Abstract
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Maternal T cell engrafment has been reported in as many as 40% of newborns with severe combined immunodeficiency (SCID)
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Hypofunctioning T cells may facilitate persistent engraftment of maternal T lymphocytes, leading to alloreactive immune response referred as graft versus host disease (GVHD). Maternal engraftment syndrome typically present in a neonate/infant as rash and/or diarrhea
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One indicator that maternal T cell engraftment is present, is predominance of either CD4+ or CD8+ T cells since maternally engrafted cells are oligoclonal. A majority of the maternally engrafted T cells have an activated or memory phenotype and express CD45RO
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HLA typing, PCR-based short tandem repeat (STR) analysis or fluorescence in-situ hybridization (FISH) analysis, can help detect maternal engrafment syndrome
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Sule, H., Candan, I., Aydan, I. (2020). Recurrent Infections, Diarrhea and Hypereosinophilia. In: Rahmani, F., Rezaei, N. (eds) Pediatric Autoimmunity and Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-26280-8_51
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