Abstract
Achalasia is a rare primary esophageal motility disorder that causes mostly progressive dysphagia and regurgitation. The goal of therapy for achalasia is to provide symptom relief by reducing esophageal outflow resistance by disrupting the muscles at the esophagogastric junction (EGJ) to allow emptying by gravity. Although there are several options to achieve this goal, surgical myotomy with partial fundoplication has been shown to be very effective and able to strike a balance between relief of symptoms and control of abnormal GER. Since reflux of gastric contents into the aperistaltic esophagus may cause esophagitis, peptic strictures, Barrett’s esophagus, and even esophageal cancer, the addition of a partial fundoplication is very important. In this chapter, we will discuss the pros and cons of the different types of fundoplication.
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References
Boeckxstaens GE, Zaninotto G, Richter JE. Achalasia. Lancet. 2014;383(9911):83–93. https://doi.org/10.1016/S0140-6736(13)60651-0.
Samo S, Carlson DA, Gregory DL, Gawel SH, Pandolfino JE, Kahrilas PJ. Incidence and prevalence of achalasia in Central Chicago, 2004–2014, since the widespread use of high-resolution manometry. Clin Gastroenterol Hepatol. 2014;15(1):34–48. https://doi.org/10.1016/j.cgh.2016.08.030.
Zaninotto G, Bennett C, Boeckxstaens G, et al. The 2018 ISDE achalasia guidelines. Dis Esophagus. 2018;31(9):1–29. https://doi.org/10.1093/dote/doy071.
Enestvedt BK, Lucas Williams J, Sonnenberg A. Epidemiology and practice patterns of achalasia in a large multi-center database. Aliment Pharmacol Ther. 2013;33(11):1–9. https://doi.org/10.1111/j.1365-2036.2011.04655.x.Epidemiology.
Molena D, Yang SC. Surgical management of end-stage achalasia. Semin Thorac Cardiovasc Surg. 2012;24(1):19–26. https://doi.org/10.1053/j.semtcvs.2012.01.015.
Schlottmann F, Patti MG. Esophageal achalasia: current diagnosis and treatment. Expert Rev Gastroenterol Hepatol. 2018;12(7):711–21. https://doi.org/10.1080/17474124.2018.1481748.
Pressman A, Behar J. Etiology and pathogenesis of idiopathic achalasia. J Clin Gastroenterol. 2017;51(3):195–202. https://doi.org/10.1097/MCG.0000000000000780.
Gockel I, Bohl JRE, Doostkam S, Eckardt VF, Junginger T. Spectrum of histopathologic findings in patients with achalasia reflects different etiologies. J Gastroenterol Hepatol. 2006;21(4):727–33. https://doi.org/10.1111/j.1440-1746.2006.04250.x.
Goyal RK, Chaudhury A. Pathogenesis of achalasia: lessons from mutant mice. Gastroenterology. 2010;139(4):1086–90. https://doi.org/10.1053/j.gastro.2010.08.013.
Schlottmann F, Herbella F, Allaix ME, Patti MG. Modern management of esophageal achalasia: from pathophysiology to treatment. Curr Probl Surg. 2018;55(1):10–37. https://doi.org/10.1067/j.cpsurg.2018.01.001.
Leeuwenburgh I, Scholten P, Alderliesten J, et al. Long-term esophageal cancer risk in patients with primary achalasia: a prospective study. Am J Gastroenterol. 2010;105(10):2144–9. https://doi.org/10.1038/ajg.2010.263.
Tustumi F, Bernardo WM, da Rocha JRM, et al. Esophageal achalasia: a risk factor for carcinoma. A systematic review and meta-analysis. Dis Esophagus. 2017;30(10):1–8. https://doi.org/10.1093/dote/dox072.
Stefanidis D, Richardson W, Farrell TM, Kohn GP, Augenstein V, Fanelli RD. SAGES guidelines for the surgical treatment of esophageal achalasia. Surg Endosc Other Interv Tech. 2012;26(2):296–311. https://doi.org/10.1007/s00464-011-2017-2.
Yamaguchi D, Tsuruoka N, Sakata Y, Shimoda R, Fujimoto K, Iwakiri R. Safety and efficacy of botulinum toxin injection therapy for esophageal achalasia in Japan. J Clin Biochem Nutr. 2015;57(3):239–43. https://doi.org/10.3164/jcbn.15-47.
Inoue H, Sato H, Ikeda H, et al. Per-Oral endoscopic Myotomy: a series of 500 patients. J Am Coll Surg. 2015;221(2):256–64. https://doi.org/10.1016/j.jamcollsurg.2015.03.057.
Lopushinsky SR, Urbach DR. Pneumatic dilatation and surgical myotomy for achalasia. J Am Med Assoc. 2006;296(18):2227–33. https://doi.org/10.1001/jama.296.18.2227.
