Skip to main content

The Use of Antiseptic and Antibacterial Agents on Wounds and the Skin

  • Chapter
  • First Online:

Part of the book series: Updates in Clinical Dermatology ((UCD))

Abstract

As our global population ages, the prevalence and frequency of both acute and chronic wounds will rise, generating increased burden on patients, healthcare professionals, and healthcare systems. Wound-related bacterial damage can be situated on either the surface compartment of the wound or the deep and surrounding compartments. Wounds that are infected on the surface component are said to have local infection and should be treated topically. Wounds infected in the deep and surrounding components should be treated systemically. Topical antimicrobial and antiseptic agents are used to treat superficial critical colonization and not deep and surrounding infection. This chapter will address the use of topical antimicrobials and antiseptics for the treatment of the superficial compartment of the wound. The five broad classes of topical antimicrobial agents currently used in chronic wounds with superficial critical colonization include PHMB, ionized silver, slow-release iodine, methylene blue and gentian violet, and honey.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   89.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341(10):738–46. https://doi.org/10.1056/NEJM199909023411006.

    Article  CAS  PubMed  Google Scholar 

  2. Sibbald RG, Elliott JA, Verma L, Brandon A, Persaud R, Ayello EA. Update: topical antimicrobial agents for chronic wounds. Adv Skin Wound Care. 2017;30(10):438–50. https://doi.org/10.1097/01.ASW.0000524471.28441.b9.

    Article  PubMed  Google Scholar 

  3. White RJ, Cutting K, Kingsley A. Topical antimicrobials in the control of wound bioburden. Ostomy Wound Manage. 2006;52(8):26–58.

    PubMed  Google Scholar 

  4. Mustoe TA, O’Shaughnessy K, Kloeters O. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. Plast Reconstr Surg. 2006;117(7 Suppl):35S–41S. https://doi.org/10.1097/01.prs.0000225431.63010.1b.

    Article  CAS  PubMed  Google Scholar 

  5. Attinger C, Wolcott R. Clinically addressing biofilm in chronic wounds. Adv Wound Care (New Rochelle). 2012;1(3):127–32. https://doi.org/10.1089/wound.2011.0333.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Lewis K. Persister cells, dormancy and infectious disease. Nat Rev Microbiol. 2007;5(1):48–56. https://doi.org/10.1038/nrmicro1557.

    Article  CAS  PubMed  Google Scholar 

  7. Clinton A, Carter T. Chronic wound biofilms: pathogenesis and potential therapies. Lab Med. 2015;46(4):277–84. https://doi.org/10.1309/LMBNSWKUI4JPN7SO.

    Article  PubMed  Google Scholar 

  8. Hurlow J, Bowler PG. Clinical experience with wound biofilm and management: a case series. Ostomy Wound Manage. 2009;55(4):38–49.

    PubMed  Google Scholar 

  9. Ryan S, Perrier L, Sibbald RG. Searching for evidence-based medicine in wound care: an introduction. Ostomy Wound Manage. 2003;49(11):67–75.

    PubMed  Google Scholar 

  10. Sibbald RG, Williamson D, Orsted HL, et al. Preparing the wound bed–debridement, bacterial balance, and moisture balance. Ostomy Wound Manage. 2000;46(11):14–22, 24–8, 30–5; quiz 36–7

    CAS  PubMed  Google Scholar 

  11. Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen. 2000;8(5):347–52.

    Article  CAS  Google Scholar 

  12. Sibbald RG, Woo K, Ayello EA. Increased bacterial burden and infection: the story of NERDS and STONES. Adv Skin Wound Care. 2006;19(8):447–61; quiz 461–3

    Article  Google Scholar 

  13. Pellizzer G, Strazzabosco M, Presi S, et al. Deep tissue biopsy vs. superficial swab culture monitoring in the microbiological assessment of limb-threatening diabetic foot infection. Diabet Med. 2001;18(10):822–7.

    Article  CAS  Google Scholar 

  14. Sibbald et. al. Wound bed preparation 2020 submitted for publication Advances in Skin and Wound Care.

    Google Scholar 

  15. Woo KY, Sibbald RG. A cross-sectional validation study of using NERDS and STONEES to assess bacterial burden. Ostomy Wound Manage. 2009;55(8):40–8.

