Abstract
Nowadays, ultrasound is an integral part of dermatologic clinical evaluation of skin cancer. The literature has demonstrated excellent ultrasound and histological correlation of the tumoral depth. Furthermore, ultrasound-guided biopsies and treatments are usually cost effective and can reduce morbidity. Almost pathognomonic ultrasound signs have been reported in basal cell carcinoma, the most common type of skin cancer in human beings. The depth of melanoma can be measured by ultrasound, which can provide a sonographic Breslow that has shown very good correlations with the histological depth. On color Doppler, the level of tumoral vascularity can also be detected and commonly correlates well with the neoplastic angiogenesis. Lastly, ultrasound supports the detection of the satellite, in-transit, and nonpalpable locoregional metastases.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lassau N, Spatz A, Avril MF, et al. Value of high frequency US for preoperative assessment of skin tumors. Radiographics. 1997;17:247–56.
Errico J, Pierre S, Pezet Y, et al. Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging. Nature. 2015;527:499–502.
Wortsman X. Atlas of dermatologic ultrasound. Cham: Springer; 2018.
Wortsman X. Sonography of facial cutaneous basal cell carcinoma. J Ultrasound Med. 2013;32:567–72.
Bobadilla F, Wortsman X, Munoz C, et al. Pre-surgical high resolution ultrasound of facial basal cell carcinoma: correlation with histology. Cancer Imaging. 2008;8:163–72.
Lassau N, Chami L, Chebil M, et al. Dynamic contrast enhanced ultrasonography and anti-angiogenic treatments. Discov Med. 2011;11:18–24.
Restreppo CS, Ocazionex D. Kaposi’s sarcoma: imaging overview. Semin Ultrasound CT MR. 2011;32:456–69.
Tacke J, Haagen G, Horstein O, et al. Clinical relevance of sonographically derived tumour thickness in malignant melanoma. Br J Dermatol. 1995;132:209–14.
Guitera P, Li PX, Crotty K, et al. Melanoma histological Breslow thickness predicted by 75MHz sonography. Br J Dermatol. 2008;159:364–9.
Hoffman K, Jung J, el Gammal S, et al. Malignant melanoma in 20 MHz B-scan sonography. Dermatology. 1992;185:49–55.
Catalano O, Siani A. Cutaneous melanoma: role of ultrasound in the assessment of locoregional spread. Curr Probl Diagn Radiol. 2010;39:30–6.
Lassau N, Mercier S, Koscielny S, et al. Prognostic value of high frequency sonography and color Doppler for preoperative assessment of melanomas. Am J Roentgenol. 1999;172:457–61.
Lassau N, Koscielny S, Avril MF, et al. Prognostic value of angiogenesis evaluated by high frequency and Doppler ultrasound for preoperative assessment of melanomas. Am J Roentgenol. 2002;178:1547–51.
Lassau N, Spatz A, Avril MF, et al. Value of high frequency US for preoperative assessment of skin tumors. Radiographics. 1997;17:1559–65.
Nicolaidou E, Mikrova A, Antoniou C, et al. Advances in Merkel cell carcinoma pathogenesis and management. Br J Dermatol. 2012;166:16–21.
Pileri A Jr, Patrizi A, Agostinelli C, et al. Primary cutaneous lymphomas: a reprisal. Semin Diagn Pathol. 2011;28:214–33.
Galper SL, Smith BD, Wilson LD. Diagnosis and management of mycosis fungoides. Oncology (Willison Park). 2010;24:491–501.
Bard R. Advances in image guided oncologic treatment. J Targ Ther Cancer. 2016;1:52–6.
Music MM, Hertl K, Kadivec M, et al. Preoperative ultrasound with 15 MHz probe reliably differentiates between melanoma thicker and thinner than 1 mm. J Eur Acad Dermatol Venereol. 2010;24:1105–8.
Rossi CR, Mocellin S, Scagnet B, et al. The role of preoperative ultrasound in detecting lymph-node metastases before sentinel node biopsy in patients with melanoma. J Surg Oncol. 2003;83:80–4.
Van Rijk MC, Teertstra HJ, Peterse JL, et al. Ultrasonography and fine needle aspiration cytology in the preoperative evaluation of patients with melanoma eligible for sentinel node biopsy. Ann Surg Oncol. 2006;13:1511–6.
