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Diagnosis, Indication and Timing

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Multimodality Imaging for Cardiac Valvular Interventions, Volume 1 Aortic Valve

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Abstract

In this first chapter, the role taken by the different imaging modalities for the diagnosis and timing of the aortic valvular diseases will be described.

The key function of multimodality imaging (transthoracic and transesophageal echocardiography, computed cardiac tomography, cardiac magnetic resonance imaging, nuclear radiology and angiography) will be illustrated in the context of aortic stenosis pathology, low-flow low-gradient aortic stenosis and aortic valve insufficiency. This will include which imaging techniques to adopt for the best stratification and quantification of valve diseases, according to international guidelines.

In the section covering anatomical assessment, the various aortic valve morphologies are discussed, in particular the comparison between bicuspid and tricuspid ones.

Anatomical criteria for understanding surgical reparability and the analysis of valve calcifications will also be discussed.

In concluding, the timing and functional evaluation of the pathology, the role and imaging techniques in the evaluation of biventricular contractility and relative contractile reserve in case of low-flow low-gradient are discussed.

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References

  1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M. Burden of valvular heart diseases: a population-based study. Lancet. 2006;368(9540):1005–11.

    Article  PubMed  Google Scholar 

  2. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Fleisher LA, Jneid H, Mack MJ, McLeod CJ, O'Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A. 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2017;135(25):e1159–95.

    Article  PubMed  Google Scholar 

  3. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, O’Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM 3rd, Thomas JD. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(22):e57–185.

    Article  PubMed  Google Scholar 

  4. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Munoz D, Rosenhek R, Sjogren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739–91.

    Article  PubMed  Google Scholar 

  5. Mitchell C, Rahko PS, Blauwet LA, Canaday B, Finstuen JA, Foster MC, Horton K, Ogunyankin KO, Palma RA, Velazquez EJ. Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2019;32(1):1–64.

    Article  PubMed  Google Scholar 

  6. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU. Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2015;16(3):233–70.

    Article  PubMed  Google Scholar 

  7. Zoghbi WA, Adams D, Bonow RO, Enriquez-Sarano M, Foster E, Grayburn PA, Hahn RT, Han Y, Hung J, Lang RM, Little SH, Shah DJ, Shernan S, Thavendiranathan P, Thomas JD, Weissman NJ. Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: a report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2017;30(4):303–71.

    Article  PubMed  Google Scholar 

  8. Lancellotti P, Tribouilloy C, Hagendorff A, Popescu BA, Edvardsen T, Pierard LA, Badano L, Zamorano JL. Recommendations for the echocardiographic assessment of native valvular regurgitation: an executive summary from the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2013;14(7):611–44.

    Article  PubMed  Google Scholar 

  9. Baumgartner H, Hung J, Bermejo J, Chambers JB, Evangelista A, Griffin BP, Iung B, Otto CM, Pellikka PA, Quinones M. Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice. J Am Soc Echocardiogr. 2009;22(1):1–23; quiz 101-2.

    Article  PubMed  Google Scholar 

  10. Feuchtner GM, Dichtl W, Friedrich GJ, Frick M, Alber H, Schachner T, Bonatti J, Mallouhi A, Frede T, Pachinger O, zur Nedden D, Muller S. Multislice computed tomography for detection of patients with aortic valve stenosis and quantification of severity. J Am Coll Cardiol. 2006;47(7):1410–7.

    Article  PubMed  Google Scholar 

  11. Pawade TA, Newby DE, Dweck MR. Calcification in aortic stenosis: the skeleton key. J Am Coll Cardiol. 2015;66(5):561–77.

    Article  PubMed  Google Scholar 

  12. Ko SM, Song MG, Hwang HK. Evaluation of the aortic and mitral valves with cardiac computed tomography and cardiac magnetic resonance imaging. Int J Cardiovasc Imaging. 2012;28(Suppl 2):109–27.

    Article  PubMed  Google Scholar 

  13. Achenbach S, Delgado V, Hausleiter J, Schoenhagen P, Min JK, Leipsic JA. SCCT expert consensus document on computed tomography imaging before transcatheter aortic valve implantation (TAVI)/transcatheter aortic valve replacement (TAVR). J Cardiovasc Comput Tomogr. 2012;6(6):366–80.

    Article  PubMed  Google Scholar 

  14. Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-Barwolf C, Levang OW, Tornos P, Vanoverschelde JL, Vermeer F, Boersma E, Ravaud P, Vahanian A. A prospective survey of patients with valvular heart disease in Europe: the Euro Heart Survey on Valvular Heart Disease. Eur Heart J. 2003;24(13):1231–43.

    Article  PubMed  Google Scholar 

  15. Baumgartner HC, Hung JC-C, Bermejo J, Chambers JB, Edvardsen T, Goldstein S, Lancellotti P, LeFevre M, Miller F Jr, Otto CM. Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2017;18(3):254–75.

    Article  Google Scholar 

  16. Currie PJ, Seward JB, Reeder GS, Vlietstra RE, Bresnahan DR, Bresnahan JF, Smith HC, Hagler DJ, Tajik AJ. Continuous-wave Doppler echocardiographic assessment of severity of calcific aortic stenosis: a simultaneous Doppler-catheter correlative study in 100 adult patients. Circulation. 1985;71(6):1162–9.

    Article  CAS  PubMed  Google Scholar 

  17. Smith MD, Kwan OL, DeMaria AN. Value and limitations of continuous-wave Doppler echocardiography in estimating severity of valvular stenosis. JAMA. 1986;255(22):3145–51.

    Article  CAS  PubMed  Google Scholar 

  18. Burwash IG, Forbes AD, Sadahiro M, Verrier ED, Pearlman AS, Thomas R, Kraft C, Otto CM. Echocardiographic volume flow and stenosis severity measures with changing flow rate in aortic stenosis. Am J Phys. 1993;265(5 Pt 2):H1734–43.

    CAS  Google Scholar 

  19. Baumgartner H, Stefenelli T, Niederberger J, Schima H, Maurer G. “Overestimation” of catheter gradients by Doppler ultrasound in patients with aortic stenosis: a predictable manifestation of pressure recovery. J Am Coll Cardiol. 1999;33(6):1655–61.

    Article  CAS  PubMed  Google Scholar 

  20. Quinones MA, Otto CM, Stoddard M, Waggoner A, Zoghbi WA. Recommendations for quantification of Doppler echocardiography: a report from the Doppler Quantification Task Force of the Nomenclature and Standards Committee of the American Society of Echocardiography. J Am Soc Echocardiogr. 2002;15(2):167–84.

    Article  PubMed  Google Scholar 

  21. Lancellotti P, Tribouilloy C, Hagendorff A, Moura L, Popescu BA, Agricola E, Monin JL, Pierard LA, Badano L, Zamorano JL. European Association of Echocardiography recommendations for the assessment of valvular regurgitation. Part 1: aortic and pulmonary regurgitation (native valve disease). Eur J Echocardiogr. 2010;11(3):223–44.

    Article  PubMed  Google Scholar 

  22. Niederberger J, Schima H, Maurer G, Baumgartner H. Importance of pressure recovery for the assessment of aortic stenosis by Doppler ultrasound. Role of aortic size, aortic valve area, and direction of the stenotic jet in vitro. Circulation. 1996;94(8):1934–40.

    Article  CAS  PubMed  Google Scholar 

  23. Schlosser T, Malyar N, Jochims M, Breuckmann F, Hunold P, Bruder O, Erbel R, Barkhausen J. Quantification of aortic valve stenosis in MRI-comparison of steady-state free precession and fast low-angle shot sequences. Eur Radiol. 2007;17(5):1284–90.

    Article  PubMed  Google Scholar 

  24. Myerson SG. Heart valve disease: investigation by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2012;14:7.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Gatehouse PD, Keegan J, Crowe LA, Masood S, Mohiaddin RH, Kreitner KF, Firmin DN. Applications of phase-contrast flow and velocity imaging in cardiovascular MRI. Eur Radiol. 2005;15(10):2172–84.

    Article  PubMed  Google Scholar 

  26. Cawley PJ, Maki JH, Otto CM. Cardiovascular magnetic resonance imaging for valvular heart disease: technique and validation. Circulation. 2009;119(3):468–78.

    Article  PubMed  Google Scholar 

  27. Bellenger NG, Burgess MI, Ray SG, Lahiri A, Coats AJ, Cleland JG, Pennell DJ. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur Heart J. 2000;21(16):1387–96.

    Article  CAS  PubMed  Google Scholar 

  28. Grothues F, Smith GC, Moon JC, Bellenger NG, Collins P, Klein HU, Pennell DJ. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol. 2002;90(1):29–34.

    Article  PubMed  Google Scholar 

  29. Dweck MR, Joshi S, Murigu T, Alpendurada F, Jabbour A, Melina G, Banya W, Gulati A, Roussin I, Raza S, Prasad NA, Wage R, Quarto C, Angeloni E, Refice S, Sheppard M, Cook SA, Kilner PJ, Pennell DJ, Newby DE, Mohiaddin RH, Pepper J, Prasad SK. Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis. J Am Coll Cardiol. 2011;58(12):1271–9.

    Article  PubMed  Google Scholar 

  30. Nigri M, Azevedo CF, Rochitte CE, Schraibman V, Tarasoutchi F, Pommerantzeff PM, Brandao CM, Sampaio RO, Parga JR, Avila LF, Spina GS, Grinberg M. Contrast-enhanced magnetic resonance imaging identifies focal regions of intramyocardial fibrosis in patients with severe aortic valve disease: Correlation with quantitative histopathology. Am Heart J. 2009;157(2):361–8.

    Article  PubMed  Google Scholar 

  31. Stankovic Z, Allen BD, Garcia J, Jarvis KB, Markl M. 4D flow imaging with MRI. Cardiovasc Diagn Ther. 2014;4(2):173–92.

    PubMed  PubMed Central  Google Scholar 

  32. Markl M, Wallis W, Harloff A. Reproducibility of flow and wall shear stress analysis using flow-sensitive four-dimensional MRI. J Magn Reson Imaging. 2011;33(4):988–94.

    Article  PubMed  Google Scholar 

  33. Bock J, Frydrychowicz A, Lorenz R, Hirtler D, Barker AJ, Johnson KM, Arnold R, Burkhardt H, Hennig J, Markl M. In vivo noninvasive 4D pressure difference mapping in the human aorta: phantom comparison and application in healthy volunteers and patients. Magn Reson Med. 2011;66(4):1079–88.

    Article  PubMed  Google Scholar 

  34. Dyverfeldt P, Gardhagen R, Sigfridsson A, Karlsson M, Ebbers T. On MRI turbulence quantification. Magn Reson Imaging. 2009;27(7):913–22.

    Article  PubMed  Google Scholar 

  35. Mahadevia R, Barker AJ, Schnell S, Entezari P, Kansal P, Fedak PW, Malaisrie SC, McCarthy P, Collins J, Carr J, Markl M. Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy. Circulation. 2014;129(6):673–82.

    Article  CAS  PubMed  Google Scholar 

  36. Omran H, Schmidt H, Hackenbroch M, Illien S, Bernhardt P, von der Recke G, Fimmers R, Flacke S, Layer G, Pohl C, Luderitz B, Schild H, Sommer T. Silent and apparent cerebral embolism after retrograde catheterisation of the aortic valve in valvular stenosis: a prospective, randomised study. Lancet. 2003;361(9365):1241–6.