    PubMed  Google Scholar 

  16. Cutting KF, Harding KG. Criteria for identifying wound infection. J Wound Care. 1994;3(4):198–201. https://doi.org/10.12968/jowc.1994.3.4.198.

    Article  CAS  PubMed  Google Scholar 

  17. Leekha S, Terrell CL, Edson RS. General principles of antimicrobial therapy. Mayo Clin Proc. 2011;86(2):156–67. https://doi.org/10.4065/mcp.2010.0639.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Antimicrobial dressings made easy – Wounds International. https://www.woundsinternational.com/resources/details/antimicrobial-dressings-made-easy. Accessed 3 Jan 2019.

  19. Bernatchez SF, Menon V, Stoffel J, et al. Nitric oxide levels in wound fluid may reflect the healing trajectory. Wound Repair Regen. 2013;21(3):410–7. https://doi.org/10.1111/wrr.12048.

    Article  PubMed  Google Scholar 

  20. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. The accuracy of venous leg ulcer prognostic models in a wound care system. Wound Repair Regen. 2004;12(2):163–8. https://doi.org/10.1111/j.1067-1927.2004.012207.x.

    Article  PubMed  Google Scholar 

  21. Lipsky BA, Hoey C. Topical antimicrobial therapy for treating chronic wounds. Clin Infect Dis. 2009;49(10):1541–9. https://doi.org/10.1086/644732.

    Article  PubMed  Google Scholar 

  22. Butcher M. PHMB: an effective antimicrobial in wound bioburden management. Br J Nurs. 2012;21(12):S16, S18–21. https://doi.org/10.12968/bjon.2012.21.Sup12.S16.

  23. Sibbald RG, Coutts P, Woo KY. Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results. Adv Skin Wound Care. 2011;24(2):78–84. https://doi.org/10.1097/01.ASW.0000394027.82702.16.

    Article  PubMed  Google Scholar 

  24. To E, Dyck R, Gerber S, Kadavil S, Woo KY. The effectiveness of topical Polyhexamethylene Biguanide (PHMB) agents for the treatment of chronic wounds: a systematic review. Surg Technol Int. 2016;29:45–51.

    PubMed  Google Scholar 

  25. Yin HQ, Langford R, Burrell RE. Comparative evaluation of the antimicrobial activity of ACTICOAT antimicrobial barrier dressing. J Burn Care Rehabil. 1999;20(3):195–200.

    Article  CAS  Google Scholar 

  26. Wright JB, Lam K, Burrell RE. Wound management in an era of increasing bacterial antibiotic resistance: a role for topical silver treatment. Am J Infect Control. 1998;26(6):572–7. https://doi.org/10.1053/ic.1998.v26.a93527.

    Article  CAS  PubMed  Google Scholar 

  27. Wright JB, Lam K, Hansen D, Burrell RE. Efficacy of topical silver against fungal burn wound pathogens. Am J Infect Control. 1999;27(4):344–50.

    Article  CAS  Google Scholar 

  28. Sibbald RG, Browne AC, Coutts P, Queen D. Screening evaluation of an ionized nanocrystalline silver dressing in chronic wound care. Ostomy Wound Manage. 2001;47(10):38–43.

    CAS  PubMed  Google Scholar 

  29. Lo S-F, Chang C-J, Hu W-Y, Hayter M, Chang Y-T. The effectiveness of silver-releasing dressings in the management of non-healing chronic wounds: a meta-analysis. J Clin Nurs. 2009;18(5):716–28. https://doi.org/10.1111/j.1365-2702.2008.02534.x.

    Article  PubMed  Google Scholar 

  30. Oliveira Ados S, VLC S. Topical iodophor use in chronic wounds: a literature review. Rev Lat Am Enfermagem. 2007;15(4):671–6.

    Article  Google Scholar 

  31. Sibbald RG, Elliott JA. The role of Inadine in wound care: a consensus document. Int Wound J. 2017;14(2):316–21. https://doi.org/10.1111/iwj.12602.

