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Follicular Neoplasm Hürthle Cell (Oncocytic) Type/Suspicious for Follicular Neoplasm Hürthle Cell (Oncocytic) Type

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Atlas of Thyroid Cytopathology on Liquid-Based Preparations

Abstract

Hürthle cells are follicular-derived oncocytic cells originally described by Askanazy in 1898. They are also referred to as oncocytic, oxyphilic, and Askanazy cells.

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Suggested Reading

  1. Bronner MP, Clevenger CV, Edmonds PR, Lowell DM, McFarland MM, LiVolsi VA. Flow cytometric analysis of DNA content in Hürthle cell adenomas and carcinomas of the thyroid. Am J Clin Pathol. 1988;89:764–9.

    Article  CAS  Google Scholar 

  2. Canberk S, Griffin AC, Goyal A, Wang H, Montone K, Livolsi V, et al. Oncocytic follicular nodules of the thyroid with or without chronic lymphocytic thyroiditis: an institutional experience. Cytojournal. 2013;10:2. https://doi.org/10.4103/1742-6413.106686.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Carpi A, Rossi G, Mechanick JI, Nicolini A, Camici M, Russo MA, et al. Large needle aspiration biopsy histology for preoperative selection of Hürthle cell thyroid nodules. Histopathology. 2011;59:892–6. https://doi.org/10.1111/j.1365-2559.2011.04014.x.

    Article  PubMed  Google Scholar 

  4. Carr AA, Yen TWF, Ortiz DI, Hunt BC, Fareau G, Massey BL, et al. Patients with oncocytic variant papillary thyroid carcinoma have a similar prognosis to matched classical papillary thyroid carcinoma controls. Thyroid. 2018;28:1462–7. https://doi.org/10.1089/thy.2017.0603.

    Article  CAS  PubMed  Google Scholar 

  5. Ali SZ, Cibas ES. The Bethesda System for reporting thyroid cytopathology; definitions, criteria, and explanatory notes. 2nd ed. Cham: Springer International Publishing AG; 2018.

    Book  Google Scholar 

  6. Cibas ES, Ali SZ. The 2017 Bethesda System for reporting thyroid cytopathology. Thyroid. 2017;27:1341–6. https://doi.org/10.1089/thy.2017.0500.

    Article  PubMed  Google Scholar 

  7. Clark DP, Faquin WC. Thyroid cytopathology. 2nd ed. New York: Springer; 2010.

    Book  Google Scholar 

  8. Cochand-Priollet B, Prat JJ, Polivka M, Thienpont L, Dahan H, Wassef M, et al. Thyroid fine needle aspiration: the morphological features on ThinPrep slide preparations. Eighty cases with histological control. Cytopathology. 2003;14:343–9.

    Article  CAS  Google Scholar 

  9. Díaz Del Arco C, Fernández Aceñero MJ. Preoperative diagnosis of neoplastic or malignant Hürthle cell lesions: a chimera? Acta Cytol. 2018;62:193–203. https://doi.org/10.1159/000488441.

    Article  PubMed  Google Scholar 

  10. Duncan LD, Forrest L, Law WM Jr, Hubbard E, Stewart LE. Evaluation of thyroid fine-needle aspirations: can ThinPrep be used exclusively to appropriately triage patients having a thyroid nodule? Diagn Cytopathol. 2011;39:341–8. https://doi.org/10.1002/dc.21392.

    Article  PubMed  Google Scholar 

  11. Elliott DD, Pitman MB, Bloom L, Faquin WC. Fine-needle aspiration biopsy of Hürthle cell lesions of the thyroid gland: a cytomorphologic study of 139 cases with statistical analysis. Cancer. 2006;108:102–9.

    Article  Google Scholar 

  12. Giorgadze T, Rossi ED, Fadda G, Gupta PK, Livolsi VA, Baloch Z. Does the fine-needle aspiration diagnosis of “Hürthle-cell neoplasm/follicular neoplasm with oncocytic features” denote increased risk of malignancy? Diagn Cytopathol. 2004;31:307–12.

    Article  Google Scholar 

  13. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26:1–133. https://doi.org/10.1089/thy.2015.0020.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hoda RS. Non-gynecologic cytology on liquid-based preparations: a morphologic review of facts and artifacts. Diagn Cytopathol. 2007;35:621–34.

    Article  Google Scholar 

  15. Hoda RS, VandenBussche C, Hoda SA. Diagnostic liquid-based cytology. New York: Springer; 2017.

    Book  Google Scholar 

  16. Jung CK, Lee A, Jung ES, Choi YJ, Jung SL, Lee KY. Split sample comparison of a liquid-based method and conventional smears in thyroid fine needle aspiration. Acta Cytol. 2008;52:313–9.