    Article  PubMed  Google Scholar 

  37. Oh JK, Taliercio CP, Holmes DR Jr, Reeder GS, Bailey KR, Seward JB, Tajik AJ. Prediction of the severity of aortic stenosis by Doppler aortic valve area determination: prospective Doppler-catheterization correlation in 100 patients. J Am Coll Cardiol. 1988;11(6):1227–34.

    Article  CAS  PubMed  Google Scholar 

  38. Otto CM, Pearlman AS, Comess KA, Reamer RP, Janko CL, Huntsman LL. Determination of the stenotic aortic valve area in adults using Doppler echocardiography. J Am Coll Cardiol. 1986;7(3):509–17.

    Article  CAS  PubMed  Google Scholar 

  39. Zoghbi WA, Farmer KL, Soto JG, Nelson JG, Quinones MA. Accurate noninvasive quantification of stenotic aortic valve area by Doppler echocardiography. Circulation. 1986;73(3):452–9.

    Article  CAS  PubMed  Google Scholar 

  40. Evangelista A, Garcia-Dorado D, Garcia del Castillo H, Gonzalez-Alujas T, Soler-Soler J. Cardiac index quantification by Doppler ultrasound in patients without left ventricular outflow tract abnormalities. J Am Coll Cardiol. 1995;25(3):710–6.

    Article  CAS  PubMed  Google Scholar 

  41. Pibarot P, Clavel MA. Left ventricular outflow tract geometry and dynamics in aortic stenosis: implications for the echocardiographic assessment of aortic valve area. J Am Soc Echocardiogr. 2015;28(11):1267–9.

    Article  PubMed  Google Scholar 

  42. Michelena HI, Margaryan E, Miller FA, Eleid M, Maalouf J, Suri R, Messika-Zeitoun D, Pellikka PA, Enriquez-Sarano M. Inconsistent echocardiographic grading of aortic stenosis: is the left ventricular outflow tract important? Heart. 2013;99(13):921–31.

    Article  PubMed  Google Scholar 

  43. LaBounty TM, Miyasaka R, Chetcuti S, Grossman PM, Deeb GM, Patel HJ, Booher A, Patel S, Bach DS. Annulus instead of LVOT diameter improves agreement between echocardiography effective orifice area and invasive aortic valve area. JACC Cardiovasc Imaging. 2014;7(10):1065–6.

    Article  PubMed  Google Scholar 

  44. Mehrotra P, Flynn AW, Jansen K, Tan TC, Mak G, Julien HM, Zeng X, Picard MH, Passeri JJ, Hung J. Differential left ventricular outflow tract remodeling and dynamics in aortic stenosis. J Am Soc Echocardiogr. 2015;28(11):1259–66.

    Article  PubMed  Google Scholar 

  45. Caballero L, Saura D, Oliva-Sandoval MJ, Gonzalez-Carrillo J, Espinosa MD, Garcia-Navarro M, Valdes M, Lancellotti P, de la Morena G. Three-dimensional morphology of the left ventricular outflow tract: impact on grading aortic stenosis severity. J Am Soc Echocardiogr. 2017;30(1):28–35.

    Article  PubMed  Google Scholar 

  46. Hahn RT, Pibarot P. Accurate measurement of left ventricular outflow tract diameter: comment on the updated recommendations for the echocardiographic assessment of aortic valve stenosis. J Am Soc Echocardiogr. 2017;30(10):1038–41.

    Article  PubMed  Google Scholar 

  47. Saitoh T, Shiota M, Izumo M, Gurudevan SV, Tolstrup K, Siegel RJ, Shiota T. Comparison of left ventricular outflow geometry and aortic valve area in patients with aortic stenosis by 2-dimensional versus 3-dimensional echocardiography. Am J Cardiol. 2012;109(11):1626–31.

    Article  PubMed  Google Scholar 

  48. Rosenhek R, Binder T, Porenta G, Lang I, Christ G, Schemper M, Maurer G, Baumgartner H. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med. 2000;343(9):611–7.

    Article  CAS  PubMed  Google Scholar 

  49. Otto CM, Burwash IG, Legget ME, Munt BI, Fujioka M, Healy NL, Kraft CD, Miyake-Hull CY, Schwaegler RG. Prospective study of asymptomatic valvular aortic stenosis. Clinical, echocardiographic, and exercise predictors of outcome. Circulation. 1997;95(9):2262–70.

    Article  CAS  PubMed  Google Scholar 

  50. Kim CJ, Berglund H, Nishioka T, Luo H, Siegel RJ. Correspondence of aortic valve area determination from transesophageal echocardiography, transthoracic echocardiography, and cardiac catheterization. Am Heart J. 1996;132(6):1163–72.

    Article  CAS  PubMed  Google Scholar 

  51. Lancellotti P, Lebois F, Simon M, Tombeux C, Chauvel C, Pierard LA. Prognostic importance of quantitative exercise Doppler echocardiography in asymptomatic valvular aortic stenosis. Circulation. 2005;112(9 Suppl):I377–82.

    PubMed  Google Scholar 

  52. Okura H, Yoshida K, Hozumi T, Akasaka T, Yoshikawa J. Planimetry and transthoracic two-dimensional echocardiography in noninvasive assessment of aortic valve area in patients with valvular aortic stenosis. J Am Coll Cardiol. 1997;30(3):753–9.

    Article  CAS  PubMed  Google Scholar 

  53. Cormier B, Iung B, Porte JM, Barbant S, Vahanian A. Value of multiplane transesophageal echocardiography in determining aortic valve area in aortic stenosis. Am J Cardiol. 1996;77(10):882–5.

    Article  CAS  PubMed  Google Scholar 

  54. Stoddard MF, Arce J, Liddell NE, Peters G, Dillon S, Kupersmith J. Two-dimensional transesophageal echocardiographic determination of aortic valve area in adults with aortic stenosis. Am Heart J. 1991;122(5):1415–22.

    Article  CAS  PubMed  Google Scholar 

  55. Pontone G, Andreini D, Bartorelli AL, Bertella E, Cortinovis S, Mushtaq S, Annoni A, Formenti A, Baggiano A, Conte E, Tamborini G, Muratori M, Gripari P, Bovis F, Veglia F, Foti C, Alamanni F, Ballerini G, Fiorentini C, Pepi M. Aortic annulus area assessment by multidetector computed tomography for predicting paravalvular regurgitation in patients undergoing balloon-expandable transcatheter aortic valve implantation: a comparison with transthoracic and transesophageal echocardiography. Am Heart J. 2012;164(4):576–84.

    Article  PubMed  Google Scholar 

  56. Nguyen G, Leipsic J. Cardiac computed tomography and computed tomography angiography in the evaluation of patients prior to transcatheter aortic valve implantation. Curr Opin Cardiol. 2013;28(5):497–504.

    Article  PubMed  Google Scholar 

  57. Blais C, Burwash IG, Mundigler G, Dumesnil JG, Loho N, Rader F, Baumgartner H, Beanlands RS, Chayer B, Kadem L, Garcia D, Durand LG, Pibarot P. Projected valve area at normal flow rate improves the assessment of stenosis severity in patients with low-flow, low-gradient aortic stenosis: the multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) study. Circulation. 2006;113(5):711–21.

    Article  PubMed  Google Scholar 

  58. Monin JL, Monchi M, Gest V, Duval-Moulin AM, Dubois-Rande JL, Gueret P. Aortic stenosis with severe left ventricular dysfunction and low transvalvular pressure gradients: risk stratification by low-dose dobutamine echocardiography. J Am Coll Cardiol. 2001;37(8):2101–7.

    Article  CAS  PubMed  Google Scholar 

  59. Monin JL, Quere JP, Monchi M, Petit H, Baleynaud S, Chauvel C, Pop C, Ohlmann P, Lelguen C, Dehant P, Tribouilloy C, Gueret P. Low-gradient aortic stenosis: operative risk stratification and predictors for long-term outcome: a multicenter study using dobutamine stress hemodynamics. Circulation. 2003;108(3):319–24.

    Article  PubMed  Google Scholar 

  60. Lancellotti P, Pellikka PA, Budts W, Chaudhry FA, Donal E, Dulgheru R, Edvardsen T, Garbi M, Ha JW, Kane GC, Kreeger J, Mertens L, Pibarot P, Picano E, Ryan T, Tsutsui JM, Varga A. The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. Eur Heart J Cardiovasc Imaging. 2016;17(11):1191–229.

    Article  PubMed  Google Scholar 

  61. Barkhausen J, Ruehm SG, Goyen M, Buck T, Laub G, Debatin JF. MR evaluation of ventricular function: true fast imaging with steady-state precession versus fast low-angle shot cine MR imaging: feasibility study. Radiology. 2001;219(1):264–9.

    Article  CAS  PubMed  Google Scholar 

  62. Sommer THM KR, Axel L,. Evaluation of aortic stenosis by direct planimetric assessment of the aortic valve area using steady-state free precession sequences (balanced FFE). J Cardiovasc Magn Reson. 2002;4.

    Google Scholar 

  63. Kupfahl C, Honold M, Meinhardt G, Vogelsberg H, Wagner A, Mahrholdt H, Sechtem U. Evaluation of aortic stenosis by cardiovascular magnetic resonance imaging: comparison with established routine clinical techniques. Heart. 2004;90(8):893–901.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Debl K, Djavidani B, Seitz J, Nitz W, Schmid FX, Muders F, Buchner S, Feuerbach S, Riegger G, Luchner A. Planimetry of aortic valve area in aortic stenosis by magnetic resonance imaging. Investig Radiol. 2005;40(10):631–6.

    Article  Google Scholar 

  65. Buchner S, Debl K, Schmid FX, Luchner A, Djavidani B. Cardiovascular magnetic resonance assessment of the aortic valve stenosis: an in vivo and ex vivo study. BMC Med Imaging. 2015;15:34.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Alkadhi H, Wildermuth S, Plass A, Bettex D, Baumert B, Leschka S, Desbiolles LM, Marincek B, Boehm T. Aortic stenosis: comparative evaluation of 16-detector row CT and echocardiography. Radiology. 2006;240(1):47–55.

    Article  PubMed  Google Scholar 

  67. Shah RG, Novaro GM, Blandon RJ, Whiteman MS, Asher CR, Kirsch J. Aortic valve area: meta-analysis of diagnostic performance of multi-detector computed tomography for aortic valve area measurements as compared to transthoracic echocardiography. Int J Cardiovasc Imaging. 2009;25(6):601–9.

    Article  PubMed  Google Scholar 

  68. Hillis LD, Firth BG, Winniford MD. Analysis of factors affecting the variability of Fick versus indicator dilution measurements of cardiac output. Am J Cardiol. 1985;56(12):764–8.

    Article  CAS  PubMed  Google Scholar 

  69. Gorlin R, Gorlin SG. Hydraulic formula for calculation of the area of the stenotic mitral valve, other cardiac valves, and central circulatory shunts. Am Heart J. 1951;41(1):1–29.

    Article  CAS  PubMed  Google Scholar 

  70. Cannon SR, Richards KL, Crawford M. Hydraulic estimation of stenotic orifice area: a correction of the Gorlin formula. Circulation. 1985;71(6):1170–8.