    Article  PubMed  Google Scholar 

  32. Mertz PM, Oliveira-Gandia MF, Davis SC. The evaluation of a cadexomer iodine wound dressing on methicillin resistant Staphylococcus aureus (MRSA) in acute wounds. Dermatol Surg. 1999;25(2):89–93.

    Article  CAS  Google Scholar 

  33. Sibbald R, Leaper D, Queen D. Iodine made easy – Wounds International. https://www.woundsinternational.com/resources/details/iodine-made-easy. Accessed 27 Dec 2018.

  34. Burks RI. Povidone-iodine solution in wound treatment. Phys Ther. 1998;78(2):212–8.

    Article  CAS  Google Scholar 

  35. Drosou A, Falabella A, Kirsner R. Antiseptics on wounds: an area of controversy. Wounds. 2003;15(5):149–66.

    Google Scholar 

  36. Fumal I, Braham C, Paquet P, Piérard-Franchimont C, Piérard GE. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology (Basel). 2002;204(Suppl 1):70–4. https://doi.org/10.1159/000057729.

    Article  CAS  Google Scholar 

  37. Moberg S, Hoffman L, Grennert ML, Holst A. A randomized trial of cadexomer iodine in decubitus ulcers. J Am Geriatr Soc. 1983;31(8):462–5.

    Article  CAS  Google Scholar 

  38. Harcup JW, Saul PA. A study of the effect of cadexomer iodine in the treatment of venous leg ulcers. Br J Clin Pract. 1986;40(9):360–4.

    CAS  PubMed  Google Scholar 

  39. International Wound Infection Institute (IWII)-Wound-infection-in-clinical-practice.pdf. http://www.woundinfection-institute.com/wp-content/uploads/2017/03/IWII-Wound-infection-in-clinical-practice.pdf. Accessed 27 Dec 2018.

  40. Coutts PM, Ryan J, Sibbald RG. Case series of lower-extremity chronic wounds managed with an antibacterial foam dressing bound with gentian violet and methylene blue. Adv Skin Wound Care. 2014;27(3 Suppl 1):9–13. https://doi.org/10.1097/01.ASW.0000443270.71030.71.

    Article  PubMed  Google Scholar 

  41. Hoffmann CE, Rahn O. The bactericidal and bacteriostatic action of crystal violet. J Bacteriol. 1944;47(2):177–86.

    Article  CAS  Google Scholar 

  42. Data on file, Hydrofera, LLC.

    Google Scholar 

  43. Shi L, Ermis R, Kiedaisch B, Carson D. The effect of various wound dressings on the activity of debriding enzymes. Adv Skin Wound Care. 2010;23(10):456–62. https://doi.org/10.1097/01.ASW.0000383224.64524.ae.

    Article  PubMed  Google Scholar 

  44. Paddle-Ledinek JE, Nasa Z, Cleland HJ. Effect of different wound dressings on cell viability and proliferation. Plast Reconstr Surg. 2006;117(7 Suppl):110S–8S. ; discussion 119S–120S. https://doi.org/10.1097/01.prs.0000225439.39352.ce.

    Article  CAS  PubMed  Google Scholar 

  45. Woo KY, Heil J. A prospective evaluation of methylene blue and gentian violet dressing for management of chronic wounds with local infection. Int Wound J. 2017;14(6):1029–35. https://doi.org/10.1111/iwj.12753.

    Article  PubMed  Google Scholar 

  46. Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015;(3):CD005083. https://doi.org/10.1002/14651858.CD005083.pub4.

  47. Sato T, Miyata G. The nutraceutical benefit, part iii: honey. Nutrition. 2000;16(6):468–9.

    Article  CAS  Google Scholar 

  48. Al-Waili NS, Salom K, Butler G, Al Ghamdi AA. Honey and microbial infections: a review supporting the use of honey for microbial control. J Med Food. 2011;14(10):1079–96. https://doi.org/10.1089/jmf.2010.0161.

