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Eggs Retrieval. Adverse Events, Complications, and Malpractice: A Medicolegal Perspective

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Abstract

Ovum pickup (OPU) or egg retrieval, also known as follicular or follicle puncture, is instrumental in carrying out in vitro fertilization (IVF) procedures.

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References

  1. ESHRE Guideline Group on good practice in IVF labs. Revised guidelines for good practice in IVF laboratories (2015) Guideline of the European Society of Human Reproduction and Embryology. December 2015.

    Google Scholar 

  2. Cassazione civile, Sezione III, 30 giugno2015, n. 13328. http://dirittocivilecontemporaneo.com/wp-content/uploads/2015/10/n.-13328-del-30-giugno-2015.pdf.

  3. Grubb A, Laing J, McHale J. Principles of medical law. New York: Oxford University Press; 2010.

    Google Scholar 

  4. Montanari Vergallo G, Busardò FP, Zaami S, Marinelli E. The static evolution of the new Italian code of medical ethics. Eur Rev Med Pharmacol Sci. 2016;20(3):575–80.

    CAS  PubMed  Google Scholar 

  5. Law n. 24/2017 “Disposizioni in materia disicurezza delle cure e della persona assistita nonché in materia di responsabilità professionale degli esercenti le professioni sanitarie”.

    Google Scholar 

  6. Tucker C. Ethical and legal issues arising from the informed consent process in fertility treatments. ABA Health Law Section. Vol. 9, No. 7; March 2013.

    Google Scholar 

  7. Cassazione civile, Sezione III, 20 maggio 2016, n. 10414. http://www.altalex.com/documents/news/2016/06/07/intervento-necessario-consenso-informato.

  8. Dicker D, Ashkenazi J, Feldberg D, Levy T, Dekel A, Ben Rafael Z. Severe abdominal complications after transvaginal ultrasonographically guided retrieval of oocytes for in vitro fertilization and embryo transfer. Fertil Steril. 1993;59(6):1313–5.

    Google Scholar 

  9. Vahratian A. Prevalence of overweight and obesity among women of childbearing age: results from the 2002 National Survey of Family Growth. Matern Child Health J. 2009;13:268–73.

    Article  Google Scholar 

  10. Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod. 2007;22:414–20.

    Article  CAS  Google Scholar 

  11. Mitchell M, Bakos HW, Lane M. Paternal diet-induced obesity impairs embryo development and implantation in the mouse. Fertil Steril. 2011;95(4):1349–53.

    Google Scholar 

  12. Tamer Erel C, Senturk LM. The impact of body mass index on assisted reproduction. Curr Opin Obstet Gynecol. 2009;21(3):228–35.

    Google Scholar 

  13. Marquard KL, Stephens SM, Jungheim ES, Ratts VS, Odem RR, Lanzendorf S, Moley KH. Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro vaginal oocyte retrieval. Gynecol Obstet Investig. 2009;67(1):32–5.

    Article  Google Scholar 

  14. Robkeor RL. Evidence that obesity alters the quality of oocytes and embryos. Pathophysiology. 2008;15(2):115–21.

    Google Scholar 

  15. Jungheim ES, Moley KH. Current knowledge of obesity’s effects in the pre- and periconceptional periods and avenues for future research. Am J Obstet Gynecol. 2010;203(6):525–30.

    Google Scholar 

  16. Brewer CJ, Balen AH. The adverse effects of obesity on conception and implantation. Reproduction. 2010;140(3):347–64.

    Google Scholar 

  17. Purcell SH, Moley KH. The impact of obesity on egg quality. J Assist Reprod Genet. 2011;28(6):517–24.

    Google Scholar 

  18. Özaltın S, Kumbasar S, Sa-van K. Evaluation of complications developing during and after transvaginal ultrasound—guided oocyte retrieval. Ginekol Pol. 2018;89(1):1–6.

    Article  Google Scholar 

  19. Ayestaran C, Matorras R, Gomez S, Arce D, Rodriguez-Escudero F. Severe bradycardia and bradypnea following vaginal oocyte retrieval: a possible toxic effect of paracervical mepivacaine. Eur J Obstet Gynecol Reprod Biol. 2000;91(1):71–3.