    Article  CAS  PubMed  Google Scholar 

  71. Goldstein SA, Evangelista A, Abbara S, Arai A, Asch FM, Badano LP, Bolen MA, Connolly HM, Cuellar-Calabria H, Czerny M, Devereux RB, Erbel RA, Fattori R, Isselbacher EM, Lindsay JM, McCulloch M, Michelena HI, Nienaber CA, Oh JK, Pepi M, Taylor AJ, Weinsaft JW, Zamorano JL, Dietz H, Eagle K, Elefteriades J, Jondeau G, Rousseau H, Schepens M. Multimodality imaging of diseases of the thoracic aorta in adults: from the American Society of Echocardiography and the European Association of Cardiovascular Imaging: endorsed by the Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance. J Am Soc Echocardiogr. 2015;28(2):119–82.

    Article  PubMed  Google Scholar 

  72. Chatzimavroudis GP, Oshinski JN, Franch RH, Pettigrew RI, Walker PG, Yoganathan AP. Quantification of the aortic regurgitant volume with magnetic resonance phase velocity mapping: a clinical investigation of the importance of imaging slice location. J Heart Valve Dis. 1998;7(1):94–101.

    CAS  PubMed  Google Scholar 

  73. Lotz J, Meier C, Leppert A, Galanski M. Cardiovascular flow measurement with phase-contrast MR imaging: basic facts and implementation. Radiographics. 2002;22(3):651–71.

    Article  PubMed  Google Scholar 

  74. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, O’Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM 3rd, Thomas JD. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63(22):2438–88.

    Article  PubMed  Google Scholar 

  75. Lee JKT, Franzone A, Lanz J, Siontis GCM, Stortecky S, Grani C, Roost E, Windecker S, Pilgrim T. Early detection of subclinical myocardial damage in chronic aortic regurgitation and strategies for timely treatment of asymptomatic patients. Circulation. 2018;137(2):184–96.

    Article  PubMed  Google Scholar 

  76. Myerson SG, d'Arcy J, Mohiaddin R, Greenwood JP, Karamitsos TD, Francis JM, Banning AP, Christiansen JP, Neubauer S. Aortic regurgitation quantification using cardiovascular magnetic resonance: association with clinical outcome. Circulation. 2012;126(12):1452–60.

    Article  PubMed  Google Scholar 

  77. Kammerlander AA, Wiesinger M, Duca F, Aschauer S, Binder C, Zotter Tufaro C, Nitsche C, Badre-Eslam R, Schonbauer R, Bartko P, Beitzke D, Loewe C, Hengstenberg C, Bonderman D, Mascherbauer J. Diagnostic and prognostic utility of cardiac magnetic resonance imaging in aortic regurgitation. JACC Cardiovasc Imaging. 2018.

    Google Scholar 

  78. Sellers RD, Levy MJ, Amplatz K, Lillehei CW. Left retrograde cardioangiography in acquired cardiac disease: technic, indications and interpretations in 700 cases. Am J Cardiol. 1964;14:437–47.

    Article  CAS  PubMed  Google Scholar 

  79. Schultz CJ, Slots TL, Yong G, Aben JP, Van Mieghem N, Swaans M, Rahhab Z, El Faquir N, van Geuns R, Mast G, Zijlstra F, de Jaegere PP. An objective and reproducible method for quantification of aortic regurgitation after TAVI. EuroIntervention. 2014;10(3):355–63.

    Article  PubMed  Google Scholar 

  80. Pascarelli EF, Bertrand CA. Comparison of arm and leg blood-pressures in aortic insufficiency: an appraisal of Hill’s sign. Br Med J. 1965;2(5453):73–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Sinning JM, Hammerstingl C, Vasa-Nicotera M, Adenauer V, Lema Cachiguango SJ, Scheer AC, Hausen S, Sedaghat A, Ghanem A, Muller C, Grube E, Nickenig G, Werner N. Aortic regurgitation index defines severity of peri-prosthetic regurgitation and predicts outcome in patients after transcatheter aortic valve implantation. J Am Coll Cardiol. 2012;59(13):1134–41.

    Article  PubMed  Google Scholar 

  82. El Khoury G, Vanoverschelde JL, Glineur D, Pierard F, Verhelst RR, Rubay J, Funken JC, Watremez C, Astarci P, Lacroix V, Poncelet A, Noirhomme P. Repair of bicuspid aortic valves in patients with aortic regurgitation. Circulation. 2006;114(1 Suppl):I610–6.

    PubMed  Google Scholar 

  83. Ridley CH, Vallabhajosyula P, Bavaria JE, Patel PA, Gutsche JT, Shah R, Feinman JW, Weiss SJ, Augoustides JG. The Sievers classification of the bicuspid aortic valve for the perioperative echocardiographer: the importance of valve phenotype for aortic valve repair in the era of the functional aortic annulus. J Cardiothorac Vasc Anesth. 2016;30(4):1142–51.

    Article  PubMed  Google Scholar 

  84. Prodromo J, D'Ancona G, Amaducci A, Pilato M. Aortic valve repair for aortic insufficiency: a review. J Cardiothorac Vasc Anesth. 2012;26(5):923–32.

    Article  PubMed  Google Scholar 

  85. Aicher D, Kunihara T, Abou Issa O, Brittner B, Graber S, Schafers HJ. Valve configuration determines long-term results after repair of the bicuspid aortic valve. Circulation. 2011;123(2):178–85.

    Article  PubMed  Google Scholar 

  86. Pettersson GB, Crucean AC, Savage R, Halley CM, Grimm RA, Svensson LG, Naficy S, Gillinov AM, Feng J, Blackstone EH. Toward predictable repair of regurgitant aortic valves: a systematic morphology-directed approach to bicommissural repair. J Am Coll Cardiol. 2008;52(1):40–9.

    Article  PubMed  Google Scholar 

  87. Nash PJ, Vitvitsky E, Li J, Cosgrove DM 3rd, Pettersson G, Grimm RA. Feasibility of valve repair for regurgitant bicuspid aortic valves—an echocardiographic study. Ann Thorac Surg. 2005;79(5):1473–9.

    Article  PubMed  Google Scholar 

  88. Perlman GY, Blanke P, Webb JG. Transcatheter aortic valve implantation in bicuspid aortic valve stenosis. EuroIntervention. 2016;12(Y):Y42–5.

    Article  PubMed  Google Scholar 

  89. Bauer T, Linke A, Sievert H, Kahlert P, Hambrecht R, Nickenig G, Hauptmann KE, Sack S, Gerckens U, Schneider S, Zeymer U, Zahn R. Comparison of the effectiveness of transcatheter aortic valve implantation in patients with stenotic bicuspid versus tricuspid aortic valves (from the German TAVI Registry). Am J Cardiol. 2014;113(3):518–21.

    Article  PubMed  Google Scholar 

  90. Jilaihawi H, Chen M, Webb J, Himbert D, Ruiz CE, Rodes-Cabau J, Pache G, Colombo A, Nickenig G, Lee M, Tamburino C, Sievert H, Abramowitz Y, Tarantini G, Alqoofi F, Chakravarty T, Kashif M, Takahashi N, Kazuno Y, Maeno Y, Kawamori H, Chieffo A, Blanke P, Dvir D, Ribeiro HB, Feng Y, Zhao ZG, Sinning JM, Kliger C, Giustino G, Pajerski B, Imme S, Grube E, Leipsic J, Vahanian A, Michev I, Jelnin V, Latib A, Cheng W, Makkar R. A bicuspid aortic valve imaging classification for the TAVR era. JACC Cardiovasc Imaging. 2016;9(10):1145–58.

    Article  PubMed  Google Scholar 

  91. Makkar R, Chakravarty T, Jilaihawi H. Transcatheter aortic valve replacement for bicuspid aortic stenosis: are we ready for the challenge? J Am Coll Cardiol. 2016;68(11):1206–8.

    Article  PubMed  Google Scholar 

  92. Phan K, Wong S, Phan S, Ha H, Qian P, Yan TD. Transcatheter aortic valve implantation (TAVI) in patients with bicuspid aortic valve stenosis—systematic review and meta-analysis. Heart Lung Circ. 2015;24(7):649–59.

    Article  PubMed  Google Scholar 

  93. Saura D, de la Morena G, Flores-Blanco PJ, Oliva MJ, Caballero L, Gonzalez-Carrillo J, Espinosa MD, Lopez-Ruiz M, Garcia-Navarro M, Valdes M. Aortic valve stenosis planimetry by means of three-dimensional transesophageal echocardiography in the real clinical setting: feasibility, reliability and systematic deviations. Echocardiography. 2015;32(3):508–15.

    Article  PubMed  Google Scholar 

  94. Boulif J, Gerber B, Slimani A, Lazam S, de Meester C, Pierard S, Pasquet A, Pouleur AC, Vancraeynest D, El Khoury G, de Kerchove L, Noirhomme P, Vanoverschelde JL. Assessment of aortic valve calcium load by multidetector computed tomography. Anatomical validation, impact of scanner settings and incremental diagnostic value. J Cardiovasc Comput Tomogr. 2017;11(5):360–6.

    Article  PubMed  Google Scholar 

  95. Clavel MA, Pibarot P, Messika-Zeitoun D, Capoulade R, Malouf J, Aggarval S, Araoz PA, Michelena HI, Cueff C, Larose E, Miller JD, Vahanian A, Enriquez-Sarano M. Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis: results of an international registry study. J Am Coll Cardiol. 2014;64(12):1202–13.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Fujita B, Kutting M, Seiffert M, Scholtz S, Egron S, Prashovikj E, Borgermann J, Schafer T, Scholtz W, Preuss R, Gummert J, Steinseifer U, Ensminger SM. Calcium distribution patterns of the aortic valve as a risk factor for the need of permanent pacemaker implantation after transcatheter aortic valve implantation. Eur Heart J Cardiovasc Imaging. 2016;17(12):1385–93.

    Article  PubMed  Google Scholar 

  97. Maeno Y, Abramowitz Y, Yoon SH, Israr S, Jilaihawi H, Watanabe Y, Sharma R, Kawamori H, Miyasaka M, Kazuno Y, Takahashi N, Hariri B, Mangat G, Kashif M, Chakravarty T, Nakamura M, Cheng W, Makkar RR. Relation between left ventricular outflow tract calcium and mortality following transcatheter aortic valve implantation. Am J Cardiol. 2017;120(11):2017–24.

    Article  CAS  PubMed  Google Scholar 

  98. Barbanti M, Yang TH, Rodes Cabau J, Tamburino C, Wood DA, Jilaihawi H, Blanke P, Makkar RR, Latib A, Colombo A, Tarantini G, Raju R, Binder RK, Nguyen G, Freeman M, Ribeiro HB, Kapadia S, Min J, Feuchtner G, Gurtvich R, Alqoofi F, Pelletier M, Ussia GP, Napodano M, de Brito FS Jr, Kodali S, Norgaard BL, Hansson NC, Pache G, Canovas SJ, Zhang H, Leon MB, Webb JG, Leipsic J. Anatomical and procedural features associated with aortic root rupture during balloon-expandable transcatheter aortic valve replacement. Circulation. 2013;128(3):244–53.

    Article  PubMed  Google Scholar 

  99. d’Humieres T, Faivre L, Chammous E, Deux JF, Bergoend E, Fiore A, Radu C, Couetil JP, Benhaiem N, Derumeaux G, Dubois-Rande JL, Ternacle J, Fard D, Lim P. A new three-dimensional echocardiography method to quantify aortic valve calcification. J Am Soc Echocardiogr. 2018;31(10):1073–9.