Weber CE, Davis CS, Kramer HJ, Gibbs JT, Robles L, Fisichella PM. Medium and long-term outcomes after pneumatic dilation or laparoscopic heller myotomy for achalasia: a meta-analysis. Surg Laparosc Endosc Percutaneous Tech. 2012;22(4):289–96. https://doi.org/10.1097/SLE.0b013e31825a2478.
Campos GM, Vittinghoff E, Rabl C, et al. Endoscopic and surgical treatments for achalasia: a systematic review and meta-analysis. Ann Surg. 2009;249(1):45–57. https://doi.org/10.1097/SLA.0b013e31818e43ab.
Schoenberg MB, Marx S, Kersten JF, et al. Laparoscopic Heller myotomy versus endoscopic balloon dilatation for the treatment of achalasia: a network meta-analysis. Ann Surg. 2013;258(6):943–52. https://doi.org/10.1097/SLA.0000000000000212.
Yaghoobi M, Mayrand S, Martel M, Roshan-Afshar I, Bijarchi R, Barkun A. Laparoscopic Heller’s myotomy versus pneumatic dilation in the treatment of idiopathic achalasia: a meta-analysis of randomized, controlled trials. Gastrointest Endosc. 2013;78(3):468–75. https://doi.org/10.1016/j.gie.2013.03.1335.
Patti MG, Andolfi C, Bowers SP, Soper NJ. POEM vs laparoscopic Heller Myotomy and fundoplication: which is now the gold standard for treatment of achalasia? J Gastrointest Surg. 2017;21(2):207–14. https://doi.org/10.1007/s11605-016-3310-0.
Zaninotto G, Costantini M, Rizzetto C, et al. Four hundred laparoscopic myotomies for esophageal achalasia a single centre experience. Ann Surg. 2008;248(6):986–93. https://doi.org/10.1097/SLA.0b013e3181907bdd.
SAGES. Quality of life outcomes after Heller Myotomy for achalasia comparing Dor and Toupet Fundoplications. https://www.sages.org/meetings/annual-meeting/abstracts-archive/quality-of-life-outcomes-after-heller-myotomy-for-achalasia-comparing-dor-and-toupet-fundoplications/.
Wei MT, He YZ, Deng XB, et al. Is Dor fundoplication optimum after laparoscopic Heller myotomy for achalasia? A meta-analysis. World J Gastroenterol. 2013;19(43):7804–12. https://doi.org/10.3748/wjg.v19.i43.7804.
Andolfi C, Baffy G, Fisichella PM. Whose patient is it? The path to multidisciplinary management of achalasia. J Surg Res. 2018;228:8–13. https://doi.org/10.1016/j.jss.2018.02.047.
Pellegrini C, Wetter LA, Patti M, et al. Thoracoscopic esophagomyotomy. Initial experience with a new approach for the treatment of achalasia. Ann Surg. 1992;216(3):291–6; discussion 296–9. http://www.ncbi.nlm.nih.gov/pubmed/1417178.
Patti MG, Pellegrini CA, Horgan S, et al. Minimally invasive surgery for achalasia: an 8-year experience with 168 patients. Ann Surg. 1999;230(4):587–93; discussion 593–4. https://doi.org/10.1097/MPG.0b013e318032062f.
Richards WO, Torquati A, Holzman MD, et al. Heller myotomy versus heller myotomy with dor fundoplication for achalasia: a prospective randomized double-blind clinical trial. Ann Surg. 2004;240(3):405–15. https://doi.org/10.1097/01.sla.0000136940.32255.51.
Rebecchi F, Allaix ME, Schlottmann F, Patti MGMM. Laparoscopic Heller myotomy and fundoplication: what is the evidence ? Am Surg. 2018;84(4):481–9. http://libproxy.lib.unc.edu/login?url=https://search.proquest.com/docview/2042209620?accountid=14244.
Rawlings A, Soper NJ, Oelschlager B, et al. Laparoscopic Dor versus Toupet fundoplication following Heller myotomy for achalasia: results of a multicenter, prospective, randomized-controlled trial. Surg Endosc Other Interv Tech. 2012;26(1):18–26. https://doi.org/10.1007/s00464-011-1822-y.
Tomasko JM, Augustin T, Tran TT, Haluck RS, Rogers AM, Lyn-Sue JR. Quality of life comparing Dor and Toupet after Heller Myotomy for achalasia. JSLS J Soc Laparoendosc Surg. 2014;18(3):e2014.00191. https://doi.org/10.4293/JSLS.2014.00191.
Nissen R. A simple operation for control of reflux esophagitis. Schweiz Med Wochenschr. 1956;86(Suppl 20):590–2. http://www.ncbi.nlm.nih.gov/pubmed/13337262.
Dor J, Humbert P, Dor V, Figarella J. L’interet de la technique de Nissen modifiee dans la prevention du reflux apres cardiomyotomie extramuqueuse de Heller. Mem Acad Chir. 1962;88:877–83.
Toupet A. Technique d’oesophago-gastroplastie avec phréno-gastropexie appliquée dans la cure radicale des hernies hiatales et comme complément de l’opération de Heller dans les cardiospasmes. Acad Chir. 1963;89:394–9.
