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Climate Crisis Impact on AIDS, IRIS and Neuro-AIDS

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Abstract

Our awareness of the climate crisis/catastrophe is a convoluted story, which began in chemistry laboratories several decades ago. In that context, scientists first described the greenhouse effect: the potential CO2 accumulation allows solar heat to penetrate the atmosphere, but prevents radiated warmth to escape from it. A theoretical proposition at first, scientists first described the greenhouse effect as the potential accumulation of CO2, allowing solar heat to penetrate the atmosphere while simultaneously preventing the radiated warmth from escaping it. This increase in atmospheric CO2 would hypothetically then raise the planet’s temperature, and if left unchecked, this phenomenon could lead to a multitude of issues including the melting of polar ice caps, rising of oceanic waters, alterations in the acidity and temperature of global water reservoirs (i.e., rivers, lakes, and seas), and changes in the patterns and strength of the gulf streams and consequently the jet stream.

Global warming is now a reality that is substantiated by an abundance of facts and evidence. The best available evidence further confirms that the climate crisis we have engendered with wanton human activity since the industrial revolution and with renewed vigor following WWII, has exacerbated within the last five decades, proffering serious threats to the health of children, adults and the elderly alike.

We discuss the implications of the climate crisis to susceptibility of HIV disease, AIDS, Neuro-AIDS and IRIS, and proffer the current measles outbreak in the Philippines as proof-of-concept of the proposition that global warming can affect morbidity and mortality to viral infections. We also propose a general Artificial Intelligence-driven statistical space-time mixture algorithm as a Bayesian predictive model for climate change-associated medical emergencies.

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References

  1. Resplandy L, Keeling RF, Eddebbar Y, Brooks MK, Wang R, Bopp L, Long MC, Dunne JP, Koeve W, Oschlies A. Quantification of ocean heat uptake from changes in atmospheric O2 and CO2 composition. Nature. 2018;563:105–8. On Line Pub. 31 October 2018 [PMID: 30382201].

    Article  CAS  PubMed  Google Scholar 

  2. Chiappelli F. Bioinformation Informs the Allostasiome: Translational Environmental Restoration (TER) for the Climate Crisis Medical Emergency. Bioinformation. 2018;14:446–8. [PMID:30310252].

    Article  PubMed  PubMed Central  Google Scholar 

  3. IPCC-2018. Global Warming ff 1.5 °C. 48th Session of the IPCC, Incheon, Republic of Korea, 6 October 2018. Accessed 1 Nov 2018. http://report.ipcc.ch/sr15/pdf/sr15_spm_final.pdf

  4. Khakshooy A, Chiappelli F. Hypothalamus-Pituitary-Adrenal cell-mediated immunity regulation in the Immune Restoration Inflammatory Syndrome. Bioinformation. 2016;12:28–31. [PMID: 27212842].

    Article  PubMed  PubMed Central  Google Scholar 

  5. Dybul M, Fauci AS, Bartlett JG, Kaplan JE, Pau AK. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents. Ann Intern Med. 2002;137:381–433. [PMID: 12617573].

    Article  PubMed  Google Scholar 

  6. Espinosa E, Ormsby CE, Vega-Barrientos RS, Ruiz-Cruz M, Moreno-Coutiño G, Peña-Jiménez A, Peralta-Prado AB, Cantoral-Díaz M, Romero-Rodríguez DP, Reyes-Terán G. Risk factors for immune reconstitution inflammatory syndrome under combination antiretroviral therapy can be aetiology-specific. Int J STD AIDS. 2010;21:573–9. [PMID: 20975091].

    Article  CAS  PubMed  Google Scholar 

  7. Chiappelli F, Shapshak P, Commins D, Singer E, Minagar A, Oluwadara O, Prolo P, Pellionisz AJ. Molecular epigenetics, chromatin, and NeuroAIDS/HIV: immunopathological implications. Bioinformation. 2008;3:47–52. [PMID:19052666].

    Article  PubMed  PubMed Central  Google Scholar 

  8. Chiappelli F, Balenton N, Khakshooy A. Future Innovations in Viral Immune Surveillance: A Novel Place for Bioinformation and Artificial Intelligence in the Administration of Health Care. Bioinformation. 2018;14(5):201–5. [PMID:30108416].

    Article  PubMed  PubMed Central  Google Scholar 

  9. Solomon GF. Psychoneuroimmunology: interactions between central nervous system and immune system. J Neurosci Res. 1987;18:1–9. [PMID: 3316677].

    Article  CAS  PubMed  Google Scholar 

  10. Chiappelli F, Abanomy A, Hodgson D, Mazey KA, Messadi DV, Mito RS, Nishimura I, Spigleman I. Chapter 64, Clinical, experimental and translational psychoneuroimmunology research models in oral biology and medicine. In: Ader R, et al., editors. Psychoneuroimmunology, III. San Diego: Academic Press; 2001. p. 645–70.