    Article  PubMed  Google Scholar 

  100. Pressman GS, Crudu V, Parameswaran-Chandrika A, Romero-Corral A, Purushottam B, Figueredo VM. Can total cardiac calcium predict the coronary calcium score? Int J Cardiol. 2011;146(2):202–6.

    Article  PubMed  Google Scholar 

  101. Thomassen HK, Cioffi G, Gerdts E, Einarsen E, Midtbo HB, Mancusi C, Cramariuc D. Echocardiographic aortic valve calcification and outcomes in women and men with aortic stenosis. Heart. 2017;103(20):1619–24.

    Article  CAS  PubMed  Google Scholar 

  102. Michelena HI, Della Corte A, Prakash SK, Milewicz DM, Evangelista A, Enriquez-Sarano M. Bicuspid aortic valve aortopathy in adults: Incidence, etiology, and clinical significance. Int J Cardiol. 2015;201:400–7.

    Article  PubMed  Google Scholar 

  103. Schaefer BM, Lewin MB, Stout KK, Gill E, Prueitt A, Byers PH, Otto CM. The bicuspid aortic valve: an integrated phenotypic classification of leaflet morphology and aortic root shape. Heart. 2008;94(12):1634–8.

    Article  CAS  PubMed  Google Scholar 

  104. Sievers HH, Schmidtke C. A classification system for the bicuspid aortic valve from 304 surgical specimens. J Thorac Cardiovasc Surg. 2007;133(5):1226–33.

    Article  PubMed  Google Scholar 

  105. Krepp JM, Roman MJ, Devereux RB, Bruce A, Prakash SK, Morris SA, Milewicz DM, Holmes KW, Ravekes W, Shohet RV, Pyeritz RE, Maslen CL, Kroner BL, Eagle KA, Preiss L, Asch FM. Bicuspid and unicuspid aortic valves: different phenotypes of the same disease? Insight from the GenTAC Registry. Congenit Heart Dis. 2017;12(6):740–5.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Mookadam F, Thota VR, Garcia-Lopez AM, Emani UR, Alharthi MS, Zamorano J, Khandheria BK. Unicuspid aortic valve in adults: a systematic review. J Heart Valve Dis. 2010;19(1):79–85.

    PubMed  Google Scholar 

  107. Tsang MY, Abudiab MM, Ammash NM, Naqvi TZ, Edwards WD, Nkomo VT, Pellikka PA. Quadricuspid aortic valve: characteristics, associated structural cardiovascular abnormalities, and clinical outcomes. Circulation. 2016;133(3):312–9.

    Article  PubMed  Google Scholar 

  108. Hayakawa M, Asai T, Kinoshita T, Suzuki T. Quadricuspid aortic valve: a report on a 10-year case series and literature review. Ann Thorac Cardiovasc Surg. 2014;20(Suppl):941–4.

    Article  PubMed  Google Scholar 

  109. Yuan SM. Quadricuspid aortic valve: a comprehensive review. Braz J Cardiovasc Surg. 2016;31(6):454–60.

    PubMed  PubMed Central  Google Scholar 

  110. Michelena HI, Prakash SK, Della Corte A, Bissell MM, Anavekar N, Mathieu P, Bosse Y, Limongelli G, Bossone E, Benson DW, Lancellotti P, Isselbacher EM, Enriquez-Sarano M, Sundt TM 3rd, Pibarot P, Evangelista A, Milewicz DM, Body SC. Bicuspid aortic valve: identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon). Circulation. 2014;129(25):2691–704.

    Article  PubMed  PubMed Central  Google Scholar 

  111. Hahn RT, Abraham T, Adams MS, Bruce CJ, Glas KE, Lang RM, Reeves ST, Shanewise JS, Siu SC, Stewart W, Picard MH. Guidelines for performing a comprehensive transesophageal echocardiographic examination: recommendations from the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists. Anesth Analg. 2014;118(1):21–68.

    Article  PubMed  Google Scholar 

  112. Doherty JU, Kort S, Mehran R, Schoenhagen P, Soman P. ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 appropriate use criteria for multimodality imaging in valvular heart disease: a report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. J Nucl Cardiol. 2017;24(6):2043–63.

    Article  PubMed  Google Scholar 

  113. Buchner S, Hulsmann M, Poschenrieder F, Hamer OW, Fellner C, Kobuch R, Feuerbach S, Riegger GA, Djavidani B, Luchner A, Debl K. Variable phenotypes of bicuspid aortic valve disease: classification by cardiovascular magnetic resonance. Heart. 2010;96(15):1233–40.

    Article  PubMed  Google Scholar 

  114. Wassmuth R, von Knobelsdorff-Brenkenhoff F, Gruettner H, Utz W, Schulz-Menger J. Cardiac magnetic resonance imaging of congenital bicuspid aortic valves and associated aortic pathologies in adults. Eur Heart J Cardiovasc Imaging. 2014;15(6):673–9.

    Article  PubMed  Google Scholar 

  115. Schulz-Menger J, Abdel-Aty H, Busjahn A, Wassmuth R, Pilz B, Dietz R, Friedrich MG. Left ventricular outflow tract planimetry by cardiovascular magnetic resonance differentiates obstructive from non-obstructive hypertrophic cardiomyopathy. J Cardiovasc Magn Reson. 2006;8(5):741–6.

    Article  PubMed  Google Scholar 

  116. Vogel-Claussen J, Santaularia Tomas M, Newatia A, Boyce D, Pinheiro A, Abraham R, Abraham T, Bluemke DA. Cardiac MRI evaluation of hypertrophic cardiomyopathy: left ventricular outflow tract/aortic valve diameter ratio predicts severity of LVOT obstruction. J Magn Reson Imaging. 2012;36(3):598–603.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Lim WY, Lloyd G, Bhattacharyya S. Mechanical and surgical bioprosthetic valve thrombosis. Heart. 2017;103(24):1934–41.

    PubMed  Google Scholar 

  118. Mankad S. Management of prosthetic heart valve complications. Curr Treat Options Cardiovasc Med. 2012;14(6):608–21.

    Article  PubMed  Google Scholar 

  119. Yanagawa B, Whitlock RP, Verma S, Gersh BJ. Anticoagulation for prosthetic heart valves: unresolved questions requiring answers. Curr Opin Cardiol. 2016;31(2):176–82.

    Article  PubMed  Google Scholar 

  120. Rodriguez-Gabella T, Voisine P, Puri R, Pibarot P, Rodes-Cabau J. Aortic bioprosthetic valve durability: incidence, mechanisms, predictors, and management of surgical and transcatheter valve degeneration. J Am Coll Cardiol. 2017;70(8):1013–28.

    Article  PubMed  Google Scholar 

  121. Cherry SV, Jain P, Rodriguez-Blanco YF, Fabbro M 2nd. Noninvasive evaluation of native valvular regurgitation: a review of the 2017 American Society of Echocardiography Guidelines for the Perioperative Echocardiographer. J Cardiothorac Vasc Anesth. 2018;32(2):811–22.

    Article  PubMed  Google Scholar 

  122. Ridley C, Sohmer B, Vallabhajosyula P, Augoustides JGT. Aortic leaflet billowing as a risk factor for repair failure after aortic valve repair. J Cardiothorac Vasc Anesth. 2017;31(3):1001–6.

    Article  PubMed  Google Scholar 

  123. Szymanski T, Maslow A, Mahmood F, Singh A. Three-dimensional echocardiographic assessment of coaptation after aortic valve repair. J Cardiothorac Vasc Anesth. 2017;31(3):993–1000.

    Article  PubMed  Google Scholar 

  124. Habertheuer A, Milewski RK, Bavaria JE, Siki M, Freas M, Desai N, Szeto W, Ram C, Hu R, Vallabhajosyula P. Predictors of recurrent aortic insufficiency in type i bicuspid aortic valve repair. Ann Thorac Surg. 2018;106(5):1316–24.

    Article  PubMed  Google Scholar 

  125. de Kerchove L, Mastrobuoni S, Boodhwani M, Astarci P, Rubay J, Poncelet A, Vanoverschelde JL, Noirhomme P, El Khoury G. The role of annular dimension and annuloplasty in tricuspid aortic valve repair. Eur J Cardiothorac Surg. 2016;49(2):428–37; discussion 437-8.

    Article  PubMed  Google Scholar 

  126. Minakata K, Schaff HV, Zehr KJ, Dearani JA, Daly RC, Orszulak TA, Puga FJ, Danielson GK. Is repair of aortic valve regurgitation a safe alternative to valve replacement? J Thorac Cardiovasc Surg. 2004;127(3):645–53.

    Article  PubMed  Google Scholar 

  127. Everett RJ, Newby DE, Jabbour A, Fayad ZA, Dweck MR. The role of imaging in aortic valve disease. Curr Cardiovasc Imaging Rep. 2016;9:21.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Baliyan V, Verdini D, Meyersohn NM. Noninvasive aortic imaging. Cardiovasc Diagn Ther. 2018;8(Suppl 1):S3–s18.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Gulsin GS, Singh A, McCann GP. Cardiovascular magnetic resonance in the evaluation of heart valve disease. BMC Med Imaging. 2017;17(1):67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  130. Wehrli FW. Magnetic resonance of calcified tissues. J Magn Reson. 2013;229:35–48.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  131. Colli A, D'Amico R, Kempfert J, Borger MA, Mohr FW, Walther T. Transesophageal echocardiographic scoring for transcatheter aortic valve implantation: impact of aortic cusp calcification on postoperative aortic regurgitation. J Thorac Cardiovasc Surg. 2011;142(5):1229–35.

    Article  PubMed  Google Scholar 

  132. Gripari P, Ewe SH, Fusini L, Muratori M, Ng AC, Cefalu C, Delgado V, Schalij MJ, Bax JJ, Marsan NA, Tamborini G, Pepi M. Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation. Heart. 2012;98(16):1229–36.

    Article  PubMed  Google Scholar 

  133. Mihara H, Shibayama K, Berdejo J, Harada K, Itabashi Y, Siegel RJ, Kashif M, Jilaihawi H, Makkar RR, Shiota T. Impact of device landing zone calcification on paravalvular regurgitation after transcatheter aortic valve replacement: a real-time three-dimensional transesophageal echocardiographic study. J Am Soc Echocardiogr. 2015;28(4):404–14.

    Article  PubMed  Google Scholar 

  134. Pawade T, Clavel MA, Tribouilloy C, Dreyfus J, Mathieu T, Tastet L, Renard C, Gun M, Jenkins WSA, Macron L, Sechrist JW, Lacomis JM, Nguyen V, Galian Gay L, Cuellar Calabria H, Ntalas I, Cartlidge TRG, Prendergast B, Rajani R, Evangelista A, Cavalcante JL, Newby DE, Pibarot P, Messika Zeitoun D, Dweck MR. Computed tomography aortic valve calcium scoring in patients with aortic stenosis. Circ Cardiovasc Imaging. 2018;11(3):e007146.

    Article  PubMed  Google Scholar 

  135. Koos R, Kuhl HP, Muhlenbruch G, Wildberger JE, Gunther RW, Mahnken AH. Prevalence and clinical importance of aortic valve calcification detected incidentally on CT scans: comparison with echocardiography. Radiology. 2006;241(1):76–82.

