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Nuclear Medicine in Infectious Diseases pp 61–71Cite as

Acquisition Protocols and Image Interpretation Criteria Nuclear Medicine Imaging of Infectious Diseases

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Abstract

Imaging infections with radiolabeled WBC requires precise strategies in order to differentiate them from sterile inflammatory conditions. Indeed, radiolabeled neutrophil, when injected into peripheral veins, has a peculiar biodistribution characterized by a short transit through the lungs (usually 30–60 min), followed by rapid accumulation into liver, spleen, and bone marrow with slow migration into infection sites. This migration process is slower in chronic, low-degree infections and faster in acute, high-degree infections, and it is believed that it is driven by the local production of chemotactic factors.

As a consequence of this biodistribution pattern, the imaging modalities, time of image acquisition, image display, and interpretation criteria should be standardized.

In this chapter, we describe the correct procedures as recently published as EANM guidelines.

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Authors and Affiliations

  1. Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, “Sapienza” University of Rome, Rome, Italy

    Alberto Signore & Chiara Lauri

  2. Regional Center of Nuclear Medicine, Pisa University Hospital, Pisa, Italy

    Elena Lazzeri

Authors
  1. Alberto Signore
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  2. Elena Lazzeri
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  3. Chiara Lauri
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Corresponding author

Correspondence to Alberto Signore .

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Editors and Affiliations

  1. Nuclear Medicine, Sapienza University of Rome, Rome, Italy

    Alberto Signore

  2. Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen, The Netherlands

    Andor W. J. M. Glaudemans

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Signore, A., Lazzeri, E., Lauri, C. (2020). Acquisition Protocols and Image Interpretation Criteria Nuclear Medicine Imaging of Infectious Diseases. In: Signore, A., Glaudemans, A. (eds) Nuclear Medicine in Infectious Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-25494-0_5

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  • DOI: https://doi.org/10.1007/978-3-030-25494-0_5

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  • Online ISBN: 978-3-030-25494-0

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