    Article  Google Scholar 

  17. Kasper KA, Stewart J 3rd, Das K. Fine-needle aspiration cytology of thyroid nodules with Hürthle cells: cytomorphologic predictors for neoplasms, improving diagnostic accuracy and overcoming pitfalls. Acta Cytol. 2014;58:145–52. https://doi.org/10.1159/000358264.

    Article  CAS  PubMed  Google Scholar 

  18. Lloyd R, Osamura R, Klöppel G, Rosai J. WHO classification of tumours of endocrine organs. Lyon: International Agency for Research on Cancer; 2017.

    Google Scholar 

  19. Malle D, Valeri RM, Pazaitou-Panajiotou K, Kiziridou A, Vainas I, Destouni C. Use of a thin-layer technique in thyroid fine needle aspiration. Acta Cytol. 2006;50:23–7.

    Article  Google Scholar 

  20. Máximo V, Lima J, Prazeres H, Soares P, Sobrinho-Simões M. The biology and the genetics of Hürthle cell tumors of the thyroid. Endocr Relat Cancer. 2012;19:R131–47. https://doi.org/10.1530/ERC-11-0354.

    Article  CAS  PubMed  Google Scholar 

  21. Mete O, Asa SL. Oncocytes, oxyphils, Hürthle, and Askanazy cells: morphological and molecular features of oncocytic thyroid nodules. Endocr Pathol. 2010;21:16–24. https://doi.org/10.1007/s12022-009-9102-2.

    Article  PubMed  Google Scholar 

  22. Nikiforov YE, Biddinger PW, Thompson LDR. Diagnostic pathology and molecular genetics of the thyroid: a comprehensive guide for practicing thyroid pathology. 3rd ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2019.

    Google Scholar 

  23. Pearlstein S, Lahouti AH, Opher E, Nikiforov YE, Kuriloff DB. Thyroseq V3 molecular profiling for tailoring the surgical management of Hürthle cell neoplasms. Case Rep Endocrinol. 2018;2018:9329035. https://doi.org/10.1155/2018/9329035.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Rekhtman N, Buonocore DJ, Rudomina D, Friedlander M, Dsouza C, Aggarwal G, et al. Novel modification of HistoGel-based cell block preparation method: improved sufficiency for molecular studies. Arch Pathol Lab Med. 2018;142:529–35. https://doi.org/10.5858/arpa.2017-0030-OA.

    Article  CAS  PubMed  Google Scholar 

  25. Renshaw AA. Hürthle cell carcinoma is a better gold standard than Hürthle cell neoplasm for fine-needle aspiration of the thyroid: defining more consistent and specific cytologic criteria. Cancer. 2002;96:261–6.

    Article  Google Scholar 

  26. Rossi ED, Martini M, Straccia P, Raffaelli M, Pennacchia I, Marrucci E, et al. The cytologic category of oncocytic (Hürthle) cell neoplasm mostly includes low-risk lesions at histology: an institutional experience. Eur J Endocrinol. 2013;169:649–55. https://doi.org/10.1530/EJE-13-0431.

    Article  CAS  PubMed  Google Scholar 

  27. Rossi ED, Zannoni GF, Moncelsi S, Stigliano E, Santeusanio G, Lombardi CP, et al. Application of liquid-based cytology to fine-needle aspiration biopsies of the thyroid gland. Front Endocrinol (Lausanne). 2012;3:57. https://doi.org/10.3389/fendo.2012.00057.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Sobrinho-Simões M, Máximo V, Castro IV, Fonseca E, Soares P, Garcia-Rostan G, et al. Hürthle (oncocytic) cell tumors of thyroid: etiopathogenesis, diagnosis and clinical significance. Int J Surg Pathol. 2005;13:29–35.

    Article  Google Scholar 

  29. Tuzun D, Ersoy R, Yazgan AK, Kiyak G, Yalcin S, Cakir B. Cytomorphologic features and ultrasonographic characteristics of thyroid nodules with Hürthle cells. Ann Diagn Pathol. 2015;19:175–9. https://doi.org/10.1016/j.anndiagpath.2015.03.002.

    Article  PubMed  Google Scholar 

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Correspondence to Rana S. Hoda .

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Hoda, R.S., Rao, R., Scognamiglio, T. (2020). Follicular Neoplasm Hürthle Cell (Oncocytic) Type/Suspicious for Follicular Neoplasm Hürthle Cell (Oncocytic) Type. In: Hoda, R., Rao, R., Scognamiglio, T. (eds) Atlas of Thyroid Cytopathology on Liquid-Based Preparations. Springer, Cham. https://doi.org/10.1007/978-3-030-25066-9_7

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  • DOI: https://doi.org/10.1007/978-3-030-25066-9_7

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