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Proangiogenic and Proarteriogenic Therapies in Coronary Microvasculature Dysfunction

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Microcirculation

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Abstract

Advances on early reperfusion therapies focused on the revascularization of the coronary epicardial arteries have lead, in the last decades, to reduced mortality in acute myocardial infarction (MI) patients. However, a large proportion of patients show inadequate myocardial perfusion because of dysfunction of the microcirculation. Importantly, impaired microvascular reperfusion correlates with the extension of infarct size. Hence, the high prevalence of microvascular dysfunction after reperfusion therapies and the poor prognostic associated with this process supports the need to search for therapeutic strategies aimed to restore the microvascular network and allow the diffusion of oxygen and nutrients to the ischemic damaged tissues. Any advancement on the molecular and cellular mechanisms that induce the repair process of microvascular dysfunction is of great interest.

In this chapter we will review the different proteins and cells known to participate in the arteriogenic and angiogenic processes to repair the coronary microcirculation. In addition, we will also discuss the potential pharmacological approaches and angiogenic and arteriogenic therapies that may promote microvasculature recovery.

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Funding

 This work was supported by the Spanish Ministry of Economy and Competition and FEDER funds [SAF2016-76819-R to L.B. and SAF2015-71653-R to G.V.]; the Instituto de Salud Carlos III [CIBERCV CN16/11/00411 to L.B., TERCEL RD16/0011/018 to L.B. and FIS2016-02014 to M.B.P.]; the Generalitat of Catalunya-Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat [2014SGR1303 to L.B.]; the Fundacion Investigación Cardiovascular to L.B.; and the Spanish Society of Cardiology [SEC2015 to M.B.P.].

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Authors and Affiliations

  1. Cardiovascular Program ICCC, Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    Lina Badimon

  2. Cardiovascular Research Chair, UAB, Barcelona, Spain

    Lina Badimon, Gemma Vilahur & Maria Borrell-Pages

  3. CIBER-CV, Instituto de Salud Carlos III, Madrid, Spain

    Lina Badimon, Gemma Vilahur & Maria Borrell-Pages

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  1. Lina Badimon
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  2. Gemma Vilahur
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  3. Maria Borrell-Pages
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Correspondence to Lina Badimon .

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Editors and Affiliations

  1. Department of Cardiology, Carol Davila University of Medicine, Bucharest, Romania

    Maria Dorobantu

  2. Cardiovascular Program-ICCC, IR- Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain

    Lina Badimon

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Badimon, L., Vilahur, G., Borrell-Pages, M. (2020). Proangiogenic and Proarteriogenic Therapies in Coronary Microvasculature Dysfunction. In: Dorobantu, M., Badimon, L. (eds) Microcirculation. Springer, Cham. https://doi.org/10.1007/978-3-030-28199-1_17

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