin and quetiapine. Neurology. 2018;91:797–9.

    Article  PubMed  Google Scholar 

Additional Resources

    Books

    • Cahalan S. Brain on fire: my month of madness. New York: Free Press; 2012. – The personal journey of a young woman who developed a serious neuropsychiatric disorder that ultimately ends well: after the correct diagnosis of an “organic” condition, anti-NMDR encephalitis is made.

      Google Scholar 

    • Lipska BK. The neuroscientist who lost her mind: my tale of madness and recovery. Boston: Houghton Mifflin Harcourt Publishing Company; 2018. – Excellent description of the effects of brain metastases on affect, cognition and perception as well as insight by a neuroscientist who developed metastatic melanoma.

      Google Scholar 

    Articles

    • Freudenreich O, Schulz SC, Goff DC. Initial medical work-up of first-episode psychosis: a conceptual review. Early Interv Psychiatry. 2009;3:10–8. – A conceptual article about the “organic” work-up of patients with psychosis.

      Article  PubMed  Google Scholar 

    • Pollak TA, Rogers JP, Nagele RG, Peakman M, Stone JM, David AS, et al. Antibodies in the diagnosis, prognosis, and prediction of psychotic disorders. Schizophr Bull. 2019;45:233–46. – An excellent review of antibodies and psychosis, including diagnostic antibodies for autoimmune encephalitis. This is an area of psychiatry where I have seen progress in my life-time, including the delineation of a new syndrome (NMDA receptor encephalitis) that psychiatrist must recognize in order to assure correct medical treatment.

      Article  PubMed  Google Scholar 

    • Hogan C, Little BP, Carlson JCT, Freudenreich O, Ivkovic A, Baron JM. Case 5–2019: a 48-year-dld woman with delusional thinking and paresthesia of the right hand. N Engl J Med. 2019;380:665–74. – A case discussion from the MGH clinico-pathological conference, highlighting the difficulties in deciding if an identified medical disease (vitamin B12 deficiency) is solely responsible for what appears to be a chronic psychotic illness.

      Article  PubMed  Google Scholar 

    Download references

    Author information

    Authors and Affiliations

    Authors

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 2020 Springer Nature Switzerland AG

    About this chapter

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this chapter

    Freudenreich, O. (2020). Secondary Schizophrenia. In: Psychotic Disorders. Current Clinical Psychiatry. Humana, Cham. https://doi.org/10.1007/978-3-030-29450-2_5

    Download citation

    • DOI: https://doi.org/10.1007/978-3-030-29450-2_5

    • Published:

    • Publisher Name: Humana, Cham

    • Print ISBN: 978-3-030-29449-6

    • Online ISBN: 978-3-030-29450-2

    • eBook Packages: MedicineMedicine (R0)

    Publish with us

    Policies and ethics