Ulrich J, van Akooi AC, Eggermont AM, et al. New developments in melanoma: utility of ultrasound imaging (initial staging). Expert Rev Anticancer Ther. 2011;11:1693–701.
Voit C, van Akooi AC, Schafer G, et al. Ultrasound morphology criteria predict metastatic disease of the sentinel nodes in patients with melanoma. J Clin Oncol. 2010;28:847–52.
Catalano O. Critical analysis of the ultrasound criteria for diagnosing lymph node metastases in patients with cutaneous melanoma. J Ultrasound Med. 2011;30:547–60.
Que SK, Grant-Kels JM, Longo C, et al. Basics of confocal microscopy and the complexity of diagnosing skin tumors. Dermatol Clin. 2016;34:367–75.
Gupta A, Forsberg M, Dulin K, et al. Comparing quantitative immunohistochemical markers of angiogenesis to contrast enhanced subharmonic imaging. J Ultrasound Med. 2016;35:1839–47.
Rivers C, Singh A. Total skin electron beam therapy for mycosis fungoides revisited with adjuvant systemic therapy. Clin Lymphoma Myeloma Leuk. 2019;19:83–8.
Glazer A, Rigel D, Winkelman R, et al. Clinical diagnosis of skin cancer. Derm Clinics. 2017;35:409–16.
Balu M, Zachary C, Harris R, et al. In vivo multiphoton microscopy of basal cell carcinoma. JAMA Dermatol. 2015;151(10):1068–74.
Hosking AM, Coakley B, Chang D, et al. Hyperspectral imaging in automated digital dermoscopy screening for melanoma. Lasers Surg Med. 2019;51(3):214–22.
Iftimia N, et al. Combined reflectance confocal microscopy/optical coherence tomography imaging for skin burn assessment. Biomed Opt Express. 2013;4(5):680–95.
Altintas AA, et al. To heal or not to heal: predictive value of in vivo reflectance-mode confocal microscopy in assessing healing course of human burn wounds. J Burn Care Res. 2009;30(6):1007–12.
Srivastava R, Reilly C, Francisco GM, Bhatti H, Rao BK. Life of a wound: serial documentation of wound healing after shave removal using reflectance confocal microscopy. J Drugs Dermatol. 2019;18(5):217–9.
Cameli N, Mariano M, Serio M, Ardigò M. Preliminary comparison of fractional laser with fractional laser plus radiofrequency for the treatment of acne scars and photoaging. Dermatol Surg. 2014;40(5):553–61.
Stumpp OF, Bedi VP, Wyatt D, Lac D, et al. In vivo confocal imaging of epidermal cell migration and dermal changes post nonablative fractional resurfacing: study of the wound healing process with corroborated histopathologic evidence. J Biomed Opt. 2009;14(2):024018.
Terhorst D, Maltusch A, Stockfleth E, Lange-Asschenfeldt S, et al. Reflectance confocal microscopy for the evaluation of acute epidermal wound healing. Wound Repair Regen. 2011;19(6):671–9.
Lange-Asschenfeldt S, Bob A, Terhorst D, Ulrich M, et al. Applicability of confocal laser scanning microscopy for evaluation and monitoring of cutaneous wound healing. J Biomed Opt. 2012;17(7):076016.
Rajadhyaksha M, Marghoob A, Rossi A, Halpern AC, Nehal KS. Reflectance confocal microscopy of skin in vivo: from bench to bedside. Lasers Surg Med. 2017;49(1):7–19.
Catalano O, Roldan F, Varelli C, Bard R, et al. Skin cancer: findings and role of high resolution ultrasound. J Ultrasound. 2019; https://doi.org/10.1007/s40477-019-00379-0.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Bard, R.L., Wortsman, X. (2020). Ultrasound Diagnosis of Non-melanoma Skin Cancer and Malignant Melanoma. In: Bard, R. (eds) Image Guided Dermatologic Treatments. Springer, Cham. https://doi.org/10.1007/978-3-030-29236-2_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-29236-2_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-29234-8
Online ISBN: 978-3-030-29236-2
eBook Packages: MedicineMedicine (R0)