    Article  PubMed  Google Scholar 

  136. Quader N, Wilansky S, Click RL, Katayama M, Chaliki HP. Visual estimation of the severity of aortic stenosis and the calcium burden by 2-dimensional echocardiography: is it reliable? J Ultrasound Med. 2015;34(10):1711–7.

    Article  PubMed  Google Scholar 

  137. Sheng SP, Howell LA, Caughey MC, Yeung M, Vavalle JP. Relation of an echocardiographic-based cardiac calcium score to mitral stenosis severity and coronary artery disease in patients with severe aortic stenosis. Am J Cardiol. 2018;121(2):249–55.

    Article  CAS  PubMed  Google Scholar 

  138. Thaden JJ, Nkomo VT, Suri RM, Maleszewski JJ, Soderberg DJ, Clavel MA, Pislaru SV, Malouf JF, Foley TA, Oh JK, Miller JD, Edwards WD, Enriquez-Sarano M. Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight. Eur Heart J. 2016;37(8):693–9.

    Article  PubMed  Google Scholar 

  139. Le Ven F, Tizon-Marcos H, Fuchs C, Mathieu P, Pibarot P, Larose E. Valve tissue characterization by magnetic resonance imaging in calcific aortic valve disease. Can J Cardiol. 2014;30(12):1676–83.

    Article  PubMed  Google Scholar 

  140. Adams LC, Bressem K, Boker SM, Bender YY, Norenberg D, Hamm B, Makowski MR. Diagnostic performance of susceptibility-weighted magnetic resonance imaging for the detection of calcifications: a systematic review and meta-analysis. Sci Rep. 2017;7(1):15506.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  141. Rader F, Sachdev E, Arsanjani R, Siegel RJ. Left ventricular hypertrophy in valvular aortic stenosis: mechanisms and clinical implications. Am J Med. 2015;128(4):344–52.

    Article  PubMed  Google Scholar 

  142. Everett RJ, Clavel MA, Pibarot P, Dweck MR. Timing of intervention in aortic stenosis: a review of current and future strategies. Heart. 2018;104(24):2067–76.

    Article  PubMed  Google Scholar 

  143. Hiendlmayr B, Nakda J, Elsaid O, Wang X, Flynn A. Timing of surgical intervention for aortic regurgitation. Curr Treat Options Cardiovasc Med. 2016;18(11):63.

    Article  PubMed  Google Scholar 

  144. Nadeau-Routhier C, Marsit O, Beaudoin J. Current management of patients with severe aortic regurgitation. Curr Treat Options Cardiovasc Med. 2017;19(2):9.

    Article  PubMed  Google Scholar 

  145. Magne J, Lancellotti P, Pierard LA. Exercise testing in asymptomatic severe aortic stenosis. JACC Cardiovasc Imaging. 2014;7(2):188–99.

    Article  PubMed  Google Scholar 

  146. Clavel MA, Magne J, Pibarot P. Low-gradient aortic stenosis. Eur Heart J. 2016;37(34):2645–57.

    Article  PubMed  PubMed Central  Google Scholar 

  147. Tribouilloy C, Rusinaru D, Marechaux S, Castel AL, Debry N, Maizel J, Mentaverri R, Kamel S, Slama M, Levy F. Low-gradient, low-flow severe aortic stenosis with preserved left ventricular ejection fraction: characteristics, outcome, and implications for surgery. J Am Coll Cardiol. 2015;65(1):55–66.

    Article  PubMed  Google Scholar 

  148. Vogelgesang A, Hasenfuss G, Jacobshagen C. Low-flow/low-gradient aortic stenosis-Still a diagnostic and therapeutic challenge. Clin Cardiol. 2017;40(9):654–9.

    Article  PubMed  PubMed Central  Google Scholar 

  149. Clavel MA, Burwash IG, Pibarot P. Cardiac imaging for assessing low-gradient severe aortic stenosis. JACC Cardiovasc Imaging. 2017;10(2):185–202.

    Article  PubMed  Google Scholar 

  150. Galderisi M, Cosyns B, Edvardsen T, Cardim N, Delgado V, Di Salvo G, Donal E, Sade LE, Ernande L, Garbi M, Grapsa J, Hagendorff A, Kamp O, Magne J, Santoro C, Stefanidis A, Lancellotti P, Popescu B, Habib G. Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2017;18(12):1301–10.

    Article  PubMed  Google Scholar 

  151. Porter TR, Mulvagh SL, Abdelmoneim SS, Becher H, Belcik JT, Bierig M, Choy J, Gaibazzi N, Gillam LD, Janardhanan R, Kutty S, Leong-Poi H, Lindner JR, Main ML, Mathias W Jr, Park MM, Senior R, Villanueva F. Clinical applications of ultrasonic enhancing agents in echocardiography: 2018 American Society of Echocardiography Guidelines update. J Am Soc Echocardiogr. 2018;31(3):241–74.

    Article  PubMed  Google Scholar 

  152. Mulvagh SL, Rakowski H, Vannan MA, Abdelmoneim SS, Becher H, Bierig SM, Burns PN, Castello R, Coon PD, Hagen ME, Jollis JG, Kimball TR, Kitzman DW, Kronzon I, Labovitz AJ, Lang RM, Mathew J, Moir WS, Nagueh SF, Pearlman AS, Perez JE, Porter TR, Rosenbloom J, Strachan GM, Thanigaraj S, Wei K, Woo A, Yu EH, Zoghbi WA. American Society of Echocardiography consensus statement on the clinical applications of ultrasonic contrast agents in echocardiography. J Am Soc Echocardiogr. 2008;21(11):1179–201; quiz 1281.

    Article  PubMed  Google Scholar 

  153. Bhave NM, Lang RM. Evaluation of left ventricular structure and function by three-dimensional echocardiography. Curr Opin Crit Care. 2013;19(5):387–96.

    Article  PubMed  Google Scholar 

  154. Dorosz JL, Lezotte DC, Weitzenkamp DA, Allen LA, Salcedo EE. Performance of 3-dimensional echocardiography in measuring left ventricular volumes and ejection fraction: a systematic review and meta-analysis. J Am Coll Cardiol. 2012;59(20):1799–808.

    Article  PubMed  PubMed Central  Google Scholar 

  155. Caiani EG, Corsi C, Zamorano J, Sugeng L, MacEneaney P, Weinert L, Battani R, Gutierrez-Chico JL, Koch R, Perez de Isla L, Mor-Avi V, Lang RM. Improved semiautomated quantification of left ventricular volumes and ejection fraction using 3-dimensional echocardiography with a full matrix-array transducer: comparison with magnetic resonance imaging. J Am Soc Echocardiogr. 2005;18(8):779–88.

    Article  PubMed  Google Scholar 

  156. Hundley WG, Bluemke DA, Finn JP, Flamm SD, Fogel MA, Friedrich MG, Ho VB, Jerosch-Herold M, Kramer CM, Manning WJ, Patel M, Pohost GM, Stillman AE, White RD, Woodard PK. ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010;55(23):2614–62.

    Article  PubMed  Google Scholar 

  157. Petersen SE, Aung N, Sanghvi MM, Zemrak F, Fung K, Paiva JM, Francis JM, Khanji MY, Lukaschuk E, Lee AM, Carapella V, Kim YJ, Leeson P, Piechnik SK, Neubauer S. Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort. J Cardiovasc Magn Reson. 2017;19(1):18.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Chuang ML, Gona P, Hautvast GL, Salton CJ, Breeuwer M, O'Donnell CJ, Manning WJ. CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: the Framingham Heart Study. J Magn Reson Imaging. 2014;39(4):895–900.

    Article  PubMed  Google Scholar 

  159. Aquaro GD, Camastra G, Monti L, Lombardi M, Pepe A, Castelletti S, Maestrini V, Todiere G, Masci P, di Giovine G, Barison A, Dellegrottaglie S, Perazzolo Marra M, Pontone G, Di Bella G. Reference values of cardiac volumes, dimensions, and new functional parameters by MR: a multicenter, multivendor study. J Magn Reson Imaging. 2017;45(4):1055–67.

    Article  PubMed  Google Scholar 

  160. Maffei E, Messalli G, Martini C, Nieman K, Catalano O, Rossi A, Seitun S, Guaricci AI, Tedeschi C, Mollet NR, Cademartiri F. Left and right ventricle assessment with Cardiac CT: validation study vs Cardiac MR. Eur Radiol. 2012;22(5):1041–9.

    Article  PubMed  PubMed Central  Google Scholar 

  161. Pibarot P, Dumesnil JG. Low-flow, low-gradient aortic stenosis with normal and depressed left ventricular ejection fraction. J Am Coll Cardiol. 2012;60(19):1845–53.

    Article  PubMed  Google Scholar 

  162. Lomon A, Comandon J. La Radiocinematographie par la photographie des ecrans renforsateurs. Bull. et miiein. Soc. radiol. med. de Paris 1911;3;127.

    Google Scholar 

  163. Chapman CB, Baker O, Reynolds J, Bonte FJ. Use of biplane cinefluorography for measurement of ventricular volume. Circulation. 1958;18(6):1105–17.

    Article  CAS  PubMed  Google Scholar 

  164. Oost E, Oemrawsingh P, Reiber JH, Lelieveldt B. Automated left ventricular delineation in X-ray angiograms: a validation study. Catheter Cardiovasc Interv. 2009;73(2):231–40.

    Article  PubMed  Google Scholar 

  165. Hesse B, Lindhardt TB, Acampa W, Anagnostopoulos C, Ballinger J, Bax JJ, Edenbrandt L, Flotats A, Germano G, Stopar TG, Franken P, Kelion A, Kjaer A, Le Guludec D, Ljungberg M, Maenhout AF, Marcassa C, Marving J, McKiddie F, Schaefer WM, Stegger L, Underwood R. EANM/ESC guidelines for radionuclide imaging of cardiac function. Eur J Nucl Med Mol Imaging. 2008;35(4):851–85.

    Article  CAS  PubMed  Google Scholar 

  166. Schaefer WM, Lipke CS, Standke D, Kuhl HP, Nowak B, Kaiser HJ, Koch KC, Buell U. Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation and comparison of the Emory Cardiac Tool Box with QGS and 4D-MSPECT. J Nucl Med. 2005;46(8):1256–63.

    PubMed  Google Scholar 

  167. Kubo N, Mabuchi M, Katoh C, Morita K, Tsukamoto E, Morita Y, Tamaki N. Accuracy and reproducibility of left ventricular function from quantitative, gated, single photon emission computed tomography using dynamic myocardial phantoms: effect of pre-reconstruction filters. Nucl Med Commun. 2002;23(6):529–36.

    Article  CAS  PubMed  Google Scholar 

  168. Sengupta PP, Tajik AJ, Chandrasekaran K, Khandheria BK. Twist mechanics of the left ventricle: principles and application. JACC Cardiovasc Imaging. 2008;1(3):366–76.

    Article  PubMed  Google Scholar 

  169. Chengode S. Left ventricular global systolic function assessment by echocardiography. Ann Card Anaesth. 2016;19(Supplement):S26–s34.

    Article  PubMed  PubMed Central  Google Scholar 

  170. Dunlay SM, Roger VL, Weston SA, Jiang R, Redfield MM. Longitudinal changes in ejection fraction in heart failure patients with preserved and reduced ejection fraction. Circ Heart Fail. 2012;5(6):720–6.

    Article  PubMed  PubMed Central  Google Scholar 

  171. Aurich M, Keller M, Greiner S, Steen H, Aus dem Siepen F, Riffel J, Katus HA, Buss SJ, Mereles D. Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking. Eur Heart J Cardiovasc Imaging. 2016;17(12):1370–8.

    Article  PubMed  Google Scholar 

  172. Weidemann F, Herrmann S, Stork S, Niemann M, Frantz S, Lange V, Beer M, Gattenlohner S, Voelker W, Ertl G, Strotmann JM. Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis. Circulation. 2009;120(7):577–84.

    Article  CAS  PubMed  Google Scholar 

  173. Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr. 2016;29(4):277–314.

    Article  PubMed  Google Scholar 

  174. Ozkan A, Kapadia S, Tuzcu M, Marwick TH. Assessment of left ventricular function in aortic stenosis. Nat Rev Cardiol. 2011;8(9):494–501.

    Article  PubMed  Google Scholar 

  175. Chahal NS, Lim TK, Jain P, Chambers JC, Kooner JS, Senior R. Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study. Eur J Echocardiogr. 2010;11(1):51–6.

    Article  PubMed  Google Scholar 

  176. Capoulade R, Le Ven F, Clavel MA, Dumesnil JG, Dahou A, Thebault C, Arsenault M, O'Connor K, Bedard E, Beaudoin J, Senechal M, Bernier M, Pibarot P. Echocardiographic predictors of outcomes in adults with aortic stenosis. Heart. 2016;102(12):934–42.

    Article  CAS  PubMed  Google Scholar 

  177. Smiseth OA, Torp H, Opdahl A, Haugaa KH, Urheim S. Myocardial strain imaging: how useful is it in clinical decision making? Eur Heart J. 2016;37(15):1196–207.

    Article  PubMed  Google Scholar 

  178. Quere JP, Monin JL, Levy F, Petit H, Baleynaud S, Chauvel C, Pop C, Ohlmann P, Lelguen C, Dehant P, Gueret P, Tribouilloy C. Influence of preoperative left ventricular contractile reserve on postoperative ejection fraction in low-gradient aortic stenosis. Circulation. 2006;113(14):1738–44.

    Article  PubMed  Google Scholar 

  179. Dweck MR, Boon NA, Newby DE. Calcific aortic stenosis: a disease of the valve and the myocardium. J Am Coll Cardiol. 2012;60(19):1854–63.

    Article  PubMed  Google Scholar 

  180. Chin CWL, Everett RJ, Kwiecinski J, Vesey AT, Yeung E, Esson G, Jenkins W, Koo M, Mirsadraee S, White AC, Japp AG, Prasad SK, Semple S, Newby DE, Dweck MR. Myocardial fibrosis and cardiac decompensation in aortic stenosis. JACC Cardiovasc Imaging. 2017;10(11):1320–33.

    Article  PubMed  PubMed Central  Google Scholar 

  181. Hein S, Arnon E, Kostin S, Schonburg M, Elsasser A, Polyakova V, Bauer EP, Klovekorn WP, Schaper J. Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms. Circulation. 2003;107(7):984–91.

    Article  PubMed  Google Scholar 

  182. Lancellotti P, Pellikka PA, Budts W, Chaudhry FA, Donal E, Dulgheru R, Edvardsen T, Garbi M, Ha JW, Kane GC, Kreeger J, Mertens L, Pibarot P, Picano E, Ryan T, Tsutsui JM, Varga A. The clinical use of stress echocardiography in non-ischaemic heart disease: recommendations from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2017;30(2):101–38.

    Article  PubMed  Google Scholar 

  183. Henri C, Pierard LA, Lancellotti P, Mongeon FP, Pibarot P, Basmadjian AJ. Exercise testing and stress imaging in valvular heart disease. Can J Cardiol. 2014;30(9):1012–26.

    Article  PubMed  Google Scholar 

  184. Thavendiranathan P, Poulin F, Lim KD, Plana JC, Woo A, Marwick TH. Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review. J Am Coll Cardiol. 2014;63(25 Pt A):2751–68.

    Article  PubMed  Google Scholar 

  185. Schuster A, Paul M, Bettencourt N, Morton G, Chiribiri A, Ishida M, Hussain S, Jogiya R, Kutty S, Bigalke B, Perera D, Nagel E. Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy. Int J Cardiol. 2013;166(2):413–20.

    Article  PubMed  Google Scholar 

  186. Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EP. Human heart: tagging with MR imaging—a method for noninvasive assessment of myocardial motion. Radiology. 1988;169(1):59–63.

    Article  CAS  PubMed  Google Scholar 

  187. Cao JJ, Ngai N, Duncanson L, Cheng J, Gliganic K, Chen Q. A comparison of both DENSE and feature tracking techniques with tagging for the cardiovascular magnetic resonance assessment of myocardial strain. J Cardiovasc Magn Reson. 2018;20(1):26.

    Article  PubMed  PubMed Central  Google Scholar 

  188. Hor KN, Gottliebson WM, Carson C, Wash E, Cnota J, Fleck R, Wansapura J, Klimeczek P, Al-Khalidi HR, Chung ES, Benson DW, Mazur W. Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging. 2010;3(2):144–51.

    Article  PubMed  Google Scholar 

  189. Nagel E, Lehmkuhl HB, Bocksch W, Klein C, Vogel U, Frantz E, Ellmer A, Dreysse S, Fleck E. Noninvasive diagnosis of ischemia-induced wall motion abnormalities with the use of high-dose dobutamine stress MRI: comparison with dobutamine stress echocardiography. Circulation. 1999;99(6):763–70.

    Article  CAS  PubMed  Google Scholar 

  190. Afridi I, Kleiman NS, Raizner AE, Zoghbi WA. Dobutamine echocardiography in myocardial hibernation. Optimal dose and accuracy in predicting recovery of ventricular function after coronary angioplasty. Circulation. 1995;91(3):663–70.

    Article  CAS  PubMed  Google Scholar 

  191. Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Klocke FJ, Bonow RO, Judd RM. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med. 2000;343(20):1445–53.

    Article  CAS  PubMed  Google Scholar 

  192. Arai AE. The cardiac magnetic resonance (CMR) approach to assessing myocardial viability. J Nucl Cardiol. 2011;18(6):1095–102.

    Article  PubMed  PubMed Central  Google Scholar 

  193. Vollema EM, Sugimoto T, Shen M, Tastet L, Ng ACT, Abou R, Marsan NA, Mertens B, Dulgheru R, Lancellotti P, Clavel MA, Pibarot P, Genereux P, Leon MB, Delgado V, Bax JJ. Association of left ventricular global longitudinal strain with asymptomatic severe aortic stenosis: natural course and prognostic value. JAMA Cardiol. 2018;3(9):839–47.

    Article  PubMed  PubMed Central  Google Scholar 

  194. Alashi A, Mentias A, Abdallah A, Feng K, Gillinov AM, Rodriguez LL, Johnston DR, Svensson LG, Popovic ZB, Griffin BP, Desai MY. Incremental prognostic utility of left ventricular global longitudinal strain in asymptomatic patients with significant chronic aortic regurgitation and preserved left ventricular ejection fraction. JACC Cardiovasc Imaging. 2018;11(5):673–82.

    Article  PubMed  Google Scholar 

  195. Marwan M, Ammon F, Bittner D, Rother J, Mekkhala N, Hell M, Schuhbaeck A, Gitsioudis G, Feyrer R, Schlundt C, Achenbach S, Arnold M. CT-derived left ventricular global strain in aortic valve stenosis patients: A comparative analysis pre and post transcatheter aortic valve implantation. J Cardiovasc Comput Tomogr. 2018;12(3):240–4.

    Article  CAS  PubMed  Google Scholar 

  196. Nishimura RA, Grantham JA, Connolly HM, Schaff HV, Higano ST, Holmes DR Jr. Low-output, low-gradient aortic stenosis in patients with depressed left ventricular systolic function: the clinical utility of the dobutamine challenge in the catheterization laboratory. Circulation. 2002;106(7):809–13.

    Article  PubMed  Google Scholar 

  197. Stahli BE, Abouelnour A, Nguyen TD, Vecchiati A, Maier W, Luscher TF, Frauenfelder T, Tanner FC. Impact of three-dimensional imaging and pressure recovery on echocardiographic evaluation of severe aortic stenosis: a pilot study. Echocardiography. 2014;31(8):1006–16.

    Article  PubMed  Google Scholar 

  198. Stahli BE, Stadler T, Holy EW, Nguyen-Kim TDL, Hoffelner L, Erhart L, Obeid S, Niemann M, Jenni R, Hamada S, Manka R, Luscher TF, Maisano F, Nietlispach F, Frauenfelder T, Tanner FC. Impact of stroke volume assessment by integrating multi-detector computed tomography and Doppler data on the classification of aortic stenosis. Int J Cardiol. 2017;246:80–6.

    Article  PubMed  Google Scholar 

  199. Hachicha Z, Dumesnil JG, Bogaty P, Pibarot P. Paradoxical low-flow, low-gradient severe aortic stenosis despite preserved ejection fraction is associated with higher afterload and reduced survival. Circulation. 2007;115(22):2856–64.

    Article  PubMed  Google Scholar 

  200. Clavel MA, Ennezat PV, Marechaux S, Dumesnil JG, Capoulade R, Hachicha Z, Mathieu P, Bellouin A, Bergeron S, Meimoun P, Arsenault M, Le Tourneau T, Pasquet A, Couture C, Pibarot P. Stress echocardiography to assess stenosis severity and predict outcome in patients with paradoxical low-flow, low-gradient aortic stenosis and preserved LVEF. JACC Cardiovasc Imaging. 2013;6(2):175–83.

    Article  PubMed  Google Scholar 

  201. Herrmann S, Stork S, Niemann M, Lange V, Strotmann JM, Frantz S, Beer M, Gattenlohner S, Voelker W, Ertl G, Weidemann F. Low-gradient aortic valve stenosis myocardial fibrosis and its influence on function and outcome. J Am Coll Cardiol. 2011;58(4):402–12.

    Article  PubMed  Google Scholar 

  202. Buckert D, Cieslik M, Tibi R, Radermacher M, Rasche V, Bernhardt P, Hombach V, Rottbauer W, Wohrle J. Longitudinal strain assessed by cardiac magnetic resonance correlates to hemodynamic findings in patients with severe aortic stenosis and predicts positive remodeling after transcatheter aortic valve replacement. Clin Res Cardiol. 2018;107(1):20–9.

    Article  PubMed  Google Scholar 

  203. Kampaktsis PN, Kokkinidis DG, Wong SC, Vavuranakis M, Skubas NJ, Devereux RB. The role and clinical implications of diastolic dysfunction in aortic stenosis. Heart. 2017;103(19):1481–7.

    Article  PubMed  Google Scholar 

  204. Yarbrough WM, Mukherjee R, Ikonomidis JS, Zile MR, Spinale FG. Myocardial remodeling with aortic stenosis and after aortic valve replacement: mechanisms and future prognostic implications. J Thorac Cardiovasc Surg. 2012;143(3):656–64.

    Article  PubMed  Google Scholar 

  205. Obasare E, Bhalla V, Gajanana D, Rodriguez Ziccardi M, Codolosa JN, Figueredo VM, Morris DL, Pressman GS. Natural history of severe aortic stenosis: diastolic wall strain as a novel prognostic marker. Echocardiography. 2017;34(4):484–90.