    Google Scholar 

  20. Andersen AN, Gianaroli L, Felberbaum R, de Mouzon J, Nygren KG; European IVF-monitoring programme (EIM), European Society of Human Reproduction and Embryology (ESHRE). European IVFmonitoring programme (EIM). Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE. Hum Reprod. 2005;20(5):1158–76.

    Google Scholar 

  21. Oyawoye OA, Chander B, Hunter J, Gadir AA. Prevention of ovarian hyperstimulation syndrome by early aspiration of small follicles in hyper-responsive patients with polycystic ovaries during assisted reproductive treatment cycles. Medscape Gen Med. 2005;7(3):60.

    Google Scholar 

  22. Ayestaran C, Matorras R, Gomez S, Arce D, Rodriguez-Escudero F. Severe bradycardia and bradypnea following vaginal oocyte retrieval: a possible toxic effect of paracervical mepivacaine. Eur J Obstet Gynecol Reprod Biol. 2000;91(1):71–3.

    Article  CAS  Google Scholar 

  23. Zaami S, Montanari Vergallo G, Napoletano S, Signore F, Marinelli E. The issue of delivery room infections in the Italian law. A brief comparative study with English and French jurisprudence. J Matern Fetal Neonatal Med. 2017;31(2):1–8.

    Google Scholar 

  24. Ragni G, Scarduelli C, Calanna G, Santi G, Benaglia L, Somigliana E. Blood loss during transvaginal oocyte retrieval. Gynecol Obstet Investig. 2009;67(1):32–5.

    Article  Google Scholar 

  25. Aragona C, Mohamed MA, Espinola MS, Linari A, Pecorini F, Micara G, Sbracia M. Clinical complications after transvaginal oocyte retrieval in 7,098 IVF cycles. Fertil Steril. 2011;95(1):293–4.

    Article  Google Scholar 

  26. Liberty G, Hyman JH, Eldar-Geva T, Latinsky B, Gal M, Margalioth EJ. Ovarian hemorrhage after transvaginal ultrasonographically guided oocyte aspiration: a potentially catastrophic and not so rare complication among lean patients with polycystic ovary syndrome. Fertil Steril. 2008;93(3):874–9.

    Article  Google Scholar 

  27. Zaami S, Malvasi A, Marinelli E. Fundal pressure: risk factors in uterine rupture. The issue of liability: complication or malpractice? J Perinat Med. 2018;46(5):567–8.

    Article  Google Scholar 

  28. Malvasi A, Montanari Vergallo G, Tinelli A, Marinelli E. Can the intrapartum ultrasonography reduce the legal liability in dystocic labor and delivery? J Matern Fetal Neonatal Med. 2018;31(8):1108–9.

    Article  Google Scholar 

  29. Jayaprakasan K, Herbert M, Moody E, Stewart JA, Murdoch AP. Estimating the risks of ovarian hyperstimulation syndrome (OHSS): implications for egg donation for research. Hum Fertil. 2007;10:183–7.

    Article  CAS  Google Scholar 

  30. Kramer W, Schneider J, Schultz N. US oocyte donors: a retrospective study of medical and psychosocial issues. Hum Reprod. 2009;24(12):3144–9.

    Article  CAS  Google Scholar 

  31. American Society for Reproductive Medicine Practice Committee. Repetitive oocyte donation. Fertil Steril. 2008;90(5 Suppl):S194–5.

    Google Scholar 

  32. Practice Committee of the American Society for Reproductive Medicine and Practice Committee of the Society for Assisted Reproductive Technology. Repetitive oocyte donation: a committee opinion. Fertil Steril. 2014;102(4):964–6.

    Google Scholar 

  33. Bodri D, Guillén JJ, Polo A, Trullenque M, Esteve C, Coll O. Complications related to ovarian stimulation and oocyte retrieval in 4052 oocyte donor cycles. Reprod Biomed Online. 2008;17(2):237–43.