    Article  CAS  PubMed  Google Scholar 

  49. Position document Management of biofilm – Wounds UK. https://www.wounds-uk.com/resources/details/position-document-management-biofilm. Accessed 3 Jan 2019.

  50. Percival SL, Mayer D, Malone M, Swanson T, Gibson D, Schultz G. Surfactants and their role in wound cleansing and biofilm management. J Wound Care. 2017;26(11):680–90. https://doi.org/10.12968/jowc.2017.26.11.680.

    Article  CAS  PubMed  Google Scholar 

  51. Burnett CL, Bergfeld WF, Belsito DV, et al. Final report of the Cosmetic Ingredient Review Expert Panel on the safety assessment of cocamidopropyl betaine (CAPB). Int J Toxicol. 2012;31(4 Suppl):77S–111S. https://doi.org/10.1177/1091581812447202.

    Article  CAS  PubMed  Google Scholar 

  52. Sibbald RG, Elliott JA, Ayello EA, Somayaji R. Optimizing the moisture management tightrope with wound bed preparation 2015©. Adv Skin Wound Care. 2015;28(10):466–76. ; quiz 477–8. https://doi.org/10.1097/01.ASW.0000470851.27030.98.

    Article  PubMed  Google Scholar 

  53. Atiyeh BS, Ioannovich J, Al-Amm CA, El-Musa KA. Management of acute and chronic open wounds: the importance of moist environment in optimal wound healing. Curr Pharm Biotechnol. 2002;3(3):179–95.

    Article  CAS  Google Scholar 

  54. Norman G, Atkinson RA, Smith TA, et al. Intracavity lavage and wound irrigation for prevention of surgical site infection. Cochrane Database Syst Rev. 2017;(10):CD012234. https://doi.org/10.1002/14651858.CD012234.pub2.

  55. Salami AA, Owoeye O. A comparison of the effect of chlorhexidine, tap water, and normal saline on healing wounds. Int Morphol. 2006;4(24):673–6.

    Google Scholar 

  56. Fernandez R, Griffiths R. Water for wound cleansing. Cochrane Database Syst Rev. 2012;(2):CD003861. https://doi.org/10.1002/14651858.CD003861.pub3.

  57. Mena KD, Gerba CP. Risk assessment of Pseudomonas aeruginosa in water. Rev Environ Contam Toxicol. 2009;201:71–115. https://doi.org/10.1007/978-1-4419-0032-6_3.

    Article  CAS  PubMed  Google Scholar 

  58. Thomas GW, Rael LT, Bar-Or R, et al. Mechanisms of delayed wound healing by commonly used antiseptics. J Trauma. 2009;66(1):82–90. ; discussion 90–1. https://doi.org/10.1097/TA.0b013e31818b146d.

    Article  CAS  PubMed  Google Scholar 

  59. Atiyeh BS, Dibo SA, Hayek SN. Wound cleansing, topical antiseptics and wound healing. Int Wound J. 2009;6(6):420–30. https://doi.org/10.1111/j.1742-481X.2009.00639.x.

    Article  PubMed  Google Scholar 

  60. Haller G, Faltin-Traub E, Faltin D, Kern C. Oxygen embolism after hydrogen peroxide irrigation of a vulvar abscess. Br J Anaesth. 2002;88(4):597–9.

    Article  CAS  Google Scholar 

  61. Okan D, Woo K, Ayello EA, Sibbald G. The role of moisture balance in wound healing. Adv Skin Wound Care. 2007;20(1):39–53; quiz 53–5

    Article  Google Scholar 

  62. Cho CY, Lo JS. Dressing the part. Dermatol Clin. 1998;16(1):25–47.

    Article  CAS  Google Scholar 

  63. Hampton S. A small study in healing rates and symptom control using a new sheet hydrogel dressing. J Wound Care. 2004;13(7):297–300. https://doi.org/10.12968/jowc.2004.13.7.26639.

    Article  CAS  PubMed  Google Scholar 

  64. Eisenbud D, Hunter H, Kessler L, Zulkowski K. Hydrogel wound dressings: where do we stand in 2003? Ostomy Wound Manage. 2003;49(10):52–7.