Wang PC, Sharp KW, Holzman MD, Clements RH, Holcomb GW, Richards WO. The outcome of laparoscopic Heller myotomy without antireflux procedure in patients with achalasia. Am Surg. 1998;64(6):515–20; discussion 521. http://www.ncbi.nlm.nih.gov/pubmed/9619171.
Diamantis T, Pikoulis E, Felekouras E, et al. Laparoscopic esophagomyotomy for achalasia without a complementary antireflux procedure. J Laparoendosc Adv Surg Tech. 2006;16(4):345–9. https://doi.org/10.1089/lap.2006.16.345.
Falkenback D, Johansson J, Öberg S, et al. Heller’s esophagomyotomy with or without a 360° floppy Nissen fundoplication for achalasia. Long-term results from a prospective randomized study. Dis Esophagus. 2003;16(4):284–90. https://doi.org/10.1111/j.1442-2050.2003.00348.x.
Patti MG, Robinson T, Galvani C, et al. Total fundoplication is superior to partial fundoplication even when esophageal peristalsis is weak. J Am Coll Surg. 2004;198(6):863–70. https://doi.org/10.1016/j.jamcollsurg.2004.01.029.
Donahue PE, Schlesinger PK, Sluss KF, et al. Esophagocardiomyotomy–floppy Nissen fundoplication effectively treats achalasia without causing esophageal obstruction. Surgery. 1994;116(4):719–24; discussion 724–5. http://www.ncbi.nlm.nih.gov/pubmed/7940171.
Patti MG, Herbella FA. Fundoplication after laparoscopic Heller Myotomy for esophageal achalasia: what type? J Gastrointest Surg. 2010;14(9):1453–8. https://doi.org/10.1007/s11605-010-1188-9.
Rebecchi F, Giaccone C, Farinella E, Campaci R, Morino M. Randomized controlled trial of laparoscopic heller myotomy plus dor fundoplication versus nissen fundoplication for achalasialong-term results. Ann Surg. 2008;248(6):1023–9. https://doi.org/10.1097/SLA.0b013e318190a776.
Topart P, Deschamps C, Taillefer R, Duranceau A. Long-term effect of total fundoplication on the myotomized esophagus. Ann Thorac Surg. 1992;54(6):1046–52. https://doi.org/10.1016/0003-4975(92)90068-F.
Rossetti G, Brusciano L, Amato G, et al. A total fundoplication is not an obstacle to esophageal emptying after heller myotomy for achalasia: results of a long-term follow up. Ann Surg. 2005;241(4):614–21. http://www.ncbi.nlm.nih.gov/pubmed/15798463.
di Martino N, Brillantino A, Monaco L, et al. Laparoscopic calibrated total vs partial fundoplication following heller myotomy for oesophageal achalasia. World J Gastroenterol. 2011;17(29):3431–40. https://doi.org/10.3748/wjg.v17.i29.3431.
Ortiz A, De Haro LFM, Parrilla P, et al. Very long-term objective evaluation of Heller myotomy plus posterior partial fundoplication in patients with achalasia of the cardia. Ann Surg. 2008;247(2):258–64. https://doi.org/10.1097/SLA.0b013e318159d7dd.
Kumagai K, Kjellin A, Tsai JA, et al. Toupet versus Dor as a procedure to prevent reflux after cardiomyotomy for achalasia: results of a randomised clinical trial. Int J Surg. 2014;12(7):673–80. https://doi.org/10.1016/j.ijsu.2014.05.077.
Kurian AA, Bhayani N, Sharata A, Reavis K, Dunst CM, Swanström LL. Partial anterior vs partial posterior fundoplication following transabdominal esophagocardiomyotomy for achalasia of the esophagus: meta-regression of objective postoperative gastroesophageal reflux and dysphagia. JAMA Surg. 2013;148(1):85–90. https://doi.org/10.1001/jamasurgery.2013.409.
Hunter JG, Trus TL, Branum GD, Waring JP. Laparoscopic Heller myotomy and fundoplication for achalasia. Ann Surg. 1997;225(6):655–64; discussion 664–5. http://www.ncbi.nlm.nih.gov/pubmed/9230806.
Tatum RP, Pellegrini CA. How i do it: laparoscopic heller myotomy with toupet fundoplication for achalasia. J Gastrointest Surg. 2009;13(6):1120–4. https://doi.org/10.1007/s11605-008-0585-9.
Patti MG, Fisichella PM. Laparoscopic heller myotomy and dor fundoplication for esophageal achalasia. How i do it. J Gastrointest Surg. 2008;12(4):764–6. https://doi.org/10.1007/s11605-007-0368-8.
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Farrell, T.M., Di Corpo, M., Patti, M.G. (2020). Laparoscopic Heller Myotomy and Posterior Partial Fundoplication. In: Patti, M., Di Corpo, M., Schlottmann, F. (eds) Foregut Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-27592-1_7
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