    Google Scholar 

  34. Shmorgun D, Claman P, Gysler M, Hemmings R, Cheung AP, Goodrow GJ, Hughes EG, Min JK, Roberts J, Senikas V, Chee-Man Wong B, Young D. The diagnosis and management of ovarian hyperstimulation syndrome. J Obstet Gynaecol Can. 2011;33(11):1156–62.

    Article  Google Scholar 

  35. Mozes M, Bogokowsky H, Antebi E, Lunenfeld B, Rabau E, Serr DM, David A, Salomy M. Thromboembolic phenomena after ovarian stimulation with human gonadotrophins. Lancet. 1965;2(7424):1213–5.

    Article  CAS  Google Scholar 

  36. Cluroe AD, Synek BJ. A fatal case of ovarian hyperstimulation syndrome with cerebral infarction. Pathology. 1995;27(4):344–6.

    Google Scholar 

  37. Tang OS, Ng EH, Wai Cheng P, Chung HP. Cortical vein thrombosis misinterpreted as intracranial haemorrhage in severe ovarian hyperstimulation syndrome: case report. Hum Reprod. 2000;15(9):1913–6.

    Google Scholar 

  38. Semba S, Moriya T, Youssef EM, Sasano H. An autopsy case of ovarian hyperstimulation syndrome with massive pulmonary edema and pleural effusion. Pathol Int. 2000;50(7):549–52.

    Google Scholar 

  39. Kim H-S, Kim M, Seo I-S, Kwon TJ, Ha H, Lee B-w. An autopsy case of severe ovarian hyperstimulation syndrome with multifocal arterial and venous thromboembolism. Korean J Legal Med. 2011;35(1):57–61.

    Google Scholar 

  40. Zaami S. Assisted heterologous fertilization and the right of donor conceived chi1dren to know their biological origins. Clin Ter. 2018;169(1):39–43.

    Google Scholar 

  41. Montanari Vergallo GM, Zaami S, Bruti V, Signore F, Marinelli E. How the legislation in medical assisted procreation has evolved in Italy. Med Law. 2017;36(2):5–28.

    Google Scholar 

  42. Montanari VG, Marinelli E, di Luca NM, Zaami S. Gamete donation: are children entitled to know their genetic origins? A comparison of opposing views. The Italian State of Affairs. Eur J Health Law. 2018;25(3):322–37.

    Article  Google Scholar 

  43. Ridley J. Being an egg donor gave me terminal cancer. The New York Post. 3 Dec 2015.

    Google Scholar 

  44. Fauser BC, Garcia VJ. Breast cancer risk after oocyte donation: should we really be concerned? Reprod Biomed Online. 2017;34(5):439–40.

    Article  Google Scholar 

  45. Lawson AK, Klock SC, Pavone ME, Hirshfeld-Cytron J, Smith KN, Kazer RR. A prospective study of depression and anxiety in female fertility preservation and infertility patients. Fertil Steril. 2014;102(5):1377–84.

    Article  Google Scholar 

  46. Reindollar RH, Regan MM, Neumann PJ, Levine BS, Thornton KL, Alper MM, Goldman MB. A randomized clinical trial to evaluate optimal treatment for unexplained infertility: the fast track and standard treatment (FASTT) trial. Fertil Steril. 2010;94(3):888–99.

    Article  Google Scholar 

  47. Zweifel JE, Rathert MA, Klock SC, Walaski HP, Pritts EA, Olive DL, Lindheim SR. Comparative assessment of pre- and post-donation attitudes towards potential oocyte and embryo disposition and management among ovum donors in an oocyte donation programme. Hum Reprod. 2006;21(5):1325–7.

    Article  Google Scholar 

  48. Gonca S, Gün I, Ovayolu A, Şilfeler D, Sofuoğlu K, Özdamar Ö, Yilmaz A, Tunali G. Effect of lower than expected number of oocyte on the IVF results after oocyte-pickup. Int J Clin Exp Med. 2014;7(7):1853–9.

    PubMed  PubMed Central  Google Scholar 

  49. Christiaens F, Janssenswillen C, Verborgh C, Moerman I, Devroey P, Van Steirteghem A, Camu F. Propofol concentrations in follicular fluid during general anaesthesia for transvaginal oocyte retrieval. Hum Reprod. 1999;14(2):345–8.

    Article  CAS  Google Scholar 

  50. Cohen J, Gilligan A, Esposito W, Schimmel T, Dale B. Ambient air and its potential effects on conception in vitro. Hum Reprod. 1997;12(8):1742–9.

    Article  CAS  Google Scholar 

  51. Cohen J, Gilligan A, Willadsen S. Culture and quality control of embryos. Hum Reprod. 1998;13(Suppl 3):137–44.

    Article  Google Scholar 

  52. Cohen J, Jones HW. In vitro fertilization: the first three decades. In: Gardner DK, editor. In vitro fertilization: a practical approach. 1st ed. New York: Informa Healthcare USA Inc.; 2009. p. 1–13.

    Google Scholar 

  53. van Loendersloot LL, van Wely M, Limpens J, Bossuyt PM, Repping S, van der Veen F. Predictive factors in in vitro fertilization (IVF): a systematic review and meta-analysis. Hum Reprod Update. 2010;16(6):577–89.

    Google Scholar 

  54. Shaban MM, Abdel Moety GA. Role of ultrasonographic markers of ovarian reserve in prediction of IVF and ICSI outcome. Gynecol Endocrinol. 2014;30(4):290–3.

    Google Scholar 

  55. Zaami S, Marinelli E, Montanari Vergallo G. Assessing malpractice lawsuits for death or injuries due to amniotic fluid embolism. Clin Ter. 2017;168(3):220–4.

    Google Scholar 

  56. Frati P, Foldes-Papp Z, Zaami S, Busardò FP. Amniotic fluid embolism: what level of scientific evidence can be drawn? a systematic review. Curr Pharm Biotechnol. 2013;14(14):1157–62.

    Article  CAS  Google Scholar 

  57. Laska LL. Medical malpractice verdicts, settlements & experts. April 2002. Philadelphia (Pa) Court Of Common Pleas. OBG Manag. 2002;14(4):86–8.

    Google Scholar 

  58. Gorrie JJ. Legal Review and Commentary: OB/GYN patient dies after egg harvest: $30 million verdict and settlements. July 1st 2001. Reference: Tony Matteo, MD, as Adm. of the Estate of Suzanne Wester Matteo, MD v. Jerome Check, MD, and Admed Nazari, MD v. Tony Matteo, MD, Holy Redeemer Hospital and Nurse Newhall, Philadelphia Court of Common Pleas. Case settled. Thomas Kline, Esq., of Philadelphia, for the plaintiff.

    Google Scholar 

  59. Egg donor’s death: internal bleeding, ovaries severely enlarged, says report. The Indian Report. July 4th 2014.

    Google Scholar 

  60. Zaami S, Busardò FP. Elective egg freezing: can you really turn back the clock? Eur Rev Med Pharmacol Sci. 2015;19(19):3537–8.

    CAS  PubMed  Google Scholar 

  61. Vergallo GM. Negligence and embryo protection: a new frontier for medical law? Med Law. 2014;33(1):2–13.

    Google Scholar 

  62. Levine AD. Self-regulation, compensation, and the ethical recruitment of oocyte donors. Hastings Cent Rep. 2010;40(2):25–36.

    Article  Google Scholar 

  63. Cone KL. Family law—egg donation and stem cell research—eggs for sale: the scrambled state of legislation in the human egg market. U Ark Little Rock L Rev. 2012;35:189.

    Google Scholar 

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Zaami, S., Stark, M., Malvasi, A., Marinelli, E. (2020). Eggs Retrieval. Adverse Events, Complications, and Malpractice: A Medicolegal Perspective. In: Malvasi, A., Baldini, D. (eds) Pick Up and Oocyte Management. Springer, Cham. https://doi.org/10.1007/978-3-030-28741-2_21

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  • DOI: https://doi.org/10.1007/978-3-030-28741-2_21

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