    Google Scholar 

  11. Kim J. Regulation of Immune Cell Functions by Metabolic Reprogramming. J Immunol Res. 2018;. On Line Pub. 13 Feb 2018: 8605471. [PMID: 29651445].

    Google Scholar 

  12. Neurological Complications of AIDS Fact Sheet: National Institute of Neurological Disorders and Stroke. Accessed 3 Oct 2018. www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Neurological-Complications-AIDS-Fact-Sheet2/9.

  13. Brandsma D, Bromberg JEC. Primary CNS lymphoma in HIV infection. Handb Clin Neurol. 2018;152:177–86. [PMID:29604975].

    Article  PubMed  Google Scholar 

  14. Grønborg HL, Jespersen S, Hønge BL, Jensen-Fangel S, Wejse C. Review of cytomegalovirus coinfection in HIV-infected individuals in Africa. Rev Med Virol. 2017. On Line Pub. 7 Oct. 2016. https://doi.org/10.1002/rmv.1907.2016. [PMID: 27714898].

  15. Hung CH, Chang KH, Kuo HC, Huang CC, Liao MF, Tsai YT, Ro LS. Features of varicella zoster virus myelitis and dependence on immune status. J Neurol Sci. 2012;318:19–24. [PMID: 22564884].

    Article  PubMed  Google Scholar 

  16. Limper AH, Adenis A, Le T, Harrison TS. Fungal infections in HIV/AIDS. Lancet Infect Dis. 2017;17:e334–43. [PMID: 2877e4701].

    Article  PubMed  Google Scholar 

  17. Chiappelli F, Bakhordarian A, Thames A, Du AM, Jan AL, Nahcivan M, Nguyen MT, Sama N, Manfrini E, Piva F, Rocha RM, Maida CA. Ebola: translational science considerations. Translational Med. 2015;13:11. https://doi.org/10.1186/s12967-014-0362-3. [PMID:25592846].

    Article  Google Scholar 

  18. Chiappelli F, Santos SM, Caldeira Brant XM, Bakhordarian A, Thames AD, Maida CA, Du AM, Jan AL, Nahcivan M, Nguyen MT, Sama N. Viral immune evasion in dengue: toward evidence-based revisions of clinical practice guidelines. Bioinformation. 2014;10:726–33. [PMID:25670874].

    Article  PubMed  PubMed Central  Google Scholar 

  19. Chiappelli F. Fundamentals of Evidence-based Health Care and Translational Science. Heidelberg: Springer–Verlag; 2014.

    Book  Google Scholar 

  20. Chiappelli F. Comparative Effectiveness Research (CER): New Methods, Challenges and Health Implications. Hauppauge: NovaScience Publisher, Inc.; 2016.

    Google Scholar 

  21. Chiappelli F. Advances in Psychophysiology Research. Hauppauge: NovaScience Publisher, Inc.; 2018.

    Google Scholar 

  22. Sulpis O, Boudreau BP, Mucci A, Jenkins C, Trossman DS, Arbic BK, Key RM. Current CaCO3 dissolution at the seafloor caused by anthropogenic CO2. Proc Natl Acad Sci USA. 115:11700–5. On Line Pub. 29 Oct. 2018 [PMID:30373837].

    Article  CAS  Google Scholar 

  23. National Ocean Service. What is Coral bleaching? 25 June 2018. Accessed 13 Nov 2018. https://oceanservice.noaa.gov/facts/coral_bleach.html

  24. Levins R, Richard Lewontin R. The Dialectical Biologist. Cambridge, MA: Harvard University Press; 1985.

    Google Scholar 

  25. National Institute of Neurological Disorders and Stroke Neurological Complications of AIDS Fact Sheet. Report 10/3/2018. Accessed 12 Nov 2018. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Neurological-Complications-AIDS-Fact-Sheet5/9.

  26. Nogueira M, Da Silva Marinho RV, Harumi Narumiya I, Bach Q, Kasar V, Khorshad D, Chiappelli F. Chapter 20, Comparative Effectiveness Research in the Pharmacological Treatment of HIV/AIDS – The Immune Reconstitution Inflammatory Syndrome (IRIS). In: Chiappelli F, editor. Comparative Effectiveness Research (CER): New Methods, Challenges and Health Implications. Hauppauge: NovaScience Publisher, Inc.; 2016.

    Google Scholar 

  27. Schooley RT. Our Warming Planet: Is the HIV-1-Infected Population in the Crosshairs. Top Antivir Med. 2016;26:67–70. [PMID:29906791].

    PubMed  Google Scholar 

  28. McDonald J, Harkin J, Harwood A, Hobday A, Lyth A, Meinke H. Supporting evidence-based adaptation decision-making in Tasmania: A synthesis of climate change adaptation research. Gold Coast: National Climate Change Adaptation Research Facility; 2013. p. 169.