    PubMed  Google Scholar 

  65. Hoffmann KK, Weber DJ, Samsa GP, Rutala WA. Transparent polyurethane film as an intravenous catheter dressing. A meta-analysis of the infection risks. JAMA. 1992;267(15):2072–6.

    Article  CAS  Google Scholar 

  66. Chang KW, Alsagoff S, Ong KT, Sim PH. Pressure ulcers–randomised controlled trial comparing hydrocolloid and saline gauze dressings. Med J Malaysia. 1998;53(4):428–31.

    CAS  PubMed  Google Scholar 

  67. Kannon GA, Garrett AB. Moist wound healing with occlusive dressings. A clinical review. Dermatol Surg. 1995;21(7):583–90.

    Article  CAS  Google Scholar 

  68. Körber A, Kohaus S, Geisheimer M, Grabbe S, Dissemond J. Allergic contact dermatitis from a hydrocolloid dressing due to colophony sensitization. Hautarzt. 2006;57(3):242–5. https://doi.org/10.1007/s00105-005-0913-x.

    Article  PubMed  Google Scholar 

  69. Campton-Johnston S, Wilson J. Infected wound management: advanced technologies, moisture-retentive dressings, and die-hard methods. Crit Care Nurs Q. 2001;24(2):64–77; quiz 2 p following 77

    Article  CAS  Google Scholar 

  70. Hilton JR, Williams DT, Beuker B, Miller DR, Harding KG. Wound dressings in diabetic foot disease. Clin Infect Dis. 2004;39(Suppl 2):S100–3. https://doi.org/10.1086/383270.

    Article  PubMed  Google Scholar 

  71. Aparicio Gallego E, Castilla Peris C, Díez García MT, et al. Therapeutic behavior of a hydrocolloid dressing. Its evolution in the treatment of acute and chronic dermal ulcers. Rev Enferm. 2005;28(12):49–55.

    PubMed  Google Scholar 

  72. Segal HC, Hunt BJ, Gilding K. The effects of alginate and non-alginate wound dressings on blood coagulation and platelet activation. J Biomater Appl. 1998;12(3):249–57. https://doi.org/10.1177/088532829801200305.

    Article  CAS  PubMed  Google Scholar 

  73. Dabiri G, Damstetter E, Phillips T. Choosing a wound dressing based on common wound characteristics. Adv Wound Care (New Rochelle). 2016;5(1):32–41. https://doi.org/10.1089/wound.2014.0586.

    Article  Google Scholar 

  74. Cutting KF. The causes and prevention of maceration of the skin. Prof Nurse. 2001;17(3):177–8.

    CAS  PubMed  Google Scholar 

  75. Faucher N, Safar H, Baret M, Philippe A, Farid R. Superabsorbent dressings for copiously exuding wounds. Br J Nurs. 2012;21(12):S22, S24, S26–28. doi:https://doi.org/10.12968/bjon.2012.21.Sup12.S22.

  76. Tadej M. The use of Flivasorb in highly exuding wounds. Br J Nurs. 2009;18(15):S38–S40–42. https://doi.org/10.12968/bjon.2009.18.Sup5.43572.

    Article  PubMed  Google Scholar 

  77. Wiegand C, Abel M, Ruth P, Hipler UC. Superabsorbent polymer-containing wound dressings have a beneficial effect on wound healing by reducing PMN elastase concentration and inhibiting microbial growth. J Mater Sci Mater Med. 2011;22(11):2583–90. https://doi.org/10.1007/s10856-011-4423-3.

    Article  CAS  PubMed  Google Scholar 

  78. Superabsorbent polymers have become an important component of diapers during the last 10 years. http://wwwcourses.sens.buffalo.edu/ce435/Diapers/Diapers.html. Accessed 28 Dec 2018.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to R. Gary Sibbald .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Maliyar, K., Mufti, A., Sibbald, R.G. (2020). The Use of Antiseptic and Antibacterial Agents on Wounds and the Skin. In: Alavi, A., Maibach, H. (eds) Local Wound Care for Dermatologists. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-28872-3_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-28872-3_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-28871-6

  • Online ISBN: 978-3-030-28872-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics