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Role of Ancillary Tests in Breast Fine Needle Aspiration Biopsy Cytopathology

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The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology

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Abstract

In this chapter, we review the main current applications of ancillary techniques in breast fine needle aspiration biopsy (FNAB) cytology. Contemporary ancillary techniques used in combination with FNAB of the breast range from “classic” immunocytochemistry (ICC) to modern molecular techniques, in particular, next-generation sequencing (NGS). The applications reviewed in this chapter include the primary diagnosis of a breast lesion, the identification of the breast as a primary source of a metastatic lesion, the evaluation of breast prognostic and predictive markers, and the tracking of tumor evolution. This chapter aims to elucidate the complexity of the many challenges traditionally associated with the application of ancillary techniques to FNAB of the breast and provide insights into some of the most cutting-edge and clinical useful application scenarios.

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Authors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA

    Francisco Beca

  2. Institute of Molecular Pathology and Immunology of Porto University (IPATIMUP), Medical Faculty of Porto University, Porto, Portugal

    Fernando Schmitt

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  1. Francisco Beca
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Correspondence to Fernando Schmitt .

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Editors and Affiliations

  1. University of NSW and University of Notre Dame Medical Schools, St Vincent’s Hospital, Sydney, Australia

    Andrew S. Field

  2. Flinders Medical Centre, Flinders University of South Australia and Clinpath Laboratories, Adelaide, Australia

    Wendy A. Raymond

  3. Institute of Molecular Pathology and Immunology of Porto University (IPATIMUP), Medical Faculty of Porto University, Porto, Portugal

    Fernando Schmitt

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Beca, F., Schmitt, F. (2020). Role of Ancillary Tests in Breast Fine Needle Aspiration Biopsy Cytopathology. In: Field, A.S., Raymond, W.A., Schmitt, F. (eds) The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology. Springer, Cham. https://doi.org/10.1007/978-3-030-26883-1_9

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