    Google Scholar 

  29. Smith DL, Dushoff J, McKenzie FE. The risk of a mosquito-borne infection in a heterogeneous environment. PLoS Biol. 2004;2:e368. OnLine Pub. 26 Oct. 2004 [PMID:15510228].

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  30. McMichael A. Climate Change and the Health of Nations: Famines, Fevers, and the Fate of Populations. 1st ed. New York, NY: Oxford University Press; 2017.

    Google Scholar 

  31. World Health Organization. Ambient (outdoor) air quality and health. 2 May 2018. Accessed 13 Nov 2018. http://www.who.int/news-room/fact-sheets/detail/ambient-(outdoor)-air-quality-and-health.

  32. Schooley RT. The human microbiome: implications for health and disease, including HIV infection. Top Antivir Med. 2018;26:75–8. [PMID:30384329].

    PubMed  PubMed Central  Google Scholar 

  33. Liang L, Gong P. Climate change and human infectious diseases: A synthesis of research findings from global and spatio-temporal perspectives. Ann Rev Virol. 2016;3(1):125–45. [PMID:27482902].

    Article  CAS  Google Scholar 

  34. Chowdhury FR, Nur Z, Hassan N, von Seidlein L, Dunachie S. Pandemics, pathogenicity and changing molecular epidemiology of cholera in the era of global warming. Ann Clin Microbiol Antimicrob. 2017;16(1):10. [PMID:28270154].

    Article  PubMed  PubMed Central  Google Scholar 

  35. Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, Waldor MK. The origin of the Haitian cholera outbreak strain. N Engl J Med. 2011;364(1):33–42. [PMID:21142692].

    Article  CAS  PubMed  Google Scholar 

  36. McMichael AJ, Woodruff RE, Hales S. Climate change and human health: present and future risks. Lancet. 2006;367(9513):859–69. [PMID:16530580].

    Article  PubMed  Google Scholar 

  37. Booth S, Zeller D. Mercury, Food Webs, and Marine Mammals: Implications of Diet and Climate Change for Human Health. Environ Health Perspect. 2005;113(5):521–6. [PMID:15866757].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Beggs PJ. Impacts of climate change on aeroallergens: past and future. Clinical and experimental allergy. 2004(10):1507–13. [PMID:15479264].

    Google Scholar 

  39. Bajin M, Cingi C, Oghan F, Gurbuz M. Global warming and allergy in Asia Minor. Eur Arch Otorhinolaryngol. 2013;270(1):27–31. [PMID:22695877].

    Article  PubMed  Google Scholar 

  40. Kaffenberger B, Shetlar D, Norton S, Rosenbach M. The effect of climate change on skin disease in North America. J Am Acad Dermatol. 2017;76(1):140–7. [PMID:27742170].

    Article  PubMed  Google Scholar 

  41. Shuman EK. Global climate change and infectious diseases. Int J Occup Environ Med. 2011;2(1):11–9. [PMID:23022814].

    CAS  PubMed  Google Scholar 

  42. Abayomi A, Cowan MN. The HIV/AIDS epidemic in South Africa: Convergence with tuberculosis, socioecological vulnerability, and climate change patterns. S Afr Med J. 2014;104(8):583. [PMID:26307805].

    Article  CAS  PubMed  Google Scholar 

  43. Cohen J. Reversal of misfortunes. Science. 2013;339(6122):898–903. [PMID:23430629].

    Article  CAS  PubMed  Google Scholar 

  44. Pope CA, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002;287(9):1132–41. [PMID:11879110].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Abayomi A. HIV/AIDS disease burden complex in South Africa: Impact on health and environmental resources, and vulnerability to climate. Climate Vulnerability. 2013;1:125–43.

    Article  Google Scholar 

  46. Akil L, Ahmad H, Reddy R. Effects of climate change on Salmonella infections. Foodborne Pathog Dis. 2014;11(12):974–80. [PMID:25496072].

    Article  PubMed  PubMed Central  Google Scholar 

  47. Checkley W, Epstein LD, Gilman RH, Figueroa D, Cama RI, Patz JA, Black RE. Effect of El Niño and ambient temperature on hospital admissions for diarrhoeal diseases in Peruvian children. Lancet. 2000;355(9202):442–50. [PMID:10841124].

    Article  CAS  PubMed  Google Scholar 

  48. Gilbert M, Slingenbergh J, Xiao X. Climate change and avian influenza. Rev Sci Tech. 2008;27(2):459–66. [PMID:18819672].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Longstreth J. Anticipated public health consequences of global climate change. Environ Health Perspect. 1991;96:139–44. [PMID:1820256].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Palmgren H. Meningococcal disease and climate. Glob Health Action. 2009;2 https://doi.org/10.3402/gha.v2i0.2061. [PMID:20052424].

    Article  Google Scholar 

  51. Semenza JC, Herbst S, Rechenburg A, Suk JE, Höser C, Schreiber C, Kistemann T. Climate Change Impact Assessment of Food- and Waterborne Diseases. Crit Rev Environ Sci Technol. 2011;42(8):857–90. [PMID:24808720].

    Article  PubMed Central  Google Scholar 

  52. McMichael AJ, Lindgren E. Climate change: present and future risks to health, and necessary responses. J Intern Med. 2011;270(5):401–13. [PMID:21682780].

    Article  CAS  PubMed  Google Scholar 

  53. Delfino RJ, Brummel S, Wu J, Stern H, Ostro B, Lipsett M, Winer A, Street DH, Zhang L, Tjoa T, Gillen DL. The relationship of respiratory and cardiovascular hospital admissions to the Southern California wildfires of 2003. Occup Environ Med. 2009;66(3):189–97. [PMID:19017694].

    Article  CAS  PubMed  Google Scholar 

  54. Benedict K, Park BJ. Invasive fungal infections after natural disasters. Emerg Infect Dis. 2014;0(3):349–55. [PMID:24565446].

    Article  Google Scholar 

  55. Fritze J, Blashki G, Burke S, Wiseman J. Hope, despair and transformation: Climate change and the promotion of mental health and wellbeing. Int J Ment Health Syst. 2008;2(1):13. https://doi.org/10.1186/1752-4458-2-13. [PMID:18799005].

    Article  PubMed  PubMed Central  Google Scholar 

  56. Burke S, Sanson A, Van Hoorn J. The Psychological Effects of Climate Change on Children. Curr Psychiatry Rep. 2018;20(5):35. https://doi.org/10.1007/s11920-018-0896-9. [PMID:29637319].

    Article  PubMed  Google Scholar 

  57. Rifkin D, Long M, Perry M. Climate change and sleep: A systematic review of the literature and conceptual framework. Sleep Med Rev. 2018;42:3–9. [PMID:30177247].

    Article  PubMed  Google Scholar 

  58. Gislason M. Climate change, health and infectious disease. Virulence. 2015;6(6):539–42. [PMID:26132053].

    Article  PubMed  PubMed Central  Google Scholar 

  59. Hayes K, Blashki G, Wiseman J, Burke S, Reifels L. Climate change and mental health: risks, impacts and priority actions. Int J Ment Health Syst. 2018;12:28. https://doi.org/10.1186/s13033-018-0210-6. [PMID:29881451].

    Article  PubMed  PubMed Central  Google Scholar 

  60. Moore FC, Obradovich N, Lehner F, Baylis P. Rapidly declining remarkability of temperature anomalies may obscure public perception of climate change. Proc Natl Acad Sci USA. 2019;116:4905–10.. 2019 Epub Feb 25. [PMID:30804179].

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Lawson AB, Choi J, Cai B, Hossain M, Kirby RS, Liu J. Bayesian 2-Stage Space-Time Mixture Modeling with Spatial Misalignment of the Exposure in Small Area Health Data. J Agric Biol Environ Stat. 2012;17:417–41. [PMID: 28943751].

    Article  PubMed  PubMed Central  Google Scholar 

  62. Lawson AB, Song HR, Cai B, Hossain MM, Huang K. Space-time latent component modeling of geo-referenced health data. Stat Med. 2010;29:2012–27. [PMID: 20683893].

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of the Health Sciences (Biostatistics), California State University, Northridge, CA, USA

    Francesco Chiappelli, Emma Reyes & Ruth Toruño

Authors
  1. Francesco Chiappelli
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  2. Emma Reyes
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  3. Ruth Toruño
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine, University of South Florida, Tampa, FL, USA

    Paul Shapshak

  2. Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India

    Seetharaman Balaji

  3. Biomedical Informatics 17, Irulan Sandy Annex, Pondicherry, Pondicherry, India

    Pandjassarame Kangueane

  4. Oral Biology and Medicine, CHS 63-090, UCLA School of Dentistry Oral Biology and Medicine, CHS 63-090, Los Angeles, CA, USA

    Francesco Chiappelli

  5. Department of Internal Medicine, University of South Florida, Tampa, FL, USA

    Charurut Somboonwit

  6. Department of Internal Medicine, University of South Florida, Tampa, FL, USA

    Lynette J. Menezes

  7. Department of Internal Medicine, University of South Florida, Tampa, FL, USA

    John T. Sinnott

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Chiappelli, F., Reyes, E., Toruño, R. (2019). Climate Crisis Impact on AIDS, IRIS and Neuro-AIDS. In: Shapshak, P., et al. Global Virology III: Virology in the 21st Century. Springer, Cham. https://doi.org/10.1007/978-3-030-29022-1_21

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