    Article  PubMed  Google Scholar 

  206. Blair JEA, Atri P, Friedman JL, Thomas JD, Brummel K, Sweis RN, Mikati I, Malaisrie SC, Davidson CJ, Flaherty JD. Diastolic function and transcatheter aortic valve replacement. J Am Soc Echocardiogr. 2017;30(6):541–51.

    Article  PubMed  Google Scholar 

  207. Dahl JS, Barros-Gomes S, Videbaek L, Poulsen MK, Issa IF, Carter-Storch R, Christensen NL, Kumme A, Pellikka PA, Moller JE. Early diastolic strain rate in relation to systolic and diastolic function and prognosis in aortic stenosis. JACC Cardiovasc Imaging. 2016;9(5):519–28.

    Article  PubMed  Google Scholar 

  208. Dahl JS, Christensen NL, Videbaek L, Poulsen MK, Carter-Storch R, Hey TM, Pellikka PA, Steffensen FH, Moller JE. Left ventricular diastolic function is associated with symptom status in severe aortic valve stenosis. Circ Cardiovasc Imaging. 2014;7(1):142–8.

    Article  PubMed  Google Scholar 

  209. Kamimura D, Suzuki T, Fox ER, Skelton TN, Winniford MD, Hall ME. Increased left ventricular diastolic stiffness is associated with heart failure symptoms in aortic stenosis patients with preserved ejection fraction. J Card Fail. 2017;23(8):581–8.

    Article  PubMed  PubMed Central  Google Scholar 

  210. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelisa A. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. Eur J Echocardiogr. 2009;10(2):165–93.

    Article  PubMed  Google Scholar 

  211. Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Alexandru Popescu B, Waggoner AD. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016;17(12):1321–60.

    Article  PubMed  Google Scholar 

  212. Kinno M, Nagpal P, Horgan S, Waller AH. Comparison of echocardiography, cardiac magnetic resonance, and computed tomographic imaging for the evaluation of left ventricular myocardial function: part 2 (diastolic and regional assessment). Curr Cardiol Rep. 2017;19(1):6.

    Article  PubMed  Google Scholar 

  213. Singh A, Addetia K, Maffessanti F, Mor-Avi V, Lang RM. LA strain for categorization of LV diastolic dysfunction. JACC Cardiovasc Imaging. 2017;10(7):735–43.

    Article  PubMed  Google Scholar 

  214. Wang J, Khoury DS, Thohan V, Torre-Amione G, Nagueh SF. Global diastolic strain rate for the assessment of left ventricular relaxation and filling pressures. Circulation. 2007;115(11):1376–83.

    Article  PubMed  Google Scholar 

  215. Dokainish H, Sengupta R, Pillai M, Bobek J, Lakkis N. Usefulness of new diastolic strain and strain rate indexes for the estimation of left ventricular filling pressure. Am J Cardiol. 2008;101(10):1504–9.

    Article  PubMed  Google Scholar 

  216. Haaf P, Garg P, Messroghli DR, Broadbent DA, Greenwood JP, Plein S. Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review. J Cardiovasc Magn Reson. 2016;18(1):89.

    Article  PubMed  PubMed Central  Google Scholar 

  217. Coelho-Filho OR, Shah RV, Mitchell R, Neilan TG, Moreno H Jr, Simonson B, Kwong R, Rosenzweig A, Das S, Jerosch-Herold M. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. 2013;128(11):1225–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  218. Miller CA, Naish JH, Bishop P, Coutts G, Clark D, Zhao S, Ray SG, Yonan N, Williams SG, Flett AS, Moon JC, Greiser A, Parker GJ, Schmitt M. Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. Circ Cardiovasc Imaging. 2013;6(3):373–83.

    Article  PubMed  Google Scholar 

  219. Bull S, White SK, Piechnik SK, Flett AS, Ferreira VM, Loudon M, Francis JM, Karamitsos TD, Prendergast BD, Robson MD, Neubauer S, Moon JC, Myerson SG. Human non-contrast T1 values and correlation with histology in diffuse fibrosis. Heart. 2013;99(13):932–7.

    Article  PubMed  Google Scholar 

  220. Dusenbery SM, Jerosch-Herold M, Rickers C, Colan SD, Geva T, Newburger JW, Powell AJ. Myocardial extracellular remodeling is associated with ventricular diastolic dysfunction in children and young adults with congenital aortic stenosis. J Am Coll Cardiol. 2014;63(17):1778–85.

    Article  PubMed  Google Scholar 

  221. Chin CW, Shah AS, McAllister DA, Joanna Cowell S, Alam S, Langrish JP, Strachan FE, Hunter AL, Maria Choy A, Lang CC, Walker S, Boon NA, Newby DE, Mills NL, Dweck MR. High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis. Eur Heart J. 2014;35(34):2312–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  222. Croisille P, Revel D, Saeed M. Contrast agents and cardiac MR imaging of myocardial ischemia: from bench to bedside. Eur Radiol. 2006;16(9):1951–63.

    Article  PubMed  Google Scholar 

  223. Mahrholdt H, Wagner A, Judd RM, Sechtem U, Kim RJ. Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies. Eur Heart J. 2005;26(15):1461–74.

    Article  PubMed  Google Scholar 

  224. Rudolph A, Abdel-Aty H, Bohl S, Boye P, Zagrosek A, Dietz R, Schulz-Menger J. Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling. J Am Coll Cardiol. 2009;53(3):284–91.

    Article  PubMed  Google Scholar 

  225. Barone-Rochette G, Pierard S, De Meester de Ravenstein C, Seldrum S, Melchior J, Maes F, Pouleur AC, Vancraeynest D, Pasquet A, Vanoverschelde JL, Gerber BL. Prognostic significance of LGE by CMR in aortic stenosis patients undergoing valve replacement. J Am Coll Cardiol. 2014;64(2):144–54.

    Article  PubMed  Google Scholar 

  226. Al Musa T, Uddin A, Swoboda PP, Garg P, Fairbairn TA, Dobson LE, Steadman CD, Singh A, Erhayiem B, Plein S, McCann GP, Greenwood JP. Myocardial strain and symptom severity in severe aortic stenosis: insights from cardiovascular magnetic resonance. Quant Imaging Med Surg. 2017;7(1):38–47.

    Article  PubMed  PubMed Central  Google Scholar 

  227. Musa TA, Uddin A, Swoboda PP, Fairbairn TA, Dobson LE, Singh A, Garg P, Steadman CD, Erhayiem B, Kidambi A, Ripley DP, McDiarmid AK, Haaf P, Blackman DJ, Plein S, McCann GP, Greenwood JP. Cardiovascular magnetic resonance evaluation of symptomatic severe aortic stenosis: association of circumferential myocardial strain and mortality. J Cardiovasc Magn Reson. 2017;19(1):13.

    Article  PubMed  PubMed Central  Google Scholar 

  228. Baumgartner H, Falk V, Bax JJ, De Bonis M, Hamm C, Holm PJ, Iung B, Lancellotti P, Lansac E, Rodriguez Munoz D, Rosenhek R, Sjogren J, Tornos Mas P, Vahanian A, Walther T, Wendler O, Windecker S, Zamorano JL, Group ESCSD. 2017 ESC/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2017;38(36):2739–91.

    Article  PubMed  Google Scholar 

  229. Habib G, Lancellotti P, Antunes MJ, Bongiorni MG, Casalta JP, Del Zotti F, Dulgheru R, El Khoury G, Erba PA, Iung B, Miro JM, Mulder BJ, Plonska-Gosciniak E, Price S, Roos-Hesselink J, Snygg-Martin U, Thuny F, Tornos Mas P, Vilacosta I, Zamorano JL, Group ESCSD. 2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM). Eur Heart J. 2015;36(44):3075–128.

    Article  PubMed  Google Scholar 

  230. Olmos C, Vilacosta I, Fernandez-Perez C, Bernal JL, Ferrera C, Garcia-Arribas D, Perez-Garcia CN, San Roman JA, Maroto L, Macaya C, Elola FJ. The evolving nature of infective endocarditis in Spain: a population-based study (2003 to 2014). J Am Coll Cardiol. 2017;70(22):2795–804.

    Article  PubMed  Google Scholar 

  231. Rodbard S. Blood velocity and endocarditis. Circulation. 1963;27:18–28.

    Article  CAS  PubMed  Google Scholar 

  232. Cahill TJ, Prendergast BD. Infective endocarditis. Lancet. 2016;387(10021):882–93.

    Article  PubMed  Google Scholar 

  233. Bansal RC. Infective endocarditis. Med Clin North Am. 1995;79(5):1205–40.

    Article  CAS  PubMed  Google Scholar 

  234. Sivak JA, Vora AN, Navar AM, Schulte PJ, Crowley AL, Kisslo J, Corey GR, Liao L, Wang A, Velazquez EJ, Samad Z. An approach to improve the negative predictive value and clinical utility of transthoracic echocardiography in suspected native valve infective endocarditis. J Am Soc Echocardiogr. 2016;29(4):315–22.

    Article  PubMed  PubMed Central  Google Scholar 

  235. Sanfilippo AJ, Picard MH, Newell JB, Rosas E, Davidoff R, Thomas JD, Weyman AE. Echocardiographic assessment of patients with infectious endocarditis: prediction of risk for complications. J Am Coll Cardiol. 1991;18(5):1191–9.

    Article  CAS  PubMed  Google Scholar 

  236. Hyafil F, Rouzet F, Lepage L, Benali K, Raffoul R, Duval X, Hvass U, Iung B, Nataf P, Lebtahi R, Vahanian A, Le Guludec D. Role of radiolabelled leucocyte scintigraphy in patients with a suspicion of prosthetic valve endocarditis and inconclusive echocardiography. Eur Heart J Cardiovasc Imaging. 2013;14(6):586–94.

    Article  PubMed  Google Scholar 

  237. Saby L, Laas O, Habib G, Cammilleri S, Mancini J, Tessonnier L, Casalta JP, Gouriet F, Riberi A, Avierinos JF, Collart F, Mundler O, Raoult D, Thuny F. Positron emission tomography/computed tomography for diagnosis of prosthetic valve endocarditis: increased valvular 18F-fluorodeoxyglucose uptake as a novel major criterion. J Am Coll Cardiol. 2013;61(23):2374–82.

    Article  PubMed  Google Scholar 

  238. Rouzet F, Chequer R, Benali K, Lepage L, Ghodbane W, Duval X, Iung B, Vahanian A, Le Guludec D, Hyafil F. Respective performance of 18F-FDG PET and radiolabeled leukocyte scintigraphy for the diagnosis of prosthetic valve endocarditis. J Nucl Med. 2014;55(12):1980–5.

    Article  CAS  PubMed  Google Scholar 

  239. Gomes A, Glaudemans A, Touw DJ, van Melle JP, Willems TP, Maass AH, Natour E, Prakken NHJ, Borra RJH, van Geel PP, Slart R, van Assen S, Sinha B. Diagnostic value of imaging in infective endocarditis: a systematic review. Lancet Infect Dis. 2017;17(1):e1–e14.

    Article  PubMed  Google Scholar 

  240. Fisher MR, Forfia PR, Chamera E, Housten-Harris T, Champion HC, Girgis RE, Corretti MC, Hassoun PM. Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. Am J Respir Crit Care Med. 2009;179(7):615–21.

    Article  PubMed  PubMed Central  Google Scholar 

  241. Weber L, Rickli H, Haager PK, Joerg L, Weilenmann D, Brenner R, Taramasso M, Baier P, Maisano F, Maeder MT. Haemodynamic mechanisms and long-term prognostic impact of pulmonary hypertension in patients with severe aortic stenosis undergoing valve replacement. Eur J Heart Fail. 2019;21(2):172–81.

    Article  PubMed  Google Scholar 

  242. Galie N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, Simonneau G, Peacock A, Vonk Noordegraaf A, Beghetti M, Ghofrani A, Gomez Sanchez MA, Hansmann G, Klepetko W, Lancellotti P, Matucci M, McDonagh T, Pierard LA, Trindade PT, Zompatori M, Hoeper M, Group ESCSD. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J. 2016;37(1):67–119.

    Article  PubMed  Google Scholar 

  243. Cohen HA, Baird MG, Rouleau JR, Fuhrmann CF, Bailey IK, Summer WR, Strauss HW, Pitt B. Thallium 201 myocardial imaging in patients with pulmonary hypertension. Circulation. 1976;54(5):790–5.

    Article  CAS  PubMed  Google Scholar 

  244. Movahed MR, Hepner A, Lizotte P, Milne N. Flattening of the interventricular septum (D-shaped left ventricle) in addition to high right ventricular tracer uptake and increased right ventricular volume found on gated SPECT studies strongly correlates with right ventricular overload. J Nucl Cardiol. 2005;12(4):428–34.

    Article  PubMed  Google Scholar 

  245. Ho NC, Tran JR, Bektas A. Marfan’s syndrome. Lancet. 2005;366(9501):1978–81.

    Article  PubMed  Google Scholar 

  246. Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, Gatzoulis MA, Gohlke-Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of C, Association for European Paediatric C, Guidelines ESCCfP. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eur Heart J. 2010;31(23):2915–57.

    Article  PubMed  Google Scholar 

  247. Mohiaddin RH, Underwood SR, Bogren HG, Firmin DN, Klipstein RH, Rees RS, Longmore DB. Regional aortic compliance studied by magnetic resonance imaging: the effects of age, training, and coronary artery disease. Br Heart J. 1989;62(2):90–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  248. Kerwin W, Pepin M, Mitsumori L, Yarnykh V, Schwarze U, Byers P. MRI of great vessel morphology and function in Ehlers-Danlos syndrome type IV. Int J Cardiovasc Imaging. 2008;24(5):519–28.

    Article  PubMed  Google Scholar 

  249. Ferencik M, Pape LA. Changes in size of ascending aorta and aortic valve function with time in patients with congenitally bicuspid aortic valves. Am J Cardiol. 2003;92(1):43–6.

    Article  PubMed  Google Scholar 

  250. Guntheroth WG. A critical review of the American College of Cardiology/American Heart Association practice guidelines on bicuspid aortic valve with dilated ascending aorta. Am J Cardiol. 2008;102(1):107–10.

    Article  PubMed  Google Scholar 

  251. O'Brien KR, Cowan BR, Jain M, Stewart RA, Kerr AJ, Young AA. MRI phase contrast velocity and flow errors in turbulent stenotic jets. J Magn Reson Imaging. 2008;28(1):210–8.

    Article  PubMed  Google Scholar 

  252. Chin CW, Khaw HJ, Luo E, Tan S, White AC, Newby DE, Dweck MR. Echocardiography underestimates stroke volume and aortic valve area: implications for patients with small-area low-gradient aortic stenosis. Can J Cardiol. 2014;30(9):1064–72.

    Article  PubMed  Google Scholar 

  253. Weigang E, Kari FA, Beyersdorf F, Luehr M, Etz CD, Frydrychowicz A, Harloff A, Markl M. Flow-sensitive four-dimensional magnetic resonance imaging: flow patterns in ascending aortic aneurysms. Eur J Cardiothorac Surg. 2008;34(1):11–6.

    Article  PubMed  Google Scholar 

  254. Barker AJ, Markl M, Burk J, Lorenz R, Bock J, Bauer S, Schulz-Menger J, von Knobelsdorff-Brenkenhoff F. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circ Cardiovasc Imaging. 2012;5(4):457–66.

    Article  PubMed  Google Scholar 

  255. Edwards FH, Hale D, Cohen A, Thompson L, Pezzella AT, Virmani R. Primary cardiac valve tumors. Ann Thorac Surg. 1991;52(5):1127–31.

    Article  CAS  PubMed  Google Scholar 

  256. Kumar V, Soni P, Hashmi A, Moskovits M. Aortic valve fibroelastoma: a rare cause of stroke. BMJ Case Rep. 2016;2016.

    Google Scholar 

  257. Fleischmann KE, Schiller NB. Papillary fibroelastoma: move over myxoma. J Am Coll Cardiol. 2015;65(22):2430–2.

    Article  PubMed  Google Scholar 

  258. Klarich KW, Enriquez-Sarano M, Gura GM, Edwards WD, Tajik AJ, Seward JB. Papillary fibroelastoma: echocardiographic characteristics for diagnosis and pathologic correlation. J Am Coll Cardiol. 1997;30(3):784–90.

    Article  CAS  PubMed  Google Scholar 

  259. Tamin SS, Maleszewski JJ, Scott CG, Khan SK, Edwards WD, Bruce CJ, Oh JK, Pellikka PA, Klarich KW. Prognostic and bioepidemiologic implications of papillary fibroelastomas. J Am Coll Cardiol. 2015;65(22):2420–9.

    Article  PubMed  Google Scholar 

  260. Laguna G, Carrascal Y, Arce N, Martinez G. Incidental aortic valve myxoma: tumour excision and aortic valve repair. Eur J Cardiothorac Surg. 2015;48(3):510–1.

    Article  PubMed  Google Scholar 

  261. Butany J, Dixit V, Leong SW, Daniel LB, Mezody M, David TE. Inflammatory myofibroblastic tumor with valvular involvement: a case report and review of the literature. Cardiovasc Pathol. 2007;16(6):359–64.

    Article  PubMed  Google Scholar 

  262. Aziz F, Baciewicz FA Jr. Lambl’s excrescences: review and recommendations. Tex Heart Inst J. 2007;34(3):366–8.

    PubMed  PubMed Central  Google Scholar 

  263. Shapira N, Fernandez J, McNicholas KW, Serra AJ, Hirschfeld K, Spagna PM, Lemole GM. Hypertrophy of nodules of Arantius and aortic insufficiency: pathophysiology and repair. Ann Thorac Surg. 1991;51(6):969–72.

    Article  CAS  PubMed  Google Scholar 

  264. Peters PJ, Reinhardt S. The echocardiographic evaluation of intracardiac masses: a review. J Am Soc Echocardiogr. 2006;19(2):230–40.

    Article  PubMed  Google Scholar 

  265. Saric M, Armour AC, Arnaout MS, Chaudhry FA, Grimm RA, Kronzon I, Landeck BF, Maganti K, Michelena HI, Tolstrup K. Guidelines for the use of echocardiography in the evaluation of a cardiac source of embolism. J Am Soc Echocardiogr. 2016;29(1):1–42.

    Article  PubMed  Google Scholar 

  266. Sun JP, Asher CR, Yang XS, Cheng GG, Scalia GM, Massed AG, Griffin BP, Ratliff NB, Stewart WJ, Thomas JD. Clinical and echocardiographic characteristics of papillary fibroelastomas: a retrospective and prospective study in 162 patients. Circulation. 2001;103(22):2687–93.

    Article  CAS  PubMed  Google Scholar 

  267. Luo W, Teng P, Ni Y. A rare cardiac inflammatory myofibroblastic tumor involving aortic valve. J Cardiothorac Surg. 2017;12(1):13.

    Article  PubMed  PubMed Central  Google Scholar 

  268. Dumaswala B, Dumaswala K, Hsiung MC, Quiroz LD, Sungur A, Escanuela MG, Mehta K, Oz TK, Bhagatwala K, Karia NM, Nanda NC. Incremental value of three-dimensional transesophageal echocardiography over two-dimensional transesophageal echocardiography in the assessment of Lambl's excrescences and nodules of Arantius on the aortic valve. Echocardiography. 2013;30(8):967–75.

    Article  PubMed  Google Scholar 

  269. Baikoussis NG, Dedeilias P, Argiriou M, Argiriou O, Vourlakou C, Prapa E, Charitos C. Cardiac papillary fibroelastoma; when, how, why? Ann Card Anaesth. 2016;19(1):162–5.

    Article  PubMed  PubMed Central  Google Scholar 

  270. Motwani M, Kidambi A, Herzog BA, Uddin A, Greenwood JP, Plein S. MR imaging of cardiac tumors and masses: a review of methods and clinical applications. Radiology. 2013;268(1):26–43.

    Article  PubMed  Google Scholar 

  271. Palaskas N, Thompson K, Gladish G, Agha AM, Hassan S, Iliescu C, Kim P, Durand JB, Lopez-Mattei JC. Evaluation and management of cardiac tumors. Curr Treat Options Cardiovasc Med. 2018;20(4):29.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Heart Center, Zurich University Hospital, Zurich, Switzerland

    Edwin Ho, Mizuki Miura & Shehab Anwer

  2. Division of Cardiology, St. Michael’s Hospital, Toronto, ON, Canada

    Edwin Ho

  3. Division of Cardiology, Montefiore Medical Center, Bronx, NY, USA

    Edwin Ho

  4. Heart Surgery Unit, Zurich University Hospital, Zurich, Switzerland

    Alberto Pozzoli

  5. Cardiology Unit, Kantonsspital St. Gallen, St. Gallen, Switzerland

    Philipp Haager & Hans Rickli

  6. Radiology Unit, Innsbruck University Hospital, Innsbruck, Austria

    Gudrun Feuchtner & Thomas Senoner

  7. Radiology Unit, Zurich University Hospital, Zurich, Switzerland

    Fabian Morsbach & Hatem Alkadhi

  8. Nuclear Medicine Unit, Zurich University Hospital, Zurich, Switzerland

    Gräni Christoph, Buechel Ronny & Philipp Kaufmann

  9. Cardiology Unit, Zurich University Hospital, Zurich, Switzerland

    Michel Zuber & Felix Tanner

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Editors and Affiliations

  1. University of Zurich, Zurich, Switzerland

    Francesco Maisano

  2. University of Zurich, Zurich, Switzerland

    Philipp Kaufmann

  3. University Hospital of Zurich, Zurich, Switzerland

    Hatem Alkadhi

  4. Cardiology Unit, Zurich University Hospital, Zurich, Switzerland

    Michel Zuber

  5. Heart Surgery Unit, Zurich University Hospital, Zurich, Switzerland

    Alberto Pozzoli

  6. Heart Center, University of Zurich, Zurich, Switzerland

    Edwin Ho

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Ho, E. et al. (2020). Diagnosis, Indication and Timing. In: Maisano, F., Kaufmann, P., Alkadhi, H., Zuber, M., Pozzoli, A., Ho, E. (eds) Multimodality Imaging for Cardiac Valvular Interventions, Volume 1 Aortic Valve. Springer, Cham. https://doi.org/10.1007/978-3-030-27584-6_1

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